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evodiamine
8,13,13b,14-tetrahydro-14-methylindolo[2'3'-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one

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CAS Number: 518-17-2Picture of molecule3D/inchi
FDA UNII: C01825BVNL
Nikkaji Web:J3.055.175C
MDL:MFCD06407824
XlogP3-AA:3.10 (est)
Molecular Weight:303.36469000
Formula:C19 H17 N3 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Appearance:white or pale yellow crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 575.07 °C. @ 760.00 mm Hg (est)
Flash Point: 575.00 °F. TCC ( 301.60 °C. ) (est)
logP (o/w): 3.888 (est)
Soluble in:
 water, 176.8 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Evodiamine 98%
BOC Sciences
For experimental / research use only.
Evodiamine >98%
Odor: characteristic
Use: Evodiamine (Isoevodiamine), an alkaloid extract from the fruit of Evodiae Fructus exhibits antitumor activities against the human tumor cells.
Changsha Organic Herb
Evodia Rutaecarpa Extract
Santa Cruz Biotechnology
For experimental / research use only.
Evodiamine 97%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for evodiamine usage levels up to:
 not for fragrance use.
 
Recommendation for evodiamine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :151289
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0000518172
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):151289
Pubchem (sid):135230371
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 indol(2',3':3,4)pyrido(2,1-b)quinazolin-5(7H)-one, 8,13,13b,14-tetrahydro-14-methyl-, (13bS)-
14-methyl-8,13,13b,14-tetrahydro-7H-indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5-one
14-methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
8,13,13b,14-tetrahydro-14-methylindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
8,13,13b,14-tetrahydro-14-methylindolo[2'3'-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one
 

Articles:

PubMed:Characteristics of evodiamine-exerted stimulatory effects on rat jejunal contractility.
PubMed:[Inhibitory effect of norcantharidin combined with evodiamine on the growth of human hepatic carcinoma cell line HepG2 in vitro].
PubMed:[Reseach on bioactive ingredients in rat liver after oral administration of different combinations of wuji pill].
PubMed:Evodiamine activates AMPK and promotes adiponectin multimerization in 3T3-L1 adipocytes.
PubMed:Antinociceptive activity of aqueous and alcohol extract of evodia rutaecarpa.
PubMed:Supermolecular evodiamine loaded water-in-oil nanoemulsions: Enhanced physicochemical and biological characteristics.
PubMed:Activation of JNK contributes to evodiamine-induced apoptosis and G2/M arrest in human colorectal carcinoma cells: a structure-activity study of evodiamine.
PubMed:Pretreatment by Evodiamine is Neuroprotective in Cerebral Ischemia: Up-Regulated pAkt, pGSK3β, Down-Regulated NF-κB Expression, and Ameliorated BBB Permeability.
PubMed:Effects of camptothecin derivatives and topoisomerase dual inhibitors on Trypanosoma cruzi growth and ultrastructure.
PubMed:Preparation, characterization, and anticancer efficacy of evodiamine-loaded PLGA nanoparticles.
PubMed:Evodiamine synergizes with doxorubicin in the treatment of chemoresistant human breast cancer without inhibiting P-glycoprotein.
PubMed:Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.
PubMed:The pharmacology of TRP channels.
PubMed:[Study on pharmacological ingredients of wuzhuyu tang treating migraine by correlating absorption ingredients in everted intestinal sac and pharmacodynamics].
PubMed:Metabolic activation of the indoloquinazoline alkaloids evodiamine and rutaecarpine by human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.
PubMed:Long-term effects of evodiamine on expressions of lipogenesis and lipolysis genes in mouse adipose and liver tissues.
PubMed:Evodiamine might inhibit TGF-beta1-induced epithelial-mesenchymal transition in NRK52E cells via Smad and PPAR-gamma pathway.
PubMed:Evodiamine induces apoptosis and enhances TRAIL-induced apoptosis in human bladder cancer cells through mTOR/S6K1-mediated downregulation of Mcl-1.
