EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes


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CAS Number: 60-81-1Picture of molecule3D/inchi
Other(deleted CASRN):112318-65-7
ECHA EINECS - REACH Pre-Reg:200-487-1
Nikkaji Web:J4.807K
Beilstein Number:066621
XlogP3:1.20 (est)
Molecular Weight:436.41428000
Formula:C21 H24 O10
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 110.00 °C. @ 760.00 mm Hg
Boiling Point: 769.95 °C. @ 760.00 mm Hg (est)
Flash Point: 519.00 °F. TCC ( 270.70 °C. ) (est)
logP (o/w): 0.452 (est)
Soluble in:
 water, 1678 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
Alfa Biotechnology
For experimental / research use only.
Phlorizin 98%
BOC Sciences
For experimental / research use only.
For experimental / research use only.
Changsha Organic Herb
Apple Extract
Changsha Organic Herb
Apple Tree Bark Extract Phloridzin
For experimental / research use only.
Phloridzin (HPLC) ≥95%
Inoveol® PHLO
Odor: characteristic
Use: Considered as ‘Eden fruit’ since age of times, apple contains the secrecy of youth and beauty through its unique polyphenols. Among those, phlorizin is more particularly recognised for its benefits in cosmetic through its antioxydant capacity and its protective effects for skin. Inoveol® PHLO active is a technology improved version of phloridzin. It acts as a UV free natural enhancer of melanogenesis, with skin matrix protection properties.
Jiangyin Healthway
New functional food ingredients
Layn Natural ingredients
Apple Extract Phloridzin 30% - 90%
Santa Cruz Biotechnology
For experimental / research use only.
Sigma-Aldrich: Sigma
For experimental / research use only.
Phloridzin dihydrate from apple wood, ≥99% (HPLC)
Skyherb Technologies
For experimental / research use only.
Phloridzin >97.0%(T)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD > 500 mg/kg
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 226, 1954.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for phloridzin usage levels up to:
 not for fragrance use.
Recommendation for phloridzin flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6072
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
RTECS:UC2080000 for cas# 60-81-1
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6072
Pubchem (sid):134970707
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C01604
HMDB (The Human Metabolome Database):HMDB36634
Export Tariff Code:2914.50.5000
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 malus spp.
Search Trop Picture
 pear bark
Search Trop Picture


PubMed:Phloridzin improves lipoprotein lipase activity in stress-loaded mice via AMPK phosphorylation.
PubMed:Evolution of polyphenols and organic acids during the fermentation of apple cider.
PubMed:Stimulation of feeding by three different glucose-sensing mechanisms requires hindbrain catecholamine neurons.
PubMed:Optimisation of the extraction of phenolic compounds from apples using response surface methodology.
PubMed:Nonanthocyanin secondary metabolites of black raspberry (Rubus occidentalis L.) fruits: identification by HPLC-DAD, NMR, HPLC-ESI-MS, and ESI-MS/MS analyses.
PubMed:Glucose transport by epithelia prepared from harvested enterocytes.
PubMed:Post-oral appetite stimulation by sugars and nonmetabolizable sugar analogs.
PubMed:Sonication enhances polyphenolic compounds, sugars, carotenoids and mineral elements of apple juice.
PubMed:Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.
PubMed:Metabolomic profiling and sensorial quality of 'Golden Delicious', 'Liberty', 'Santana', and 'Topaz' apples grown using organic and integrated production systems.
PubMed:RNA interference silencing of CHS greatly alters the growth pattern of apple (Malus x domestica).
PubMed:Correlation between changes in polyphenol composition of peels and incidence of COâ‚‚ skin burning of 'Cameo' apples as influenced by controlled atmosphere storage.
PubMed:The role of enoyl reductase genes in phloridzin biosynthesis in apple.
PubMed:Phenolic profile and antioxidant capacity of the principal apples produced in Brazil.
PubMed:Apple peel bioactive rich extracts effectively inhibit in vitro human LDL cholesterol oxidation.
PubMed:Recovery and characterisation of coloured phenolic preparations from apple seeds.
PubMed:Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.
PubMed:Time of methyl jasmonate application influences the development of 'Cripps Pink' apple fruit colour.
PubMed:Uptake and phloem transport of glucose-fipronil conjugate in Ricinus communis involve a carrier-mediated mechanism.
PubMed:Phloridzin reduces blood glucose levels and alters hepatic gene expression in normal BALB/c mice.
PubMed:Characterization and quantitation of low and high molecular weight phenolic compounds in apple seeds.
PubMed:Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats.
PubMed:Impact of phloretin and phloridzin on the formation of Maillard reaction products in aqueous models composed of glucose and L-lysine or its derivatives.
PubMed:Polyphenol fatty acid esters as serine protease inhibitors: a quantum-chemical QSAR analysis.
PubMed:Characterization of phenolic components in polar extracts of Eucalyptus globulus Labill. bark by high-performance liquid chromatography-mass spectrometry.
