EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

docetaxel
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol

Supplier Sponsors

CAS Number: 114977-28-5Picture of molecule3D/inchi
Other(deleted CASRN):129522-72-1
FDA UNII: 699121PHCA
Nikkaji Web:MFCD00800737
XlogP3:1.60 (est)
Molecular Weight:807.89121000
Formula:C43 H53 N O14
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 232.00 °C. @ 760.00 mm Hg
Boiling Point: 900.54 °C. @ 760.00 mm Hg (est)
Flash Point: 929.00 °F. TCC ( 498.40 °C. ) (est)
logP (o/w): 2.456 (est)
Soluble in:
 water, 0.02518 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Docetaxel 98%
BOC Sciences
For experimental / research use only.
Docetaxel > 95%
Odor: characteristic
Use: Docetaxel is a semisynthetic analog of taxol that inhibits microtubule disassembly (IC50 = 0.2 ?M) and inhibits cell replication (IC50 = 0.13 ?M). It has proven more effective than taxol in preventing the proliferation of cancer cells.
Carbosynth
For experimental / research use only.
Docetaxel
Glentham Life Sciences
Docetaxel
Santa Cruz Biotechnology
For experimental / research use only.
Docetaxel
Sigma-Aldrich
For experimental / research use only.
Docetaxel purum, ≥97.0% (HPLC)
Sinoway Industrial
For experimental / research use only.
Docetaxel
TCI AMERICA
For experimental / research use only.
Docetaxel >98.0%(HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50 2500 ug/kg
Seminars in Oncology. Vol. 22(Suppl

intravenous-man TDLo 24 mg/kg/9W-I
PERIPHERAL NERVE AND SENSATION: PARESTHESIS PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE BEHAVIORAL: MUSCLE WEAKNESS
Annals of Oncology. Vol. 8, Pg. 187, 1997.

intravenous-mouse LD50 156 mg/kg
Seminars in Oncology. Vol. 22(Suppl

intravenous-rat LDLo 20 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 39, Pg. 659, 1997.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for docetaxel usage levels up to:
 not for fragrance use.
 
Recommendation for docetaxel flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :64780
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0114977285
RTECS:DA4172750 for cas# 114977-28-5
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):64780
Pubchem (sid):135023101
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.99.9090
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
 docetaxel trihydrate
 

Articles:

PubMed:FDA Approval Summary: Pembrolizumab for Treatment of Metastatic Non-Small Cell Lung Cancer: First-Line Therapy and Beyond.
PubMed:New PD-L1 inhibitors in non-small cell lung cancer - impact of atezolizumab.
PubMed:Docetaxel-induced cardiac-respiratory arrest in a patient with chronic atrial fibrillation.
PubMed:U.S. Food and Drug Administration Approval Summary: Atezolizumab for Metastatic Non-Small Cell Lung Cancer.
PubMed:Immunotherapy in head and neck cancer: aiming at EXTREME precision.
PubMed:Impact of body composition parameters on clinical outcomes in patients with metastatic castrate-resistant prostate cancer treated with docetaxel.
PubMed:Safety and efficacy evaluation of pertuzumab in patients with solid tumors.
PubMed:The role of chemotherapy in unresectable or metastatic adenocarcinoma of the stomach and gastroesophageal junction.
PubMed:Development of MBRI-001, a deuterium-substituted plinabulin derivative as a potent anti-cancer agent.
PubMed:Prevalence of Circulating Tumor Cells After Adjuvant Chemotherapy With or Without Anthracyclines in Patients With HER2-negative, Hormone Receptor-positive Early Breast Cancer.
PubMed:Docetaxel-loaded PLGA and PLGA-PEG nanoparticles for intravenous application: pharmacokinetics and biodistribution profile.
PubMed:Pertuzumab and breast cancer: another piece in the anti-HER2 puzzle.
PubMed:Estimation of tumour regression and growth rates during treatment in patients with advanced prostate cancer: a retrospective analysis.
PubMed:Prostate-Specific Membrane Antigen Targeted Polymersomes for Delivering Mocetinostat and Docetaxel to Prostate Cancer Cell Spheroids.
PubMed:Generic oncology drugs: are they all safe?
PubMed:Ramucirumab for the treatment of advanced or metastatic non-small cell lung cancer.
PubMed:HALT-D: A Phase II Evaluation of Crofelemer for the Prevention and Prophylaxis of Diarrhea in Patients With Breast Cancer on Pertuzumab-Based Regimens.
PubMed:Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel improves survival for patients with peritoneal carcinomatosis from abdominal and pelvic malignancies.
PubMed:Delayed Anaphylaxis with Methimazole: Nicolau Syndrome After Oxytocin Intramuscular Administration Anastrazole-Induced Autoimmune Hepatitis Amoxicillin- and Cephalexin-Induced Eosinophilic Colitis Docetaxel-Induced Supravenous Erythematous Eruption.
PubMed:(-)-Epigallocatechin gallate (EGCG)-nanoethosomes as a transdermal delivery system for docetaxel to treat implanted human melanoma cell tumors in mice.
PubMed:Fabrication and biological evaluation of chitosan coated hyaluronic acid-docetaxel conjugate nanoparticles in CD44(+) cancer cells.
PubMed:Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulation.
PubMed:Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia.
PubMed:APOBEC3B expression in drug resistant MCF-7 breast cancer cell lines.
PubMed:Synergistic and attenuated effect of HSS in combination treatment with docetaxel plus cisplatin in human non-small-cell lung SPC-A-1 tumor xenograft.
PubMed:FDA Approval Summary: Nivolumab for the Treatment of Metastatic Non-Small Cell Lung Cancer With Progression On or After Platinum-Based Chemotherapy.
PubMed:Managing Liposarcomas: Cutting Through the Fat.
PubMed:Mechanistic Study of Inhibitory Effects of Atorvastatin and Docetaxel in Combination on Prostate Cancer.
PubMed:Some Anticancer Agents Act on Human Serum Paraoxonase-1 to Reduce Its Activity.
PubMed:Evaluation of TPGS-modified thermo-sensitive Pluronic PF127 hydrogel as a potential carrier to reverse the resistance of P-gp-overexpressing SMMC-7721 cell lines.
PubMed:The Effect of Docetaxel-Loaded Micro-Bubbles Combined with Low-Frequency Ultrasound in H22 Hepatocellular Carcinoma-Bearing Mice.
PubMed:Physio-Biochemical Composition and Untargeted Metabolomics of Cumin (Cuminum cyminum L.) Make It Promising Functional Food and Help in Mitigating Salinity Stress.
PubMed:Current Perspectives in Immunotherapy for Non-Small Cell Lung Cancer.
PubMed:Benefit-Risk Summary of Nivolumab for Patients With Metastatic Squamous Cell Lung Cancer After Platinum-Based Chemotherapy: A Report From the US Food and Drug Administration.
PubMed:U.S. Food and Drug Administration Approval Summary: Ramucirumab for the Treatment of Metastatic Non-Small Cell Lung Cancer Following Disease Progression On or After Platinum-Based Chemotherapy.
PubMed:Chemotherapy-associated paronychia treated with a dilute povidone-iodine/dimethylsulfoxide preparation.
PubMed:[Hormone therapy in prostate cancer; a pharmacotherapeutic challenge].
PubMed:Raspberry pulp polysaccharides inhibit tumor growth via immunopotentiation and enhance docetaxel chemotherapy against malignant melanoma in vivo.
PubMed:Pretreatment of in vitro matured bovine oocytes with docetaxel before vitrification: Effects on cytoskeleton integrity and developmental ability after warming.
PubMed:Genistein and cancer: current status, challenges, and future directions.
