| PubMed:Nobiletin suppresses cell viability through AKT Pathways in PC-3 and DU-145 prostate cancer cells. |
| PubMed:Nobiletin Protects Dopaminergic Neurons in the 1-Methyl-4-Phenylpyridinium-Treated Rat Model of Parkinson's Disease. |
| PubMed:Chemical fingerprint and metabolic profile analysis of Citrus reticulate 'Chachi' decoction by HPLC-PDA-IT-MS(n) and HPLC-Quadrupole-Orbitrap-MS method. |
| PubMed:The citrus flavone nobiletin reduces pro-inflammatory and pro-labour mediators in fetal membranes and myometrium: implications for preterm birth. |
| PubMed:Simultaneous Determination of 10 Active Components in Baizhu Shaoyao San and Its Single Herbs by High-Performance Liquid Chromatography Coupled with Diode Array Detection. |
| PubMed:Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies. |
| PubMed:Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells. |
| PubMed:Identification and evaluation of anti-inflammatory compounds from Kaempferia parviflora. |
| PubMed:Upregulation of N-methyl-D-aspartate receptor subunits and c-Fos expressing genes in PC12D cells by nobiletin. |
| PubMed:Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium). |
| PubMed:An investigation of molecular dynamics simulation and molecular docking: interaction of citrus flavonoids and bovine β-lactoglobulin in focus. |
| PubMed:Soluble and insoluble phenolic compounds and antioxidant activity of immature calamondin affected by solvents and heat treatment. |
| PubMed:Identification of the effective constituents for anti-inflammatory activity of Ju-Zhi-Jiang-Tang, an ancient traditional Chinese medicine formula. |
| PubMed:Spectroscopy and molecular docking study on the interaction behavior between nobiletin and pepsin. |
| PubMed:Nobiletin, a flavone from Citrus depressa, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells. |
| PubMed:[Chemical constituents from leaves of Ilex latifolia]. |
| PubMed:An HPLC method for the quantitation of 3-pentylbenzo[c]thiophen-1(3H)-one in dog plasma and its application to a pharmacokinetic study. |
| PubMed:Antiproliferative and apoptosis-inducing activity of nobiletin against three subtypes of human breast cancer cell lines. |
| PubMed:Synergistic antitumor effect of a combination of paclitaxel and carboplatin with nobiletin from Citrus depressa on non-small-cell lung cancer cell lines. |
| PubMed:Simultaneous determination of 13 chemical marker compounds in Gwakhyangjeonggi-san, a herbal formula, with validated analytical methods. |
| PubMed:Nobiletin restores impaired hippocampal mitochondrial bioenergetics in hypothyroidism through activation of matrix substrate-level phosphorylation. |
| PubMed:Neuroprotective effect of nobiletin on cerebral ischemia-reperfusion injury in transient middle cerebral artery-occluded rats. |
| PubMed:Carrier-mediated uptake of nobiletin, a citrus polymethoxyflavonoid, in human intestinal Caco-2 cells. |
| PubMed:Sonochemical effects on 14 flavonoids common in citrus: relation to stability. |
| PubMed:New insights into the pharmacological potential of plant flavonoids in the catecholamine system. |
| PubMed:Characteristics of nobiletin-induced effects on jejunal contractility. |
| PubMed:Nobiletin suppresses MMP-9 expression through modulation of p38 MAPK activity in human dermal fibrobalsts. |
| PubMed:Antiviral activity of polymethoxylated flavones from "Guangchenpi", the edible and medicinal pericarps of citrus reticulata 'Chachi'. |
| PubMed:Establishment of reporter platforms capable of detecting NF-κB mediated immuno-modulatory activity. |
| PubMed:Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice. |
| PubMed:Application of the solvent extraction technique to investigation of the anti-inflammatory activity of adlay bran. |
| PubMed:Stimulatory effect of nobiletin, a citrus polymethoxy flavone, on catecholamine synthesis through Ser19 and Ser40 phosphorylation of tyrosine hydroxylase in cultured bovine adrenal medullary cells. |
| PubMed:Simultaneous determination of six bioactive flavonoids in Citri Reticulatae Pericarpium by rapid resolution liquid chromatography coupled with triple quadrupole electrospray tandem mass spectrometry. |
| PubMed:[The activation effect of nobiletin on cystic fibrosis transmembrane conductance regulator chloride channel]. |
| PubMed:Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes. |
| PubMed:The ethanol extract isolated from Weiqi Decoction induces G₂/M arrest and apoptosis in AGS cells. |
| PubMed:Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-κB, AP-1 and p38. |
| PubMed:6-demethoxynobiletin, a nobiletin-analog citrus flavonoid, enhances extracellular signal-regulated kinase phosphorylation in PC12D cells. |
| PubMed:Structure-activity relationship of flavonoids on their anti-Escherichia coli activity and inhibition of DNA gyrase. |
| PubMed:Monitoring the chemical production of citrus-derived bioactive 5-demethylnobiletin using surface-enhanced Raman spectroscopy. |
| PubMed:Inhibitory effects of nobiletin on hepatocellular carcinoma in vitro and in vivo. |
