EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

isoflavone
3-phenyl-4H-chromen-4-one

Supplier Sponsors

CAS Number: 574-12-9Picture of molecule3D/inchi
FDA UNII:OVO2KUW8H8
Nikkaji Web:J46.301I
Beilstein Number:157731
MDL:MFCD00100851
XlogP3-AA:3.20 (est)
Molecular Weight:222.24310000
Formula:C15 H10 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Google Patents:Search
US Patents:Search
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Pubchem Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 1 Soy isoflavone extract View - notice PDF
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 367.01 °C. @ 760.00 mm Hg (est)
Flash Point: 340.00 °F. TCC ( 171.10 °C. ) (est)
logP (o/w): 3.013 (est)
Soluble in:
 water, 33.8 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
ADM
NOVASOY® ISOFLAVONES CONCENTRATE 40%
Flavor: characteristic
NOVASOY® ISOFLAVONES CONCENTRATE 40% is a fine powder ideally suited for most applications.
ADM
NOVASOY®--ISOFLAVONES CONCENTRATE 20%
Flavor: characteristic
NOVASOY®--Isoflavones Concentrate 20% is a fine powder that works well in food ingredients and bars.
ADM
NOVASOY®--ISOFLAVONES CONCENTRATE 70%
Flavor: characteristic
NOVASOY®--ISOFLAVONES CONCENTRATE 70% is a fine powder that works well in functional beverages.
Austrade
Soy Isoflavones
Flavor: characteristic
A standardized soy isoflavone concentrate in powder form with a high biological value for the food industry. Produced without chemical washing to ensure and retain the natural soy profile, this isoflavone is free from solvents and additives. It contains 20 times the amount of isoflavones than traditional soy products. The addition of 1g product not only adds 20 mg isoflavones but also the complete natural soy matrix. Applications include baked goods, confectionery products, spreads and cereals.
BOC Sciences
For experimental / research use only.
3-phenylchromen-4-one 95%
Carbosynth
For experimental / research use only.
isoFlavone
Changsha Organic Herb
Soy Isoflavones
Changsha Organic Herb
Soybean Extract 40% Isoflavones
Jiangyin Healthway
Soy Isoflavones
New functional food ingredients
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
special dietary and nutritional additives
Recommendation for isoflavone usage levels up to:
 not for fragrance use.
 
Recommendation for isoflavone flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Preparatory work to support the risk assessment for peri- and postmenopausal women taking food supplements containing isolated isoflavones
View page or View pdf

Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :72304
National Institute of Allergy and Infectious Diseases:Data
3-phenylchromen-4-one
Chemidplus:0000574129
 
References:
 3-phenylchromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):72304
Pubchem (sid):135030737
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C00799
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
4H-1-benzopyran-4-one, 3-phenyl-
isoflavon
soy isoflavone
3-phenyl-4H-1-benzopyran-4-one
3-phenyl-4H-chromen-4-on
3-phenyl-4H-chromen-4-one
3-phenylchromen-4-one
3-phenylchromone
 

Articles:

PubMed:Glycation is regulated by isoflavones.
PubMed:Soy Isoflavones for Reducing Bone Loss Study: effects of a 3-year trial on hormones, adverse events, and endometrial thickness in postmenopausal women.
PubMed:Conversion of major soy isoflavone glucosides and aglycones in in vitro intestinal models.
PubMed:Soy isoflavone: The multipurpose phytochemical (Review).
PubMed:Oxidative metabolism enhances the cytotoxic and genotoxic properties of the soy isoflavone daidzein.
PubMed:High concentrations of genistein exhibit pro-oxidant effects in primary muscle cells through mechanisms involving 5-lipoxygenase-mediated production of reactive oxygen species.
PubMed:S-(-)equol producing status not associated with breast cancer risk among low isoflavone-consuming US postmenopausal women undergoing a physician-recommended breast biopsy.
PubMed:Pharmacokinetics of equol, a soy isoflavone metabolite, changes with the form of equol (dietary versus intestinal production) in ovariectomized rats.
PubMed:Effects of short-term fructooligosaccharide intake on equol production in Japanese postmenopausal women consuming soy isoflavone supplements: a pilot study.
PubMed:Probiotic Beverage with Soy Isoflavone Consumption for Breast Cancer Prevention: A Case-control Study.
PubMed:Soy and its isoflavones: the truth behind the science in breast cancer.
PubMed:Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation.
PubMed:Possible role of S-equol on bone loss via amelioration of inflammatory indices in ovariectomized mice.
PubMed:Combination of low dose of genistein and daidzein has synergistic preventive effects on isogenic human prostate cancer cells when compared with individual soy isoflavone.
PubMed:Pharmacological administration of the isoflavone daidzein enhances cell proliferation and reduces high fat diet-induced apoptosis and gliosis in the rat hippocampus.
PubMed:Soy isoflavones and breast cancer.
PubMed:Activation of AMP-activated protein kinase alleviates homocysteine-mediated neurotoxicity in SH-SY5Y cells.
PubMed:Self-reported menopausal symptoms in a racially diverse population and soy food consumption.
PubMed:Soy isoflavone intake and breast cancer risk in Japan: from the Takayama study.
PubMed:[Effects of soy isoflavone on the reproductive system development and ER-beta expression in male rat offspring in different postnatal periods].
PubMed:Soy isoflavone attenuates brain mitochondrial oxidative stress induced by β-amyloid peptides 1-42 injection in lateral cerebral ventricle.
PubMed:Daidzein-estrogen interaction in the rat uterus and its effect on human breast cancer cell growth.
PubMed:[Effects of soybean isoflavone on reproductive development in SD rats].
PubMed:Effects of dietary genistein on hormone-dependent rat mammary carcinogenesis induced by ethyl methanesulphonate.
PubMed:Anti-diabetic functions of soy isoflavone genistein: mechanisms underlying its effects on pancreatic β-cell function.
PubMed:Dose-dependent effects of a genistein-enriched diet in the heart of ovariectomized mice.
PubMed:Formation of phosphoglycosides in Caenorhabditis elegans: a novel biotransformation pathway.
PubMed:Soy products in the management of breast cancer.
PubMed:Urinary isoflavonoids and risk of coronary heart disease.
PubMed:The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein.
PubMed:Effects of estrogen and estrus cycle on pharmacokinetics, absorption, and disposition of genistein in female Sprague-Dawley rats.
PubMed:Impact of food matrix on isoflavone metabolism and cardiovascular biomarkers in adults with hypercholesterolemia.
PubMed:Phytoestrogens genistein and daidzein affect immunity in the nematode Caenorhabditis elegans via alterations of vitellogenin expression.
PubMed:Glyceollins, soy isoflavone phytoalexins, improve oral glucose disposal by stimulating glucose uptake.
PubMed:Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women.
PubMed:Study on soy isoflavone consumption and risk of breast cancer and survival.
PubMed:Optimization of soy isoflavone extraction with different solvents using the simplex-centroid mixture design.
PubMed:Positive effects of soy isoflavone food on survival of breast cancer patients in China.
PubMed:Determination of 15 isoflavone isomers in soy foods and supplements by high-performance liquid chromatography.
PubMed:Separation of soybean isoflavone aglycone homologues by ionic liquid-based extraction.
PubMed:In utero and lactational exposure to low-dose genistein-vinclozolin mixture affects the development and growth factor mRNA expression of the submandibular salivary gland in immature female rats.
PubMed:[Equol-producing phenotype and in relation to serum sex hormones among healthy adults in Beijing].
PubMed:Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39.
PubMed:Epigenetic modifications of metastasis suppressor genes in colon cancer metastasis.
PubMed:Improvement of high-fat diet-induced obesity by a mixture of red grape extract, soy isoflavone and L-carnitine: implications in cardiovascular and non-alcoholic fatty liver diseases.
PubMed:Effect of soy isoflavones on circulating C-reactive protein in postmenopausal women: meta-analysis of randomized controlled trials.
PubMed:Effects of S-equol and natural S-equol supplement (SE5-OH) on the growth of MCF-7 in vitro and as tumors implanted into ovariectomized athymic mice.
PubMed:[Changes of serum lipids after soy isoflavone and calcium supplementation in postmenopausal Chinese women with different ER-beta genotypes].
PubMed:The role of soy isoflavones in menopausal health: report of The North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago, IL (October 2010).
PubMed:Genistein selectively inhibits estrogen-induced cell proliferation and other responses to hormone stimulation in the prepubertal rat uterus.
PubMed:Soy isoflavone genistein induces cell death in breast cancer cells through mobilization of endogenous copper ions and generation of reactive oxygen species.
PubMed:Single-dose and steady-state pharmacokinetic studies of S-equol, a potent nonhormonal, estrogen receptor β-agonist being developed for the treatment of menopausal symptoms.
PubMed:Effect of free or protein-associated soy isoflavones on the antioxidant status in rats.
PubMed:Relationship between soy food intake and breast cancer in China.
PubMed:Estrogen receptor-β mediates the inhibition of DLD-1 human colon adenocarcinoma cells by soy isoflavones.
PubMed:Micro total bioassay system for ingested substances: assessment of intestinal absorption, hepatic metabolism, and bioactivity.
PubMed:Acute and subchronic toxicity of FCD, a soybean extract combined with L-carnitine, in Sprague-Dawley rats.
PubMed:Combined effects of soy isoflavone and fish oil on ovariectomy-induced bone loss in mice.
PubMed:Bioavailability of soy isoflavones through placental/lactational transfer and soy food.
PubMed:Effect of soy isoflavones on breast cancer recurrence and death for patients receiving adjuvant endocrine therapy.
PubMed:Mammary gland differentiation by early life exposure to enantiomers of the soy isoflavone metabolite equol.
PubMed:The antioxidant effects of genistein are associated with AMP-activated protein kinase activation and PTEN induction in prostate cancer cells.
PubMed:Genistein aglycone: a dual mode of action anti-osteoporotic soy isoflavone rebalancing bone turnover towards bone formation.
PubMed:Polymorphic catechol-O-methyltransferase gene, soy isoflavone intake and breast cancer in postmenopausal women: a case-control study.
PubMed:PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation.
PubMed:Enhancing the biotransformation of isoflavones in soymilk supplemented with lactose using probiotic bacteria during extended fermentation.
PubMed:Soy isoflavone and its effect to regulate hypothalamus and peripheral orexigenic gene expression in ovariectomized rats fed on a high-fat diet.
PubMed:Effects of surfactant and salt species in reverse micellar forward extraction efficiency of isoflavones with enriched protein from soy flour.
PubMed:Inhibition by genistein of the lipopolysaccharide-induced down-regulation of programmed cell death 4 in RAW 264.7 mouse macrophages.
PubMed:[Prevalence of equol producer phenotype and its relations to lifestyle factors and dietary intakes among lifestyle factors and dietary intakes among healthy Chinese adults in Beijing].
PubMed:[Relationship between dietary soy isoflavones and blood lipid levels in 40 - 65 year-olds in Guangzhou].
PubMed:Factors to consider in the association between soy isoflavone intake and breast cancer risk.
PubMed:Extraction methods determine the antioxidant capacity and induction of quinone reductase by soy products in vitro.
PubMed:Soy food intake and breast cancer survival.
PubMed:Impact of dietary genistein and aging on executive function in rats.
PubMed:The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women.
PubMed:Soy product and isoflavone intake and breast cancer risk defined by hormone receptor status.
PubMed:Cellular DNA breakage by soy isoflavone genistein and its methylated structural analogue biochanin A.
PubMed:Efficacy of isoflavones in relieving vasomotor menopausal symptoms - A systematic review.
