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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | yellow crystals (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 416.80 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 428.00 °F. TCC ( 220.00 °C. ) (est)
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| logP (o/w): | 1.420 (est) |
| Soluble in: |
| | water, 5.407e+004 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for trans-caffeic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for trans-caffeic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (E)- | caffeic acid | | | caffeic acid, trans- | | (E)-3-(3,4- | dihydroxy-phenyl)-acrylic acid | | (E)-3,4- | dihydroxycinnamic acid | | trans-3,4- | dihydroxycinnamic acid | | (2E)-3-(3,4- | dihydroxyphenyl)-2-propenoic acid | | (E)-3-(3,4- | dihydroxyphenyl)-2-propenoic acid | | (2E)-3-(3,4- | dihydroxyphenyl)acrylic acid | | (E)-3-(3,4- | dihydroxyphenyl)acrylic acid | | (2E)-3-(3,4- | dihydroxyphenyl)prop-2-enoic acid | | (E)-3-(3,4- | dihydroxyphenyl)prop-2-enoic acid | | 2- | propenoic acid, 3-(3,4-dihydroxyphenyl)-, (2E)- | | 2- | propenoic acid, 3-(3,4-dihydroxyphenyl)-, (E)- |
Articles:
| PubMed:Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents. |
| PubMed:Leaf Extract of Markhamia platycalyx: Polyphenolic Profile, Acute Toxicity, Anti-inflammatory, Hepatoprotective and in vitro Antioxidant Activities. |
| PubMed:[Chemical constituents from ethyl acetate extract of Artemisia rupestris]. |
| PubMed:Biotransformation of 4,5-O-dicaffeoylquinic acid methyl ester by human intestinal flora and evaluation on their inhibition of NO production and antioxidant activity of the products. |
| PubMed:[Chemical constituents of the roots of Vaccinium bracteatum]. |
| PubMed:trans-Caffeic acid stearyl ester from Paeonia suffruticosa inhibits melanin synthesis by cAMP-mediating down-regulation of α-melanocyte-stimulating hormone-stimulated melanogenesis signaling pathway in B16 cells. |
| PubMed:[Chemical constituents of Phymatopteris hastate and their antioxidant activity]. |
| PubMed:Absorption, disposition, metabolism, and excretion of [3-(14)C]caffeic acid in rats. |
| PubMed:Melissa officinalis extract inhibits attachment of herpes simplex virus in vitro. |
| PubMed:Antioxidant, anti-glycation and anti-inflammatory activities of phenolic constituents from Cordia sinensis. |
| PubMed:[Studies on the chemical constituents from the roots of Kalopanax septemlobus]. |
| PubMed:The blue anthocyanin pigments from the blue flowers of Heliophila coronopifolia L. (Brassicaceae). |
| PubMed:Profiling of resveratrol oligomers, important stress metabolites, accumulating in the leaves of hybrid Vitis vinifera (Merzling × Teroldego) genotypes infected with Plasmopara viticola. |
| PubMed:Relationship between nonvolatile composition and sensory properties of premium Spanish red wines and their correlation to quality perception. |
| PubMed:Identification of new derivatives of 2-S-glutathionylcaftaric acid in aged white wines by HPLC-DAD-ESI-MS(n). |
| PubMed:[Two new phenolic acids from Drynariae rhizoma]. |
| PubMed:Depsides and other polar constituents from Origanum dictamnus L. and their in vitro antimicrobial activity in clinical strains. |
| PubMed:Enantioselective synthesis and antioxidant activity of 3-(3,4-dihydroxyphenyl)-glyceric acid--basic monomeric moiety of a biologically active polyether from Symphytum asperum and S. caucasicum. |
| PubMed:[HPLC fingerprint of chemical constituents of Flos Farfarae]. |
| PubMed:[Studies on chemical constituents of Evodia rutaecarpa]. |
| PubMed:Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays. |
| PubMed:Anemonin, from Clematis crassifolia, potent and selective inducible nitric oxide synthase inhibitor. |
| PubMed:[Study on the terpenoids of chemical constituents of Buddleja purdomii (II)]. |
| PubMed:Bioactive constituents from Chinese natural medicines. XXVI. Chemical structures and hepatoprotective effects of constituents from roots of Rhodiola sachalinensis. |
| PubMed:Occurrence of N-phenylpropenoyl-L-amino acid amides in different herbal drugs and their influence on human keratinocytes, on human liver cells and on adhesion of Helicobacter pylori to the human stomach. |
| PubMed:Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. |
| PubMed:[Phenolic compounds isolated from rhizoma of Aster tataricus]. |
| PubMed:NMR assignments and single-crystal X-ray diffraction analysis of deoxyloganic acid. |
| PubMed:Hydroxycinnamic acids do not prevent aortic atherosclerosis in hypercholesterolemic golden Syrian hamsters. |
| PubMed:Neuroprotective phenylpropanoid esters of rhamnose isolated from roots of Scrophularia buergeriana. |
| PubMed:Spanish sparkling wines (Cavas) as inhibitors of in vitro human low-density lipoprotein oxidation. |
| PubMed:Metabolites of orally administered Perilla frutescens extract in rats and humans. |
| PubMed:Metabolism of rosmarinic acid in rats. |
| PubMed:Two novel compounds from Paeonia suffructicosa. |
| PubMed:Caffeic acid and glycerol are constituents of the suberin layers in green cotton fibres. |
| PubMed:[Structure of swertiamacroside from Swertia macrosperma C.B. Clark]. |
| PubMed:Formation of trans-caffeoyl-CoA from trans-4-coumaroyl-CoA by Zn2+-dependent enzymes in cultured plant cells and its activation by an elicitor-induced pH shift. |
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Widespread in plants, free and as glycosides. Present in fruits, cereals, wine and coffee in free and conjugated forms
3,4-Dihydroxy-trans-cinnamate is a polyphenol present in normal human urine positively correlated to coffee consumption and influenced by the dietary intake of diverse types of food. (PMID:16870009)
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3D/inchi