EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

riboflavin 5'-phosphate
vitamin B2 phosphate

Supplier Sponsors

Name:[(2S,3R,4R)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] dihydrogen phosphate
CAS Number: 146-17-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:205-664-7
FDA UNII: 7N464URE7E
Beilstein Number:0068086
XlogP3:-2.60 (est)
Molecular Weight:456.34893200
Formula:C17 H21 N4 O9 P
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1697 Riboflavin-5'-phosphate View - review
FDA Mainterm (SATF):146-17-8 ; RIBOFLAVIN 5'-PHOSPHATE
 
Physical Properties:
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -1.747 (est)
Soluble in:
 water, 1996 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
AIDP
Riboflavin 5 Phosphate (R5P) R5P 73.0-79.0%
Charkit Chemical
RIBOFLAVIN 5 PHOSPHATE
ECSA Chemicals
VITAMINE B2 5-SODIUMPHOSPHATE BP/USP
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 365 mg/kg
Toxicology and Applied Pharmacology. Vol. 44, Pg. 225, 1978.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nutrient supplements
Recommendation for riboflavin 5'-phosphate usage levels up to:
 not for fragrance use.
 
Recommendation for riboflavin 5'-phosphate flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Assessment of one published review on health risks associated with phosphate additives in food
View page or View pdf

Safety and efficacy of vitamin B2 (riboflavin and riboflavin 5’-phosphate ester monosodium salt) produced by Bacillus subtilis for all animal species based on a dossier submitted by DSM
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8965
National Institute of Allergy and Infectious Diseases:Data
[(2S,3R,4R)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] dihydrogen phosphate
Chemidplus:0000146178
 
References:
 [(2S,3R,4R)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] dihydrogen phosphate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):8965
Pubchem (sid):134974780
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
Metabolomics Database:Search
KEGG (GenomeNet):C00061
HMDB (The Human Metabolome Database):HMDB01520
FooDB:FDB001984
YMDB (Yeast Metabolome Database):YMDB00085
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
[(2S,3R,4R)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] dihydrogen phosphate
 flanin
 riboflavin mononucleotide
 riboflavine dihydrogen phosphate
 vitamin B2 phosphate
 

Articles:

PubMed:A thixotropic supramolecular hydrogel of adenine and riboflavin-5'-phosphate sodium salt showing enhanced fluorescence properties.
PubMed:Matrix tablets based on a carrageenan with the modified-release of sodium riboflavin 5'-phosphate.
PubMed:Evaluating in vivo delivery of riboflavin with coulomb-controlled iontophoresis for corneal collagen cross-linking: a pilot study.
PubMed:[Ion-pair HPLC analysis of B vitamins in syrup products in Indonesia].
PubMed:Modified-release capsules containing sodium riboflavin 5'-phosphate.
PubMed:Tailored beads made of dissolved cellulose--investigation of their drug release properties.
PubMed:Electron acceptor dependence of electron shuttle secretion and extracellular electron transfer by Shewanella oneidensis MR-1.
PubMed:Enhancement of corneal permeation of riboflavin-5'-phosphate through vitamin E TPGS: a promising approach in corneal trans-epithelial cross linking treatment.
PubMed:Oxidative mechanisms for the biotransformation of 1-methyl-1,6-dihydropyridine-2-carbaldoxime to pralidoxime chloride.
PubMed:The antibiotics roseoflavin and 8-demethyl-8-amino-riboflavin from Streptomyces davawensis are metabolized by human flavokinase and human FAD synthetase.
PubMed:Simultaneous controlled vitamin release from multiparticulates: theory and experiment.
PubMed:A novel riboflavin gastro-mucoadhesive delivery system based on ion-exchange fiber.
PubMed:Simultaneous determination of some water-soluble vitamins and preservatives in multivitamin syrup by validated stability-indicating high-performance liquid chromatography method.
PubMed:Shewanella secretes flavins that mediate extracellular electron transfer.
PubMed:Molecular determinants for FMN-binding in Desulfovibrio gigas flavoredoxin.
PubMed:Relationship between the redox change in yellow fluorescent protein of Vibrio fischeri strain Y1 and the reversible change in color of bioluminescence in vitro.
PubMed:Activity coupling of Vibrio harveyi luciferase and flavin reductase (FRP): oxygen as a probe.
PubMed:Kinetic mechanism and quaternary structure of Aminobacter aminovorans NADH:flavin oxidoreductase: an unusual flavin reductase with bound flavin.
PubMed:Energy transfer evidence for in vitro and in vivo complexes of Vibrio harveyi flavin reductase P and luciferase.
PubMed:A two [4Fe-4S]-cluster-containing ferredoxin as an alternative electron donor for 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans.
PubMed:Automated determination of selected water-soluble vitamins in tablets using a bench-top robotic system coupled to reversed-phase (RP-18) HPLC with UV detection.
PubMed:Rapid determination of thiamine, riboflavin, pyridoxine, and niacinamide in infant formulas by liquid chromatography.
PubMed:The iron-sulfur clusters in 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans. Biochemical and spectroscopic investigations.
PubMed:Activities of the bimodal fluorescent protein produced by Photobacterium phosphoreum strain bmFP in the luciferase reaction in vitro.
PubMed:2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum.
PubMed:Antimutagenic effects and possible mechanisms of action of vitamins and related compounds against genotoxic heterocyclic amines from cooked food.
PubMed:Computational analysis of the oxygen addition at the C4a site of reduced flavin in the bacterial luciferase bioluminescence reaction.
PubMed:Effects of mutations of the alpha His45 residue of Vibrio harveyi luciferase on the yield and reactivity of the flavin peroxide intermediate.
PubMed:Preparation of riboflavin 4',5'-cyclic phosphate by incubation of flavin-adenine dinucleotide with Mn2+ in the absence of riboflavin 5'-phosphate cyclase.
PubMed:Development of a novel controlled-release system for gastric retention.
PubMed:Extent of Intramolecular Aromatic-Ring Stacking in Ternary Cu(2+) Complexes Formed by 2,2'-Bipyridyl or 1,10-Phenanthroline and Flavin Mononucleotide (FMN(2)(-))(1)(,)(2).
PubMed:Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by vitamins, porphyrins and related compounds, and vegetable and fruit juices and solvent extracts.
PubMed:Binding of the oxidized, reduced, and radical flavin species to chorismate synthase. An investigation by spectrophotometry, fluorimetry, and electron paramagnetic resonance and electron nuclear double resonance spectroscopy.
