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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.002364 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for 8,11,14-eicosatrienoic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for 8,11,14-eicosatrienoic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (8E,11E,14E)- | icosa-8,11,14-trienoic acid | | homo-gamma- | linolenic acid |
Articles:
| PubMed:Plasma phospholipids fatty acids, dietary fatty acids, and breast cancer risk. |
| PubMed:Metabolic engineering of long chain-polyunsaturated fatty acid biosynthetic pathway in oleaginous fungus for dihomo-gamma linolenic acid production. |
| PubMed:Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor. |
| PubMed:Effects of tung oilseed FAD2 and DGAT2 genes on unsaturated fatty acid accumulation in Rhodotorula glutinis and Arabidopsis thaliana. |
| PubMed:Plasma phospholipids, non-esterified plasma polyunsaturated fatty acids and oxylipids are associated with BMI. |
| PubMed:Epoxyeicosatrienoic acids attenuate cigarette smoke extract-induced interleukin-8 production in bronchial epithelial cells. |
| PubMed:Food allergy in small children carries a risk of essential fatty acid deficiency, as detected by elevated serum mead acid proportion of total fatty acids. |
| PubMed:Serum phospholipid monounsaturated fatty acid composition and Δ-9-desaturase activity are associated with early alteration of fasting glycemic status. |
| PubMed:Dietary zinc deficiency affects blood linoleic acid: dihomo-γ-linolenic acid (LA:DGLA) ratio; a sensitive physiological marker of zinc status in vivo (Gallus gallus). |
| PubMed:EETs alleviate ox-LDL-induced inflammation by inhibiting LOX-1 receptor expression in rat pulmonary arterial endothelial cells. |
| PubMed:Pathogen induced chemo-attractant hepoxilin A3 drives neutrophils, but not eosinophils across epithelial barriers. |
| PubMed:Nutritional immunomodulation in critically ill children with acute lung injury: feasibility and impact on circulating biomarkers. |
| PubMed:Interrelated effects of dihomo-γ-linolenic and arachidonic acids, and sesamin on hepatic fatty acid synthesis and oxidation in rats. |
| PubMed:Serum cytokeratin 18 M30 antigen level and its correlation with nutritional parameters in middle-aged Japanese males with nonalcoholic fatty liver disease (NAFLD). |
| PubMed:Subchronic (13-week) oral toxicity study of dihomo-gamma-linolenic acid (DGLA) oil in rats. |
| PubMed:Fish oil prevents essential fatty acid deficiency and enhances growth: clinical and biochemical implications. |
| PubMed:Randomized clinical trial of the effects of perioperative use of immune-enhancing enteral formula on metabolic and immunological status in patients undergoing esophagectomy. |
| PubMed:Distribution and metabolism of dihomo-gamma-linolenic acid (DGLA, 20:3n-6) by oral supplementation in rats. |
| PubMed:Effects of long-term continuous use of immune-enhancing enteral formula on nutritional and immunologic status in non-surgical patients. |
| PubMed:Effects of sesamin and capsaicin on the mRNA expressions of delta6 and delta5 desaturases in rat primary cultured hepatocytes. |
| PubMed:Isolation and characterization of a delta5 FA desaturase from Pythium irregulare by heterologous expression in Saccharomyces cerevisiae and oilseed crops. |
| PubMed:Antioxidant and cyclooxygenase activities of fatty acids found in food. |
| PubMed:Hepoxilins raise circulating insulin levels in vivo. |
| PubMed:Evidence for age-related differences in the fatty acid composition of human adipose tissue, independent of diet. |
| PubMed:Dietary supplementation with gamma-linolenic acid alters fatty acid content and eicosanoid production in healthy humans. |
| PubMed:Influence of dietary arachidonic acid on metabolism in vivo of 8cis,11cis,14-eicosatrienoic acid in humans. |
| PubMed:Dietary (n-9) eicosatrienoic acid from a cultured fungus inhibits leukotriene B4 synthesis in rats and the effect is modified by dietary linoleic acid. |
| PubMed:Effect of diet on the fatty acid composition of the major phospholipids of infant cerebral cortex. |
| PubMed:Borage or primrose oil added to standardized diets are equivalent sources for gamma-linolenic acid in rats. |
| PubMed:Infant brain lipids and diet. |
| PubMed:Fatty acid composition of serum phospholipids in an elderly institutionalized Japanese population. |
| PubMed:Phospholipid fatty acid composition of various mouse tissues after feeding alpha-linolenate (18:3n-3) or eicosatrienoate (20:3n-3). |
| PubMed:Plasma fatty acid composition during the first week of life following feeding with human milk or formula. |
| PubMed:The effect of essential fatty acid and specific vitamin supplements on vascular sensitivity in the mid-trimester of human pregnancy. |
| PubMed:Loss of delta-6-desaturase activity as a key factor in aging. |
| PubMed:The effect of dihomo-gamma-linolenic acid (20: 3,n-6) on the composition of phospholipid fatty acids in the liver of rats deficient in essential fatty acids. |
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8,11,14-Eicosatrienoic acid is a 20-carbon-chain omega-6 fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid (5,8,11,14-eicosatetraenoic acid) only at position 5. 8,11,14-Eicosatrienoic acid is also known as Dihomo-gamma-linolenic acid (DGLA). In physiological literature, it is given the name 20:3(n-6). DGLA is the elongation product of the 18 carbon gamma-linolenic acid (GLA). DGLA can be converted into prostaglandin E1 (PGE1). PGE1 inhibits platelet aggregation and also exerts a vasodilatory effect. DGLA competes with arachadonic acid for COX and lipoxygenase, inhibiting the production of arachadonic acid's eicosanoids [HMDB]
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3D/inchi