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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.005814 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for 5,8,11,14,17-eicosapentaenoic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for 5,8,11,14,17-eicosapentaenoic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | icosa-5,8,11,14,17-pentaenoic acid | | | timnodonic acid |
Articles:
| PubMed:Mammalian ALOX15 orthologs exhibit pronounced dual positional specificity with docosahexaenoic acid. |
| J-Stage:Regulation of Lipid Metabolism by Palmitoleate and Eicosapentaenoic Acid (EPA) in Mice Fed a High-Fat Diet |
| PubMed:Omega-3 production by fermentation of Yarrowia lipolytica: From fed-batch to continuous. |
| PubMed:Fatty acids with in vitro binding affinity for human opioid receptors from the fungus Emericella nidulans. |
| PubMed:Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase. |
| PubMed:Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms. |
| PubMed:Inhibitory activities of omega-3 Fatty acids and traditional african remedies on keloid fibroblasts. |
| PubMed:Anticholinesterase and antioxidant constituents from Gloiopeltis furcata. |
| PubMed:Teratogenic effects of diatom metabolites on sea urchin Paracentrotus lividus embryos. |
| PubMed:Biochemical composition of some red and brown macro algae from the Northeastern Mediterranean Sea. |
| PubMed:Comparison of fatty acid, mineral and proximate composition of body and legs of edible frog (Rana esculenta). |
| PubMed:Effects of different dietary fatty acids on the fatty acid compositions and the expression of lipid metabolic-related genes in mammary tumor tissues of rats. |
| PubMed:Acanthopleuribacter pedis gen. nov., sp. nov., a marine bacterium isolated from a chiton, and description of Acanthopleuribacteraceae fam. nov., Acanthopleuribacterales ord. nov., Holophagaceae fam. nov., Holophagales ord. nov. and Holophagae classis nov. in the phylum 'Acidobacteria'. |
| PubMed:Fat content and fatty acid compositions of 34 marine water fish species from the Mediterranean Sea. |
| PubMed:Cold adaptation of eicosapentaenoic acid-less mutant of Shewanella livingstonensis Ac10 involving uptake and remodeling of synthetic phospholipids containing various polyunsaturated fatty acids. |
| PubMed:Seasonal effects in the nutritional quality of the body structural tissue of cephalopods. |
| PubMed:Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized products. |
| PubMed:The quality properties and saturated and unsaturated fatty acid profiles of quail egg: the alterations of fatty acids with process effects. |
| PubMed:Oxidized derivatives of omega-3 fatty acids: identification of IPF3 alpha-VI in human urine. |
| PubMed:Properties of trans isomers of eicosapentaenoic acid and docosahexaenoic acid methyl esters on cyanopropyl stationary phases. |
| PubMed:Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responses. |
| PubMed:Activating omega-6 polyunsaturated fatty acids and inhibitory purine nucleotides are high affinity ligands for novel mitochondrial uncoupling proteins UCP2 and UCP3. |
| PubMed:Upgrading of maatjes herring byproducts: production of crude fish oil. |
| PubMed:Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs. |
| PubMed:Effects of eicosapentaenoic acid and its 15-hydroperoxy and 15-hydroxy derivatives on glucosamine synthetase activity in rabbit gastric mucosa. |
| PubMed:The membrane lipids of the marine ciliated protozoan Parauronema acutum. |
| PubMed:Dietary essential fatty acid deficiency differentially affects tissues of rats. |
| PubMed:Modification of cultured Madin-Darby canine kidney cells with dietary unsaturated fatty acids and regulation of arachidonate cascade reaction. |
| PubMed:15-Hydroperoxyeicosapentaenoic acid inhibits arachidonic acid metabolism in rabbit platelets more potently than eicosapentaenoic acid. |
| PubMed:Thin-layer chromatography and high-performance liquid chromatography for the assay of fatty acid compositions of individual phospholipids in platelets from non-insulin-dependent diabetes mellitus patients: effect of eicosapentaenoic acid ethyl ester administration. |
| PubMed:Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils. |
| PubMed:Blocking effects of polyunsaturated fatty acids on Na+ channels of neonatal rat ventricular myocytes. |
| PubMed:Development and characterization of essential fatty acid deficiency in human endothelial cells in culture. |
| PubMed:Modulation of the beta-adrenergic response of cardiomyocytes by specific lipoxygenase products involves their incorporation into phosphatidylinositol and activation of protein kinase C. |
| PubMed:[Eicosanoids as mediators in ARDS]. |
| PubMed:Bio-anticlastogenic effects of unsaturated fatty acids included in fish oil--docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid--in cultured Chinese hamster cells. |
| PubMed:The enteral bioavailability of eicosapentaenoic acid and docosahexaenoic acid is as good from ethyl esters as from glyceryl esters in spite of lower hydrolytic rates by pancreatic lipase in vitro. |
| PubMed:[Inactivation of prostaglandin H synthase from sheep vesicular glands with acetylenic fatty acids]. |
| PubMed:Stearidonic acid, an inhibitor of the 5-lipoxygenase pathway. A comparison with timnodonic and dihomogammalinolenic acid. |
| PubMed:Effect of cultural conditions on production of eicosapentaenoic acid by Pythium irregulare. |