PubMed:New limonoids from Coptidis Rhizoma-Euodiae Fructus couple.
PubMed:Evodiamine and rutaecarpine alkaloids as highly selective transient receptor potential vanilloid 1 agonists.
PubMed:Growth inhibition and induction of apoptosis in SGC‑7901 human gastric cancer cells by evodiamine.
PubMed:Evodiamine Induces Transient Receptor Potential Vanilloid-1-Mediated Protective Autophagy in U87-MG Astrocytes.
PubMed:Study on pharmacokinetic and tissue distribution of lycorine in mice plasma and tissues by liquid chromatography-mass spectrometry.
PubMed:Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice.
PubMed:Design, synthesis and evaluation of N13-substituted evodiamine derivatives against human cancer cell lines.
PubMed:Capsaicin and evodiamine ingestion does not augment energy expenditure and fat oxidation at rest or after moderately-intense exercise.
PubMed:Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins.
PubMed:Berberine counteracts enhanced IL-8 expression of AGS cells induced by evodiamine.
PubMed:Activation of transient receptor potential vanilloid 1 decreases endothelial nitric oxide synthase phosphorylation at Thr497 by protein phosphatase 2B-dependent dephosphorylation of protein kinase C.
PubMed:Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels.
PubMed:Anti-Proliferative Effects of Evodiamine on Human Breast Cancer Cells.
PubMed:Evodiamine, a plant alkaloid, induces calcium/JNK-mediated autophagy and calcium/mitochondria-mediated apoptosis in human glioblastoma cells.
PubMed:Synergistic anticancer effects of polyphyllin I and evodiamine on freshly-removed human gastric tumors.
PubMed:A superparamagnetic Fe3O4-loaded polymeric nanocarrier for targeted delivery of evodiamine with enhanced antitumor efficacy.
PubMed:Simultaneous Quantification of Limonin, Two Indolequinazoline Alkaloids, and Four Quinolone Alkaloids in Evodia rutaecarpa (Juss.) Benth by HPLC-DAD Method.
PubMed:Evodiamine induces apoptosis and inhibits metastasis in MDA‑MB-231 human breast cancer cells in vitro and in vivo.
PubMed:Chiral high-performance liquid chromatographic separation of evodiamine enantiomers and rutaecarpine, isolated from Evodiae fructus.
PubMed:Simultaneous determination of three alkaloids, four ginsenosides and limonin in the plasma of normal and headache rats after oral administration of Wu-Zhu-Yu decoction by a novel ultra fast liquid chromatography-tandem mass spectrometry method: application to a comparative pharmacokinetics and ethological study.
PubMed:[Simultaneous determination of nine effective components in jiaweizuojin pills by ultra performance liquid chromatography with tandem mass spectrometry].
PubMed:Pharmacological actions of multi-target-directed evodiamine.
PubMed:Simultaneous determination of evodiamine and evodine in Beagle dog plasma using liquid chromatography tandem mass spectrometry.
PubMed:Simultaneous determination of six bioactive compounds in Evodiae Fructus by high-performance liquid chromatography with diode array detection.
PubMed:Differential expression of lipid metabolism genes in the liver and adipose tissue of mice treated with evodiamine.
PubMed:Topoisomerase I inhibitor evodiamine acts as an antibacterial agent against drug-resistant Klebsiella pneumoniae.
PubMed:Evodiamine activates autophagy as a cytoprotective response in murine Lewis lung carcinoma cells.
PubMed:Effect of novel synthetic evodiamine analogue on sexual behavior in male rats.
PubMed:Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells.
PubMed:Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis.
PubMed:Alkaloids isolated from natural herbs as the anticancer agents.
PubMed:Variations in the composition of Fructus Evodiae after processing with Radix Glycyrrhizae extract.
PubMed:Binding Mode Prediction of Evodiamine within Vanilloid Receptor TRPV1.
PubMed:A drug screening method based on the autophagy pathway and studies of the mechanism of evodiamine against influenza A virus.
PubMed:New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations.