PubMed:U.S. Food and Drug Administration Approval Summary: Enzalutamide for the Treatment of Patients With Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer.
PubMed:Enzalutamide for patients with metastatic castration-resistant prostate cancer.
PubMed:Effects of Combined Soy Isoflavone Extract and Docetaxel Treatment on Murine 4T1 Breast Tumor Model.
PubMed:Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.
PubMed:Recombinant mutated human TNF in combination with chemotherapy for stage IIIB/IV non-small cell lung cancer: a randomized, phase III study.
PubMed:Therapy decisions for the symptomatic patient with metastatic castration-resistant prostate cancer.
PubMed:Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium.
PubMed:Survivin and PSMA Loaded Dendritic Cell Vaccine for the Treatment of Prostate Cancer.
PubMed:Protective effect of astragalus polysaccharides on liver injury induced by several different chemotherapeutics in mice.
PubMed:Radionuclide therapy for osseous metastases in prostate cancer.
PubMed:Docetaxel Loaded PEG-PLGA Nanoparticles: Optimized Drug Loading, In-vitro Cytotoxicity and In-vivo Antitumor Effect.
PubMed:First FDA approval of neoadjuvant therapy for breast cancer: pertuzumab for the treatment of patients with HER2-positive breast cancer.
PubMed:Population pharmacokinetic analysis of abiraterone in chemotherapy-naïve and docetaxel-treated patients with metastatic castration-resistant prostate cancer.
PubMed:FDA approval summary: crizotinib for the treatment of metastatic non-small cell lung cancer with anaplastic lymphoma kinase rearrangements.
PubMed:[Enzalutamide-a novel androgen receptor inhibitor that provides treatment options for patients with castration-resistant prostate cancer].
PubMed:Activity of cabazitaxel after docetaxel and abiraterone acetate therapy in patients with castration-resistant prostate cancer.
PubMed:Castration-resistant prostate cancer: latest evidence and therapeutic implications.
PubMed:Rat injury model of docetaxel extravasation.
PubMed:Pertuzumab in neoadjuvant treatment of HER2-positive early breast cancer.
PubMed:The role of cabazitaxel in the treatment of metastatic castration-resistant prostate cancer.
PubMed:Effects of anticancer drug docetaxel on the structure and function of the rabbit olfactory mucosa.
PubMed:Novel designed polyoxyethylene nonionic surfactant with improved safety and efficiency for anticancer drug delivery.
PubMed:Practical guide to the use of chemotherapy in castration resistant prostate cancer.
PubMed:Practical guide to the use of enzalutamide.
PubMed:Psoralen reverses docetaxel-induced multidrug resistance in A549/D16 human lung cancer cells lines.
PubMed:Targeted poly (L-γ-glutamyl glutamine) nanoparticles of docetaxel against folate over-expressed breast cancer cells.
PubMed:Solid lipid nanoparticle formulations of docetaxel prepared with high melting point triglycerides: in vitro and in vivo evaluation.
PubMed:Sequencing of agents for castration-resistant prostate cancer.
PubMed:Clinical Evaluation of Abiraterone in the Treatment of Metastatic Prostate Cancer.
PubMed:Enzalutamide (Xtandi) for patients with metastatic, resistant prostate cancer.
PubMed:Experimentation with inhaled bronchodilators and corticosteroids.
PubMed:US Food and Drug Administration approval of drugs for the treatment of prostate cancer: a new era has begun.
PubMed:Metastatic castration resistant prostate cancer: current strategies of management in the Middle East.
PubMed:The ErbB/HER family of protein-tyrosine kinases and cancer.
PubMed:An automated nanoparticle-based homogeneous immunoassay for determining docetaxel concentrations in plasma.
PubMed:Cabazitaxel: A novel taxane for metastatic castration-resistant prostate cancer-current implications and future prospects.
PubMed:Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis.
PubMed:Abiraterone acetate in combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer: U.S. Food and Drug Administration drug approval summary.
PubMed:Enzalutamide for treatment of patients with metastatic castration-resistant prostate cancer who have previously received docetaxel: U.S. Food and Drug Administration drug approval summary.
PubMed:Combined quantification of paclitaxel, docetaxel and ritonavir in human feces and urine using LC-MS/MS.
PubMed:Pertuzumab for the treatment of human epidermal growth factor receptor type 2-positive metastatic breast cancer.
PubMed:Prevalence of pain and analgesic use in men with metastatic prostate cancer using a patient-reported outcome measure.
PubMed:Pertuzumab: optimizing HER2 blockade.
PubMed:Potential use of custirsen to treat prostate cancer.
PubMed:Pertuzumab in breast cancer: a systematic review.
PubMed:First FDA approval of dual anti-HER2 regimen: pertuzumab in combination with trastuzumab and docetaxel for HER2-positive metastatic breast cancer.
PubMed:Role of immunotherapy in castration-resistant prostate cancer (CRPC).
PubMed:New treatment options for castration-resistant prostate cancer.
PubMed:Pertuzumab : evolving therapeutic strategies in the management of HER2-overexpressing breast cancer.
PubMed:Enzalutamide for the treatment of castration-resistant prostate cancer.
PubMed:Castrate-resistant prostate cancer: postdocetaxel management.
PubMed:Dynamic cost-effectiveness of oncology drugs.
PubMed:Agents that target androgen synthesis in castration-resistant prostate cancer.
PubMed:Enzalutamide: a novel antiandrogen for patients with castrate-resistant prostate cancer.
PubMed:Update on taxane development: new analogs and new formulations.
PubMed:Paclitaxel-based versus docetaxel-based regimens in metastatic breast cancer: a systematic review and meta-analysis of randomized controlled trials.
PubMed:The unfolding treatment landscape for men with castration-resistant prostate cancer.
PubMed:Enzalutamide (formerly MDV3100) as a new therapeutic option for men with metastatic castration-resistant prostate cancer.
PubMed:Involvement of hypothalamic cyclooxygenase-2, interleukin-1β and melanocortin in the development of docetaxel-induced anorexia in rats.
PubMed:Taste alteration in breast cancer patients treated with taxane chemotherapy: experience, effect, and coping strategies.
PubMed:A changing landscape in castration-resistant prostate cancer treatment.
PubMed:Pertuzumab (Perjecta) for HER2-positive metastatic breast cancer.
PubMed:Medical strategies for treatment of castration resistant prostate cancer (CRPC) docetaxel resistant.
PubMed:NC-6301, a polymeric micelle rationally optimized for effective release of docetaxel, is potent but is less toxic than native docetaxel in vivo.
PubMed:Abiraterone for the treatment of metastatic castrate-resistant prostate cancer.
PubMed:Low morbidity after palliation of obstructing gastro-oesophageal adenocarcinoma to restore swallowing function.
PubMed:Managing side effects of the novel taxane cabazitaxel in castrate-resistant prostate cancer.
PubMed:Novel agents for the management of castration-resistant prostate cancer.
PubMed:Emerging and second line therapies for the management of metastatic castration-resistant prostate cancer: the Australian perspective.
PubMed:Paeoniflorin inhibits growth of human colorectal carcinoma HT 29 cells in vitro and in vivo.
PubMed:Novel strategies in the treatment of castration-resistant prostate cancer (Review).
PubMed:State-of-the-Art Management for the Patient with Castration-Resistant Prostate Cancer in 2012.
PubMed:Trastuzumab Emtansine (T-DM1): Hitching a Ride on a Therapeutic Antibody.
PubMed:New and emerging agents for the treatment of castration-resistant prostate cancer.
PubMed:Management Options in Advanced Prostate Cancer: What is the Role for Sipuleucel-T?
PubMed:EGCG inhibits the invasion of highly invasive CL1-5 lung cancer cells through suppressing MMP-2 expression via JNK signaling and induces G2/M arrest.
PubMed:Hypersensitivity reactions to anticancer agents: data mining of the public version of the FDA adverse event reporting system, AERS.
PubMed:Clinical roundtable monograph: new and emerging treatments for advanced prostate cancer.
PubMed:Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report.
PubMed:New treatment options for castrate-resistant prostate cancer: a urology perspective.
PubMed:Effect of grapefruit juice on the pharmacokinetics of docetaxel in cancer patients: a case report.
PubMed:Translating scientific advancement into clinical benefit for castration-resistant prostate cancer patients.
PubMed:New and emerging treatments for advanced prostate cancer.
PubMed:Broadening horizons in medical management of prostate cancer.
PubMed:Description of anaphylactic reactions to paclitaxel and docetaxel reported to the FDA, with a focus on the role of premedication.
PubMed:Current clinical trials in castrate-resistant prostate cancer.
PubMed:Trastuzumab emtansine: a novel antibody-drug conjugate for HER2-positive breast cancer.
PubMed:Eribulin -- a review of preclinical and clinical studies.
PubMed:PROVENGE (Sipuleucel-T) in prostate cancer: the first FDA-approved therapeutic cancer vaccine.
PubMed:Current treatment strategies for castration-resistant prostate cancer.
PubMed:Cabazitaxel: a novel second-line treatment for metastatic castration-resistant prostate cancer.
PubMed:Role of second-line systemic treatment post-docetaxel in metastatic castrate resistant prostate cancer- current strategies and future directions.
PubMed:Unresectable gastric cancer with gastric outlet obstruction and distant metastasis responding to intraperitoneal and folfox chemotherapy after palliative laparoscopic gastrojejunostomy: report of a case.
PubMed:Approval summary: erlotinib maintenance therapy of advanced/metastatic non-small cell lung cancer (NSCLC).
PubMed:FDA-approved drugs.
PubMed:Update: immunological strategies for prostate cancer.
PubMed:Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial.
PubMed:Peripheral olfactory sensitivity in rodents after treatment with docetaxel.
PubMed:Optimizing the use of docetaxel in men with castration-resistant metastatic prostate cancer.
PubMed:Approval summary: pemetrexed in the initial treatment of advanced/metastatic non-small cell lung cancer.
PubMed:Reversal of docetaxel resistance with bevacizumab and thalidomide.
PubMed:Lack of in vitro interactions using human liver microsomes between rabeprazole and anticancer drugs.
PubMed:Ovarian cancer (advanced).
PubMed:Gefitinib in advanced non-small cell lung cancer: does it deserve a second chance?
PubMed:Second-line chemotherapy for advanced hormone-refractory prostate cancer.
PubMed:Systemic treatment for advanced (stage IIIb/IV) non-small cell lung cancer: more treatment options; more things to consider. Introduction.
PubMed:Sipuleucel-T: a vaccine for metastatic, asymptomatic, androgen-independent prostate cancer.
PubMed:New paradigms for advanced prostate cancer.
PubMed:Salvage therapy in patients with advanced non-small cell lung cancer.
PubMed:New, expanded, and modified use of approved antineoplastic agents in ovarian cancer.
PubMed:Second-line Therapy for advanced non-small-cell lung cancer.
PubMed:[A case report of small cell carcinoma of the esophagus successfully treated by irinotecan and cisplatin].
PubMed:Nanoparticle albumin-bound paclitaxel for treatment of metastatic breast cancer.
PubMed:The treatment of hormone-refractory prostate cancer: docetaxel and beyond.
PubMed:The role of capecitabine in first-line treatment for patients with metastatic breast cancer.
PubMed:Second-line treatment for advanced-stage non-small-cell lung cancer: current and future options.
PubMed:Determination of docetaxel and Paclitaxel in human plasma by high-performance liquid chromatography: validation and application to clinical pharmacokinetic studies.
PubMed:Clinical features and correlates of gemcitabine-associated lung injury: findings from the RADAR project.
PubMed:Docetaxel-based regimens, the standard of care for metastatic androgen-insensitive prostate cancer.
PubMed:Atrasentan for metastatic hormone refractory prostate cancer.
PubMed:Second- and third-line treatments in non-small cell lung cancer.
PubMed:Adjuvant chemotherapy for early breast cancer: optimal use of epirubicin.
PubMed:Pemetrexed: a multitargeted antifolate.
PubMed:Topotecan: weighing in when there are many options.
PubMed:Phase II trial of tesmilifene plus mitoxantrone and prednisone for hormone refractory prostate cancer: high subjective and objective response in patients with symptomatic metastases.
PubMed:Novel therapeutic approaches to advanced prostate cancer.
PubMed:FDA drug approval summary: pemetrexed for injection (Alimta) for the treatment of non-small cell lung cancer.
PubMed:Future directions in the treatment of androgen-independent prostate cancer.
PubMed:Docetaxel in the management of ovarian cancer.
PubMed:Chemotherapy for advanced prostate cancer: results of new clinical trials and future studies.
PubMed:[Stomach cancer].
PubMed:A sesquiterpenelactone from Inula britannica induces anti-tumor effects dependent on Bcl-2 phosphorylation.
PubMed:Capecitabine: a review.
PubMed:Innovations in antineoplastic therapy.
PubMed:[Treatment of androgen-independent hormone refractory prostate cancer using docetaxel].
PubMed:Development of docetaxel in advanced non-small-cell lung cancer.
PubMed:Approval summary: Docetaxel in combination with prednisone for the treatment of androgen-independent hormone-refractory prostate cancer.
PubMed:Therapeutic advances in second-line treatment of advanced non-small-cell lung cancer.
PubMed:CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line.
PubMed:Accelerated approval of oncology products: a decade of experience.
PubMed:Pemetrexed in advanced NSCLC: a review of the clinical data.
PubMed:Pemetrexed: a novel antifolate agent enters clinical practice.
PubMed:Gefitinib: a new antineoplastic for advanced non-small-cell lung cancer.
PubMed:Highlights from the Tenth World Conference on Lung Cancer.
PubMed:United States Food and Drug Administration Drug Approval summary: Gefitinib (ZD1839; Iressa) tablets.
PubMed:Temozolomide in non-small-cell lung cancer: preliminary results of a phase II trial in previously treated patients.
PubMed:FDA drug approval summary: gefitinib (ZD1839) (Iressa) tablets.
PubMed:A third-generation matrix metalloproteinase (MMP) inhibitor (ONO-4817) combined with docetaxel suppresses progression of lung micrometastasis of MMP-expressing tumor cells in nude mice.
PubMed:Gemcitabine-based therapy in pancreas cancer: gemcitabine-docetaxel and other novel combinations.
PubMed:Trastuzumab/chemotherapy combinations in metastatic breast cancer.
PubMed:Docetaxel for locally advanced or metastatic non-small-cell lung cancer. Current data and future directions as front-line therapy.
PubMed:Preclinical and clinical studies of docetaxel and exisulind in the treatment of human lung cancer.
PubMed:Drug combination approved for advanced breast cancer.
PubMed:From the Food and Drug Administration.
PubMed:Clinical pharmacokinetics of capecitabine.
PubMed:Chemotherapy for advanced hormone refractory prostate cancer.
PubMed:Docetaxel (Taxotere) and estramustine versus mitoxantrone and prednisone for hormone-refractory prostate cancer: scientific basis and design of Southwest Oncology Group Study 9916.
PubMed:Docetaxel and gemcitabine released for cancer chemotherapy.
 
Notes:
semisynthetic analog of taxol; 148408-66-6 is the isomer (2ar-(2aalpha,4beta,4abeta,6beta,9alpha(alphar*,betas*),11alpha,12alpha,12aalpha,12balpha)).
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