PubMed:Isoflavonoid content of Hong Kong soy foods.
PubMed:Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes.
PubMed:Soy isoflavones and risk of cancer recurrence in a cohort of breast cancer survivors: the Life After Cancer Epidemiology study.
PubMed:Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-beta.
PubMed:Soybean and soy isoflavone intake indicate a positive change in bone mineral density for 2 years in young Korean women.
PubMed:[Relationship between estrogen receptor gene Px haplotype and the effect of calcium and soy isoflavone supplementation on bone mineral density of Chinese postmenopausal women].
PubMed:Soy food and isoflavone intake in relation to semen quality parameters among men from an infertility clinic.
PubMed:Synthesis of haptens and conjugates for ELISA of glycitein: development and validation of an immunological test.
PubMed:Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo.
PubMed:Effects of isoflavone supplements vs. soy foods on blood concentrations of genistein and daidzein in adults.
PubMed:Soy intake and breast cancer risk in Singapore Chinese Health Study.
PubMed:Dose-response assessment of the anti-cancer efficacy of soy isoflavones in dimethylhydrazine-treated rats fed 6% fructooligosaccharide.
PubMed:The combination of genistin and ipriflavone prevents mammary tumorigenesis and modulates lipid profile.
PubMed:The key importance of soy isoflavone bioavailability to understanding health benefits.
PubMed:Determination of total soy isoflavones in dietary supplements, supplement ingredients, and soy foods by high-performance liquid chromatography with ultraviolet detection: collaborative study.
PubMed:Development of techniques for the analysis of isoflavones in soy foods and nutraceuticals.
PubMed:Fructooligosaccharide and soy isoflavone suppress colonic aberrant crypt foci and cyclooxygenase-2 expression in dimethylhydrazine-treated rats.
PubMed:Long-term effects of phytoestrogen daidzein on penile cavernosal structures in adult rats.
PubMed:Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study.
PubMed:Demographic, anthropometric, and lifestyle factors and dietary intakes in relation to daidzein-metabolizing phenotypes among premenopausal women in the United States.
PubMed:Puma is a novel target of soy isoflavone genistein but is dispensable for genistein-induced cell fate determination.
PubMed:Validation of a food frequency questionnaire for assessing dietary soy isoflavone intake among midlife Chinese women in Hong Kong.
PubMed:Dietary soy isoflavone-aglycone lowers food intake in female rats with and without ovariectomy.
PubMed:Epidemiology of soy exposures and breast cancer risk.
PubMed:A combination of soy isoflavone supplementation and exercise improves lipid profiles and protects antioxidant defense-systems against exercise-induced oxidative stress in ovariectomized rats.
PubMed:Effects of lactational exposure to soy isoflavones on reproductive system in neonatal female rats.
PubMed:Increased expression of catalase in human hepatoma cells by the soy isoflavone, daidzein.
PubMed:Proteomic biomarkers of peripheral blood mononuclear cells obtained from postmenopausal women undergoing an intervention with soy isoflavones.
PubMed:Dietary sources and determinants of soy isoflavone intake among midlife Chinese Women in Hong Kong.
PubMed:Isoflavone intake in persons at high risk of cardiovascular events: implications for vascular endothelial function and the carotid atherosclerotic burden.
PubMed:Studies on the anti-tumor activities of the soy isoflavone daidzein on murine neuroblastoma cells.
PubMed:Interaction of soy food and tea consumption with CYP19A1 genetic polymorphisms in the development of endometrial cancer.
PubMed:Effect of daidzein, a soy isoflavone, on bone metabolism in Cd-treated ovariectomized rats.
PubMed:Age-related uterotrophic response of soy isoflavone intake in rats.
PubMed:Plasma levels of genistein following a single dose of soy extract capsule in Indian women.
PubMed:In vitro and in vivo metabolism of the soy isoflavone glycitein.
PubMed:Oral intake of soy isoflavone aglycone improves the aged skin of adult women.
PubMed:Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women.
