EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

boswellic acid
urs-12-en-23-oic acid, 3-hydroxy-, (3alpha,4beta)-

Supplier Sponsors

CAS Number: 631-69-6Picture of molecule3D/inchi
FDA UNII: B252M1YO2V
Nikkaji Web:J6.895K
MDL:MFCD04039448
Molecular Weight:456.71016000
Formula:C30 H48 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:dietary supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 556.02 °C. @ 760.00 mm Hg (est)
Flash Point: 579.00 °F. TCC ( 304.10 °C. ) (est)
logP (o/w): 9.105 (est)
Soluble in:
 water, 0.001876 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Beta-Boswellic acid 97%
BOC Sciences
For experimental / research use only.
beta-Boswellic Acid 98%
Odor: characteristic
Use: beta-Boswellic Acid is a triterpenoid with anti-hyperlipidemic, anti-carcinogenic and anti-tumor activities.
Changsha Organic Herb
Boswellin Extract Boswellic Acid
ExtraSynthese
For experimental / research use only.
beta-Boswellic acid (HPLC) ≥90%
P.L. Thomas
5-LOXIN®
Santa Cruz Biotechnology
For experimental / research use only.
β-Boswellic Acid
Shaanxi Y-Herb Biotechnology
Gum Olibanum Frankincense Boswellic Acid Powder Boswellin Boswelia Serrata Extract
Sigma-Aldrich
For experimental / research use only.
Boswellic acid, mixture of a and β
analytical standard
Sigma-Aldrich
For experimental / research use only.
β-Boswellic acid
analytical standard
The Perfumery
Boswellia carterii Resin Powder/Boswellic Acid (Dry)
Odor: characteristic
Use: Bosewellia carterii resin, or Boswellic acid powder, is a special product that contains essential oil remnants leaving a woody, fresh, clean, fruity aroma. This proprietary process, invented by Dr. Robert Pappas, leaves the larger, non-volatie components in higher concentrations, including Boswellic acid. Boswellic carterii powder has approximately 10% total Boswellic acids while including other beneficial non-volatile components of the resin. This material is also available in its "pre-dried" state under [BosCarWP]. PLEASE NOTE: The 4 ounce price category listed is a 100 gram container.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
dietary supplements
Recommendation for boswellic acid usage levels up to:
 not for fragrance use.
 
Recommendation for boswellic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :168928
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picene-4-carboxylic acid
Chemidplus:0000631696
 
References:
 (3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picene-4-carboxylic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):168928
Pubchem (sid):135123796
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB02388
FooDB:FDB013798
FDA Listing of Food Additive Status:View
MedlinePlusSupp:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 salai guggal
Search Trop Picture
 
Synonyms:
beta-boswellic acid
(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picene-4-carboxylic acid
(3alpha,4beta)-3-hydroxy-Urs-12-en-23-oic acid
(3a)-3-hydroxyurs-12-en-24-oic acid
 urs-12-en-23-oic acid, 3-hydroxy-, (3alpha,4beta)-
 urs-12-en-24-oic acid, 3-hydroxy-, (3a)-
 

Articles:

Info:Frankincense (Boswellic Acid)
PubMed:Caspase mediated synergistic effect of Boswellia serrata extract in combination with doxorubicin against human hepatocellular carcinoma.
PubMed:Design, synthesis and biological evaluation of β-boswellic acid based HDAC inhibitors as inducers of cancer cell death.
PubMed:A boswellic acid-containing extract ameliorates schistosomiasis liver granuloma and fibrosis through regulating NF-κB signaling in mice.
PubMed:Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1.
PubMed:Complementary and alternative medicine in inflammatory bowel diseases: what is the future in the field of herbal medicine?
PubMed:Comparative pharmacokinetic study of two boswellic acids in normal and arthritic rat plasma after oral administration of Boswellia serrata extract or Huo Luo Xiao Ling Dan by LC-MS.