PubMed:Kinetics and thermodynamics of the binding of riboflavin, riboflavin 5'-phosphate and riboflavin 3',5'-bisphosphate by apoflavodoxins.
PubMed:Cloning and analysis of structural genes from Streptomyces pristinaespiralis encoding enzymes involved in the conversion of pristinamycin IIB to pristinamycin IIA (PIIA): PIIA synthase and NADH:riboflavin 5'-phosphate oxidoreductase.
PubMed:Purification of the two-enzyme system catalyzing the oxidation of the D-proline residue of pristinamycin IIB during the last step of pristinamycin IIA biosynthesis.
PubMed:Catalytically active forms of the individual subunits of Vibrio harveyi luciferase and their kinetic and binding properties.
PubMed:Probing the Vibrio harveyi luciferase beta subunit functionality and the intersubunit domain by site-directed mutagenesis.
PubMed:Mechanism of aldehyde inhibition of Vibrio harveyi luciferase. Identification of two aldehyde sites and relationship between aldehyde and flavin binding.
PubMed:Purification and characterization of a NADH oxidase from the thermophile Thermus thermophilus HB8.
PubMed:Flavin levels in the rat retina.
PubMed:[Effect of preliminarily administered aspartate to the body and its combination with a vitamin-coenzyme complex on the catabolism of L-[14C]-aspartate in tissues of various mouse organs in hermetically closed space].
PubMed:Amplified colorimetric assay of alkaline phosphatase using riboflavin 4'-phosphate: a simple method for measuring riboflavin and riboflavin 5'-phosphate.
PubMed:A new reducing agent of flavins and its application to the assay of bacterial luciferase.
PubMed:Effect of vitamin B2 deficiency on rat liver dihydropyrimidine dehydrogenase activity.
PubMed:[Mechanisms of organic drug electrophoresis].
PubMed:Analysis of water-soluble vitamins in total parenteral nutrition solution by high pressure liquid chromatography.
PubMed:Enhancement of adriamycin-induced mortality during riboflavin administration and riboflavin deficiency in rats.
PubMed:The simultaneous assay of riboflavin 5-phosphate sodium and other water-soluble vitamins in liquid multivitamin formulations by liquid chromatograph.
PubMed:Quantification of riboflavin, riboflavin 5'-phosphate and flavin adenine dinucleotide in plasma and urine by high-performance liquid chromatography.
PubMed:Riboflavin metabolism in the hypothyroid human adult.
PubMed:A comparative carbon-13, nitrogen-15, and phosphorus-31 nuclear magnetic resonance study on the flavodoxins from Clostridium MP, Megasphaera elsdenii, and Azotobacter vinelandii.
PubMed:Vitamin stability in a TPN mixture stored in an EVA plastic bag.
PubMed:[A variant of pathogenetic therapy in the acute period of perinatal hypoxic-traumatic brain lesions in premature infants].
PubMed:Carbon-13 and nitrogen-15 nuclear-magnetic-resonance investigation on Desulfovibrio vulgaris flavodoxin.
PubMed:Effects of vitamins on lipid peroxidation and suppression of DNA synthesis induced by adriamycin in Ehrlich cells.
PubMed:Factors modulating the formation of DNA adduct by aflatoxin B1 in vitro.
PubMed:Metabolism of vitamin B-6 by human liver.
PubMed:Direct cross-linking of three domains in the myosin head.
PubMed:In-vitro riboflavin binding and endogenous flavins in Phycomyces blakesleeanus.
PubMed:On the mobility of riboflavin 5'-phosphate in Megasphaera elsdenii flavodoxin as studied by 13C-nuclear-magnetic-resonance relaxation.
PubMed:Phosphates of riboflavin and riboflavin analogs: a reinvestigation by high-performance liquid chromatography.
PubMed:Isolation of bacterial luciferases by affinity chromatography on 2,2-diphenylpropylamine-Sepharose: phosphate-mediated binding to an immobilized substrate analogue.
PubMed:Mechanism of the inhibition of mutagenicity of a benzo[a]pyrene 7,8-diol 9,10-epoxide by riboflavin 5'-phosphate.
PubMed:Studies on the NADH and NADPH: riboflavin 5'-phosphate (FMN) oxidoreductases from Beneckea harveyi: characterization of the FMN binding sites.
PubMed:New polyacrylamide matrices for drift-free isoelectric focusing.
PubMed:Structural and dynamic information on the complex of Megasphaera elsdenii apoflavodoxin and riboflavin 5'-phosphate. A phosphorus-31 nuclear magnetic resonance study.
