EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

huperzine A
5,9-methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R)-

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CAS Number: 102518-79-6Picture of molecule3D/inchi
FDA UNII: 0111871I23
MDL:MFCD01714949
Molecular Weight:242.32166000
Formula:C15 H18 N2 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 505.01 °C. @ 760.00 mm Hg (est)
Flash Point: 499.00 °F. TCC ( 259.20 °C. ) (est)
logP (o/w): 0.833 (est)
Soluble in:
 water, 124 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Huperzine A 98%
BOC Sciences
For experimental / research use only.
(-)-Huperzine A >98%
Odor: characteristic
Use: (-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.
Changsha Organic Herb
Huperzine A
Charkit Chemical
HUPERZINE A HUPERZIA SERRATE EXTRACT
Glentham Life Sciences
(-)-Huperzine A
Hunan Astar Bio-Chemical Technology
For experimental / research use only.
Huperzine A
Odor: characteristic
Use: Huperzine A is used as a drug for the treatment of Alzheimer disease used as an herbal supplement, used as an food additive ,It has been studied for potential use in treating other CNS disorders
Jiangyin Healthway
Huperzine A 99.0%
New functional food ingredients
Sigma-Aldrich: Sigma
For experimental / research use only.
(-)-Huperzine A
sds
Sinoway Industrial
For experimental / research use only.
Huperzine A
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intramuscular-cat LD50 1200 ug/kg
Zhongguo Yaolixue Yu Dulixue Zazhi. Vol. 3, Pg. 246, 1989.

intraperitoneal-mouse LD50 1793 ug/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 8, Pg. 117, 1987.

intravenous-mouse LD50 630 ug/kg
United States Patent Document. Vol. #5177082

oral-mouse LD50 5200 ug/kg
United States Patent Document. Vol. #5177082

intraperitoneal-rat LD50 2472 ug/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 8, Pg. 117, 1987.

intravenous-rat LD50 2500 ug/kg
United States Patent Document. Vol. #5177082

oral-rat LD50 15 mg/kg
Zhongguo Yaolixue Yu Dulixue Zazhi. Vol. 3, Pg. 246, 1989.

Dermal Toxicity:
subcutaneous-mouse LD50 3 mg/kg
United States Patent Document. Vol. #5177082

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for huperzine A usage levels up to:
 not for fragrance use.
 
Recommendation for huperzine A flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5912039
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0102518796
RTECS:PB9185700 for cas# 102518-79-6
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5912039
Pubchem (sid):135066307
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
[5R-(5a,9b,11E)]-5-amino-11-ethylidene-5,8,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one
(5R,9R,11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
(5R,9R)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
(1R,9R,13E)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one
(1R,9R)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one
 huperaine A
 huperazine A
(-)-huperzine A
 huperzine A (naturally extracted)
 huperzine A (synthetic)
 huperzine A 1%
 huperzine, 1% – 5% huperzine A
5,9-methanocycloocta(b)pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)-
5,9-methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R,11E)-
5,9-methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (5R,9R)-
 selagine
(-)-selagine
 

Articles:

PubMed:Biotransformation of Huperzine A by a Fungal Endophyte of Huperzia serrata Furnished Sesquiterpenoid-Alkaloid Hybrids.
PubMed:Identification of a novel endophytic fungus from Huperzia serrata which produces huperzine A.
PubMed:[Design, synthesis and evaluation of N-acyl-4-phenylthiazole-2-amines as acetylcholinesterase inhibitors].
PubMed:Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer's Disease?
PubMed:Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways.
PubMed:Lumazine peptides penilumamides B-D and the cyclic pentapeptide asperpeptide A from a gorgonian-derived Aspergillus sp. fungus.
PubMed:The neurovascular protective effects of huperzine a on d-galactose-induced inflammatory damage in the rat hippocampus.
PubMed:The protective effect of huperzine A against hepatic ischemia reperfusion injury in mice.
PubMed:Cholinesterase Inhibition in Alzheimer's Disease: Is Specificity the Answer?
PubMed:Design, synthesis, and evaluation of 7H-thiazolo-[3,2-b]-1,2,4-triazin-7-one derivatives as dual binding site acetylcholinesterase inhibitors.
PubMed:Huperzine A attenuates hepatic ischemia reperfusion injury via anti-oxidative and anti-apoptotic pathways.
PubMed:Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds.
PubMed:Efficient strategy for maintaining and enhancing the huperzine A production of Shiraia sp. Slf14 through inducer elicitation.
PubMed:Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats.
PubMed:Marine natural products as acetylcholinesterase inhibitor: comparative quantum mechanics and molecular docking study.
