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EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

steareth-1
octadecyl polyoxyethylene ether

Supplier Sponsors

Name:	2-octadecoxyethanol
CAS Number:	9005-00-9	3D/inchi
Other(deleted CASRN):	106707-02-2
ECHA ELINCS - REACH Pre-Reg:	500-017-8
FDA UNII:	Search
Nikkaji Web:	J110.984G
XlogP3:	8.40 (est)
Molecular Weight:	314.55314000
Formula:	C20 H42 O2
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:emulsifiers, surfactants

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search
FDA Mainterm (IAUFC):	9005-00-9 ; PEG STEARYL ETHER

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Boiling Point:	413.00 to 414.00 °C. @ 760.00 mm Hg (est)
Flash Point:	> 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w):	7.966 (est)
Soluble in:
	water, 0.01014 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor Strength:none

Odor Description:at 100.00 %. bland

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	surfactants surfactant - emulsifying

Suppliers:

None found

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 25000 mg/kg Yakkyoku. Pharmacy. Vol. 31, Pg. 471, 1980. oral-rat LD50 2900 mg/kg "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 690, 1969. oral-rat LD50 1900 mg/kg "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 690, 1969.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
emulsifiers, surfactants
Recommendation for steareth-1 usage levels up to:
	not for fragrance use.

Recommendation for steareth-1 flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):9005-00-9

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :75050

National Institute of Allergy and Infectious Diseases:Data

2-octadecoxyethanol

Chemidplus:0002136723

RTECS:WI6250000 for cas# 9005-00-9

References:

	2-octadecoxyethanol
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	9005-00-9
Pubchem (cid):	75050
Pubchem (sid):	135031380

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:	View
CHEMBL:	View
KEGG (GenomeNet):	D08975
HMDB (The Human Metabolome Database):	Search
ChemSpider:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

not found in nature

Synonyms:

2-	octadecoxyethanol
	octadecyl polyoxyethylene ether
	polyoxyl stearyl ether

Articles:

PubMed:Surfactant effect on the physicochemical characteristics of cationic solid lipid nanoparticles.

PubMed:A cost-effective method to prepare curcumin nanosuspensions with enhanced oral bioavailability.

PubMed:A simple derivation of the critical condition for the ultrasonic atomization of polymer solutions.

PubMed:Kinetically stable propofol emulsions with reduced free drug concentration for intravenous delivery.

PubMed:The in vitro impact of toothpaste extracts on cell viability.

PubMed:Curcumin-loaded solid lipid nanoparticles with Brij78 and TPGS improved in vivo oral bioavailability and in situ intestinal absorption of curcumin.

PubMed:Thermosensitive liposomes for the delivery of gemcitabine and oxaliplatin to tumors.

PubMed:Key structure of brij for overcoming multidrug resistance in cancer.

PubMed:EliA facilitates the induction of lipase expression by stearyl alcohol in Ralstonia sp. NT80.

PubMed:Solubilisation capacity of Brij surfactants.

PubMed:A thermosensitive liposome prepared with a Cu²⁺ gradient demonstrates improved pharmacokinetics, drug delivery and antitumor efficacy.

PubMed:In vitro and in vivo assessment of targeting lipid-based nanoparticles to the epidermal growth factor-receptor (EGFR) using a novel Heptameric ZEGFR domain.

PubMed:Tailored microcrystal growth: a facile solution-phase synthesis of gold rings.

PubMed:Efficient tumor regression by a single and low dose treatment with a novel and enhanced formulation of thermosensitive liposomal doxorubicin.

PubMed:Tresyl-based conjugation of protein antigen to lipid nanoparticles increases antigen immunogenicity.

PubMed:Development of the loratadine gel for enhanced transdermal delivery.

PubMed:Templating multiple length scales by combining phase separation, self-assembly and photopatterning in porous films.

PubMed:Preparation and characterization of solid lipid nanoparticles containing silibinin.

PubMed:Cell-free production of G protein-coupled receptors for functional and structural studies.

PubMed:Preparation and characterization of nickel nanoparticles for binding to his-tag proteins and antigens.

PubMed:The metabolism of fatty alcohols in lipid nanoparticles by alcohol dehydrogenase.

PubMed:Highly enantioselective epoxidation of 2,4-diarylenones by using dimeric cinchona phase-transfer catalysts: enhancement of enantioselectivity by surfactants.

PubMed:Paclitaxel nanoparticles for the potential treatment of brain tumors.

PubMed:A collaborative evaluation of the cytotoxicity of two surfactants by using the human corneal epithelial cell line and the WST-1 test.

PubMed:Intranasal administration of plasmid DNA-coated nanoparticles results in enhanced immune responses.

PubMed:Scale-up of an oil/water cream containing 40% diethylene glycol monoethyl ether.

PubMed:Growth and survival of Helicobacter pylori in defined medium and susceptibility to Brij 78.

PubMed:Inhibitory effects of polyoxyethylene stearate, PANTA, and neutral pH on growth of Mycobacterium genavense in BACTEC primary cultures.

PubMed:Effect of Brij-78 on systemic delivery of insulin from an ocular device.

PubMed:Immobilization of functionalized alkyl-poly(ethylene oxide) surfactants on poly(ethylene) surfaces by means of an argon plasma treatment.

PubMed:Effects of the structures of polyoxyethylene alkyl ethers on uptake of butyl p-hydroxybenzoate by Escherichia coli and its antibacterial activity.

PubMed:Albumin can reverse the release of potassium from human erythrocytes treated with the non-ionic detergent, Brij 58.

PubMed:Feasibility of glucagon eyedrops for clinical use in hypoglycemia.

PubMed:Chronic systemic delivery of insulin through the ocular route.

PubMed:Enhancement of systemic delivery of met-enkephalin and leu-enkephalin eyedrops with permeation enhancers.

PubMed:Effects of permeation enhancers BL-9 and Brij-78 on absorption of four peptide eyedrops in rabbits.

PubMed:Glucagon administration to the rat via eye drops.

PubMed:Systemic absorption of oxytocin and vasopressin through eyes in rabbits.

PubMed:Effect of permeation enhancers on beta-endorphin systemic uptake after topical application to the eye.

PubMed:Adjustment of blood sugar levels with insulin and glucagon eyedrops in normal and diabetic rabbits.

PubMed:A nuclear magnetic resonance (nmr) investigation of the micellar structure of a long-chain non-ionic surfactant.

Notes:

None found

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