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Category:food additive
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Food Chemicals Codex Listed: | No |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 320 ul/kg
Problemi na Onkologiyata. Problems of Oncology. Vol. 9, Pg. 75, 1981.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | food additive |
| Recommendation for laevo-glutaminase usage levels up to: | | | not for fragrance use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| L- | glutaminase | | protein | glutaminase enzyme preparation derived from chryseobacterium proteolyticum | | | glutaminase from bacillus licheniformis produced in bacillus licheniformis | | | glutamine aminohydrolase |
Articles:
| PubMed:Actinobacteriological research in India. |
| PubMed:Biochemical characterization and antitumor study of L-glutaminase from Bacillus cereus MTCC 1305. |
| PubMed:Immobilization of glutaminase enzyme from Hypocria jecorina on polyacrylic acid: preparation and biochemical characterization. |
| PubMed:[Recombinant intracellular Rhodospirillum rubrum L-asparaginase with low L-glutaminase activity and antiproliferative effect]. |
| PubMed:[Physicochemical properties and antiproliferative activity of recombinant Yersinia pseudotuberculosis L-asparaginase]. |
| PubMed:Optimization of cultural conditions using response surface methodology versus artificial neural network and modeling of L-glutaminase production by Bacillus cereus MTCC 1305. |
| PubMed:Production and optimization of L-glutaminase enzyme from Hypocrea jecorina pure culture. |
| PubMed:Partitioning studies of L-glutaminase production by Bacillus cereus MTCC 1305 in different PEG-salt/dextran. |
| PubMed:A temperature and salt-tolerant L-glutaminase from gangotri region of uttarakhand himalaya: enzyme purification and characterization. |
| PubMed:Cloning, expression and characterization of the recombinant Yersinia pseudotuberculosis L-asparaginase. |
| PubMed:L-glutaminase production by Trichoderma koningii under solid-state fermentation. |
| PubMed:Screening and selection of marine isolate for L-glutaminase production and media optimization using response surface methodology. |
| PubMed:L-asparaginase and L-glutaminase activities in submerged rice soil amended with municipal solid waste compost and decomposed cow manure. |
| PubMed:Optimum conditions for L-glutaminase production by actinomycete strain isolated from estuarine fish, Chanos chanos (Forskal, 1775). |
| PubMed:Expression of recombinant human L-glutaminase in Escherichia coli: polyclonal antibodies production and immunological analysis of mouse tissues. |
| PubMed:Genomic organization and transcriptional analysis of the human l-glutaminase gene. |
| PubMed:Continuous production of extracellular L-glutaminase by Ca-alginate-immobilized marine Beauveria bassiana BTMF S-10 in packed-bed reactor. |
| PubMed:Do bacterial L-asparaginases utilize a catalytic triad Thr-Tyr-Glu? |
| PubMed:Structural basis for the activity and substrate specificity of Erwinia chrysanthemi L-asparaginase. |
| PubMed:Identification of two human glutaminase loci and tissue-specific expression of the two related genes. |
| PubMed:The treatment of heroin addicts with dextromethorphan: a double-blind comparison of dextromethorphan with chlorpromazine. |
| PubMed:The characterization of amidohydrolases in a freshwater lake sediment. |
| PubMed:Mechanism of resistance of a variant of P388 leukemia to L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin). |
| PubMed:Kinetic properties and inhibition of Acinetobacter glutaminase-asparaginase. |
| PubMed:The effect of histidine ammonia-lyase on some murine tumours. |
| PubMed:A radioisotope assay for L-glutaminase: the measurement of tritiated water formation from the reaction of L-[2-3H]glutamine with the L-glutaminase and glutamate oxalacetate transaminase couple. |
| PubMed:Sensitivity of cultured pancreatic carcinoma cells to Acinetobacter glutaminase-asparaginase. |
| PubMed:Tumoricidal potential of nutritional manipulations. |
| PubMed:L-glutaminase and L-asparaginase by extracorporeal route in acute lymphoblastic leukemia therapy. |
| PubMed:Formation and properties of L-glutaminase and L-asparaginase activities in Pichia polymorpha. |
| PubMed:Partial purification and properties of L-asparagine synthetase from mouse pancreas. |
| PubMed:Treatment of L5178Y tumor-bearing BDF1 mice with a nonimmunogenic L-glutaminase-L-asparaginase. |
| PubMed:Enhanced effect of an L-glutamine antagonist, L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, by Acinetobacter L-glutaminase-L-asparaginase. |
| PubMed:Phase I study of succinylated acinetobacter L-glutaminase-L-asparaginase. |
| PubMed:Achromobacter L-glutaminase-L-asparaginase: human pharmacology, toxicology, and activity in acute leukemias. |
| PubMed:Mechanism of sensitivity of cultured pancreatic carcinoma to asparaginase. |
| PubMed:[L-glutaminase-asparaginase biosynthesis by a Pseudomonas boreopolis culture dependent on cultivation conditions]. |
| PubMed:Characterization of crystals of L-glutaminase-asparaginase from Acinetobacter glutaminasificans and Pseudomonas 7A. |
| PubMed:Purification and properties of L-glutaminase-L-asparaginase from Pseudomonas acidovorans. |
| PubMed:[L-asparaginase and L-glutaminase activity in staphylococci]. |
| PubMed:Kinetics and properties of L-glutaminase and L-asparaginase activities of Pseudomonas ovalis. |
| PubMed:Studies of two crystal forms of L-glutaminase-asparaginase from Acinetobacter glutaminasificans. |
| PubMed:The properties and large-scale production of L-asparaginase from citrobacter. |
| PubMed:[Deaminase activity of Cl. botulinum type A, B, E and F cultures]. |
| PubMed:Reinvestigation of the physicochemical and enzymic properties of L-glutaminase from Pseudomonas. |
| PubMed:L-glutaminase activity in lymphocytes of patients with chronic lymphatic leukemia. |
| PubMed:L-glutamine as a substrate for L-asparaginase from Serratia marcescens. |
| PubMed:[L-asparaginase and L-glutaminase activities in leukocytes and plasma in polycythemia vera]. |
| PubMed:Purification and physicochemical properties of L-glutaminase from Pseudomonas. |
| PubMed:Effect of L-glutaminase on transformation and DNA synthesis of normal lymphocytes. |
| PubMed:[Effect of L-glutaminase from Pseudomonas aureofaciens in experimental tumors]. |
| PubMed:In vitro cytocidal effect of L-glutaminase on leukaemic lymphocytes. |
| PubMed:L-glutaminase: suppression of lymphocyte blastogenic responses in vitro. |
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Used to hydrolyse defatted soy beans in soy sauce manuf.
Glutaminase is also expressed in the epithelial cells of the renal tubules, where the produced ammonia is excreted as ammonium ions. This excretion of ammonium ions is an important mechanism of renal acid-base regulation. During an acidosis, glutaminase is induced in the kidney, which leads to an increase in the amount of ammonium ions excreted.; Glutaminase is an amidohydrolase enzyme which generates glutamate from glutamine. Glutaminase has tissue-specific isoenzymes. Importantly, glutaminase is found in glial cells.
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