PubMed:A novel approach to medical countermeasures against organophosphorus compound toxicity.
PubMed:Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis.
PubMed:A new role for the nonpathogenic nonsynonymous single-nucleotide polymorphisms of acetylcholinesterase in the treatment of Alzheimer's disease: a computational study.
PubMed:Whole-Genome Shotgun Assembly and Analysis of the Genome of Shiraia sp. Strain Slf14, a Novel Endophytic Fungus Producing Huperzine A and Hypocrellin A.
PubMed:Compound danshen tablet ameliorated aβ25-35-induced spatial memory impairment in mice via rescuing imbalance between cytokines and neurotrophins.
PubMed:Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease.
PubMed:Divergent total synthesis of the Lycopodium alkaloids huperzine A, huperzine B, and huperzine U.
PubMed:Synergistic Effect and Mechanism of Cineole and Terpineol on In-vitro Transdermal Delivery of Huperzine A from Microemulsions.
PubMed:Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease.
PubMed:Huperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidant, anti-apoptotic and anti-inflammatory mechanisms.
PubMed:Indentification of huperzine A-producing endophytic fungi isolated from Huperzia serrata.
PubMed:Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials.
PubMed:Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain.
PubMed:Huperzine A inhibits CCL2 production in experimental autoimmune encephalomyelitis mice and in cultured astrocyte.
PubMed:[Effect of PNS on the activity and content of BACE1 in the brain of SAMP8 mice with Alzheimer's disease].
PubMed:Current acetylcholinesterase-inhibitors: a neuroinformatics perspective.
PubMed:Controlled iontophoretic transport of huperzine A across skin in vitro and in vivo: effect of delivery conditions and comparison of pharmacokinetic models.
PubMed:[Effect of litchi seed aqueous extracts on learning and memory obstacles induced by D-galactose in mice and its mechanism].
PubMed:[Determination of huperzine A and semi-quantitative RT-PCR analysis of lysine decarboxylase gene in different parts of Huperzia serrata from western Hunan].
PubMed:Natural products as sources of new lead compounds for the treatment of Alzheimer's disease.
PubMed:Study of the interaction of Huperzia saururus Lycopodium alkaloids with the acetylcholinesterase enzyme.
PubMed:The role of cholinergic anti-inflammatory pathway in acetic acid-induced colonic inflammation in the rat.
PubMed:[Effect of Huperzine A on neural lesion of acute organophosphate poisoning in mice].
PubMed:[Determination of Huperzine A in the extract of Huperzia serrata by high performance liquid chromatography].
PubMed:[The effect of PNS on the content and activity of alpha-secretase in the brains of SAMP8 mice with alzheimer's disease].
PubMed:Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer's disease.
PubMed:The use of borneol as an enhancer for targeting aprotinin-conjugated PEG-PLGA nanoparticles to the brain.
PubMed:Ethanol and methanol can improve huperzine A production from endophytic Colletotrichum gloeosporioides ES026.
PubMed:Eleutheroside B or E enhances learning and memory in experimentally aged rats.
PubMed:Integrative proteomics.
PubMed:Huperzine a restores cortico-hippocampal functional connectivity after bilateral AMPA lesion of the nucleus basalis of meynert.
PubMed:Preparation and in vitro and in vivo evaluation of HupA PLGA microsphere.
PubMed:Huperzine A promotes hippocampal neurogenesis in vitro and in vivo.
PubMed:Free energy landscape for the binding process of Huperzine A to acetylcholinesterase.
PubMed:Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastoma N2a cells.
PubMed:Comparative in vitro and in vivo evaluation of lipid based nanocarriers of Huperzine A.
PubMed:Multitarget drugs of plants origin acting on Alzheimer's disease.
PubMed:The effects of huperzine A on gastrointestinal acetylcholinesterase activity and motility after single and multiple dosing in mice.
PubMed:Huperzine A, but not tacrine, stimulates S100B secretion in astrocyte cultures.
PubMed:[Effect and mechanism of dingzhixiao wan on scopolamine-induced learning-memory impairment in mice].
PubMed:Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.
PubMed:Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A.
PubMed:A novel synthesis of (-)-huperzine A via tandem intramolecular aza-Prins cyclization-cyclobutane fragmentation.
PubMed:Transepithelial transport of a natural cholinesterase inhibitor, huperzine A, along the gastrointestinal tract: the role of ionization on absorption mechanism.
PubMed:Investigating the antioxidant and acetylcholinesterase inhibition activities of Gossypium herbaceam.
PubMed:New nicotinic analogue ZY-1 enhances cognitive functions in a transgenic mice model of Alzheimer's disease.
PubMed:The anti-inflamm-aging and hepatoprotective effects of huperzine A in D-galactose-treated rats.