PubMed:Transdermal microemulsions of Boswellia carterii Bird: formulation, characterization and in vivo evaluation of anti-inflammatory activity.
PubMed:Frankincense ( rǔ xiāng; boswellia species): from the selection of traditional applications to the novel phytotherapy for the prevention and treatment of serious diseases.
PubMed:The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice.
PubMed:Holy Saturday asthma.
PubMed:Effect of Boswellia serrata gum resin on the morphology of hippocampal CA1 pyramidal cells in aged rat.
PubMed:Boswellic acids reduce Th17 differentiation via blockade of IL-1β-mediated IRAK1 signaling.
PubMed:Investigating permeability related hurdles in oral delivery of 11-keto-β-boswellic acid.
PubMed:Three pentacyclic triterpenes protect H9c2 cardiomyoblast cells against high-glucose-induced injury.
PubMed:Micropropagation and non-steroidal anti-inflammatory and anti-arthritic agent boswellic acid production in callus cultures of Boswellia serrata Roxb.
PubMed:Preparation of amorphous solid dispersions by rotary evaporation and KinetiSol Dispersing: approaches to enhance solubility of a poorly water-soluble gum extract.
PubMed:A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial.
PubMed:Oral and topical boswellic acid attenuates mouse osteoarthritis.
PubMed:Microbial transformation of acetyl-11-keto-boswellic acid by Cunninghamella elegans.
PubMed:The tyrosine phosphatase SHP-1 inhibits proliferation of activated hepatic stellate cells by impairing PDGF receptor signaling.
PubMed:Biotransformation of 11-keto-β-boswellic acid by Cunninghamella blakesleana.
PubMed:Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059.
PubMed:11α-Ethoxy-β-boswellic acid and nizwanone, a new boswellic acid derivative and a new triterpene, respectively, from Boswellia sacra.
PubMed:Acetyl-11-keto-beta-boswellic acid (AKBA) prevents human colonic adenocarcinoma growth through modulation of multiple signaling pathways.
PubMed:A new cytochrome P450 system from Bacillus megaterium DSM319 for the hydroxylation of 11-keto-β-boswellic acid (KBA).
PubMed:The selective 5-LOX inhibitor 11-keto-β-boswellic acid protects against myocardial ischemia reperfusion injury in rats: involvement of redox and inflammatory cascades.
PubMed:Disease-modifying effect of anthraquinone prodrug with boswellic acid on collagenase-induced osteoarthritis in Wistar rats.
PubMed:[Change in dissolution of chemical components of frankincense-myrrh before and after their compatibility and effect on no release of LPS-induced macrophage cells].
PubMed:Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105.
PubMed:Boswellic acid and its inhibitory effect on tumor growth in systemic malignancies: an emerging concept in oncology.
PubMed:Acetyl-11-keto-β-boswellic acid (AKBA) inhibits human gastric carcinoma growth through modulation of the Wnt/β-catenin signaling pathway.
PubMed:Microbial transformation of acetyl-11-keto-β-boswellic acid and their inhibitory activity on LPS-induced NO production.
PubMed:Urease inhibitory activities of β-boswellic acid derivatives.
PubMed:Acetyl-keto-β-boswellic acid induces lipolysis in mature adipocytes.
PubMed:A boswellic acid-containing extract attenuates hepatic granuloma in C57BL/6 mice infected with Schistosoma japonicum.
PubMed:A novel semisynthetic inhibitor of the FRB domain of mammalian target of rapamycin blocks proliferation and triggers apoptosis in chemoresistant prostate cancer cells.
PubMed:NF-κB down-regulation and PARP cleavage by novel 3-α-butyryloxy-β-boswellic acid results in cancer cell specific apoptosis and in vivo tumor regression.
PubMed:Chemoprevention of intestinal adenomatous polyposis by acetyl-11-keto-beta-boswellic acid in APC(Min/+) mice.
PubMed:Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugate.
PubMed:In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins.
PubMed:An in vitro study of the role of β-boswellic acid in the microtubule assembly dynamics.