PubMed:Investigation of the in vitro metabolism of evodiamine: characterization of metabolites and involved cytochrome p450 isoforms.
PubMed:In vitro cellular uptake of evodiamine and rutaecarpine using a microemulsion.
PubMed:New glycosidic alkaloid from the nearly ripe fruits of Euodia rutaecarpa.
PubMed:Transdermal behaviors comparisons among Evodia rutaecarpa extracts with different purity of evodiamine and rutaecarpine and the effect of topical formulation in vivo.
PubMed:Standardless 1H NMR determination of pharmacologically active substances in dietary supplements and medicines that have been illegally traded over the internet.
PubMed:Mosquito larvicidal activity of alkaloids and limonoids derived from Evodia rutaecarpa unripe fruits against Aedes albopictus (Diptera: Culicidae).
PubMed:Simultaneous determination of six alkaloids and one monoterpene in rat plasma by liquid chromatography-tandem mass spectrometry and pharmacokinetic study after oral administration of a Chinese medicine Wuji Pill.
PubMed:Preparation of evodiamine solid dispersions and its pharmacokinetics.
PubMed:Design and evaluation of a novel evodiamine-phospholipid complex for improved oral bioavailability.
PubMed:Implication of AMP-activated protein kinase in transient receptor potential vanilloid type 1-mediated activation of endothelial nitric oxide synthase.
PubMed:Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells.
PubMed:[Comparative study on pharmacokinetics of six major alkaloids in Zuojin Wan microemulsion based gel and hydrogel].
PubMed:[Effect of different compatibility of Wuji Wan on bile excretion of representative ingredient].
PubMed:Simultaneous determination and pharmacokinetic analysis of seven alkaloids and two flavonoids from rat plasma by HPLC-DAD after oral administration of Wuzhuyu decoction.
PubMed:[Studies on pharmacokinetics of evodiamine and rutaecarpine in rats plasma after oral administration extracts of euodiae fructus].
PubMed:Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy.
PubMed:[Synthesis, physicochemical and pharmacological properties of pentacyclic alkaloid-analogues].
PubMed:Simultaneous determination of evodiamine and rutecarpine in rabbit plasma by LC-ESI-MS and its application to pharmacokinetics.
PubMed:Pharmacokinetics and urine metabolite identification of dehydroevodiamine in the rat.
PubMed:Enhanced antitumor efficacy of gemcitabine by evodiamine on pancreatic cancer via regulating PI3K/Akt pathway.
PubMed:Pharmacokinetic comparisons of rutaecarpine and evodiamine after oral administration of Wu-Chu-Yu extracts with different purities to rats.
PubMed:Six alkaloids inhibit secretion of IL-1α, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.
PubMed:Enhanced transdermal delivery of evodiamine and rutaecarpine using microemulsion.
PubMed:Induction of apoptosis by evodiamine involves both activation of mitotic arrest and mitotic slippage.
PubMed:New strategies in the discovery of novel non-camptothecin topoisomerase I inhibitors.
PubMed:Evodia rutaecarpa and Three Major Alkaloids Abrogate Influenza A Virus (H1N1)-Induced Chemokines Production and Cell Migration.
PubMed:[Determination of evodiamine and rutacarpine in zhuyu hewei zhitong capsules by HPLC].
PubMed:Berberine and evodiamine influence serotonin transporter (5-HTT) expression via the 5-HTT-linked polymorphic region.
PubMed:[Optimization of a HPLC determination method for Evodia rutaecarpa].
PubMed:Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1.
PubMed:Inhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor-κB, and cellular transformation in HepG2 cells.
PubMed:Acid sphingomyelinase contributes to evodiamine-induced apoptosis in human gastric cancer SGC-7901 cells.
PubMed:Evodiamine improves congnitive abilities in SAMP8 and APP(swe)/PS1(ΔE9) transgenic mouse models of Alzheimer's disease.
PubMed:Evodiamine inhibits 12-O-tetradecanoylphorbol-13-acetate-induced activator protein 1 transactivation and cell transformation in human hepatocytes.
