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Category:antioxidants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 688.04 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 473.00 °F. TCC ( 245.10 °C. ) (est)
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| logP (o/w): | 0.408 (est) |
| Soluble in: |
| | water, 8845 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-mouse LD50 738 mg/kg
Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 6, Pg. 166, 1985.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | antioxidants |
| Recommendation for puerarin usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for puerarin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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Preparatory work to support the risk assessment for peri- and postmenopausal women taking food supplements containing isolated isoflavones
View page or View pdf
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Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones
View page or View pdf
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| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :5486172 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 7-hydroxy-3-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one |
| Chemidplus:0003681990 |
| RTECS:UO5216000 for cas# 3681-99-0 |
References:
| | 7-hydroxy-3-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5486172 |
| Pubchem (sid): | 135069817 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 8-beta-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)- | | | daidzein-8-C-glucoside | | 8-beta-d- | glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-one | | 7- | hydroxy-3-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one |
Articles:
| PubMed:Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway. |
| PubMed:A diet formula of Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma alleviates insulin resistance and hepatic steatosis in CD-1 mice and HepG2 cells. |
| PubMed:Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway. |
| PubMed:The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKCε. |
| PubMed:Anti-inflammatory potency of nano-formulated puerarin and curcumin in rats subjected to the lipopolysaccharide-induced inflammation. |
| PubMed:Anti-inflammatory effects of total isoflavones from Pueraria lobata on cerebral ischemia in rats. |
| PubMed:Anti-diabetic effects of puerarin, isolated from Pueraria lobata (Willd.), on streptozotocin-diabetogenic mice through promoting insulin expression and ameliorating metabolic function. |
| PubMed:Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial. |
| PubMed:Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway. |
| PubMed:Physicochemical [corrected] properties of the inclusion complex of puerarin and glucosyl-β-cyclodextrin. |
| PubMed:Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. |
| PubMed:Optimization of ionic liquid based ultrasonic assisted extraction of puerarin from Radix Puerariae Lobatae by response surface methodology. |
| PubMed:Enzymatic synthesis of puerarin glucosides using Leuconostoc dextransucrase. |
| PubMed:Acute effect of high-dose isoflavones from Pueraria lobata (Willd.) Ohwi on lipid and bone metabolism in ovariectomized mice. |
| PubMed:Kudzu (Pueraria lobata) vine ethanol extracts improve ovariectomy-induced bone loss in female mice. |
| PubMed:Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats. |
| PubMed:Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase. |
| PubMed:Phenol acidity and ease of oxidation in isoflavonoid/β-carotene antioxidant synergism. |
| PubMed:The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems. |
| PubMed:Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. |
| PubMed:Thermodynamic versus kinetic control of antioxidant synergism between β-carotene and (iso)flavonoids and their glycosides in liposomes. |
| PubMed:Evaluation of quality of Radix Puerariae herbal medicine by isoflavonoids. |
| PubMed:Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds. |
| PubMed:Effect of genistein and daidzein on the proliferation and differentiation of human preadipocyte cell line. |
| PubMed:Enzymatic synthesis of glycosylated puerarin using maltogenic amylase from Bacillus stearothermophilus expressed in Bacillus subtilis. |
| PubMed:Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells. |
| PubMed:Comparison of urodynamic effects of phytoestrogens equol, puerarin and genistein with these of estradiol 17beta in ovariectomized rats. |
| PubMed:[Identification of three-step IR spectra of radix Puerariae from different habitats]. |
| PubMed:Glycosylation of dietary flavonoids decreases the affinities for plasma protein. |
| PubMed:Identification of a naturally-occurring 8-[alpha-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl]daidzein from cultivated kudzu root. |
| PubMed:Comparison of flavonoids and isoflavonoids as antioxidants. |
| PubMed:Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. |
| PubMed:Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. |
| PubMed:Isolation of radiolabeled isoflavones from kudzu (Pueraria lobata) root cultures. |
| PubMed:Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. |
| PubMed:Determination of phytoestrogens in dietary supplements by LC-MS/MS. |
| PubMed:Selective adsorption of tannin from flavonoids by organically modified attapulgite clay. |
| PubMed:[Studies on the interaction between puerarin and bovine serum albumin]. |
| PubMed:Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice. |
| PubMed:Herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in P rats receiving free choice water and 15% ethanol in pure water. |
| PubMed:Puerarin and conjugate bases as radical scavengers and antioxidants: molecular mechanism and synergism with beta-carotene. |
| PubMed:Analysis of isoflavones in foods and dietary supplements. |
| PubMed:Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid hydrolysis. |
| PubMed:Isoflavone levels in five soybean (Glycine max) genotypes are altered by phytochrome-mediated light treatments. |
| PubMed:Suppression of arachidonic acid metabolism and nitric oxide formation by kudzu isoflavones in murine macrophages. |
| PubMed:Contrasting effects of puerarin and daidzin on glucose homeostasis in mice. |
| PubMed:Human gut microbial degradation of flavonoids: structure-function relationships. |
| PubMed:In vitro enzymatic modification of puerarin to puerarin glycosides by maltogenic amylase. |
| PubMed:Effects of purified puerarin on voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. |
| PubMed:Kudzu root extract suppresses voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. |
| PubMed:Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry. |
| PubMed:Plant derivatives in the treatment of alcohol dependency. |
| PubMed:Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. |
| PubMed:Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. |
| PubMed:Composition, red blood cell uptake, and serum protein binding of phytoestrogens extracted from commercial kudzu-root and soy preparations. |
| PubMed:Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. |
| PubMed:Toxicity study of an antidipsotropic Chinese herbal mixture in rats: NPI-028. |
| PubMed:Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. |
| PubMed:Isoflavonoid compounds extracted from Pueraria lobata suppress alcohol preference in a pharmacogenetic rat model of alcoholism. |
| PubMed:Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives. |
| PubMed:Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology. |
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3D/inchi