PubMed:Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.
PubMed:Effect of phospholipid-based formulations of Boswellia serrata extract on the solubility, permeability, and absorption of the individual boswellic acid constituents present.
PubMed:Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family.
PubMed:PARP cleavage and perturbance in mitochondrial membrane potential by 3-α-propionyloxy-β-boswellic acid results in cancer cell death and tumor regression in murine models.
PubMed:In vitro and in vivo inhibitory activities of four Indian medicinal plant extracts and their major components on rat aldose reductase and generation of advanced glycation endproducts.
PubMed:Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice.
PubMed:The synergistic effect of beta-boswellic acid and Nurr1 overexpression on dopaminergic programming of antioxidant glutathione peroxidase-1-expressing murine embryonic stem cells.
PubMed:Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs.
PubMed:Boswellia serrata, a potential antiinflammatory agent: an overview.
PubMed:Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells.
PubMed:Anti-inflammatory agents from plants: progress and potential.
PubMed:[Chemopreventive effect of boswellic acid and curcumin on 7,12-dimethyl benzanthracene-induced hamster cheek pouch carcinogenesis].
PubMed:Efficacy of boswellic acid on lysosomal acid hydrolases, lipid peroxidation and anti-oxidant status in gouty arthritic mice.
PubMed:Hydroxylation of the triterpenoid dipterocarpol with CYP106A2 from Bacillus megaterium.
PubMed:Increased bioavailability of 11-keto-β-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: modeling and simulation considerations for evaluating drug exposures.
PubMed:Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs.
PubMed:Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.
PubMed:Boswellic acid suppresses growth and metastasis of human pancreatic tumors in an orthotopic nude mouse model through modulation of multiple targets.
PubMed:Targeting Sp1 transcription factors in prostate cancer therapy.
PubMed:Boswellic acids from frankincense inhibit lipopolysaccharide functionality through direct molecular interference.
PubMed:Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens.
PubMed:The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis.
PubMed:Boswellic acids extract attenuates pulmonary fibrosis induced by bleomycin and oxidative stress from gamma irradiation in rats.
PubMed:Boswellic acid inhibits inflammatory angiogenesis in a murine sponge model.
PubMed:Determination of major boswellic acids in plasma by high-pressure liquid chromatography/mass spectrometry.
PubMed:[Determination of five boswellic acids in Boswellia serrata].
PubMed:Potentiation of the antitumor effect of 11-keto-β-boswellic acid by its 3-α-hexanoyloxy derivative.
PubMed:A new Bacillus megaterium whole-cell catalyst for the hydroxylation of the pentacyclic triterpene 11-keto-β-boswellic acid (KBA) based on a recombinant cytochrome P450 system.
PubMed:A novel cyano derivative of 11-keto-β-boswellic acid causes apoptotic death by disrupting PI3K/AKT/Hsp-90 cascade, mitochondrial integrity, and other cell survival signaling events in HL-60 cells.
PubMed:Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers.
PubMed:Growth inhibitory, apoptotic and anti-inflammatory activities displayed by a novel modified triterpenoid, cyano enone of methyl boswellates.
PubMed:Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data.
PubMed:Antitumor properties of Boswellic acid against Ehrlich ascites cells bearing mouse.
PubMed:Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract.
PubMed:Antituberculosis cycloartane triterpenoids from Radermachera boniana.
PubMed:Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression.
PubMed:A cyano analogue of boswellic acid induces crosstalk between p53/PUMA/Bax and telomerase that stages the human papillomavirus type 18 positive HeLa cells to apoptotic death.
PubMed:Two new triterpenoids from the resin of Boswellia carterii.
PubMed:Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-β-boswellic acid from Boswellia serrata.
PubMed:A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid.
PubMed:Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial.
PubMed:[Effect of acetyl-11-keto-β-boswellic acid on proliferation, apoptosis and cell cycle of human acute myeloid leukemia cell line HL-60].
PubMed:Development and evaluation of vesicular system for curcumin delivery.
