EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

aloin
barbaloin

Supplier Sponsors

CAS Number: 1415-73-2Picture of molecule3D/inchi
Other:10361-17-8
ECHA EINECS - REACH Pre-Reg:215-808-0
FDA UNII:648RW354S9
Nikkaji Web:J14.990J
Beilstein Number:6077558
MDL:MFCD00151160
XlogP3-AA:-0.10 (est)
Molecular Weight:434.39834000
Formula:C21 H22 O10
NMR Predictor:Predict (works with chrome or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:yellow powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 752.60 °C. @ 760.00 mm Hg (est)
Flash Point: 514.00 °F. TCC ( 268.00 °C. ) (est)
logP (o/w): 0.944 (est)
Soluble in:
 water, 8300 mg/L @ 20 °C (exp)
 water, 237.7 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
barbaloin
Carbosynth
For experimental / research use only.
Aloin
ExtraSynthese
For experimental / research use only.
Aloin A (HPLC) ≥98%
Glentham Life Sciences
Aloin A, 97%
Glentham Life Sciences
Aloin
OQEMA
Aloin (20% and 40%)
Santa Cruz Biotechnology
For experimental / research use only.
Aloin
Sigma-Aldrich: Sigma
For experimental / research use only.
Aloin from Aloe barbadensis Miller leaves, ≥97%
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-cat LDLo 500 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1298, 1935.

intravenous-mouse LD50 200 mg/kg
"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 8(2), Pg. 314, 1982.

Dermal Toxicity:
subcutaneous-rabbit LDLo 200 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1298, 1935.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: natural substances and extractives
Recommendation for aloin usage levels up to:
 not for fragrance use.
 
Recommendation for aloin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :14989
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(10R)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one
Chemidplus:0001415732
RTECS:LZ6520000 for cas# 1415-73-2
 
References:
 (10R)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):14989
Pubchem (sid):134978872
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
KEGG (GenomeNet):C17778
HMDB (The Human Metabolome Database):HMDB35219
FooDB:FDB013867
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 aloe leaf
Search Trop Picture
 
Synonyms:
 aloinum
10-(1',5'-anhydroglucosyl)-aloe-emodin-9-anthrone
 barbaloin
(10R)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one
(10R)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-9(10H)-anthracenone
 

Articles:

PubMed:Formulation of an aloe-based product according to Iranian traditional medicine and development of its analysis method.
PubMed:Quantitative Analysis of Aloins and Aloin-Emodin in Aloe Vera Raw Materials and Finished Products Using High-Performance Liquid Chromatography: Single-Laboratory Validation, First Action 2016.09.
PubMed:Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India.
PubMed:Barbaloin pretreatment attenuates myocardial ischemia-reperfusion injury via activation of AMPK.
PubMed:Anti-proliferation and anti-metastasis effect of barbaloin in non-small cell lung cancer via inactivating p38MAPK/Cdc25B/Hsp27 pathway.
PubMed:Aloin, a Component of the Aloe Vera Plant Leaf, Induces Pathological Changes and Modulates the Composition of Microbiota in the Large Intestine of F344/N Male Rats.
PubMed:Quantitative Analysis of Aloins and Aloin-Emodin in Aloe Vera Raw Materials and Finished Products Using High-Performance Liquid Chromatography: Single-Laboratory Validation, First Action 2016.09.
PubMed:Correction: Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks.
PubMed:Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks.
PubMed:Aloe activated P-glycoprotein and CYP 3A: a study on the serum kinetics of aloe and its interaction with cyclosporine in rats.
PubMed:An HPLC Procedure for the Quantification of Aloin in Latex and Gel from Aloe barbadensis Leaves.
PubMed:Medicinal plants used in Lesotho for treatment of reproductive and post reproductive problems.
PubMed:Use of Random Amplified Polymorphic DNA (RAPD) Technique to Study the Genetic Diversity of Eight Aloe Species.
PubMed:In Silico Screening of Antibacterial Compounds from Herbal Sources Against Vibrio cholerae.
PubMed:NF-κB pathway inhibition by anthrocyclic glycoside aloin is key event in preventing osteoclastogenesis in RAW264.7 cells.
PubMed:Aloin Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells.
PubMed:The Inhibitory Effect of Natural Products on Protein Fibrillation May Be Caused by Degradation Products--A Study Using Aloin and Insulin.
PubMed:Anthraquinone Glycoside Aloin Induces Osteogenic Initiation of MC3T3-E1 Cells: Involvement of MAPK Mediated Wnt and Bmp Signaling.
PubMed:Poorly soluble cobalt oxide particles trigger genotoxicity via multiple pathways.
PubMed:Protective effects of aloin on oxygen and glucose deprivation-induced injury in PC12 cells.
PubMed:Aloin Protects Skin Fibroblasts from Heat Stress-Induced Oxidative Stress Damage by Regulating the Oxidative Defense System.
PubMed:Physico-chemical evaluation of bitter and non-bitter Aloe and their raw juice for human consumption.
PubMed:Structural elucidation of some antimicrobial constituents from the leaf latex of Aloe trigonantha L.C. Leach.
PubMed:A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs.
PubMed:Ethnobotanical survey of medicinal plants used in the Maseru district of Lesotho.
PubMed:Determination of Aloin A and Aloin B in Aloe vera Raw Materials and Finished Products by High-Performance Liquid Chromatography: Single-Laboratory Validation.
PubMed:Rapid in situ identification of bioactive compounds in plants by in vivo nanospray high-resolution mass spectrometry.
PubMed:Chick embryo chorioallantoic membrane (CAM): an alternative predictive model in acute toxicological studies for anti-cancer drugs.
PubMed:Natural phosphodiesterase-4 inhibitors from the leaf skin of Aloe barbadensis Miller.
PubMed:Prioritizing targets for structural biology through the lens of proteomics: the archaeal protein TGAM_1934 from Thermococcus gammatolerans.
PubMed:Aloin delivery on buccal mucosa: ex vivo studies and design of a new locoregional dosing system.
PubMed:Phytochemical constituents and in vitro radical scavenging activity of different Aloe species.
PubMed:Aloin: a natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities.
PubMed:A new antimicrobial anthrone from the leaf latex of Aloe trichosantha.
PubMed:Phytochemistry and antileishmanial activity of the leaf latex of Aloe calidophila Reynolds.
PubMed:[Structural characterization and spectroscopic analysis of the aloin].
PubMed:New cytotoxic cycloartane triterpene from Cassia italica aerial parts.
PubMed:Anti-inflammatory and antioxidant effects of Aloe saponaria Haw in a model of UVB-induced paw sunburn in rats.
PubMed:Low-solubility particles and a Trojan-horse type mechanism of toxicity: the case of cobalt oxide on human lung cells.
PubMed:Aloin protects against chronic alcoholic liver injury via attenuating lipid accumulation, oxidative stress and inflammation in mice.
PubMed:Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolense field isolate.
PubMed:Controlled Aloin Release from Crosslinked Polyacrylamide Hydrogels: Effects of Mesh Size, Electric Field Strength and a Conductive Polymer.
PubMed:Chemical constituents of Aloe barbadensis Miller and their inhibitory effects on phosphodiesterase-4D.
PubMed:Evaluation of therapeutic potential of nanosilver particles synthesised using aloin in experimental murine mastitis model.
PubMed:Chemopreventive effects of aloin against 1,2-dimethylhydrazine-induced preneoplastic lesions in the colon of Wistar rats.
PubMed:Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo.
PubMed:Immobilization of aloin encapsulated into liposomes in layer-by-layer films for transdermal drug delivery.
PubMed:Barbaloin: a concise report of its pharmacological and analytical aspects.
PubMed:Antimycobacterial effect of extract and its components from Rheum rhaponticum.
PubMed:Is it possible to increase the aloin content of Aloe vera by the use of ultraviolet light?
PubMed:Anthraquinone-2-sulfonic acid (AQ2S) is a novel neurotherapeutic agent.
PubMed:Synergic study of α-glucosidase inhibitory action of aloin and its antioxidant activity with and without camel β-casein and its peptides.
PubMed:Antiviral activity of Aloe hijazensis against some haemagglutinating viruses infection and its phytoconstituents.
PubMed:Use of complementary medicine amongst patients on antiretroviral drugs in an HIV treatment centre in Lagos, Nigeria.
PubMed:On the novel action of melanolysis by a leaf extract of Aloe vera and its active ingredient aloin, potent skin depigmenting agents.
PubMed:Isolation and identification of phosphate solubilizing bacteria able to enhance the growth and aloin-A biosynthesis of Aloe barbadensis Miller.
PubMed:Microwave-assisted extraction performed in low temperature and in vacuo for the extraction of labile compounds in food samples.
PubMed:Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation.
PubMed:Effect of high hydrostatic pressure on functional properties and quality characteristics of Aloe vera gel (Aloe barbadensis Miller).
PubMed:Bioactive compounds from natural resources against skin aging.
PubMed:Single- and repeated-dose toxicities of aloe fermentation products in rats.
PubMed:In vitro accelerated mass propagation and ex vitro evaluation of Aloe vera L. with aloin content and superoxide dismutase activity.
PubMed:In vitro antimicrobial and antioxidant activities of anthrone and chromone from the latex of Aloe harlana Reynolds.
PubMed:[The protective effects of sodium selenite and aloin against ultraviolet A radiation].
PubMed:Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model.
PubMed:Selective determination of aloin in different matrices by HPTLC densitometry in fluorescence mode.
PubMed:Analysis of Aloe-based phytotherapeutic products by using nano-LC-MS.
PubMed:DNA degradation by aqueous extract of Aloe vera in the presence of copper ions.
PubMed:Synthesis of cytotoxic and antioxidant Schiff's base analogs of aloin.
PubMed:[Effects of enhanced UV-B radiation on leaf anthraquinones content and cell ultrastructure of Aloe vera L].
PubMed:Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models.
PubMed:Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction.
PubMed:Ultraviolet light absorption of an ophthalmic formulation with Aloe extracts.
PubMed:Possible hypoglycemic effect of Aloe vera L. high molecular weight fractions on type 2 diabetic patients.
PubMed:New bioactive compounds from Aloe hijazensis.
PubMed:Gold nanoparticles prepared using cape aloe active components.
PubMed:Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages.
PubMed:Novel type III polyketide synthases from Aloe arborescens.
PubMed:In vitro effect of Chinese herb extracts on caries-related bacteria and glucan.
PubMed:Comparison of high-performance liquid chromatographic and thin-layer chromatographic methods for determination of aloin in herbal products containing Aloe vera.
PubMed:The content of secondary phenol metabolites in pruned leaves of Aloe arborescens, a comparison between two methods: leaf exudates and leaf water extract.
PubMed:Production, characterization of a monoclonal antibody against aristolochic acid-II and development of its assay system.
PubMed:Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin.
PubMed:On the interaction of the anthraquinone barbaloin with negatively charged DMPG bilayers.
PubMed:Separation of diastereomeric anthrone-C-glucosyls of aloes by micellar electrokinetic capillary chromatography.
PubMed:Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice.
PubMed:Aloin induces apoptosis in Jurkat cells.
PubMed:Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower Extract, Aloe Barbadensis Leaf, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Juice,aloe Barbadensis Leaf Polysaccharides, Aloe Barbadensis Leaf Water, Aloe Ferox Leaf Extract, Aloe Ferox Leaf Juice, and Aloe Ferox Leaf Juice Extract.
PubMed:Effect of vehicles on topical application of aloe vera and arnica montana components.
PubMed:A reversed-phase high-performance liquid chromatographic method for the determination of aloesin, aloeresin A and anthraquinone in Aloe ferox.
PubMed:Antitumor effects of a natural anthracycline analog (Aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells.
PubMed:Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.
PubMed:Antioxidant actions of phenolic compounds found in dietary plants on low-density lipoprotein and erythrocytes in vitro.
PubMed:Phenolic constituents in dried flowers of aloe vera (Aloe barbadensis) and their in vitro antioxidative capacity.
PubMed:Determination of the anthraquinones aloe-emodin and aloin-A by liquid chromatography with mass spectrometric and diode array detection.
PubMed:[Ultracytochemical studies of aloin in Aloe arborescens leaves].
PubMed:[Preparative separation of aloin diastereoisomers by high-speed countercurrent chromatography combined with silica gel column chromatography].
PubMed:Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low-dose streptozotocin-induced diabetes in mice: investigation on hypoglycemic action and systemic absorption dynamics of aloe components.
PubMed:Inhibitory effects of aloe carboxypeptidase fraction on streptozotocin-induced enhancement of vascular permeability in the pancreatic islets.
PubMed:Cytotoxicity of a natural anthraquinone (Aloin) against human breast cancer cell lines with and without ErbB-2: topoisomerase IIalpha coamplification.
PubMed:Spectroscopic characterization of effective components anthraquinones in Chinese medicinal herbs binding with serum albumins.
PubMed:Standardization of marketed Kumariasava--an Ayurvedic Aloe vera product.
PubMed:[Determination of aloin content in callus of Aloe vera var. chinensis].
PubMed:DNA ploidy and S phase fraction of breast and ovarian tumor cells treated with a natural anthracycline analog (aloin).
PubMed:[Relationship between antibacterial activity of aloe and its anthaquinone compounds].
PubMed:Analysis of the anthraquinones aloe-emodin and aloin by gas chromatography/mass spectrometry.
PubMed:Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin.
PubMed:[Determination of aloin in aloes by HPLC].
PubMed:[90-day subchronic toxicity study of aloe whole-leaf powder].
PubMed:[Development of aloin cells and accumulation of anthraquinone in aloe leaf].
PubMed:Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation of an adherent variant cell line of Merkel cell carcinoma.
PubMed:Radical-scavenging effects of Aloe arborescens Miller on prevention of pancreatic islet B-cell destruction in rats.
PubMed:Inhibition of azoxymethane-induced DNA adduct formation by Aloe arborescens var. natalensis.
PubMed:Technology of eye drops containing aloe (Aloe arborescens Mill.--Liliaceae) and eye drops containing both aloe and neomycin sulphate.
PubMed:Fluorescence studies on the interactions of barbaloin with bovine serum albumin.
PubMed:The phytochemical profile and identification of main phenolic compounds from the leaf exudate of Aloe secundiflora by high-performance liquid chromatography-mass spectroscopy.
PubMed:[Distribution of anthraquinones in leaves of two Aloe species and their defence strategy].
PubMed:Aloin, cinnamic acid and sophorcarpidine are potent inhibitors of tyrosinase.
PubMed:Physicochemical and microbiological properties as well as stability of ointments containing aloe extract (Aloe arborescens Mill.) or aloe extract associated to neomycin sulphate.
PubMed:[Quantitative determination of barbaloin in aloe capsule by high performance liquid chromatography].
PubMed:[Determination of the active components in Chinese herb Aloe vera L. var. chinensis (Haw.) Berger by capillary zone electrophoresis].
PubMed:In vitro studies on the photobiological properties of aloe emodin and aloin A.
PubMed:[Contents of barbaloin-related compounds in aloe drinks and their change during storage].
PubMed:[Structural analyses of barbaloin-related compounds in aloe drinks].
PubMed:Aloe arborescens extract inhibits TPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin.
PubMed:Hypotensive effect of chemical constituents from Aloe barbadensis.
PubMed:[Studies on the voltammetric behaviour of barbaloin and its application].
PubMed:Determination of aloenin, barbaloin and isobarbaloin in aloe species by micellar electrokinetic chromatography.
PubMed:Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride.
PubMed:The occurrence and taxonomic distribution of the anthrones aloin, aloinoside and microdontin in Aloe.
PubMed:Growth, soluble carbohydrates, and aloin concentration of Aloe vera plants exposed to three irradiance levels.
PubMed:The distribution of the phenolic metabolites barbaloin, aloeresin and aloenin as a peripheral defense strategy in the succulent leaf parts of Aloe arborescens.
PubMed:The role of nitric oxide in aloe-induced diarrhoea in the rat.
PubMed:Studies of aloe. VI. Cathartic effect of isobarbaloin.
PubMed:Serum LDH and ALP isozyme activities in mice bearing solid Ehrlich carcinoma and/or treated with the maximum tolerated dose (MTD) of aloin.
PubMed:Cytotoxicity of a low molecular weight fraction from Aloe vera (Aloe barbadensis Miller) gel.
PubMed:Effects of aloin and some structure-related anthracene, anthracenone, and anthraquinone derivatives on lipid peroxidation in rat brain cortex homogenates.
PubMed:Effects of highly purified anthraquinoid compounds from Aloe vera on sensitive and multidrug resistant leukemia cells.
PubMed:Acceleration of the alcohol oxidation rate in rats with aloin, a quinone derivative of Aloe.
PubMed:The substances of plant origin that inhibit protein biosynthesis.
PubMed:Metabolism of aloin--the influence of nutrition.