PubMed:Production of huperzine A and other Lycopodium alkaloids in Huperzia species grown under controlled conditions and in vitro.
PubMed:Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.
PubMed:Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice.
PubMed:Huperzine A for mild cognitive impairment.
PubMed:Acetylcholinesterase deficiency decreases apoptosis in dopaminergic neurons in the neurotoxin model of Parkinson's disease.
PubMed:Energy landscapes of human acetylcholinesterase and its Huperzine A-inhibited counterpart.
PubMed:[Effect of Panax notoginseng saponins on expression of alpha-secretase mRNA in brains of senescence-accelerated SAMP8 mice].
PubMed:A combination of [+] and [-]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs.
PubMed:The protection of acetylcholinesterase inhibitor on β-amyloid-induced the injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells.
PubMed:Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade.
PubMed:Huperzia quadrifariata and Huperzia reflexa alkaloids inhibit acetylcholinesterase activity in vivo in mice brain.
PubMed:New insights into huperzine A for the treatment of Alzheimer's disease.
PubMed:On-line immobilized acetylcholinesterase microreactor for screening of inhibitors from natural extracts by capillary electrophoresis.
PubMed:Molecular cloning and characterization of copper amine oxidase from Huperzia serrata.
PubMed:An efficient total synthesis of (-)-huperzine A.
PubMed:Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography.
PubMed:Lycopodiaceae from Panama: a new source of acetylcholinesterase inhibitors.
PubMed:Huperzine A ameliorates cognitive deficits and oxidative stress in the hippocampus of rats exposed to acute hypobaric hypoxia.
PubMed:Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD).
PubMed:Examining the interactome of huperzine A by magnetic biopanning.
PubMed:Huperzine A-phospholipid complex-loaded biodegradable thermosensitive polymer gel for controlled drug release.
PubMed:Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships.
PubMed:Decreased accumulation of subcellular amyloid-β with improved mitochondrial function mediates the neuroprotective effect of huperzine A.
PubMed:Huperzine A ameliorates experimental autoimmune encephalomyelitis via the suppression of T cell-mediated neuronal inflammation in mice.
PubMed:Development and validation of a simple assay for the determination of cholinesterase activity in whole blood of laboratory animals.
PubMed:Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease.
PubMed:Validation of a microscale extraction and high-throughput UHPLC-QTOF-MS analysis method for huperzine A in Huperzia.
PubMed:Chiral separation of Huperzine A using CE - method validation and application in pharmaceutical formulations.
PubMed:Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model.
PubMed:Huperzine A derivative M3 protects PC12 cells against sodium nitroprusside-induced apoptosis.
PubMed:Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model.
PubMed:Surrogate based accurate quantification of endogenous acetylcholine in murine brain by hydrophilic interaction liquid chromatography-tandem mass spectrometry.
PubMed:Microemulsion-based patch for transdermal delivery of huperzine A and ligustrazine phosphate in treatment of Alzheimer's disease.
PubMed:Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice.
PubMed:Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets.
PubMed:Treatment with Huperzine A improves cognition in vascular dementia patients.
PubMed:[+]-Huperzine A protects against soman toxicity in guinea pigs.
PubMed:Huperzine a as potential treatment of Alzheimer's disease: an assessment on chemistry, pharmacology, and clinical studies.
PubMed:An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production.
PubMed:Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR.
PubMed:The role of phytochemicals in the treatment and prevention of dementia.
PubMed:Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation.
PubMed:A phase II trial of huperzine A in mild to moderate Alzheimer disease.
PubMed:Improved thin-layer chromatography bioautographic assay for the detection of actylcholinesterase inhibitors in plants.
PubMed:Preventing H₂O₂-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone.
PubMed:Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model.
PubMed:The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.
PubMed:[Analysis of dynamic change of huperzine A content in Huperzia serrata].
PubMed:Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners.
PubMed:Modification and validation of a high-performance liquid chromatography method for quantification of Huperzine A in Huperzia crispata.
PubMed:Isolation and characterization of endophytic huperzine A-producing fungi from Huperzia serrata.
PubMed:Synthesis and biological evaluation of 3,6-diaryl-7H-thiazolo[3,2-b] [1,2,4]triazin-7-one derivatives as acetylcholinesterase inhibitors.
PubMed:Pharmacological agents in the prophylaxis/treatment of organophosphorous pesticide intoxication.
PubMed:Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation.
PubMed:Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method.
PubMed:Acetylcholinesterase inhibitory activity of uleine from Himatanthus lancifolius.
PubMed:Huperzine alkaloids from Australasian and southeast Asian Huperzia.
PubMed:Effect of huprine X on β-amyloid, synaptophysin and α7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice.
PubMed:Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats.
PubMed:A novel endophytic Huperzine A-producing fungus, Shiraia sp. Slf14, isolated from Huperzia serrata.
PubMed:Preparation, optimization and characteristic of huperzine a loaded nanostructured lipid carriers.
PubMed:Photohuperzine A-A new photoisomer of huperzine A: structure elucidation, formation kinetics and activity assessment.
PubMed:Analysis of expressed sequence tags from the Huperzia serrata leaf for gene discovery in the areas of secondary metabolite biosynthesis and development regulation.
PubMed:AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusion.
PubMed:Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats.
PubMed:Acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic Lycopodium annotinum ssp. alpestre.
PubMed:[Research advances of Huperzia serrata (Thunb.) Trev].
PubMed:Detection by UPLC/ESI-TOF-MS of alkaloids in three Lycopodiaceae species from French Polynesia and their anticholinesterase activity.
PubMed:Systemic administration of the potential countermeasure huperzine reversibly inhibits central and peripheral acetylcholinesterase activity without adverse cognitive-behavioral effects.
PubMed:[Release mechanism of huperzine-A swelling sustained-release tablets].
PubMed:Total synthesis of (-)-huperzine A.
PubMed:Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion.
PubMed:Pharmacokinetic behavior of huperzine A in plasma and cerebrospinal fluid after intranasal administration in rats.
PubMed:Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine.
PubMed:A systematic review of single chinese herbs for Alzheimer's disease treatment.
PubMed:Matrine determination and pharmacokinetics in human plasma using LC/MS/MS.
PubMed:Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.
PubMed:Development of a sensitive high-performance liquid chromatographic method with simple extraction for simultaneous determination of huperzine A and huperzine B in the species containing lycopodium alkaloids.
PubMed:Chemical aspects of pharmacological prophylaxis against nerve agent poisoning.
PubMed:Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin.
PubMed:Clinical use of an herbal-derived compound (Huperzine A) to treat putative complex partial seizures in a dog.
PubMed:Drug development for Alzheimer's disease: where are we now and where are we headed?
PubMed:Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment.
PubMed:The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease.
PubMed:Huperzine A for vascular dementia.
PubMed:BZYX, a novel acetylcholinesterase inhibitor, significantly improved chemicals-induced learning and memory impairments on rodents and protected PC12 cells from apoptosis induced by hydrogen peroxide.
PubMed:Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide.
PubMed:Lycojapodine A, a novel alkaloid from Lycopodium japonicum.
PubMed:Role of huperzine a in the treatment of Alzheimer's disease.
PubMed:Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis.
PubMed:Two-dimensional turbulent flow chromatography coupled on-line to liquid chromatography-mass spectrometry for solution-based ligand screening against multiple proteins.
PubMed:Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets.
PubMed:Review: insufficient evidence on Huperzine A for Alzheimer's.
PubMed:Monitoring enzyme reaction and screening of inhibitors of acetylcholinesterase by quantitative matrix-assisted laser desorption/ionization Fourier transform mass spectrometry.
PubMed:Alternative medicine and Alzheimer disease.
PubMed:The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice.
PubMed:Age-related expression of calcium/calmodulin-dependent protein kinase II A in the hippocampus and cerebral cortex of senescence accelerated mouse prone/8 mice is modulated by anti-Alzheimer's disease drugs.
PubMed:Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway.
PubMed:[Effects of microbes on rooting and on several physiological and biochemical indexes of cuttings of Huperzia serrata].
PubMed:[+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats.
PubMed:Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase.
PubMed:Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia.
PubMed:Comparison of methods used for the determination of cholinesterase activity in whole blood.
PubMed:In vitro production of huperzine A, a promising drug candidate for Alzheimer's disease.
PubMed:Huperzine A exhibits anti-inflammatory and neuroprotective effects in a rat model of transient focal cerebral ischemia.
PubMed:Flexibility versus "rigidity" of the functional architecture of AChE active center.
PubMed:Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats.
PubMed:Huperzine A for Alzheimer's disease.
PubMed:Enzyme inhibitor screening by electrospray mass spectrometry with immobilized enzyme on magnetic silica microspheres.
PubMed:[Progress of study on treatment of Alzheimer's disease with active ingredients of Chinese herbal medicines].
PubMed:Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death.
PubMed:Pharmacokinetics of huperzine A following oral administration to human volunteers.
PubMed:Pharmacokinetics of Huperzine A after transdermal and oral administration in beagle dogs.
PubMed:[Effects of huperzine A on cognitive function of rats recovering from general anesthesia].
PubMed:An update on huperzine A as a treatment for Alzheimer's disease.
PubMed:Investigation of the mechanism of enhanced effect of EGCG on huperzine A's inhibition of acetylcholinesterase activity in rats by a multispectroscopic method.
PubMed:Huprines for Alzheimer's disease drug development.
PubMed:Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
PubMed:Hopeahainol A: an acetylcholinesterase inhibitor from Hopea hainanensis.
PubMed:Determination of huperzine A in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study on Chinese volunteers.
PubMed:The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine.
PubMed:East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.
PubMed:Complete (1)H NMR spectral fingerprint of huperzine A.
PubMed:Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase.
PubMed:Huperzine A from Huperzia species--an ethnopharmacolgical review.
PubMed:Huperzine A reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats.
PubMed:Interactions of Lycopodium alkaloids with acetylcholinesterase investigated by 1H NMR relaxation rate.
PubMed:Matrix-assisted laser desorption/ionization mass spectrometry (MALDI TOF MS) study of Huperzine A, a natural anti-Alzheimer's disease product, its derivatization and its detection by highly sensitive laser induced fluorescence (LIF).
PubMed:Involvement of M1-muscarinic acetylcholine receptors, protein kinase C and mitogen-activated protein kinase in the effect of huperzine A on secretory amyloid precursor protein-alpha.
PubMed:Poly(lactic-co-glycolic acid) microspheres for the controlled release of huperzine A: in vitro and in vivo studies and the application in the treatment of the impaired memory of mice.
PubMed:Determination of Huperzine A in rat plasma by high-performance liquid chromatography with a fluorescence detector.
PubMed:Huperzine A as add-on therapy in patients with treatment-resistant schizophrenia: an open-labeled trial.
PubMed:The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse.
PubMed:Prolonged effects of poly(lactic-co-glycolic acid) microsphere-containing huperzine A on mouse memory dysfunction induced by scopolamine.
PubMed:Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.
PubMed:[Preparation of huperzine A nasal in situ gel and evaluation of its brain targeting following intranasal administration].
PubMed:Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury.
PubMed:Huperzine A in rat plasma and CSF following intranasal administration.
PubMed:Drug brain distribution following intranasal administration of Huperzine A in situ gel in rats.
PubMed:A concise and convergent (formal) total synthesis of huperzine A.
PubMed:Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
PubMed:Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation.
PubMed:Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
PubMed:Preparative isolation of huperzines A and B from Huperzia serrata by displacement centrifugal partition chromatography.
PubMed:[Plant metabolites as nootropics and cognitives].
PubMed:[Effect of huperzine A on cerebral cholinesterase and acetylcholine in elderly patients during recovery from general anesthesia].
PubMed:Ensembles of Bayesian-regularized genetic neural networks for modeling of acetylcholinesterase inhibition by huprines.
PubMed:Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge.
PubMed:Simple determination of huperzine A in human plasma by liquid chromatographic-tandem mass spectrometric method.
PubMed:Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease.
PubMed:The determination of huperzine A in European Lycopodiaceae species by HPLC-UV-MS.
PubMed:[Effect of preparation technique on in vitro release mechanism of huperzine A microspheres].
PubMed:Editorial: natural products chemistry in China.
PubMed:Controlled release of huperzine A from biodegradable microspheres: In vitro and in vivo studies.
PubMed:Harmless herbs? Think again: merits of a complete medication history.
PubMed:Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats.
PubMed:[Effect of HuperzineA on neurophathologic change of mouse exposed by isocarbophos and phoxim].
PubMed:Towards a unifying hypothesis of Alzheimer's disease: cholinergic system linked to plaques, tangles and neuroinflammation.
PubMed:Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents.
PubMed:Pharmacokinetics and in vitro and in vivo correlation of huperzine A loaded poly(lactic-co-glycolic acid) microspheres in dogs.
PubMed:Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
PubMed:[Experimental study on protective effects of HupA in the treatment of isocarbophos poisoning].
PubMed:Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease.
PubMed:Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds.
PubMed:Pharmacokinetics of huperzine A in dogs following single intravenous and oral administrations.
PubMed:Acetylcholinesterase triggers the aggregation of PrP 106-126.
PubMed:Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
PubMed:Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice.
PubMed:[Synthesis and AchE inhibitory activity of 2-phenoxy-indan-1-one derivatives].
PubMed:Herbal medicine in the treatment of Alzheimer's disease.
PubMed:Butyrylcholinesterase in guinea pig lung lavage: a novel biomarker to assess lung injury following inhalation exposure to nerve agent VX.
PubMed:Application of L-Amino acid in determination of Huperzine A by high performance liquid chromatography.
PubMed:[Effect of yizhi jiannao granule on the behavior and neuron apoptosis in SAMP/8 mice].
PubMed:High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural extracts.
PubMed:Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism.
PubMed:Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres.
PubMed:Molecular lipophilicity determination of a huperzine series by HPLC: comparison of C18 and IAM stationary phases.
PubMed:In vitro and in vivo characterization of huperzine a loaded microspheres made from end-group uncapped poly(d,l-lactide acid) and poly(d,l-lactide-co-glycolide acid).
PubMed:Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation.
PubMed:Pharmacological strategies for the prevention of Alzheimer's disease.
PubMed:Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine.
PubMed:A cyanopropyl reversed phase chromatography enables resolution of huperzine A and B on analytical and preparative scales.
PubMed:Quantification of huperzine A in Huperzia serrata by HPLC-UV and identification of the major constituents in its alkaloid extracts by HPLC-DAD-MS-MS.
PubMed:Simultaneous determination of ZT-1 and its metabolite Huperzine A in plasma by high-performance liquid chromatography with ultraviolet detection.
PubMed:Molecular and pharmacological characterization of muscarinic receptors in retinal pigment epithelium: role in light-adaptive pigment movements.
PubMed:Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman.
PubMed:Simultaneous determination of metformin and gliclazide in human plasma by liquid chromatography-tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers.
PubMed:Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors.
PubMed:How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations.
PubMed:Preparation and in vivo evaluation of huperzine A-loaded PLGA microspheres.
PubMed:A survey of potential huperzine A natural resources in China: the Huperziaceae.
PubMed:Preparation and in vitro and in vivo release studies of Huperzine A loaded microspheres for the treatment of Alzheimer's disease.
PubMed:Optimization of the capillary zone electrophoresis method for Huperzine A determination using experimental design and artificial neural networks.
PubMed:Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production.
PubMed:Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres.
PubMed:Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer's disease.
PubMed:Natural products and derivatives affecting neurotransmission relevant to Alzheimer's and Parkinson's disease.
PubMed:[Advances on study of organophosphate poisoning prevented by Huperzine A].
PubMed:Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine.
PubMed:Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells.
PubMed:Huperzine A--human serum albumin association: chromatographic and thermodynamic approach.
PubMed:Is there a better source of huperzine A than Huperzia serrata? Huperzine A content of Huperziaceae species in China.
PubMed:Ion-pair reverse-phase high performance liquid chromatography method for determination of Huperzine-A in beagle dog serum.
PubMed:(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration.
PubMed:Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms.
PubMed:Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterase.
PubMed:The Lycopodium alkaloids.
PubMed:Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease.
PubMed:Protective effect of tetramethylpyrazine on learning and memory function in D-galactose-lesioned mice.
PubMed:Recent pharmacological studies on natural products in China.
PubMed:Regulation of nicotinic acetylcholine receptor channel function by acetylcholinesterase inhibitors in rat hippocampal CA1 interneurons.
PubMed:Cholinesterase inhibitors modify the activity of intrinsic cardiac neurons.
PubMed:Identification and characterization of the major huperzine a metabolite in rat blood.
PubMed:Selagoline, a new alkaloid from Huperzia selago.
PubMed:Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats.
PubMed:Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells.
PubMed:Liquid chromatographic-tandem mass spectrometric method for the quantitation of huperzine A in dog plasma.
PubMed:A sensitive method for the determination of the novel cholinesterase inhibitor ZT-1 and its active metabolite huperzine A in rat blood using liquid chromatography/tandem mass spectrometry.
PubMed:1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative.
PubMed:[Huperzine A attenuates cognitive deficits and brain injury after hypoxia-ischemic brain damage in neonatal rats].
PubMed:Huperzine A.
PubMed:Natural monomeric form of fetal bovine serum acetylcholinesterase lacks the C-terminal tetramerization domain.
PubMed:Synthesis and docking studies of alkylene-linked dimers of (-)-huperzine A.
PubMed:[Effect of tetramethylpyrazine on learning, memory and cholinergic system in D-galactose-lesioned mice].
PubMed:Complementary and alternative medicines in the treatment of dementia: an evidence-based review.
PubMed:Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: a drug of traditional chinese medicine origin for the treatment of Alzheimer's disease.
PubMed:A convergent approach to huperzine A and analogues.
PubMed:[Studies on analogues of huperzine A for treatment of senile dementia. VI. Asymmetric total synthesis of 14-nor-huperzine A and its inhibitory activity of acetylcholinesterase].
PubMed:Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells.
PubMed:Effects of huperzine A on liver cytochrome P-450 in rats.
PubMed:Analysis of optically active compounds using conventional chromatography with a circular dichroism detector.
PubMed:The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease.
PubMed:Potentiation of acetylcholine action by huperzine-A and physostigmine on some vertebrate effectors, including human iris sphincter muscle.
PubMed:Determination of huperzine A in formulated products by reversed-phase-liquid chromatography using diode array and electrospray ionization mass spectrometric detection.
PubMed:Enantiomer effects of huperzine A on the aryl acylamidase activity of human cholinesterases.
PubMed:Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids.
PubMed:Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons.
PubMed:Acute effects of huperzine A and tacrine on rat liver.
PubMed:Identification of cytochrome P450 1A2 as enzyme involved in the microsomal metabolism of Huperzine A.
PubMed:[Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis].
PubMed:Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders.
PubMed:Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.
PubMed:Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
PubMed:Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity.
PubMed:Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
PubMed:Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia.
PubMed:Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons.
PubMed:X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.
PubMed:[Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial].
PubMed:Subchronic administration of pyridostigmine or huperzine to primates: compared efficacy against soman toxicity.
PubMed:Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons.
PubMed:Review of the value of huperzine as pretreatment of organophosphate poisoning.
PubMed:Have you had your moss today?
PubMed:Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons.
PubMed:[Ethological examination of Alzheimer's disease model rats treated with bushen yizhi decoction].
PubMed:The NMDA receptor ion channel: a site for binding of Huperzine A.
PubMed:3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.
PubMed:Effects of chronic administration of huperzine A on memory in guinea pigs.
PubMed:Spermidine antagonizes the inhibitory effect of huperzine A on [3H]dizocilpine (MK-801) binding in synaptic membrane of rat cerebral cortex.
PubMed:Tricyclic cyanoguanidines: synthesis, site of action and insecticidal activity of a novel class of reversible acetylcholinesterase inhibitors.
PubMed:Insecticidal activity of huperzine A from the New Zealand clubmoss, Lycopodium varium.
PubMed:[Effects of bushen yizhi recipe on somatostatin-like immunopositive and somatostatin messenger ribonucleic acid expressed-positive neurons in Alzheimer's disease model rats].
PubMed:Stereoselectivities of enantiomers of huperzine A in protection against beta-amyloid(25-35)-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice.
PubMed:Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys.
PubMed:Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation.
PubMed:Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils.
PubMed:Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick.
PubMed:Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives.
PubMed:Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells.
PubMed:Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.
PubMed:Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat.
PubMed:Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation.
PubMed:Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?
PubMed:Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.
PubMed:The pharmacology of novel acetylcholinesterase inhibitors, (+/-)-huprines Y and X, on the Torpedo electric organ.
PubMed:Subchronic administration of various pretreatments of nerve agent poisoning. II. Compared efficacy against soman toxicity.
PubMed:Subchronic administration of various pretreatments of nerve agent poisoning. I. Protection of blood and central cholinesterases, innocuousness towards blood-brain barrier permeability.
PubMed:Effects of Huperzine used as pre-treatment against soman-induced seizures.
PubMed:Ginkgolide A, B, and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells.
PubMed:Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance.
PubMed:Improving effects of huperzine A on abnormal lipid peroxidation and superoxide dismutase in aged rats.
PubMed:Long-term potentiation in hippocampus of rats is enhanced by endogenous acetylcholine in a way that is independent of N-methyl-D-aspartate receptors.
PubMed:Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss.
PubMed:New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
PubMed:Similar potency of the enantiomers of huperzine A in inhibition of [(3)H]dizocilpine (MK-801) binding in rat cerebral cortex.
PubMed:Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A.
PubMed:Dementia research in China.
PubMed:Synthesis of 5-substituted analogues of huperzine A.
PubMed:Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury.
PubMed:Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product This work was supported by the Research Grants Council of Hong Kong (HKUST6156/97M), the Biotechnology Research Institute (HKUST), the Mayo Foundation, and the Istituto Pasteur Fondazione Cenci Bolognetti (E.P.). We thank Prof. X. C. Tang (Shanghai Institute of Materia Medica) for a gift of (-)-1.
PubMed:Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats.
PubMed:Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells.
PubMed:Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students.
PubMed:Huperzine-A in capsules and tablets for treating patients with Alzheimer disease.
PubMed:Huperzine A.
PubMed:Treatment of Alzheimer's disease.
PubMed:[Pretreatment of organophosphate poisoning: potential interests of huperzine A].
PubMed:Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica.
PubMed:Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease.
PubMed:Huperzine A, a potential therapeutic agent for treatment of Alzheimer's disease.
PubMed:Molecular modelling and QSAR of reversible acetylcholines-terase inhibitors.
PubMed:Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound.
PubMed:Predicting relative binding free energies of tacrine-huperzine A hybrids as inhibitors of acetylcholinesterase.
PubMed:Suppressive action produced by beta-amyloid peptide fragment 31-35 on long-term potentiation in rat hippocampus is N-methyl-D-aspartate receptor-independent: it's offset by (-)huperzine A.