PubMed:[Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1].
PubMed:A propionyloxy derivative of 11-keto-β-boswellic acid induces apoptosis in HL-60 cells mediated through topoisomerase I & II inhibition.
PubMed:Inhibition of microsomal prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense.
PubMed:[Treatment of atrophic and irritative vulvovaginal symptoms with an anhydrous lipogel and its complementary effect with vaginal estrogenic therapy: new evidences].
PubMed:Modulation of the immune system by Boswellia serrata extracts and boswellic acids.
PubMed:Complexation with phosphatidyl choline as a strategy for absorption enhancement of boswellic acid.
PubMed:Synthesis of an antitumor active endoperoxide from 11-keto-beta-boswellic acid.
PubMed:3-Acetyl-11-keto-beta-boswellic acid loaded-polymeric nanomicelles for topical anti-inflammatory and anti-arthritic activity.
PubMed:Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer.
PubMed:In vitro zygotic embryo germination and propagation of an endangered Boswellia serrata Roxb., a source of boswellic acid.
PubMed:The enhancement effect of beta-boswellic acid on hippocampal neurites outgrowth and branching (an in vitro study).
PubMed:Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.
PubMed:Topical Boswellic acids for treatment of photoaged skin.
PubMed:Boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells.
PubMed:Effects of topical boswellic acid on photo and age-damaged skin: clinical, biophysical, and echographic evaluations in a double-blind, randomized, split-face study.
PubMed:Boswellia resin: from religious ceremonies to medical uses; a review of in-vitro, in-vivo and clinical trials.
PubMed:Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis.
PubMed:In vivo genotoxicity evaluation of a plant based antiarthritic and anticancer therapeutic agent Boswelic acids in rodents.
PubMed:LY294002 enhances boswellic acid-induced apoptosis in colon cancer cells.
PubMed:Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense.
PubMed:Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis.
PubMed:Recent developments in anti-inflammatory natural products.
PubMed:On the interference of boswellic acids with 5-lipoxygenase: mechanistic studies in vitro and pharmacological relevance.
PubMed:Boswellic acids: a group of medicinally important compounds.
PubMed:Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity.
PubMed:Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1.
PubMed:Chemical modifications of natural triterpenes - glycyrrhetinic and boswellic acids: evaluation of their biological activity.
PubMed:Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2.
PubMed:A simple high-performance liquid chromatographic method for the estimation of boswellic acids from the market formulations containing Boswellia serrata extract.
PubMed:A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee.
PubMed:Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration.
PubMed:Inhibitory effect of acetyl-11-keto-beta-boswellic acid on androgen receptor by interference of Sp1 binding activity in prostate cancer cells.
PubMed:The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats.
PubMed:Bioactive constituents of myrrh and frankincense, two simultaneously prescribed gum resins in chinese traditional medicine.
PubMed:Metabolism of boswellic acids in vitro and in vivo.
PubMed:Comparison of the irritation potentials of Boswellia serrata gum resin and of acetyl-11-keto-beta-boswellic acid by in vitro cytotoxicity tests on human skin-derived cell lines.
PubMed:A norsesquiterpene lactone and a benzoic acid derivative from the leaves of Cyclocarya paliurus and their glucosidase and glycogen phosphorylase inhibiting activities.
PubMed:Acetyl-keto-beta-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells.
PubMed:Boswellic acids: A leukotriene inhibitor also effective through topical application in inflammatory disorders.
PubMed:Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice.
PubMed:Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids.
PubMed:Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids.
PubMed:Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation.
PubMed:Boswellic acids and glucosamine show synergistic effect in preclinical anti-inflammatory study in rats.
PubMed:Natural products as a gold mine for arthritis treatment.
PubMed:CEC and EKC of natural compounds.
PubMed:Screening of plant extracts for antimicrobial activity against bacteria and yeasts with dermatological relevance.
PubMed:Effect of acetyl 11-keto beta-boswellic acid on metastatic growth factor responsible for angiogenesis.