PubMed:Optimization of extraction of evodiamine and rutaecarpine from fruit of Evodia rutaecarpa using modified supercritical CO(2).
PubMed:Identification of marker compounds in herbal drugs on TLC with DART-MS.
PubMed:Selection of evodiamine as a novel topoisomerase I inhibitor by structure-based virtual screening and hit optimization of evodiamine derivatives as antitumor agents.
PubMed:Enhancement of shrimp antiviral immune response through caspase-dependent apoptosis by small molecules.
PubMed:Evodiamine as a novel antagonist of aryl hydrocarbon receptor.
PubMed:[Everted intestinal sac method for quick finding absorption ingredients of Wuzhuyu decoction].
PubMed:Simultaneous analysis of seven alkaloids in Coptis-Evodia herb couple and Zuojin pill by UPLC with accelerated solvent extraction.
PubMed:Targeting apoptosis pathways in cancer by Chinese medicine.
PubMed:A new quinolone and other constituents from the fruits of Tetradium ruticarpum: effects on neutrophil pro-inflammatory responses.
PubMed:Evodiamine induces caspase-dependent apoptosis and S phase arrest in human colon lovo cells.
PubMed:Immobilizing topoisomerase I on a surface plasmon resonance biosensor chip to screen for inhibitors.
PubMed:Anti-proliferative effects of evodiamine on human thyroid cancer cell line ARO.
PubMed:Protein tyrosine kinase pathway-derived ROS/NO productions contribute to G2/M cell cycle arrest in evodiamine-treated human cervix carcinoma HeLa cells.
PubMed:[Optimal processing techniques of preparing evodiae juice by orthognal experiment].
PubMed:[Determination of evodiamine and rutaecarpine of compound Wuzhuyu cataplasm in plasma by SPE-HPLC: application to its pharmacokinetics].
PubMed:[Assay of evodin, evodiamine and rutaecarpine in Fructus Evodiae by QAMS].
PubMed:Antagonistic effects of two herbs in Zuojin Wan, a traditional Chinese medicine formula, on catecholamine secretion in bovine adrenal medullary cells.
PubMed:Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-kappaB signaling pathways and augmented by ubiquitin-proteasome inhibition.
PubMed:Inhibitory effect of evodiamine alone and in combination with rosiglitazone on in vitro adipocyte differentiation and in vivo obesity related to diabetes.
PubMed:Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway.
PubMed:Inhibitory effect and transcriptional impact of berberine and evodiamine on human white preadipocyte differentiation.
PubMed:[Study on vitro release and transdermal behaviors of Yulian cataplasm].
PubMed:Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats.
PubMed:Antiproliferation and apoptosis induced by evodiamine in human colorectal carcinoma cells (COLO-205).
PubMed:Evodiamine: a novel anti-cancer alkaloid from Evodia rutaecarpa.
PubMed:Evodiamine stabilizes topoisomerase I-DNA cleavable complex to inhibit topoisomerase I activity.
PubMed:Evodiamine and rutaecarpine inhibit migration by LIGHT via suppression of NADPH oxidase activation.
PubMed:Evodiamine represses hypoxia-induced inflammatory proteins expression and hypoxia-inducible factor 1alpha accumulation in RAW264.7.
PubMed:Effect of herbal Ephedra sinica and Evodia rutaecarpa on body composition and resting metabolic rate: a randomized, double-blind clinical trial in Korean premenopausal women.
PubMed:Intragastric administration of evodiamine suppresses NPY and AgRP gene expression in the hypothalamus and decreases food intake in rats.
PubMed:Quality evaluation of Evodia rutaecarpa (Juss.) Benth by high performance liquid chromatography with photodiode-array detection.
PubMed:Immunoregulatory effect of evodiamine in mice of various germlines.
PubMed:The permeability and the efflux of alkaloids of the Evodiae fructus in the Caco-2 model.
PubMed:[Study of liquorice processing fructus].