PubMed:Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury.
PubMed:[Huperzine a: an acetylcholinesterase inhibitor with high pharmacological potential].
PubMed:Comparison of the effects of cholinesterase inhibitors on [3H]MK-801 binding in rat cerebral cortex.
PubMed:Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.
PubMed:Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
PubMed:Modulation of NMDA receptor by huperzine A in rat cerebral cortex.
PubMed:Molecular dynamics of mouse acetylcholinesterase complexed with huperzine A.
PubMed:Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase.
PubMed:Effects of synthetic (-)-huperzine A on cholinesterase activities and mouse water maze performance.
PubMed:Anticholinesterase effects of huperzine A, E2020, and tacrine in rats.
PubMed:Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit.
PubMed:Mouse acetylcholinesterase unliganded and in complex with huperzine A: a comparison of molecular dynamics simulations.
PubMed:An analysis of low level doses of cholinesterase inhibitors in cultured neurons and hippocampal slices of rats.
PubMed:Huperzine A--an interesting anticholinesterase compound from the Chinese herbal medicine.
PubMed:Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment.
PubMed:Synthesis and acetylcholinesterase inhibitory activity of (+/-)-14-fluorohuperzine A.
PubMed:Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring.
PubMed:Interpreting the effect of methyl group at the three carbon bridge of (-)-huperzine A on its anticholinesterase activity by molecular dynamics method.
PubMed:Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity.
PubMed:The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors.
PubMed:Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
PubMed:Inhibition of cholinesterase-associated aryl acylamidase activity by anticholinesterase agents: focus on drugs potentially effective in Alzheimer's disease.
PubMed:Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities.
PubMed:Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
PubMed:Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands.
PubMed:Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase.
PubMed:Old Chinese herbal medicine used for fever yields possible new Alzheimer disease therapy.
PubMed:Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate.
PubMed:Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro.
PubMed:Efficacy of huperzine in preventing soman-induced seizures, neuropathological changes and lethality.
PubMed:Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
PubMed:Huperzine A, a novel promising acetylcholinesterase inhibitor.
PubMed:Huperzine A (shuangyiping): a promising drug for Alzheimer's disease.
PubMed:Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro.
PubMed:Huperzine A ameliorates the spatial working memory impairments induced by AF64A.
PubMed:Pharmacokinetics of tablet huperzine A in six volunteers.
PubMed:Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease.
PubMed:Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease.
PubMed:Second generation cholinesterase inhibitors: effect of (L)-huperzine-A on cortical biogenic amines.
PubMed:Effect of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats.
PubMed:Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment.
PubMed:[Intelligence promoting Chinese materia medica].
PubMed:Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo.
PubMed:Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program.
PubMed:Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies.
PubMed:Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases.
PubMed:Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.
PubMed:[Facilitation of cholinergic transmission by huperzine A in toad paravertebral ganglia in vitro].
PubMed:Effect of cholinesterase inhibition in vitro by huperzine analogs.
PubMed:Huperzine A as a pretreatment candidate drug against nerve agent toxicity.
PubMed:Revised Stereochemistry of So-Called Isoselagine and Spectroscopic Analysis of 6alpha-Hydroxylycopodine from Lycopodium serratum var. longipetiolatum.
PubMed:Natural and synthetic Huperzine A: effect on cholinergic function in vitro and in vivo.
PubMed:Mechanism of inhibition of cholinesterases by huperzine A.
PubMed:Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity.
PubMed:Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase.
PubMed:Acute and chronic studies with the anticholinesterase Huperzine A: effect on central nervous system cholinergic parameters.
PubMed:[Drug evaluation of huperzine A in the treatment of senile memory disorders].
PubMed:Huperzine A--a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease.
PubMed:Development of natural products as drugs acting on central nervous system.
PubMed:[Effects of huperzine A on electroencephalography power spectrum in rabbits].
PubMed:Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat.
PubMed:[Improvement of impaired memory in mice by huperzine A and huperzine B].
PubMed:[Effects of huperzine A on cholinesterase isoenzymes in plasma of mice and dogs].
PubMed:[Pharmacokinetics of huperzine A in rats and mice].
PubMed:[Improving effect of huperzine A on discrimination performance in aged rats and adult rats with experimental cognitive impairment].
PubMed:[Facilitatory effects of huperzine A and B on learning amd memory of spatial discrimination in mice].
PubMed:[Effects of huperzine A and B on skeletal muscle and the electroencephalogram].
PubMed:[Effects of huperzine A on learning and the retrieval process of discrimination performance in rats].
PubMed:[Anti-cholinesterase activity of huperzine A].
 
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