PubMed:Boswellic acids: biological actions and molecular targets.
PubMed:Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice.
PubMed:Estimation of boswellic acids from market formulations of Boswellia serrata extract and 11-keto beta-boswellic acid in human plasma by high-performance thin-layer chromatography.
PubMed:Separation and quantification of terpenoids of Boswellia serrata Roxb. extract by planar chromatography techniques (TLC and AMD).
PubMed:Boswellic acids in chronic inflammatory diseases.
PubMed:Characterization of 3alpha-acetyl-11-keto-alpha-boswellic acid, a pentacyclic triterpenoid inducing apoptosis in vitro and in vivo.
PubMed:Boswellic acids stimulate arachidonic acid release and 12-lipoxygenase activity in human platelets independent of Ca2+ and differentially interact with platelet-type 12-lipoxygenase.
PubMed:Acetyl-keto-beta-boswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells.
PubMed:Modulation of Pgp function by boswellic acids.
PubMed:Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia.
PubMed:Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation.
PubMed:Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri.
PubMed:Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.
PubMed:Potentiation of antinociceptive effect of NSAIDs by a specific lipooxygenase inhibitor, acetyl 11-keto-beta boswellic acid.
PubMed:Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis.
PubMed:Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-beta-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin(R)).
PubMed:Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction.
PubMed:High-performance liquid chromatographic determination of acetyl-11-keto-alpha-boswellic acid, a novel pentacyclic triterpenoid, in plasma using a fluorinated stationary phase and photodiode array detection: application in pharmacokinetic studies.
PubMed:Protective effects of nimesulide (COX Inhibitor), AKBA (5-LOX Inhibitor), and their combination in aging-associated abnormalities in mice.
PubMed:Determination of boswellic acids in brain and plasma by high-performance liquid chromatography/tandem mass spectrometry.
PubMed:3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells.
PubMed:Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid.
PubMed:Boswellia carterii extract inhibits TH1 cytokines and promotes TH2 cytokines in vitro.
PubMed:Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells.
PubMed:Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells.
PubMed:Bioactive constituents from Boswellia papyrifera.
PubMed:Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers.
PubMed:Acetyl-boswellic acids inhibit lipopolysaccharide-mediated TNF-alpha induction in monocytes by direct interaction with IkappaB kinases.
PubMed:Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo.
PubMed:Effects of Boswellia serrata in mouse models of chemically induced colitis.
PubMed:Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb.
PubMed:Pharmacokinetic study of 11-Keto beta-Boswellic acid.
PubMed:Characterization of archaeological frankincense by gas chromatography-mass spectrometry.
PubMed:Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes.
PubMed:[Boswellic acids (the active agent in incense) for the treatment of chronic inflammatory diseases].
PubMed:Analysis of 12 different pentacyclic triterpenic acids from frankincense in human plasma by high-performance liquid chromatography and photodiode array detection.
PubMed:Immunomodulatory triterpenoids from the oleogum resin of Boswellia carterii Birdwood.
PubMed:Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase.
PubMed:Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors.
PubMed:Acetyl-11-keto-beta-boswellic acid (AKBA) is cytotoxic for meningioma cells and inhibits phosphorylation of the extracellular-signal regulated kinase 1 and 2.
PubMed:Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells.
PubMed:[Chemical components of Boswellia carterii].
PubMed:A lupane triterpene from frankincense (Boswellia sp., Burseraceae).
PubMed:Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro.
PubMed:Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells.
PubMed:[Boswellic acids (components of frankincense) as the active principle in treatment of chronic inflammatory diseases].
PubMed:Keto- and acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway.
PubMed:Cytotoxic action of acetyl-11-keto-beta-boswellic acid (AKBA) on meningioma cells.
PubMed:Determination of 11-keto-boswellic acid in human plasma.
PubMed:High-performance thin layer chromatographic analysis of anti-inflammatory triterpenoids from Boswellia serrata Roxb.
PubMed:Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization.
