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10-deacetyl baccatin III
5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate

Supplier Sponsors

CAS Number: 32981-86-5Picture of molecule3D/inchi
FDA UNII: 4K6EWW2Z45
Nikkaji Web:J510.941H
MDL:MFCD00132913
XlogP3:0.60 (est)
Molecular Weight:544.59792000
Formula:C29 H36 O10
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white to pale yellow crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 716.84 °C. @ 760.00 mm Hg (est)
Flash Point: 452.00 °F. TCC ( 233.50 °C. ) (est)
logP (o/w): 0.156 (est)
Soluble in:
 water, 83.38 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
10-Deacetylbaccatin III 98%
BOC Sciences
For experimental / research use only.
10-Deacetyl Baccatin III >98%
Odor: characteristic
Use: 10-Deacetylbaccatin-III is an antineoplastic agent and an anti-cancer intermediate.
Jiangyin Healthway
10-Deacetyl Baccation III
New functional food ingredients
Santa Cruz Biotechnology
For experimental / research use only.
10-Deacetylbaccatin-III
Sigma-Aldrich: Sigma
For experimental / research use only.
10-Deacetylbaccatin III from Taxus baccata ≥95% (HPLC)
sds
TCI AMERICA
For experimental / research use only.
10-Deacetylbaccatin III >98.0%(HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for 10-deacetyl baccatin III usage levels up to:
 not for fragrance use.
 
Recommendation for 10-deacetyl baccatin III flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :154272
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0032981865
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):154272
Pubchem (sid):135109896
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C11700
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.99.7000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 taxus baccata
Search Trop Picture
 
Synonyms:
10-deacetylbaccatin
10-deacetylbaccatin III
5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate
 

Articles:

PubMed:Docetaxel epimerization in silicone films: a case of drug excipient incompatibility.
PubMed:Enhanced taxane production and secretion from Taxus baccata cell culture by adding dimethylsulfoxide.
PubMed:Concomitant pseudopolymorphs of 10-deacetyl baccatin III.
PubMed:Optimization of the basal medium for improving production and secretion of taxanes from suspension cell culture of Taxus baccata L.
PubMed:Development of an indirect competitive enzyme-linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel.
PubMed:[High performance liquid chromatographic fingerprints method for the analysis of chloroform extracts of Taxus wallichiana].
PubMed:Encapsulated activated charcoal as a potent agent for improving taxane synthesis and recovery from cultures.
PubMed:Production, purification and characterization of taxol and 10DAB III from a new endophytic fungus Gliocladium sp. isolated from the Indian yew tree, Taxus baccata.
PubMed:Isolation and characterization of degradation impurities in docetaxel drug substance and its formulation.
PubMed:[The extraction and separation of an active and available component from Taxus mairei].
PubMed:Isolation and characterization of impurities in docetaxel.
PubMed:Cytotoxic, antiviral (in-vitro and in-vivo), immunomodulatory activity and influence on mitotic divisions of three taxol derivatives: 10-deacetyl-baccatin III, methyl (N-benzoyl-(2'R,3'S)-3'-phenylisoserinate) and N-benzoyl-(2'R,3'S)-3'-phenylisoserine.
PubMed:Dependence of selectivity on eluent composition and temperature in the HPLC separation of taxanes using fluorinated and hydrocarbon phases.
PubMed:Analysis of pharmaceutically relevant taxoids in wild yew trees from Sardinia.
PubMed:13C NMR investigation of solid-state polymorphism in 10-deacetyl baccatin III.
PubMed:Antiangiogenic and antitumor activity of IDN 5390, a new taxane derivative.
PubMed:10-Deacetyl baccatin III dimethyl sulfoxide disolvate.
PubMed:Synthesis of taxoids 5. Synthesis and evaluation of novel water-soluble prodrugs of a 3'-desphenyl-3'-cyclopropyl analogue of docetaxel.
PubMed:[Chemical constituents of Taxus yunnanensis Cheng et L. K. Fu].
PubMed:Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew.
PubMed:[Taxoids: structural and experimental properties].
PubMed:Preclinical evaluation of docetaxel (Taxotere).
PubMed:Structure-activity relationships of Taxol and Taxotere analogues.
 
Notes:
None found
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