acarbose
precose

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  A2485 Acarbose Hydrate >98.0%(HPLC)(N)
  SDS

CAS Number: 56180-94-0 3D/inchi ECHA EINECS - REACH Pre-Reg: 260-030-7 FDA UNII: T58MSI464G Nikkaji Web: J33.395F MDL: MFCD00869592 XlogP3-AA: -8.50 (est) Molecular Weight: 645.61031000 Formula: C25 H43 N O18 BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:natural substances and extractives   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Boiling Point: 971.64 °C. @ 760.00 mm Hg (est) Flash Point: 1007.00 °F. TCC ( 541.40 °C. ) (est) logP (o/w): -7.935 (est) Soluble in:   water, 1e+006 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: Alfa Biotechnology For experimental / research use only. Acarbose 98% BOC Sciences For experimental / research use only. Acarbose Carbosynth For experimental / research use only. Acarbose Glentham Life Sciences Acarbose Santa Cruz Biotechnology For experimental / research use only. Acarbose Sigma-Aldrich: Sigma For experimental / research use only. Acarbose ≥95% sds TCI AMERICA For experimental / research use only. Acarbose Hydrate >98.0%(HPLC)(N) sds Tocris Bioscience For experimental / research use only. Acarbose   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: oral-dog LDLo 10000 mg/kg Pharmaceutical Chemistry Journal Vol. 23, Pg. 82, 1989. oral-man TDLo 56 mg/kg/13D-I BLOOD: EOSINOPHILIA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Lancet. Vol. 354, Pg. 396, 1999. intravenous-mouse LD50 12000 mg/kg Drugs in Japan Vol. -, Pg. 2, 1995. oral-mouse LD50 24000 mg/kg Drugs in Japan Vol. -, Pg. 2, 1995. intravenous-rat LD50 6000 mg/kg Drugs in Japan Vol. -, Pg. 2, 1995. oral-rat LD50 24000 mg/kg Drugs in Japan Vol. -, Pg. 2, 1995. Dermal Toxicity: subcutaneous-rat LD50 12000 mg/kg Drugs in Japan Vol. -, Pg. 2, 1995. Inhalation Toxicity: Not determined   Safety in Use Information: Category: natural substances and extractives Recommendation for acarbose usage levels up to:   not for fragrance use.   Recommendation for acarbose flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View ClinicalTrials.gov:search Daily Med:search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :41774 National Institute of Allergy and Infectious Diseases:Data WGK Germany:1 (3R,4R,5S,6R)-5-[(2R,3R,4R,5S,6R)-5-[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,4-triol Chemidplus:0056180940   References:   (3R,4R,5S,6R)-5-[(2R,3R,4R,5S,6R)-5-[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,4-triol NIST Chemistry WebBook: Search Inchi Pubchem (cid): 41774 Pubchem (sid): 135003847   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View KEGG (GenomeNet): C06802 HMDB (The Human Metabolome Database): HMDB14429 Export Tariff Code: 2940.00.6000 MedlinePlusSupp: View VCF-Online: VCF Volatile Compounds in Food ChemSpider: View Wikipedia: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   found in nature   Synonyms:   acarbosum   bay g 5421   bay-g 5421 (3R,4R,5S,6R)-5-[(2R,3R,4R,5S,6R)-5-[(2R,3R,4S,5S,6R)-3,4- dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,4-triol   glucobay   precose   Articles: J-Stage:Enzymatic Synthesis of Acarviosyl-maltooligosaccharides Using Disproportionating Enzyme 1

Notes: an inhibitor of alpha glucosidase that retards the digestion and absorption of carbohydrates in the small intestine and hence reduces the increase in blood-glucose concentrations after a carbohydrate load. it is given orally to non-insulin dependent diabetes mellitus patients where diet modification or oral hypoglycemic agents do not control their condition. (from martindale the extra pharmacopoeia, 31st ed)