PubMed:A reversed phase high performance liquid chromatography method for the analysis of boswellic acids in Boswellia serrata.
PubMed:Development of a high-performance liquid chromatographic method for the determination of 11-keto-beta-boswellic acid in human plasma.
PubMed:Acetyl-11-keto-beta-boswellic acid, a constituent of a herbal medicine from Boswellia serrata resin, attenuates experimental ileitis.
PubMed:Response of radiochemotherapy-associated cerebral edema to a phytotherapeutic agent, H15.
PubMed:Boswellic acid, a potent antiinflammatory drug, inhibits rejection to the same extent as high dose steroids.
PubMed:Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid.
PubMed:[Therapy of active Crohn disease with Boswellia serrata extract H 15].
PubMed:3-Acetoxy group of genuine AKBA (acetyl-11-keto-beta-boswellic acid) is alpha-configurated.
PubMed:Boswellic acids in the palliative therapy of children with progressive or relapsed brain tumors.
PubMed:Synthesis of beta-Boswellic acid analogues with a carboxyl group at C-17 isolated from the bark of Schefflera octophylla.
PubMed:Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues.
PubMed:Boswellic acids inhibit glioma growth: a new treatment option?
PubMed:Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity.
PubMed:Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines.
PubMed:Acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I.
PubMed:Characterization of an acetyl-11-keto-beta-boswellic acid and arachidonate-binding regulatory site of 5-lipoxygenase using photoaffinity labeling.
PubMed:Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis.
PubMed:Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity.
PubMed:Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture.
PubMed:Inhibition by boswellic acids of human leukocyte elastase.
PubMed:Effects of boswellic acid of Boswellia serrata and other triterpenic acids on the complement system.
PubMed:Boswellic acids and protease activities.
PubMed:Structure-activity relationships of the nonredox-type non-competitive leukotriene biosynthesis inhibitor acetyl-11-keto-β-boswellic acid.
PubMed:5-Lipoxygenase inhibition by acetyl-11-keto-β-boswellic acid (AKBA) by a novel mechanism.
PubMed:Acetyl-11-keto-beta-boswellic acid (AKBA): structure requirements for binding and 5-lipoxygenase inhibitory activity.
PubMed:Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid.
PubMed:Recent progress in the study of anticancer drugs originating from plants and traditional medicines in China.
PubMed:Highlight on the studies of anticancer drugs derived from plants in China.
PubMed:Mechanism of antiinflammatory actions of curcumine and boswellic acids.
PubMed:Anticomplementary activity of boswellic acids--an inhibitor of C3-convertase of the classical complement pathway.
PubMed:A sensitive and relevant model for evaluating anti-inflammatory activity-papaya latex-induced rat paw inflammation.
PubMed:Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.
PubMed:Protection by boswellic acids against galactosamine/endotoxin-induced hepatitis in mice.
PubMed:Studies on the metabolism of glycosaminoglycans under the influence of new herbal anti-inflammatory agents.
PubMed:Anti-arthritic activity of boswellic acids in bovine serum albumin (BSA)-induced arthritis.
PubMed:Effect of a new non-steroidal anti-inflammatory agent on lysosomal stability in adjuvant induced arthritis.
 
Notes:
ursane type; active principle of salai guggal; see also record for salai guggal. Constit. of frankincense (Boswellia spp.) and olibanum oil Boswellic acid (BA) is an active component of Boswellia serrata (also known as Salai guggul). Extensive research in the past 30 years identified the active component of this resin as BA (a pentacyclic triterpenic acid) and its derivatives (acetyl-beta-boswellic acid, 11-keto-beta-boswellic acid and acetyl-11-keto-beta-boswellic acid). In animal models of inflammation, BA has been shown to be an effective adjuvant mitigating bovine serum albumin-induced arthritis and osteoarthritis. The anti-arthritic potential of BA is a result of its anti-inflammatory activity, mediated through inhibition of NF-kB, COX-2 and 5-LOX. ((PMID: 17475558, 3429205)
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