|
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 110.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 769.95 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 519.00 °F. TCC ( 270.70 °C. ) (est)
|
| logP (o/w): | 0.452 (est) |
| Soluble in: |
| | water, 1678 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD > 500 mg/kg
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 226, 1954.
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | cosmetic agents |
| Recommendation for phloridzin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for phloridzin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| EPI System: View |
| Daily Med:search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :6072 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one |
| Chemidplus:0000060811 |
| RTECS:UC2080000 for cas# 60-81-1 |
References:
| | 1-[2,4-dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 6072 |
| Pubchem (sid): | 134970707 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | asebotin | | 4,6- | dihydroxy-2-(b-D-glucosido)-b-(p-hydroxyphenyl)propiophenone | | 1-[2,4- | dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one | | 1-(2,4- | dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}phenyl)-3-(4-hydroxyphenyl)-1-propanone | | 1-(2,4- | dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}phényl)-3-(4-hydroxyphényl)-1-propanone | | | floridzin | | 1-[2-(b-D- | glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone | | | phloretin-2'-b-glucoside | | | phlorhizin | | | phlorizin | | | phlorizoside | | | phlorrhizen | | 1-{6-[(2S,4S,5S,3R,6R)-3,4,5- | trihydroxy-6-(hydroxymethyl)(2H-3,4,5,6-tetrahydropyran-2-yloxy)]-2,4-dihydroxyphenyl}-3-(4-hydroxyphenyl)propan-1-one |
Articles:
| PubMed:Phloridzin improves lipoprotein lipase activity in stress-loaded mice via AMPK phosphorylation. |
| PubMed:Evolution of polyphenols and organic acids during the fermentation of apple cider. |
| PubMed:Stimulation of feeding by three different glucose-sensing mechanisms requires hindbrain catecholamine neurons. |
| PubMed:Optimisation of the extraction of phenolic compounds from apples using response surface methodology. |
| PubMed:Nonanthocyanin secondary metabolites of black raspberry (Rubus occidentalis L.) fruits: identification by HPLC-DAD, NMR, HPLC-ESI-MS, and ESI-MS/MS analyses. |
| PubMed:Glucose transport by epithelia prepared from harvested enterocytes. |
| PubMed:Post-oral appetite stimulation by sugars and nonmetabolizable sugar analogs. |
| PubMed:Sonication enhances polyphenolic compounds, sugars, carotenoids and mineral elements of apple juice. |
| PubMed:Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions. |
| PubMed:Metabolomic profiling and sensorial quality of 'Golden Delicious', 'Liberty', 'Santana', and 'Topaz' apples grown using organic and integrated production systems. |
| PubMed:RNA interference silencing of CHS greatly alters the growth pattern of apple (Malus x domestica). |
| PubMed:Correlation between changes in polyphenol composition of peels and incidence of COâ‚‚ skin burning of 'Cameo' apples as influenced by controlled atmosphere storage. |
| PubMed:The role of enoyl reductase genes in phloridzin biosynthesis in apple. |
| PubMed:Phenolic profile and antioxidant capacity of the principal apples produced in Brazil. |
| PubMed:Apple peel bioactive rich extracts effectively inhibit in vitro human LDL cholesterol oxidation. |
| PubMed:Recovery and characterisation of coloured phenolic preparations from apple seeds. |
| PubMed:Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions. |
| PubMed:Time of methyl jasmonate application influences the development of 'Cripps Pink' apple fruit colour. |
| PubMed:Uptake and phloem transport of glucose-fipronil conjugate in Ricinus communis involve a carrier-mediated mechanism. |
| PubMed:Phloridzin reduces blood glucose levels and alters hepatic gene expression in normal BALB/c mice. |
| PubMed:Characterization and quantitation of low and high molecular weight phenolic compounds in apple seeds. |
| PubMed:Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats. |
| PubMed:Impact of phloretin and phloridzin on the formation of Maillard reaction products in aqueous models composed of glucose and L-lysine or its derivatives. |
| PubMed:Polyphenol fatty acid esters as serine protease inhibitors: a quantum-chemical QSAR analysis. |
| PubMed:Characterization of phenolic components in polar extracts of Eucalyptus globulus Labill. bark by high-performance liquid chromatography-mass spectrometry. |
| PubMed:Anti-aging effects of phloridzin, an apple polyphenol, on yeast via the SOD and Sir2 genes. |
| PubMed:On the formulation design and rheological evaluations of pectin-based functional gels. |
| PubMed:Flavonoids and the CNS. |
| PubMed:High-salt diet advances molecular circadian rhythms in mouse peripheral tissues. |
| PubMed:Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells. |
| PubMed:Effect of storage on the content of polyphenols of minimally processed skin-on apple wedges from ten cultivars and two growing seasons. |
| PubMed:Combined effect of storage temperature and water activity on the antiglycoxidative properties and color of dehydrated apples. |
| PubMed:Phloridzin-induced melanogenesis is mediated by the cAMP signaling pathway. |
| PubMed:Dietary phloridzin reduces blood glucose levels and reverses Sglt1 expression in the small intestine in streptozotocin-induced diabetic mice. |
| PubMed:Chemical composition and in vitro anti-inflammatory activity of apple phenolic extracts and of their sub-fractions. |
| PubMed:The potential influence of fruit polyphenols on colonic microflora and human gut health. |
| PubMed:Polyphenols are intensively metabolized in the human gastrointestinal tract after apple juice consumption. |
| PubMed:Inhibitory effect of fruit extracts on the formation of heterocyclic amines. |
| PubMed:Identification and quantification of flavonoids of Mexican oregano (Lippia graveolens) by LC-DAD-ESI/MS analysis. |
| PubMed:Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo. |
| PubMed:Electromigration profiles of Cynomorium songaricum based on capillary electrophoresis with amperometric detection. |
| PubMed:Modulation of key elements of the Wnt pathway by apple polyphenols. |
| PubMed:Repetitive fluctuations in blood glucose enhance monocyte adhesion to the endothelium of rat thoracic aorta. |
| PubMed:The flavonol quercetin-3-glucoside inhibits cyanidin-3-glucoside absorption in vitro. |
| PubMed:Use of the 1H nuclear magnetic resonance spectra signals from polyphenols and acids for chemometric characterization of cider apple juices. |
| PubMed:Modulation of oxidative cell damage by reconstituted mixtures of phenolic apple juice extracts in human colon cell lines. |
| PubMed:Phenolic profile of Asturian (Spain) natural cider. |
| PubMed:Existence of two parallel mechanisms for glucose uptake in heterotrophic plant cells. |
| PubMed:Serotonin-type 3 receptors mediate intestinal Polycose- and glucose-induced suppression of intake. |
| PubMed:Intestinal SGLT1-mediated absorption and metabolism of benzyl beta-glucoside contained in Prunus mume: carrier-mediated transport increases intestinal availability. |
| PubMed:Activity and concentration of polyphenolic antioxidants in apple juice. 3. Stability during storage. |
| PubMed:Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes. |
| PubMed:Influence of variety and storage on the polyphenol composition of apple flesh. |
| PubMed:Phloridzin improves absorption of genistin in isolated rat small intestine. |
| PubMed:Radical scavenging activities of peels and pulps from cv. Golden Delicious apples as related to their phenolic composition. |
| PubMed:Apple phytochemicals and their health benefits. |
| PubMed:Improved HPLC determination of phenolic compounds in cv. golden delicious apples using a monolithic column. |
| PubMed:Response of scab-susceptible (McIntosh) and scab-resistant (Liberty) apple tissues to treatment with yeast extract and Venturia inaequalis. |
| PubMed:Purification and characterization of vanilla bean (Vanilla planifolia Andrews) beta-D-glucosidase. |
| PubMed:Detection of phloridzin in strawberries (Fragaria x ananassa Duch.) by HPLC-PDA-MS/MS and NMR spectroscopy. |
| PubMed:On-line HPLC-DPPH screening method for evaluation of radical scavenging phenols extracted from apples (Malus domestica L.). |
| PubMed:Low temperature metabolism of apple phenolics and quiescence of Phlyctaena vagabunda. |
| PubMed:Bioavailability of phloretin and phloridzin in rats. |
| PubMed:Activity and concentration of polyphenolic antioxidants in apple: effect of cultivar, harvest year, and storage conditions. |
| PubMed:Diurnal rhythmicity in intestinal SGLT-1 function, V(max), and mRNA expression topography. |
| PubMed:Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat. |
| PubMed:Apple juice inhibits human low density lipoprotein oxidation. |
| PubMed:Phloridzin derivatives; food additives/chemopreventative drugs of the future. |
| PubMed:Vagally mediated feeding responses to phloridzin infusion in the rabbit. |
| PubMed:Kinetic heterogeneity of Na-D-glucose cotransport in teleost gastrointestinal tract. |
| PubMed:The effects of chronic exposure to elevated environmental temperature on intestinal morphology and nutrient absorption in the domestic fowl (Gallus domesticus). |
| PubMed:Hexose transport and mucosal morphology in the small intestine of the zinc-deficient rat. |
| PubMed:Effects of cerebral lateral, ventricular infusions of phloridzin on feeding and body weight in Gallus domesticus (L.). |
| PubMed:STUDIES ON MILK SECRETION : THE INFLUENCE OF INANITION. |
|
3D/inchi