| PubMed:Differential effects of omega-3 fish oils on protein kinase activities in vitro. |
| PubMed:Dietary fish and prostanoid formation in man. |
| PubMed:Influence of dietary fish on eicosanoid metabolism in man. |
| PubMed:Transformation of 15-hydroperoxide of eicosapentaenoic acid to lipoxins and trihydroxyeicosatetraenoic acids by 5-lipoxygenase partially purified from potato tubers. |
| PubMed:[General pharmacological studies on 5,8,11,14,17-eicosapentaenoic acid ethyl ester (EPA-E)]. |
| PubMed:Fatty acid composition of umbilical arteries and veins: possible implications for the fetal EFA-status. |
| PubMed:[Effects of omega-3-fatty acids on the prostaglandin system in healthy probands]. |
| PubMed:Habitual fish consumption, fatty acids of serum phospholipids and platelet function. |
| PubMed:Normalization by dietary cod-liver oil of reduced thrombogenesis in essential fatty acid deficient rats. |
| PubMed:Effect of a fish oil diet on the composition of rat neutrophil lipids and the molecular species of choline and ethanolamine glycerophospholipids. |
| PubMed:Comparison between habitual intake of polyunsaturated fatty acids and their concentrations in serum lipid fractions. |
| PubMed:Eskimo plasma constituents, dihomo-gamma-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid inhibit the release of atherogenic mitogens. |
| PubMed:Oxidation of 5,8,11,14,17-eicosapentaenoic acid by hepatic and renal microsomes. |
| PubMed:Modulation of the contractile activity of the guinea-pig lung parenchymal strip by exogenous 5,8,11,14,17-eicosapentaenoic acid. |
| PubMed:Quantitative determination of prostaglandins E1, E2 and E3 in frog tissue. |
| PubMed:Naturally occurring conjugated octadecatrienoic acids are strong inhibitors of prostaglandin biosynthesis. |
| PubMed:Transformation of 15-hydroperoxyeicosapentaenoic acid to lipoxin A5 and B5, mono- and dihydroxyeicosapentaenoic acids by porcine leukocytes. |
| PubMed:Effect of exogenous 5,8,11,14,17-eicosapentaenoic acid on cardiac anaphylaxis. |
| PubMed:Modulation of the anaphylactic reaction in sensitized guinea-pig hearts by timnodonic acid. |
| PubMed:Modulation of the contractile activity of the guinea-pig lung parenchymal strip by timnodonic acid. |
| PubMed:Effect of dietary menhaden oil on tumor cell loss and the accumulation of mass of a transplantable mammary adenocarcinoma in BALB/c mice. |
| PubMed:Formation of hepoxilin A4, B4 and the corresponding trioxilins from 12(S)-hydroperoxy-5,8,10,14,17-icosapentaenoic acid. |
| PubMed:Comparison of the in vitro effect of eicosapentaenoic acid (EPA)-derived lipoxygenase metabolites on human platelet function with those of arachidonic acid. |
| PubMed:Lipoxene: a new group of trihydroxy pentaenes of eicosapentaenoic acid derived from porcine leukocytes. |
| PubMed:Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. |
| PubMed:Eicosapentaenoic acid: its effects on arachidonic acid metabolism by cells in culture. |
| PubMed:Effect of omega-3 fatty acids on growth of a rat mammary tumor. |
| PubMed:Arachidonic acid, 5,8,11-eicosatrienoic acid and 5,8,11,14, 17-eicosapentaenoic acid. Dietary manipulation of the levels of these acids in rat liver and platelet phospholipids and their incorporation into human platelet lipids. |
| PubMed:Dietary fish oil augments the induction of arthritis in rats immunized with type II collagen. |
| PubMed:Dietary alpha-linolenic acid and prostaglandin synthesis: a time course study. |
| PubMed:Sera fatty acid effects on cultured rat splenocytes. |
| PubMed:Arachidonate 5-lipoxygenase of guinea pig peritoneal polymorphonuclear leukocytes. Activation by adenosine 5'-triphosphate. |
| PubMed:Partial purification and characterization of arachidonate 12-lipoxygenase from rat lung. |
| PubMed:Distinctive selectivity for docosatetraenoic acid incorporation by Ehrlich ascites tumor cells. |
| PubMed:Human umbilical blood vessel converts all cis-5, 8, 11, 14, 17 eicosapentaenoic acid to prostaglandin I3. |
| PubMed:Formation of leukotrienes E3, E4 and E5 in rat basophilic leukemia cells. |
| PubMed:Metabolism of radioactive 5,8,11,14,17-eicosapentaenoic acid by human platelets. |
| PubMed:The influence of ambient peroxides on the conversion of 5,8,11,14,17-eicosapentaenoic acid to prostaglandins. |
| PubMed:Transformations of 5,8,11,14,17-eicosapentaenoic acid in human platelets. |
| PubMed:All cis-5, 8, 11, 14, 17 eicosapentaenoic acid and triene prostaglandins: potential anti-thrombotic agents. |
| PubMed:The effect of arachidonic- and eicosapentaenoic acid on the synthesis of prostacyclin-like material in human umbilical vasculature. |
| PubMed:Manipulation of platelet aggregation by prostaglandins and their fatty acid precursors: pharmacological basis for a therapeutic approach. |
| PubMed:Effects of all cis-5,8,11,14,17 eicosapentaenoic acid and PGH3 on platelet aggregation. |
| PubMed:Preparation and biochemical properties of PGH3. |
| PubMed:Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. |
| PubMed:Methyl-directed desaturation of arachidonic to eicosapentaenoic acid in the fungus, Saprolegnia parasitica. |
| PubMed:Synthesis and function of 9,12,15-octadecatrien-6-ynoic acid in the moss ceratodon purpureus. |
| PubMed:On the phospholipase activity in bovine seminal vesicles and its possible role in the regulation of the prostaglandin biosynthesis. |
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3D/inchi