PubMed:Enhancement of apoptosis of human hepatocellular carcinoma SMMC-7721 cells through synergy of berberine and evodiamine.
PubMed:Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells.
PubMed:Nitric oxide activated by p38 and NF-kappaB facilitates apoptosis and cell cycle arrest under oxidative stress in evodiamine-treated human melanoma A375-S2 cells.
PubMed:Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa.
PubMed:Synthesis of novel migrastatin and dorrigocin A analogues from D-glucal.
PubMed:A novel alkaloid from the fruits of Evodia officinalis.
PubMed:Critical roles of reactive oxygen species in mitochondrial permeability transition in mediating evodiamine-induced human melanoma A375-S2 cell apoptosis.
PubMed:Evodiamine improves diet-induced obesity in a uncoupling protein-1-independent manner: involvement of antiadipogenic mechanism and extracellularly regulated kinase/mitogen-activated protein kinase signaling.
PubMed:[Methodological studies on equivalent relationship between granule for clinical prescription and clinical decoction of fructus evodiae].
PubMed:[TLC-SERS study on evodiamine in evodia rutaecarpa].
PubMed:Anti-proliferative effects of evodiamine on human prostate cancer cell lines DU145 and PC3.
PubMed:Contents of constituents in mature and immature fruits of evodia species.
PubMed:YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia.
PubMed:In vitro and in vivo antiallergic effect of the fructus of Evodia rutaecarpa and its constituents.
PubMed:Studies on the alkaloid constituents of Evodia rutaecarpa (Juss) Benth var. bodinaieri (Dode) Huang and their acute toxicity in mice.
PubMed:Anti-inflammatory effects and mechanisms of the ethanol extract of Evodia rutaecarpa and its bioactive components on neutrophils and microglial cells.
PubMed:Quantitative analyses of indoloquinazoline alkaloids in Fructus Evodiae by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry.
PubMed:Caspase-dependent and caspase-independent apoptosis induced by evodiamine in human leukemic U937 cells.
PubMed:Chemical and biological comparisons on Evodia with two related species of different locations and conditions.
PubMed:Determination of evodiamine and rutecarpine in human serum by liquid chromatography-tandem mass spectrometry.
PubMed:Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms.
PubMed:Development and validation of HPLC methods for the analysis of phenethylamine and indoloquinazoline alkaloids in Evodia species.
PubMed:[Effect of protein kinase C on human melanoma A375-S2 cell death induced by evodiamine].
PubMed:Potential contribution of vasoconstriction to suppression of heat loss and homeothermic regulation in UCP1-deficient mice.
PubMed:Evodiamine inhibits in vitro angiogenesis: Implication for antitumorgenicity.
PubMed:Preparative isolation and purification of alkaloids from the Chinese medicinal herb Evodia rutaecarpa (Juss.) Benth by high-speed counter-current chromatography.
PubMed:Evodiamine induced human melanoma A375-S2 cell death partially through interleukin 1 mediated pathway.
PubMed:Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death.
PubMed:Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion.
PubMed:Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo.
PubMed:Protective effects of evodiamine on myocardial ischemia-reperfusion injury in rats.
PubMed:Induction of mitotic arrest and apoptosis in human prostate cancer pc-3 cells by evodiamine.
PubMed:[Studies on the chemical constituents of Evodia rutaecarpa (Juss.) Benth].
PubMed:Evodiamine functions as an agonist for the vanilloid receptor TRPV1.
PubMed:Inhibitory effects of evodiamine on the growth of human prostate cancer cell line LNCaP.
PubMed:Induction of mitotic arrest and apoptosis by evodiamine in human leukemic T-lymphocytes.
PubMed:Inhibition by evodiamine of hepatocyte growth factor-induced invasion and migration of tumor cells.
PubMed:Atypical apoptosis in L929 cells induced by evodiamine isolated from Evodia rutaecarpa.
PubMed:[Evodiamine induces A375-S2 cell death through two different pathways].
PubMed:Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis.
PubMed:[Advances in pharmacological study of Evodia rutaecarpa and its effective constituents].
PubMed:Intracellular regulation of evodiamine-induced A375-S2 cell death.
PubMed:The nociceptive and anti-nociceptive effects of evodiamine from fruits of Evodia rutaecarpa in mice.
PubMed:[Determination of evodiamine and rutaecarpine in Evodia rutaecarpa (Juss.) Benth after compatibility with Coptis chinensis Franch].
PubMed:Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells.
PubMed:Protective effects of calcitonin gene-related peptide-mediated evodiamine on guinea-pig cardiac anaphylaxis.
PubMed:[Studies on evodiamine induced HeLa cell apoptosis].
PubMed:Effects of evodiamine on gastrointestinal motility in male rats.
PubMed:Anti-invasive and metastatic activities of evodiamine.
PubMed:Effects of Wu-chu-yu-tang and its component herbs on drug-metabolizing enzymes.
PubMed:Modulation of drug-metabolizing enzymes by extracts of a herbal medicine Evodia rutaecarpa in C57BL/6J mice.
PubMed:Pharmacological profile of evodiamine in isolated rabbit corpus cavernosum.
PubMed:The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes.
PubMed:Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist.
PubMed:Inhibitory effect of evodiamine on aldosterone release by Zona glomerulosa cells in male rats.
PubMed:Inhibitory effects of evodiamine on in vitro invasion and experimental lung metastasis of murine colon cancer cells.
PubMed:Screening of natural compounds for inhibitory activity on colon cancer cell migration.
PubMed:The positive inotropic and chronotropic effects of evodiamine and rutaecarpine, indoloquinazoline alkaloids isolated from the fruits of Evodia rutaecarpa, on the guinea-pig isolated right atria: possible involvement of vanilloid receptors.
PubMed:The bronchoconstrictive action of evodiamine, an indoloquinazoline alkaloid isolated from the fruits of Evodia rutaecarpa, on guinea-pig isolated bronchus: possible involvement on vanilloid receptors.
PubMed:Effects of evodiamine on the secretion of testosterone in rat testicular interstitial cells.
PubMed:Effect of evodiamine on catecholamine secretion from bovine adrenal medulla.
PubMed:Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages.
PubMed:[Comparison of 4 extraction methods of chemical constituents in medicinal tea sishen chaji].
PubMed:Antinociceptive activities of 70% methanol extract of evodiae fructus (fruit of Evodia rutaecarpa var. bodinieri) and its alkaloidal components.
PubMed:Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa.
PubMed:[A simultaneous determination of evodiamine and rutaecarpine in oriental pharmaceutical decoctions containing Evodia fruit by ion-pair high-performance liquid chromatography].
PubMed:High-performance liquid chromatographic determination of evodiamine in rat plasma: application to pharmacokinetic studies.
PubMed:Thermoregulatory effects of alkaloids isolated from Wu-chu-yu in afebrile and febrile rats.
PubMed:Pharmacological properties of galenical preparation. XVI. Pharmacokinetics of evodiamine and the metabolite in rats.
PubMed:The vasorelaxant effect of evodiamine in rat isolated mesenteric arteries: mode of action.
PubMed:Pharmacological properties of galenical preparation. XIV. Body temperature retaining effect of the Chinese traditional medicine, "goshuyu-to" and component crude drugs.
PubMed:[On the evaluation of the preparation of Chinese medicinal prescriptions. VI. The changes of the alkaloid contents by processing of Evodia fruit].
PubMed:Antianoxic action of evodiamine, an alkaloid in Evodia rutaecarpa fruit.
PubMed:Antianoxic action and active constituents of evodiae fructus.
PubMed:Isolation of evodiamine, a powerful cardiotonic principle, from Evodia rutaecarpa Bentham (Rutaceae).
PubMed:Uterotonic effect of Evodia rutaecarpa alkaloids.
PubMed:[On the blood pressure and respiratory effects of Yasuhico Asahima's evodiamine].
 
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