PubMed:Quercetin-induced PC12 cell death accompanied by caspase-mediated DNA fragmentation.
PubMed:Dietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status.
PubMed:Interaction of soy and 17beta-HSD1 gene polymorphisms in the risk of endometrial cancer.
PubMed:Effect of genistein with carnitine administration on lipid parameters and obesity in C57Bl/6J mice fed a high-fat diet.
PubMed:Enhanced estrogenic responses and sensitivity to azoxymethane following dietary soy isoflavone supplementation in older female rats.
PubMed:[Effects of soy isoflavone on levels of low-grade inflammatory peptides in rats with insulin resistance].
PubMed:[Effects of soy isoflavone on gene expression of resistin in insulin-resistance rats].
PubMed:[Prevention of osteoporosis by foods and dietary supplements. "Daizuga-cha", Kuromame-cha"].
PubMed:Phytoestrogens as bioactive ingredients in functional foods: Canadian regulatory update.
PubMed:Equol: a comparison of the effects of the racemic compound with that of the purified S-enantiomer on the growth, invasion, and DNA integrity of breast and prostate cells in vitro.
PubMed:Genistein protects prostate cells against hydrogen peroxide-induced DNA damage and induces expression of genes involved in the defence against oxidative stress.
PubMed:Intake of dietary soy isoflavones in relation to perimenstrual symptoms of Korean women living in the USA.
PubMed:Oncogenicity evaluations of chemopreventive soy components in p53((+/-)) (p53 knockout) mice.
PubMed:[Effect of soy isoflavone on gene expression of leptin and insulin sensibility in insulin-resistant rats].
PubMed:Prevalence of daidzein-metabolizing phenotypes differs between Caucasian and Korean American women and girls.
PubMed:[Effects of soy isoflavone on gene expression of adiponectin in insulin-resistance rats induced by high-fat and high-sugar diet].
PubMed:Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: interactions with genotype and equol production.
PubMed:Menopause: a review of botanical dietary supplements.
PubMed:Effects of soy isoflavone and/or estrogen treatments on bone metabolism in ovariectomized rats.
PubMed:Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: a possible mechanism of the growth inhibitory effect of Genistein.
PubMed:Genistein enhances N-nitrosomethylurea-induced rat mammary tumorigenesis.
PubMed:Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production.
PubMed:Soy isoflavone supplementation alleviates oxidative stress and improves systolic blood pressure in male spontaneously hypertensive rats.
PubMed:Characterization and quantification of soy isoflavone metabolites in serum of renal transplanted patients by high-performance liquid chromatography/electrospray ionization mass spectrometry.
PubMed:Lactational transfer of the soy isoflavone, genistein, in Sprague-Dawley rats consuming dietary genistein.
PubMed:Metabolism of glycitein (7,4'-dihydroxy-6-methoxy-isoflavone) by human gut microflora.
PubMed:Structural elucidation of hydroxylated metabolites of the isoflavan equol by gas chromatography-mass spectrometry and high-performance liquid chromatography-mass spectrometry.
PubMed:Effects of dietary genistein on mouse reproduction, postnatal development and weight-regulation.
PubMed:Soy isoflavones and cognitive function.
PubMed:Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of Daidzein in cultured human Ishikawa cells.
PubMed:Genistein blocks homocysteine-induced alterations in the proteome of human endothelial cells.
PubMed:Long-term dietary habits affect soy isoflavone metabolism and accumulation in prostatic fluid in caucasian men.
PubMed:Dynamic profiling of estrogen receptor and epidermal growth factor signaling in the uteri of genistein- and estrogen-treated rats.
PubMed:Antioxidant properties of soybean isoflavone extract and tofu in vitro and in vivo.
PubMed:The effect of soy consumption on the urinary 2:16-hydroxyestrone ratio in postmenopausal women depends on equol production status but is not influenced by probiotic consumption.
PubMed:Genistein, a soy isoflavone, enhances necrotic-like cell death in a breast cancer cell treated with a chemotherapeutic agent.
