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(R,S)-hesperetin
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one

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Name:5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one
CAS Number: 69097-99-0Picture of molecule3D/inchi
FDA UNII: Search
Nikkaji Web:J294.471E
MDL:MFCD00016956
XlogP3-AA:2.40 (est)
Molecular Weight:302.28278000
Formula:C16 H14 O6
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
EFSA/JECFA Comments:
CASrn is 69097-99-0 according to Industry, which refers to the (R,S)-hesperitin ((R,S)- 5,7,3'-Trihydroxy-4'-methoxyflavanone). CASrn to be confirmed by Industry.
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Perfumer and Flavorist:Search
Google Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
FEMA Number:4313 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one
FDA:No longer provide for the use of these seven synthetic flavoring substances
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 586.00 to 587.00 °C. @ 760.00 mm Hg (est)
Flash Point: 433.00 °F. TCC ( 223.00 °C. ) (est)
logP (o/w): 1.938 (est)
Soluble in:
 water, 272.5 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Hesperetin > 95%
Odor: characteristic
Use: Hesperetin is a derivative of Hesperidine with potential antihyperglycemic activity.
Santa Cruz Biotechnology
For experimental / research use only.
Hesperetin ≥95%
Sigma-Aldrich
Hesperetin, ≥95%
Certified Food Grade Products
WholeChem
HESPERETIN, >=95%
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
flavoring agents
Recommendation for (R,S)-hesperetin usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 23
Click here to view publication 23
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): 10.0000050.00000
beverages(alcoholic): 10.00000100.00000
breakfast cereal: 30.0000060.00000
cheese: 20.00000150.00000
chewing gum: --
condiments / relishes: 10.00000100.00000
confectionery froastings: 50.00000100.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 20.00000150.00000
fruit ices: 20.00000150.00000
gelatins / puddings: 10.00000100.00000
granulated sugar: 100.00000250.00000
gravies: 10.00000100.00000
hard candy: 50.00000100.00000
imitation dairy: --
instant coffee / tea: 10.0000050.00000
jams / jellies: 20.0000050.00000
meat products: --
milk products: 20.00000150.00000
nut products: 0.2000050.00000
other grains: 30.0000060.00000
poultry: --
processed fruits: 20.0000050.00000
processed vegetables: 20.0000050.00000
reconstituted vegetables: 20.0000050.00000
seasonings / flavors: 10.00000100.00000
snack foods: 60.00000120.00000
soft candy: 50.00000100.00000
soups: 10.00000100.00000
sugar substitutes: 100.00000250.00000
sweet sauces: 10.00000100.00000
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3593
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one
 
References:
 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):3593
Pubchem (sid):162863617
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
Golm Metabolome Database:Search
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 citrus
Search PMC Picture
 
Synonyms:
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one
 
 
Notes:
None found
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