PubMed:Anti-aging effects of phloridzin, an apple polyphenol, on yeast via the SOD and Sir2 genes.
PubMed:On the formulation design and rheological evaluations of pectin-based functional gels.
PubMed:Flavonoids and the CNS.
PubMed:High-salt diet advances molecular circadian rhythms in mouse peripheral tissues.
PubMed:Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells.
PubMed:Effect of storage on the content of polyphenols of minimally processed skin-on apple wedges from ten cultivars and two growing seasons.
PubMed:Combined effect of storage temperature and water activity on the antiglycoxidative properties and color of dehydrated apples.
PubMed:Phloridzin-induced melanogenesis is mediated by the cAMP signaling pathway.
PubMed:Dietary phloridzin reduces blood glucose levels and reverses Sglt1 expression in the small intestine in streptozotocin-induced diabetic mice.
PubMed:Chemical composition and in vitro anti-inflammatory activity of apple phenolic extracts and of their sub-fractions.
PubMed:The potential influence of fruit polyphenols on colonic microflora and human gut health.
PubMed:Polyphenols are intensively metabolized in the human gastrointestinal tract after apple juice consumption.
PubMed:Inhibitory effect of fruit extracts on the formation of heterocyclic amines.
PubMed:Identification and quantification of flavonoids of Mexican oregano (Lippia graveolens) by LC-DAD-ESI/MS analysis.
PubMed:Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo.
PubMed:Electromigration profiles of Cynomorium songaricum based on capillary electrophoresis with amperometric detection.
PubMed:Modulation of key elements of the Wnt pathway by apple polyphenols.
PubMed:Repetitive fluctuations in blood glucose enhance monocyte adhesion to the endothelium of rat thoracic aorta.
PubMed:The flavonol quercetin-3-glucoside inhibits cyanidin-3-glucoside absorption in vitro.
PubMed:Use of the 1H nuclear magnetic resonance spectra signals from polyphenols and acids for chemometric characterization of cider apple juices.
PubMed:Modulation of oxidative cell damage by reconstituted mixtures of phenolic apple juice extracts in human colon cell lines.
PubMed:Phenolic profile of Asturian (Spain) natural cider.
PubMed:Existence of two parallel mechanisms for glucose uptake in heterotrophic plant cells.
PubMed:Serotonin-type 3 receptors mediate intestinal Polycose- and glucose-induced suppression of intake.
PubMed:Intestinal SGLT1-mediated absorption and metabolism of benzyl beta-glucoside contained in Prunus mume: carrier-mediated transport increases intestinal availability.
PubMed:Activity and concentration of polyphenolic antioxidants in apple juice. 3. Stability during storage.
PubMed:Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes.
PubMed:Influence of variety and storage on the polyphenol composition of apple flesh.
PubMed:Phloridzin improves absorption of genistin in isolated rat small intestine.
PubMed:Radical scavenging activities of peels and pulps from cv. Golden Delicious apples as related to their phenolic composition.
PubMed:Apple phytochemicals and their health benefits.
PubMed:Improved HPLC determination of phenolic compounds in cv. golden delicious apples using a monolithic column.
PubMed:Response of scab-susceptible (McIntosh) and scab-resistant (Liberty) apple tissues to treatment with yeast extract and Venturia inaequalis.
PubMed:Purification and characterization of vanilla bean (Vanilla planifolia Andrews) beta-D-glucosidase.
PubMed:Detection of phloridzin in strawberries (Fragaria x ananassa Duch.) by HPLC-PDA-MS/MS and NMR spectroscopy.
PubMed:On-line HPLC-DPPH screening method for evaluation of radical scavenging phenols extracted from apples (Malus domestica L.).
PubMed:Low temperature metabolism of apple phenolics and quiescence of Phlyctaena vagabunda.
PubMed:Bioavailability of phloretin and phloridzin in rats.
PubMed:Activity and concentration of polyphenolic antioxidants in apple: effect of cultivar, harvest year, and storage conditions.
PubMed:Diurnal rhythmicity in intestinal SGLT-1 function, V(max), and mRNA expression topography.
PubMed:Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat.
PubMed:Apple juice inhibits human low density lipoprotein oxidation.
PubMed:Phloridzin derivatives; food additives/chemopreventative drugs of the future.
PubMed:Vagally mediated feeding responses to phloridzin infusion in the rabbit.
PubMed:Kinetic heterogeneity of Na-D-glucose cotransport in teleost gastrointestinal tract.
PubMed:The effects of chronic exposure to elevated environmental temperature on intestinal morphology and nutrient absorption in the domestic fowl (Gallus domesticus).
PubMed:Hexose transport and mucosal morphology in the small intestine of the zinc-deficient rat.
PubMed:Effects of cerebral lateral, ventricular infusions of phloridzin on feeding and body weight in Gallus domesticus (L.).
Isol. from apple leaves and bark Phlorizin is a toxic glycoside made by some plants. It belongs to the group of flavonoids. It is a competitive inhibitor of renal glucose transport.
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