PubMed:Quality, labeling accuracy, and cost comparison of purified soy isoflavonoid products.
PubMed:Soy isoflavones modify liver free radical scavenger systems and liver parameters in Sprague-Dawley rats.
PubMed:Dietary intake of soy genistein is associated with lung function in patients with asthma.
PubMed:A simple method for the characterization and quantification of soy isoflavone metabolites in the serum of MMTV-Neu mice using high-performance liquid chromatography/electrospray ionization mass spectrometry with multiple reaction monitoring.
PubMed:Anticancer therapeutic potential of soy isoflavone, genistein.
PubMed:Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy.
PubMed:Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice.
PubMed:Intake of soy foods and soy isoflavones by rural adult women in China.
PubMed:Fructooligosaccharides maximize bone-sparing effects of soy isoflavone-enriched diet in the ovariectomized rat.
PubMed:LC/UV/ESI-MS analysis of isoflavones in Edamame and Tofu soybeans.
PubMed:Lack of an inducible effect of dietary soy isoflavones on the mRNA abundance of hepatic cytochrome P-450 isozymes in rats.
PubMed:Regulative actions of dietary soy isoflavone on biological antioxidative system and lipid metabolism in rats.
PubMed:Screening for oestrogenic activity of plant and food extracts using in vitro trout hepatocyte cultures.
PubMed:Genistein may prevent cadmium-induced bone loss in ovariectomized rats.
PubMed:Inhibition of reactive nitrogen species effects in vitro and in vivo by isoflavones and soy-based food extracts.
PubMed:Plasma isoflavone levels versus self-reported soy isoflavone levels in Asian-American women in Los Angeles County.
PubMed:Dietary soy and fats in relation to serum insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 levels in premenopausal Japanese women.
PubMed:[Effects of soy extract on energy balance in ovariectomized rats].
PubMed:Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats.
PubMed:Soy product intake is inversely associated with serum homocysteine level in premenopausal Japanese women.
PubMed:Validation of a soy food-frequency questionnaire and evaluation of correlates of plasma isoflavone concentrations in postmenopausal women.
PubMed:Validation of a soy food frequency questionnaire with plasma concentrations of isoflavones in US adults.
PubMed:Solvent extraction selection in the determination of isoflavones in soy foods.
PubMed:Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice.
PubMed:Hormonal effects of soy in premenopausal women and men.
PubMed:Identification and concentration of soy isoflavones in commercial cat foods.
PubMed:Dietary soy isoflavone intake in older Japanese American women.
PubMed:Transfer of soy isoflavone into the egg yolk of chickens.
PubMed:Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice.
PubMed:Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein.
PubMed:Oxidative metabolism of the soy isoflavones daidzein and genistein in humans in vitro and in vivo.
PubMed:New advances in the understanding of the role of steroids and steroid receptors in disease.
PubMed:Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats.
PubMed:Effects of genistein on cell proliferation and cell cycle arrest in nonneoplastic human mammary epithelial cells: involvement of Cdc2, p21(waf/cip1), p27(kip1), and Cdc25C expression.
PubMed:Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women.
PubMed:Soy consumption alters endogenous estrogen metabolism in postmenopausal women.
PubMed:Isoflavone phytoestrogens consumed in soy decrease F(2)-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans.
PubMed:Soy isoflavone conjugation differs in fed and food-deprived rats.
PubMed:Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic mice.
PubMed:Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women.
PubMed:Quantification of soy isoflavones, genistein and daidzein, and conjugates in rat blood using LC/ES-MS.
PubMed:Estrogenic activity of glycitein, a soy isoflavone.
PubMed:Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women.
PubMed:Soy isoflavone analysis: quality control and a new internal standard.
PubMed:Urinary equol excretion with a soy challenge: influence of habitual diet.
PubMed:HPLC-mass spectrometry analysis of isoflavones.
PubMed:Induction of micronucleus formation in mouse splenocytes by the soy isoflavone genistein in vitro but not in vivo.
 
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