PubMed:A purgative action of barbaloin is induced by Eubacterium sp. strain BAR, a human intestinal anaerobe, capable of transforming barbaloin to aloe-emodin anthrone.
PubMed:High-performance liquid chromatographic profiles of aloe constituents and determination of aloin in beverages, with reference to the EEC regulation for flavouring substances.
PubMed:Geographical variation in the major compounds of Aloe ferox leaf exudate.
PubMed:Studies of aloe. V. Mechanism of cathartic effect. (4).
PubMed:Studies of aloe. IV. Mechanism of cathartic effect. (3).
PubMed:Inhibitory effects of phenolics on xanthine oxidase.
PubMed:Rat selection test with respect to laxative activity induced by barbaloin.
PubMed:Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice.
PubMed:Cleavages of the O- and C-glucosyl bonds of anthrone and 10,10'-bianthrone derivatives by human intestinal bacteria.
PubMed:A rapid high-performance thin-layer chromatographic urine screen for laxative abuse.
PubMed:Structure revision of 4-hydroxyaloin: 10-hydroxyaloins a and B as main in vitro-oxidation products of the diastereomeric aloins1.
PubMed:Microdontin A and B: Two New Aloin Derivatives from Aloe microdonta.
PubMed:Inactivation of enveloped viruses by anthraquinones extracted from plants.
PubMed:Barbaloin stimulates growth of Eubacterium sp. strain BAR, a barbaloin-metabolizing bacterium from human feces.
PubMed:Isolation of a human intestinal bacterium capable of transforming barbaloin to aloe-emodin anthrone.
PubMed:Studies of aloe. III. Mechanism of cathartic effect. (2).
PubMed:[Purification, glucose-6-phosphate dehydrogenase inhibition, and HPLC analysis of four 1,8-dihydroxyanthrones].
PubMed:Metabolism of barbaloin by intestinal bacteria.
PubMed:[Studies of aloe. II. Mechanism of cathartic effect].
PubMed:The influence of selected potential oncostatics of plant origin on the protein biosynthesis in vitro.
PubMed:[Saccular aneurysm of the superior vena cava].
PubMed:Determination of barbaloin in rat serum.
PubMed:Barbaloin in aloe species.
PubMed:The first Naturally Occuring Esters in Aloin-type Glycosyls.
PubMed:Liquid chromatographic determination of barbaloin (aloin) in foods.
PubMed:Fluorophotometry of barbaloin in Aloe.
PubMed:Effect of indomethacin on aloin and 1,8 dioxianthraquinone-induced production of prostaglandins in rat isolated colon.
PubMed:In vitro biosynthesis of the C-glycosidic bond in aloin.
PubMed:Cascarosides A and B.
PubMed:Biologically active constituents of leaves and roots of Aloe arborescens var. natalensis.
PubMed:[Comparison of various methods for the spectrophotmetric determination of aloin in aloe DAB 7-DDR (German Pharmacopoeia 7-German Democratic Republic)].
PubMed:A comparative investigation of methods used to estimate aloin and related compounds in Aloes.
PubMed:[Methods of quantitative determination of aloin].
PubMed:[Quantitative microdetermination of aloin by thin layer chromatography].
PubMed:[3. On methods of constituent determination of aloe. On photometric aloin determination by the method of B. Janiak and H. Böhmert].
PubMed:MICRO-DETERMINATION OF ALOIN IN SOME SOUTH AFRICAN ALOE SPECIES.
PubMed:CHEMOTAXONOMY OF ASPHODELIODEAE (LILIACEAE) KRAUSE 1930. VI. ALOIN AND HOMONATALOIN IN ALOE SPECIES.
PubMed:[On the quantitative determination of aloin by means of paper and thin-layer chromatography. 1. On methods for the valuation of aloe].
PubMed:The quantitative conversion of barbaloin to aloe-emodin and its application to the evaluation of aloes.
PubMed:[On the occurrence of aloin in Aloe vera in addition to comparative studies with the fresh juice of Capealoe (Aloe ferox) and the dried extract prepared from it].
PubMed:[Microanalytical determination of aloin].
PubMed:[A method for the quantitative determination of aloin].
PubMed:[On the constituents of the bark of Rhamnus purshiana (Cascara Sagrada Ph. Helv. V). 1. Assay for the presence of xanthorhamnin and the detection of aloin].
PubMed:Vegetable purgatives containing anthracene derivatives. XI. Further work on the aloin-like substance of Rhamnus purshiana DC.
PubMed:[Aloin, some observations on its constitution].
PubMed:[The demonstration of barbaloin in the bark of Rhamnus purshiani].
PubMed:The chromatographic behaviour of aloin.
PubMed:Vegetable purgatives containing anthracene derivatives. IX. An aloin-like substance in Rhamnus purshiana DC.
PubMed:[Quantitative determination of aloin in Aloe capensis. I. Determination by paper chromatography with planimetric evaluation of spot surfaces].
PubMed:[Vasomotor influence on auditive troubles].
PubMed:[Assay of aloe; photometric determination of aloin].
PubMed:A paper chromatographic study of aloe, aloin and of cascara sagrada.
PubMed:[Studies on the aloin of the cape aloe].
PubMed:[Vasomotor effect on hearing disorders].
PubMed:[In memoriam: Henri Aloin].
PubMed:[Statistical study on the immediate future of premature infants].
PubMed:[Diagnosis and indication for surgery in otomastoiditis of the infant].
PubMed:[Not Available].
PubMed:[Not Available].
PubMed:The estimation of aloin in pharmaceuticals.
PubMed:[Not Available].
 
