EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

puerarin
4H-1-benzopyran-4-one, 8-beta-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-

Sponsors

Name:7-hydroxy-3-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
CAS Number: 3681-99-0Picture of molecule3D/inchi
FDA UNII:Z9W8997416
Beilstein Number:0064198
MDL:MFCD00076007
Molecular Weight:416.38320000
Formula:C21 H20 O9
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:antioxidants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 688.04 °C. @ 760.00 mm Hg (est)
Flash Point: 473.00 °F. TCC ( 245.10 °C. ) (est)
logP (o/w): 0.408 (est)
Soluble in:
 water, 8845 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
 
Suppliers:
BOC Sciences
For experimental / research use only.
Puerarin
Carbosynth
For experimental / research use only.
Puerarin
Changsha Organic Herb
kudzu extract
Coompo
For experimental / research use only.
Puerarin from Plants ≥98%
Odor: characteristic
Use: Puerarin has been shown to be effective in treating heart diseases such as angina and myocardial infarction. puerarin can also increase cerebral blood flow in dogs, and reduces cerebral and spinal cord injury in ischemia-reperfusion rats and rabbits. Several studies have also revealed that puerarin possesses protective effects against cortical neuron and astrocyte damage induced by oxygen-glucose deprivation or glutamate excitotoxicity in vitro. Puerarin treatment may represent a novel approach to lowering the risk of or improving function in ischemia-reperfusion brain injury-related disorders. Puerarin isoflavon is the kind of phytoestrogen that is most similar in molecular structure to the estrogens secreted by the human body Puerarin is a 5-HT2C receptor and benzodiazepine site antagonist. Puerarin is being investigated as a self-microemulsifying drug delivery system.
ExtraSynthese
For experimental / research use only.
Puerarin (HPLC) ≥99%
Jiangyin Healthway
Puerarin 98%
New functional food ingredients
Santa Cruz Biotechnology
For experimental / research use only.
Puerarin
Sigma-Aldrich: Sigma
For experimental / research use only.
Puerarin ≥98.0% (HPLC)
Xian Healthway Biotech
PUERARIN
Flavor: characteristic
Kudzu (also called Japanese arrowroot) is a group of plants in the genus Pueraria, in the pea family Fabaceae, subfamily Faboideae. They are climbing, coiling, and trailing perennial vines native to much of eastern Asia, Southeast Asia, and some Pacific islands.
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 738 mg/kg
Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 6, Pg. 166, 1985.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: antioxidants
Recommendation for puerarin usage levels up to:
 not for fragrance use.
 
Recommendation for puerarin flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Preparatory work to support the risk assessment for peri- and postmenopausal women taking food supplements containing isolated isoflavones
View page or View pdf

Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5486172
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
7-hydroxy-3-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
Chemidplus:0003681990
RTECS:UO5216000 for cas# 3681-99-0
 
References:
 7-hydroxy-3-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5486172
Pubchem (sid):135069817
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
MedlinePlusSupp:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 radix puerariae root
Search Trop Picture
 
Synonyms:
4H-1-benzopyran-4-one, 8-beta-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-
 daidzein-8-C-glucoside
8-beta-d-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-one
7-hydroxy-3-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
 

Articles:

PubMed:Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway.
PubMed:A diet formula of Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma alleviates insulin resistance and hepatic steatosis in CD-1 mice and HepG2 cells.
PubMed:Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway.
PubMed:The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKCε.
PubMed:Anti-inflammatory potency of nano-formulated puerarin and curcumin in rats subjected to the lipopolysaccharide-induced inflammation.
PubMed:Anti-inflammatory effects of total isoflavones from Pueraria lobata on cerebral ischemia in rats.
PubMed:Anti-diabetic effects of puerarin, isolated from Pueraria lobata (Willd.), on streptozotocin-diabetogenic mice through promoting insulin expression and ameliorating metabolic function.
PubMed:Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial.
PubMed:Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway.
PubMed:Physicochemical [corrected] properties of the inclusion complex of puerarin and glucosyl-β-cyclodextrin.
PubMed:Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function.
PubMed:Optimization of ionic liquid based ultrasonic assisted extraction of puerarin from Radix Puerariae Lobatae by response surface methodology.
PubMed:Enzymatic synthesis of puerarin glucosides using Leuconostoc dextransucrase.
PubMed:Acute effect of high-dose isoflavones from Pueraria lobata (Willd.) Ohwi on lipid and bone metabolism in ovariectomized mice.
PubMed:Kudzu (Pueraria lobata) vine ethanol extracts improve ovariectomy-induced bone loss in female mice.
PubMed:Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats.
PubMed:Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase.
PubMed:Phenol acidity and ease of oxidation in isoflavonoid/β-carotene antioxidant synergism.
PubMed:The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems.
PubMed:Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose.
PubMed:Thermodynamic versus kinetic control of antioxidant synergism between β-carotene and (iso)flavonoids and their glycosides in liposomes.
PubMed:Evaluation of quality of Radix Puerariae herbal medicine by isoflavonoids.
PubMed:Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds.
PubMed:Effect of genistein and daidzein on the proliferation and differentiation of human preadipocyte cell line.
PubMed:Enzymatic synthesis of glycosylated puerarin using maltogenic amylase from Bacillus stearothermophilus expressed in Bacillus subtilis.
PubMed:Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells.
PubMed:Comparison of urodynamic effects of phytoestrogens equol, puerarin and genistein with these of estradiol 17beta in ovariectomized rats.
PubMed:[Identification of three-step IR spectra of radix Puerariae from different habitats].
PubMed:Glycosylation of dietary flavonoids decreases the affinities for plasma protein.
PubMed:Identification of a naturally-occurring 8-[alpha-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl]daidzein from cultivated kudzu root.
PubMed:Comparison of flavonoids and isoflavonoids as antioxidants.
PubMed:Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells.
PubMed:Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity.
PubMed:Isolation of radiolabeled isoflavones from kudzu (Pueraria lobata) root cultures.
PubMed:Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells.
PubMed:Determination of phytoestrogens in dietary supplements by LC-MS/MS.
PubMed:Selective adsorption of tannin from flavonoids by organically modified attapulgite clay.
PubMed:[Studies on the interaction between puerarin and bovine serum albumin].
PubMed:Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice.
PubMed:Herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in P rats receiving free choice water and 15% ethanol in pure water.
PubMed:Puerarin and conjugate bases as radical scavengers and antioxidants: molecular mechanism and synergism with beta-carotene.
PubMed:Analysis of isoflavones in foods and dietary supplements.
PubMed:Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid hydrolysis.
PubMed:Isoflavone levels in five soybean (Glycine max) genotypes are altered by phytochrome-mediated light treatments.
PubMed:Suppression of arachidonic acid metabolism and nitric oxide formation by kudzu isoflavones in murine macrophages.
PubMed:Contrasting effects of puerarin and daidzin on glucose homeostasis in mice.
PubMed:Human gut microbial degradation of flavonoids: structure-function relationships.
PubMed:In vitro enzymatic modification of puerarin to puerarin glycosides by maltogenic amylase.
PubMed:Effects of purified puerarin on voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol.
PubMed:Kudzu root extract suppresses voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol.
PubMed:Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry.
PubMed:Plant derivatives in the treatment of alcohol dependency.
PubMed:Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry.
PubMed:Evaluation of the estrogenic effects of legume extracts containing phytoestrogens.
PubMed:Composition, red blood cell uptake, and serum protein binding of phytoestrogens extracted from commercial kudzu-root and soy preparations.
PubMed:Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method.
PubMed:Toxicity study of an antidipsotropic Chinese herbal mixture in rats: NPI-028.
PubMed:Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats.
PubMed:Isoflavonoid compounds extracted from Pueraria lobata suppress alcohol preference in a pharmacogenetic rat model of alcoholism.
PubMed:Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives.
PubMed:Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology.
 
Notes:
None found
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2018 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy