matrine
matridin-15-one
 
Notes:
alkaloid from sophora flavescens with anthelmintic activity.
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      Product(s):
      M2120 Matrine >98.0%(GC)(T)
       
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CAS Number: 519-02-8Picture of molecule
FDA UNII: N390W430AC
Beilstein Number: 0085851
MDL: MFCD00210527
XlogP3-AA: 1.60 (est)
Molecular Weight: 248.36948000
Formula: C15 H24 N2 O
BioActivity Summary: listing
Category: antioxidants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 76.00 °C. @ 760.00 mm Hg
Boiling Point: 396.00 to  397.00 °C. @ 760.00 mm Hg (est)
Flash Point: 343.00 °F. TCC ( 172.70 °C. ) (est)
logP (o/w): 1.440 (est)
Soluble in:
 water, 831.5 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
skin conditioning
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Suppliers:
AuNutra® Industries
Matrine P.E.
BOC Sciences
For experimental / research use only.
Matrine >98%
Odor: characteristic
Use: Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist.
Coompo
For experimental / research use only.
Matrine from Plants ≥95%
Odor: characteristic
Use: Matrine has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and -receptor agonist. Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities. The main clinical applications are treatment of people with cancer, viral hepatitis, cardiac diseases (such as viral myocarditis), and skin diseases (such as psoriasis and eczema).
Santa Cruz Biotechnology
For experimental / research use only.
Matrine ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Matrine
TCI AMERICA
For experimental / research use only.
Matrine >98.0%(GC)(T)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50  125 mg/kg
Chemical and Pharmaceutical Bulletin. Vol. 18, Pg. 2555, 1970.

intravenous-mouse LD50  64.85 mg/kg
Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 27, Pg. 201, 1992.

intraperitoneal-mouse LD50  150 mg/kg
Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 18, Pg. 214, 1987.

intramuscular-mouse LD50  74150 ug/kg
Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 27, Pg. 201, 1992.

intravenous-mouse LD50  64850 ug/kg
Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 27, Pg. 201, 1992.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antioxidants
Recommendation for matrine usage levels up to:
 not for fragrance use.
 
Recommendation for matrine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 638232
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0000519028
RTECS: OQ1754000 for cas# 519-02-8
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References:
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 638232
Pubchem (sid): 135048634
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2933.99.9700
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 sophora flavescens
Search Trop  Picture
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Synonyms:
 matridin-15-one
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Articles:
PubMed: Active ingredients from natural botanicals in the treatment of obesity.
PubMed: Simultaneous determination of matrine and berberine in fruits, vegetables, and soil using ultra-performance liquid chromatography/tandem mass spectrometry.
PubMed: Protective effects of matrine against progression of high-fructose diet-induced steatohepatitis by enhancing antioxidant and anti-inflammatory defences involving Nrf2 translocation.
PubMed: [Determination of matrine in matrine injection by microfluidic chip with contactless conductivity detection].
PubMed: Sophocarpine and matrine inhibit the production of TNF-alpha and IL-6 in murine macrophages and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in mice.
PubMed: [HPCE determination of matrine in matrine liposome].
PubMed: [Techniques of diseases, insect pests and weeds control and their efficacy in bio-rational rice production].
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