| PubMed:Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells. |
| PubMed:[Determination of the active constituents in aurantii fructus from Jiangxi province at different harvest time by HPLC]. |
| PubMed:Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse. |
| PubMed:Physicochemical and biopharmaceutical characterization of amorphous solid dispersion of nobiletin, a citrus polymethoxylated flavone, with improved hepatoprotective effects. |
| PubMed:Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat. |
| PubMed:Natural polyphenols in the management of major depression. |
| PubMed:Chemical constituents of the root of Jasminum giraldii. |
| PubMed:Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. |
| PubMed:Simultaneous quantification of paeoniflorin, nobiletin, tangeretin, liquiritigenin, isoliquiritigenin, liquiritin and formononetin from Si-Ni-San extract in rat plasma and tissues by liquid chromatography-tandem mass spectrometry. |
| PubMed:Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I Induced by Chronic Unpredictable Mild Stress. |
| PubMed:Nobiletin, a polymethoxyflavone in citrus fruits, reduces TAFI expression in HepG2 cells through transcriptional inhibition. |
| PubMed:Nobiletin induces inhibitions of Ras activity and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling to suppress cell proliferation in C6 rat glioma cells. |
| PubMed:Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells. |
| PubMed:Nobiletin induces apoptosis and potentiates the effects of the anticancer drug 5-fluorouracil in p53-mutated SNU-16 human gastric cancer cells. |
| PubMed:[Activating effect of citrus flavonoids on neuromedin U2 receptor and analysis on siRNA interference]. |
| PubMed:Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines. |
| PubMed:Phytochemical profile and antioxidant activity of physiological drop of citrus fruits. |
| PubMed:Nobiletin-rich Citrus reticulata peels, a kampo medicine for Alzheimer's disease: a case series. |
| PubMed:Identification of active compounds from Aurantii Immatri Pericarpium attenuating brain injury in a rat model of ischemia-reperfusion. |
| PubMed:Citrus flavonoids and lipid metabolism. |
| PubMed:Polymethoxyflavones as agents that prevent formation of cataract: nobiletin congeners show potent growth inhibitory effects in human lens epithelial cells. |
| PubMed:Antioxidant activity and effective compounds of immature calamondin peel. |
| PubMed:Chemical constituents of Arisaema franchetianum tubers. |
| PubMed:Inhibition of nitric oxide production and inducible nitric oxide synthase expression by a polymethoxyflavone from young fruits of Citrus unshiu in rat primary astrocytes. |
| PubMed:Chemical markers of shiikuwasha juice adulterated with calamondin juice. |
| PubMed:Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress. |
| PubMed:Inhibitory effects of Citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells. |
| PubMed:HPLC-PDA-MS and NMR characterization of a hydroalcoholic extract of Citrus aurantium L. var. amara peel with antiedematogenic activity. |
| PubMed:Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice. |
| PubMed:Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9. |
| PubMed:Polymethoxy flavonoids, nobiletin and tangeretin, prevent lipopolysaccharide-induced inflammatory bone loss in an experimental model for periodontitis. |
| PubMed:Dietary polyphenols and mechanisms of osteoarthritis. |
| PubMed:The composition of volatile aroma components, flavanones, and polymethoxylated flavones in Shiikuwasha (Citrus depressa Hayata) peels of different cultivation lines. |
| PubMed:Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells. |
| PubMed:In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: identifying sinensetin as a novel antiangiogenesis agent. |
| PubMed:Mild mitochondrial depolarization is involved in a neuroprotective mechanism of Citrus sunki peel extract. |
| PubMed:Evaluation of Citrus aurantifolia peel and leaves extracts for their chemical composition, antioxidant and anti-cholinesterase activities. |
| PubMed:Polymethoxyflavonoids tangeretin and nobiletin increase glucose uptake in murine adipocytes. |
| PubMed:Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model. |
| PubMed:Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents. |
| PubMed:Phenolic constituents from the heartwood of Artocapus altilis and their tyrosinase inhibitory activity. |
| PubMed:[Identification of metabolites of nobiletin in rats using ultra-performance liquid chromatography coupled with triple-quadrupole mass spectrometry]. |
| PubMed:Development and validation of a highly sensitive LC-MS/MS-ESI method for the determination of nobiletin in rat plasma: application to a pharmacokinetic study. |
| PubMed:Synergistic anti-inflammatory effects of nobiletin and sulforaphane in lipopolysaccharide-stimulated RAW 264.7 cells. |
| PubMed:Antiproliferative effects of Dangyuja (Citrus grandis Osbeck) leaves through suppression of constitutive signal transducer and activator of transcription 3 activation in human prostate carcinoma DU145 cells. |
| PubMed:Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction. |
| PubMed:Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells. |
| PubMed:Nobiletin suppresses adipogenesis by regulating the expression of adipogenic transcription factors and the activation of AMP-activated protein kinase (AMPK). |
| PubMed:Simultaneous quantification of polymethoxylated flavones and coumarins in Fructus aurantii and Fructus aurantii immaturus using HPLC-ESI-MS/MS. |
| PubMed:3',4'-didemethylnobiletin induces phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells. |
| PubMed:B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production. |
| PubMed:Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination. |
| PubMed:Permeability determination and pharmacokinetic study of nobiletin in rat plasma and brain by validated high-performance liquid chromatography method. |
| PubMed:Chemical composition and biological activity of Citrus jambhiri Lush. |
| PubMed:Nobiletin, a polymethoxylated flavonoid from citrus, shows anti-angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model. |
| PubMed:Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells. |
| PubMed:In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450. |
| PubMed:Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production. |
| PubMed:High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound. |
| PubMed:Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability. |
| PubMed:Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance. |
| PubMed:Molecular structures of citrus flavonoids determine their effects on lipid metabolism in HepG2 cells by primarily suppressing apoB secretion. |
| PubMed:Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes. |
| PubMed:Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid. |
| PubMed:Effects of nobiletin on PhIP-induced prostate and colon carcinogenesis in F344 rats. |
| PubMed:Regulation of adipocytokine secretion and adipocyte hypertrophy by polymethoxyflavonoids, nobiletin and tangeretin. |
| PubMed:Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NFκB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency. |
| PubMed:PET imaging of nobiletin based on a practical total synthesis. |
| PubMed:Citrus flavonoid 5-demethylnobiletin suppresses scavenger receptor expression in THP-1 cells and alters lipid homeostasis in HepG2 liver cells. |
| PubMed:Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry. |
| PubMed:Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation. |
| PubMed:Nutraceuticals: do they represent a new era in the management of osteoarthritis? - a narrative review from the lessons taken with five products. |
| PubMed:Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells. |
| PubMed:Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin. |
| PubMed:Effects of selected food phytochemicals in reducing the toxic actions of TCDD and p,p'-DDT in U937 macrophages. |
| PubMed:Simultaneous determination of flavonoids in different parts of Citrus reticulata 'Chachi' fruit by high performance liquid chromatography-photodiode array detection. |
| PubMed:[Isolation and purification of flavones from Murraya exotica L. by high-speed counter-current chromatography]. |
| PubMed:Protective effects of the citrus flavanones to PC12 cells against cytotoxicity induced by hydrogen peroxide. |
| PubMed:Nobiletin, a citrus polymethoxyflavonoid, suppresses multiple angiogenesis-related endothelial cell functions and angiogenesis in vivo. |
| PubMed:[Study on the contents of flavonoids in Citrus reticulata 'Chachi' from various habitats and different collecting periods]. |
| PubMed:Induction of apoptosis in human cervical carcinoma HeLa cells by polymethoxylated flavone-rich Citrus grandis Osbeck (Dangyuja) leaf extract. |
| PubMed:Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources. |
| PubMed:Dual effects of nobiletin, a citrus polymethoxy flavone, on catecholamine secretion in cultured bovine adrenal medullary cells. |
| PubMed:Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats. |
| PubMed:Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines ( Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand. |
| PubMed:Inhibitory effects of 5-hydroxy polymethoxyflavones on colon cancer cells. |
| PubMed:[Preventive action of nobiletin, a constituent of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, against amyloid-beta peptide-induced neurotoxicity expression and memory impairment]. |
| PubMed:Hepatoprotective effects of flavonoids from shekwasha (Citrus depressa) against D-galactosamine-induced liver injury in rats. |
| PubMed:Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. |
| PubMed:Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice. |
| PubMed:Study of nobiletin binding to bovine serum albumin by capillary electrophoresis-frontal analysis and circular dichroism. |
| PubMed:Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. |
| PubMed:Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition. |
| PubMed:Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. |
| PubMed:Nobiletin metabolite, 3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone, inhibits LDL oxidation and down-regulates scavenger receptor expression and activity in THP-1 cells. |
| PubMed:[Effect of nobiletin on K562 cells xenograft in nude mice]. |
| PubMed:Simultaneous determination of five bioactive flavonoids in pericarpium Citri reticulatae from china by high-performance liquid chromatography with dual wavelength detection. |
| PubMed:Fingerprinting alterations of secondary metabolites of tangerine peels during growth by HPLC-DAD and chemometric methods. |
| PubMed:Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation. |
| PubMed:[Inhibition effect and its mechanism of nobiletin on proliferation of lung cancer cells]. |
| PubMed:4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. |
| PubMed:Nobiletin, a dietary phytochemical, inhibits vascular smooth muscle cells proliferation via calcium-mediated c-Jun N-terminal kinases pathway. |
| PubMed:[Preparation of self-assemble nobiletin proliposomes and its pharmacokinetics in rats]. |
| PubMed:Chemoprevention with phytochemicals targeting inducible nitric oxide synthase. |
| PubMed:Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion. |
| PubMed:[Effect of nobiletin on tubulin polymerization in vitro]. |
| PubMed:Effect of natsudaidain isolated from Citrus plants on TNF-alpha and cyclooxygenase-2 expression in RBL-2H3 cells. |
| PubMed:Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis. |
| PubMed:Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1. |
| PubMed:Anti-inflammatory and antitumor promotional effects of a novel urinary metabolite, 3',4'-didemethylnobiletin, derived from nobiletin. |
| PubMed:Suppressive Effects of Selected Food Phytochemicals on CD74 Expression in NCI-N87 Gastric Carcinoma Cells. |
| PubMed:Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells. |
| PubMed:Preparation of nobiletin in self-microemulsifying systems and its intestinal permeability in rats. |
| PubMed:Pharmacological action of nobiletin, a component of AURANTII NOBILIS PERICARPIUM with anti-dementia activity, and its application for development of functional foods. |
| PubMed:Investigation of heat treating conditions for enhancing the anti-inflammatory activity of citrus fruit (Citrus reticulata) peels. |
| PubMed:The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells. |
| PubMed:Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease. |
| PubMed:Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice. |
| PubMed:Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: possible involvement of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis regulation. |
| PubMed:Inhibition of oral carcinogenesis by citrus flavonoids. |
| PubMed:Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivo. |
| PubMed:Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice. |
| PubMed:Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells. |
| PubMed:Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activation. |
| PubMed:Minerals, phenolic compounds, and antioxidant capacity of citrus peel extract by hot water. |
| PubMed:Validated reversed phase LC method for quantitative analysis of polymethoxyflavones in citrus peel extracts. |
| PubMed:Comparative study on nobiletin metabolism with liver microsomes from rats, Guinea pigs and hamsters and rat cytochrome p450. |
| PubMed:A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells. |
| PubMed:Distribution of nobiletin chitosan-based microemulsions in brain following i.v. injection in mice. |
| PubMed:Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus. |
| PubMed:LPS-induced IL-6, IL-8, VCAM-1, and ICAM-1 expression in human lymphatic endothelium. |
| PubMed:Antimicrobial activity of wax and hexane extracts from Citrus spp. peels. |
| PubMed:Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice. |
| PubMed:Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3. |
| PubMed:Comparison of two sample preconcentration strategies for the sensitivity enhancement of flavonoids found in Chinese herbal medicine in micellar electrokinetic chromatography with UV detection. |
| PubMed:[Characteristics of nobiletin-loaded nanoemulsion and its in vivo distribution in mice]. |
| PubMed:Anti-inflammatory property of the urinary metabolites of nobiletin in mouse. |
| PubMed:Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells. |
| PubMed:Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-kappaB and ROS production in LPS-activated RAW 264.7 cells. |
| PubMed:A citrus polymethoxy flavonoid, nobiletin inhibits sebum production and sebocyte proliferation, and augments sebum excretion in hamsters. |
| PubMed:Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass? |
| PubMed:Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells. |
| PubMed:Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland. |
| PubMed:Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ mice. |
| PubMed:Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes. |
| PubMed:Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits. |
| PubMed:Quality control and discrimination of pericarpium citri reticulatae and pericarpium citri reticulatae viride based on high-performance liquid chromatographic fingerprints and multivariate statistical analysis. |
| PubMed:Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts. |
| PubMed:Tyrosinase inhibitory effects and inhibition mechanisms of nobiletin and hesperidin from citrus peel crude extracts. |
| PubMed:Effects of TNF-alpha on leukocyte adhesion molecule expressions in cultured human lymphatic endothelium. |
| PubMed:Identification of polymethoxylated flavones from green tangerine peel (Pericarpium Citri Reticulatae Viride) by chromatographic and spectroscopic techniques. |
| PubMed:Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells. |
| PubMed:Nobiletin, a citrus flavonoid, reverses learning impairment associated with N-methyl-D-aspartate receptor antagonism by activation of extracellular signal-regulated kinase signaling. |
| PubMed:Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells. |
| PubMed:Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells. |
| PubMed:Determination of polymethoxylated flavones in peels of selected Jamaican and Mexican citrus (Citrus spp.) cultivars by high-performance liquid chromatography. |
| PubMed:Simultaneous analysis of eight bioactive compounds in Danning tablet by HPLC-ESI-MS and HPLC-UV. |
| PubMed:Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. |
| PubMed:[Antitumor effects of nobiletin on Heps and its mechanism]. |
| PubMed:Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography. |
| PubMed:Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China. |
| PubMed:Comparison of supercritical fluid chromatography and liquid chromatography for the separation of urinary metabolites of nobiletin with chiral and non-chiral stationary phases. |
| PubMed:Nobiletin, a citrus flavonoid, suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells. |
| PubMed:Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells. |
| PubMed:Nobiletin restoring beta-amyloid-impaired CREB phosphorylation rescues memory deterioration in Alzheimer's disease model rats. |
| PubMed:Identification of nobiletin metabolites in mouse urine. |
| PubMed:Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen. |
| PubMed:Liquid chromatography/mass spectrometry and liquid chromatography/nuclear magnetic resonance as complementary analytical techniques for unambiguous identification of polymethoxylated flavones in residues from molecular distillation of orange peel oils (Citrus sinensis). |
| PubMed:Antagonistic effects of nobiletin, a polymethoxyflavonoid, on eosinophilic airway inflammation of asthmatic rats and relevant mechanisms. |
| PubMed:Zingiberaceous and citrus constituents, 1'-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action. |
| PubMed:Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities. |
| PubMed:Mechanism of neurotrophic action of nobiletin in PC12D cells. |
| PubMed:Preparative isolation and purification of polymethoxylated flavones from Tangerine peel using high-speed counter-current chromatography. |
| PubMed:Scavenger receptors: friend or foe in atherosclerosis? |
| PubMed:Nobiletin: efficient and large quantity isolation from orange peel extract. |
| PubMed:Anti-hepatitis C virus effect of citrus unshiu peel and its active ingredient nobiletin. |
| PubMed:Effect of flavones on rat brain and lung matrix metalloproteinase activity measured by film in-situ zymography. |
| PubMed:Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats. |
| PubMed:[Chemical study of citrus plants in the search for cancer chemopreventive agents]. |
| PubMed:Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells. |
| PubMed:Cancer prevention by antioxidants. |
| PubMed:Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo. |
| PubMed:Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages. |
| PubMed:Biotransformation of nobiletin by Aspergillus niger and the antimutagenic activity of a metabolite, 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone. |
| PubMed:Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. |
| PubMed:Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulation. |
| PubMed:Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin. |
| PubMed:Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro. |
| PubMed:Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. |
| PubMed:Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of Citrus sinensis (cv. Valencia Late) fruits against Phytophthora citrophthora. |
| PubMed:Rapid analysis of gene expression changes caused by liver carcinogens and chemopreventive agents using a newly developed three-dimensional microarray system. |
| PubMed:Urinary metabolites of nobiletin orally administered to rats. |
| PubMed:Effect of extraction method on the concentrations of selected bioactive compounds in mandarin juice. |
| PubMed:Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin. |
| PubMed:Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. |
| PubMed:Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages. |
| PubMed:[Studies on the chemical constituents of Citrus reticulata]. |
| PubMed:Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells. |
| PubMed:[Studies on chemical constituents of processed green tangerine peel]. |
| PubMed:Nobiletin as a tyrosinase inhibitor from the peel of Citrus fruit. |
| PubMed:[Determination of three flavonoids and ferulic acid in Pleurospermum hookeri C. B. Clarke var. thomsonii C. B. Clarke by HPLC]. |
| PubMed:Increasing resistance against Phytophthora citrophthora in tangelo Nova fruits by modulating polymethoxyflavones levels. |
| PubMed:Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones. |
| PubMed:Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells. |
| PubMed:Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. |
| PubMed:The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice. |
| PubMed:Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. |
| PubMed:Immunotoxicity of a standardized citrus polymethoxylated flavone extract. |
| PubMed:Dietary administration of citrus nobiletin inhibits azoxymethane-induced colonic aberrant crypt foci in rats. |
| PubMed:Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro. |
| PubMed:In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits. |
| PubMed:Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-inflammatory polymethoxyflavonoid. |
| PubMed:Antibacterial activity of Citrus reticulata peel extracts. |
| PubMed:Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants. |
| PubMed:Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells. |
| PubMed:Inhibitors of 15-lipoxygenase from orange peel. |
| PubMed:Inhibitory effect of citrus nobiletin on phorbol ester-induced skin inflammation, oxidative stress, and tumor promotion in mice. |
| PubMed:Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. |
| PubMed:Effect of gamma-irradiation on phenolic compounds and phenylalanine ammonia-lyase activity during storage in relation to peel injury from peel of Citrus clementina hort. Ex. tanaka. |
| PubMed:A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts. |
| PubMed:Antimutagenic activity of polymethoxyflavonoids from Citrus aurantium. |
| PubMed:HL-60 differentiating activity and flavonoid content of the readily extractable fraction prepared from citrus juices. |
| PubMed:Influence of putative antiinvasive agents on matrix metalloproteinase secretion by human neoplastic glia in vitro. |
| PubMed:The citrus flavonoid nobiletin suppresses the production and gene expression of matrix metalloproteinases-9/gelatinase B in rabbit synovial cells. |
| PubMed:Antiproliferative activity of flavonoids on several cancer cell lines. |
| PubMed:Effect of citrus flavonoids on HL-60 cell differentiation. |
| PubMed:Simultaneous separation of flavanone glycosides and polymethoxylated flavones in citrus juices using liquid chromatography. |
| PubMed:Inhibition of bacterial mutagenesis by Citrus flavonoids. |
| PubMed:Isolation of anti-leukemia compounds from Citrus reticulata. |
| PubMed:Pharmacological profile of gastric mucosal protection by marmin and nobiletin from a traditional herbal medicine, Aurantii fructus immaturus. |
| PubMed:Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes. |
| PubMed:Citrus flavonoids stimulate secretion by human colonic T84 cells. |
| PubMed:Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids. |
| PubMed:Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro. |
| PubMed:Effect of catechins and citrus flavonoids on invasion in vitro. |
| PubMed:C18 solid-phase isolation and high-performance liquid chromatography/ultraviolet diode array determination of fully methoxylated flavones in citrus juices. |
| PubMed:Flavones in citrus exhibit antiadhesive action on platelets. |
| PubMed:Tumor promoter-induced basophil histamine release: effect of selected flavonoids. |
| PubMed:In vitro and in vivo activation of oxidative drug metabolism by flavonoids. |
| PubMed:Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids. |
| PubMed:Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids. |
| PubMed:Regulation of human drug metabolism by dietary factors. |
| PubMed:Quantitation of polymethoxylated flavones in orange juice by high-performance liquid chromatography. |
| PubMed:Inhibition of aflatoxin B1-induced cytotoxicity and binding to DNA in cultured rat liver cells by naturally occurring flavones. |
| PubMed:Effect of flavonoids on the platelet adhesiveness in repeatedly bred rats. |
| PubMed:Nobiletin is main fungistat in tangerines resistant to mal secco. |
3D/inchi