Notes:
Constit. of various Aloe spp. Aloin extracted from natural sources is a mixture of two diastereomers, termed aloin A (also called barbaloin) and aloin B (or isobarbaloin), which have similar chemical properties. Aloin is an anthraquinone glycoside, meaning that its anthraquinone skeleton has been modified by the addition of a sugar molecule. Anthraquinones are a common family of naturally occurring yellow, orange, and red pigments of which many have cathartic properties, attributes shared by aloin. Aloin is related to aloe emodin, which lacks a sugar group but shares aloin's biological properties.; Aloin, also known as Barbaloin [Reynolds, Aloes - The genus Aloe, 2004], is a bitter, yellow-brown colored compound noted in the exudate of at least 68 Aloe species at levels from 0.1 to 6.6% of leaf dry weight (making between 3% and 35% of the toal exudate) (Groom & Reynolds, 1987), and in another 17 species at indeterminate levels [Reynolds, 1995b]. It is used as a stimulant-laxative, treating constipation by inducing bowel movements. The compound is present in what is commonly referred to as the aloe latex that exudes from cells adjacent to the vascular bundles, found under the rind of the leaf and in between it and the gel. When dried, it has been used as a bittering agent in commerce (alcoholic beverages) [21 CFR 172.510. Scientific names given include Aloe perryi, A. barbadensis (= A. vera), A. ferox, and hybrids of A. ferox with A. africana and A. spicata.]. Aloe is listed in federal regulations as a natural substance that may be ?safely used in food? when used ?in the minimum quantity required to produce their intended physical or technical effect and in accordance with all the principles of good manufacturing practice.? This food application is generally limited to use in quite small quantities as a flavoring in alcoholic beverages and may usually be identified only as a ?natural flavor.?; In May 2002, the U.S. Food and Drug Administration (FDA) issued a ruling that aloe laxatives are no longer generally recognized as safe (GRAS) and effective, meaning that aloin-containing products are no longer available in over-the-counter drug products in the United States. Aloe vera leaf latex is a concentrate of an herb or other botanical, and so meets the statutory description of an ingredient that may be used in dietary supplements.
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