PubMed:Binding of 2,2-diphenylpropylamine at the aldehyde site of bacterial luciferase increases the affinity of the reduced riboflavin 5'-phosphate site.
PubMed:Interaction of riboflavin-5'-phosphate with poly-(alpha-L-lysine) & poly-(alpha-L-histidine) in aqueous medium.
PubMed:Apoflavodoxin aggregation following dissociation of flavin.
PubMed:Preparation and properties of immobilized flavokinase.
PubMed:Spectroscopic studies of pyridoxamine (pyridoxine) 5'-phosphate oxidase. Equilibrium dissociation constants and spectra for riboflavin 5'-phosphate and analogues.
PubMed:Solubilization and properties of a particulate hydrogenase from Methanobacterium strain G2R.
PubMed:Purification and properties of nitroalkane oxidase from Fusarium oxysporum.
PubMed:In vitro photodecomposition of uric acid in presence of riboflavin II.
PubMed:A route dependent bioavailability in active metabolite suggested in riboflavin-5'-phosphate pharmacokinetics.
PubMed:A continuous fluorometric assay for flavokinase. Properties of flavokinase from Peptostreptococcus elsdenii.
PubMed:15N nuclear magnetic resonance of flavins.
PubMed:Histochemistry of normal and diseased human lymph nodes.
PubMed:Properties of immobilized flavodoxin from Peptostreptococcus elsdenii. An affinity ligand for the purification of riboflavin 5'-phosphate (FMN) and its analogues.
PubMed:Fluorescence titration with apoflavodoxin: a sensitive assay for riboflavin 5'-phosphate and flavin adenine dinucleotide in mixtures.
PubMed:Effect of carbonated beverages and of an antiemetic containing carbohydrate and phosphoric acid on riboflavin bioavailability and salicylamide biotransformation in humans.
PubMed:[Effect of riboflavin mononucleotide, ATP and nospanum hydrochloricum on the electric activity of the retina, ocular hemodynamics and ophthalmotonus (experimental-clinical study)].
PubMed:[Characteristics of the subconjunctival administration of a riboflavin-mononucleotide solution].
PubMed:The binding of riboflavin-5'-phosphate in a flavoprotein: flavodoxin at 2.0-Angstrom resolution.
PubMed:[Riboflavin-mononucleotide in the ophthalmic practice].
PubMed:[Riboflavin mononucleotide].
PubMed:Riboflavin 5'-phosphate: a potent activator or brain glutaminase.
PubMed:Studies on riboflavin metabolism in the rat. 3. Disappearance rate and urinary excretion rate of flavin after intravenous infusion of riboflavin-5'-phosphate.
PubMed:Studies on riboflavin metabolism in the rat. I. Urinary and faecal excretion after oral administration of riboflavin-5'-phosphate.
PubMed:Plasma protein binding of riboflavin and riboflavin-5'-phosphate in man.
PubMed:Studies on riboflavin metabolism in the rat. II. Metabolic flavin elimination after oral or intraperitoneal administration of riboflavin-5'-phosphate.
PubMed:Absorption, metabolism, and excretion of riboflavin-5'-phosphate in man.
PubMed:Hydrolysis of riboflavin 5'-phosphate by phosphatases of rat kidney.
PubMed:[Resorption of cocarboxylase, riboflavin-5'-phosphate sodium and vitamin A in the colon].
PubMed:[Riboflavin-5'-phosphate as electron donor in photosensibilized reduction of oxidized glutathione].
PubMed:[Riboflavin-5'-phosphate and hematoporphyrin sensitized by photooxidation of yeast alcohol dehydrogenase].
PubMed:Interaction between riboflavin and rutin.
PubMed:Metal chelates and antitubercular activity. V. Riboflavin, riboflavin-5'-phosphate, alloxan, phthaloylhydrazine.
PubMed:Photooxidations catalyzed by plant and bacterial extracts and by riboflavin-5'-phosphate.
PubMed:[Influence of the reaction of the medium on the chemical hydrolysis of riboflavin-5'-phosphate].
PubMed:Synthetic riboflavin-5'-phosphate.
 
Notes:
Vitamin. Sodium salt used as dietary and nutrient supplement Flavin mononucleotide (FMN), or riboflavin-5?-phosphate, is a biomolecule produced from riboflavin (vitamin B2) by the enzyme riboflavin kinase and functions as prosthetic group of various oxidoreductases including NADH dehydrogenase as well as cofactor in biological blue-light photo receptors. Designated with E number E101a, it is used as a food dye. (Wikipedia)
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy