monopotassium glutamate, 19473-49-5

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Name:	potassium (2S)-2-amino-5-hydroxy-5-oxopentanoate
CAS Number:	19473-49-5	3D/inchi
Other(deleted CASRN):	70938-17-9
ECHA EINECS - REACH Pre-Reg:	243-094-0
FDA UNII:	GQ82EXX32T
Molecular Weight:	185.22086000
Formula:	C5 H8 K N O4
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:flavor enhancers, salt substitute

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Perfumer and Flavorist:	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search
	FDA/DG SANTE Petitions, Reviews, Notices:
182.1516	Monopotassium L-glutamate View - review
JECFA Food Additive:	Monopotassium L-Glutamate
GSFA Codex:	Monopotassium L-glutamate (622)
DG SANTE Food Additives:	monopotassium glutamate
FDA Mainterm (SATF):	19473-49-5 ; MONOPOTASSIUM GLUTAMATE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart D--Special Dietary and Nutritional Additives Sec. 172.320 Amino acids. FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE Subpart B--Multiple Purpose GRAS Food Substances Sec. 182.1516 Monopotassium glutamate.

Physical Properties:

Assay:	99.00 to 100.00
Food Chemicals Codex Listed:	No
Soluble in:
	water, 1e+006 mg/L @ 25 °C (est)
	alcohol, slightly

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

Ajinomoto USA

Monopotassium Glutamate

Flavor: characteristic

Effective, low-sodium flavor enhancers which provide exceptional mouthfeel and a fuller flavor profile.

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 4500 mg/kg Farmakologiya i Toksikologiya Vol. 42, Pg. 274, 1979.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
flavor enhancers, salt substitute
Recommendation for monopotassium glutamate usage levels up to:
	not for fragrance use.

Safety References:

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the safety of the change in the production method of L-glutamic acid (E620), monosodium L-glutamate (E621), monopotassium L-glutamate (E622), calcium di-L-glutamate (E623), monoammonium L-glutamate (E624) and magnesium di-L-glutamate (E625)
View page or View pdf

Re-evaluation of glutamic acid (E 620), sodium glutamate (E 621), potassium glutamate (E 622), calcium glutamate (E 623), ammonium glutamate (E 624) and magnesium glutamate (E 625) as food additives
View page or View pdf

EPI System: View

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA GENetic TOXicology:Search

EPA Substance Registry Services (TSCA):19473-49-5

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :23669634

National Institute of Allergy and Infectious Diseases:Data

potassium (2S)-2-amino-5-hydroxy-5-oxopentanoate

Chemidplus:0019473495

References:

	potassium (2S)-2-amino-5-hydroxy-5-oxopentanoate
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	19473-49-5
Pubchem (cid):	23669634
Pubchem (sid):	135019167

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
HMDB (The Human Metabolome Database):	Search
FooDB:	FDB020321
FDA Listing of Food Additive Status:	View
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

not found in nature

Synonyms:

L-	glutamic acid potassium salt (1:1)
laevo-	glutamic acid potassium salt (1:1)
	potassium (2S)-2-amino-5-hydroxy-5-oxopentanoate
	potassium diglutamate
mono	potassium L-glutamate
mono	potassium laevo-glutamate

Articles:

Google Patents:Potassium chloride, glutamic acid, monopotassium glutamate, potassium citrate, potassium phosphate

PubMed:Mice Perceive Synergistic Umami Mixtures as Tasting Sweet.

J-Stage:Evaluation of the Suppressive Effect on Bitter Taste of Gluconate

PubMed:Gustatory modulation of the responses of trigeminal subnucleus caudalis neurons to noxious stimulation of the tongue in rats.

PubMed:Speed and accuracy of taste identification and palatability: impact of learning, reward expectancy, and consummatory licking.

PubMed:Evaluation of genotoxic effects of five flavour enhancers (glutamates) on the root meristem cells of Allium cepa.

PubMed:Sweet-bitter and umami-bitter taste interactions in single parabrachial neurons in C57BL/6J mice.

PubMed:Umami taste in mice uses multiple receptors and transduction pathways.

PubMed:Gustatory neural responses to umami stimuli in the parabrachial nucleus of C57BL/6J mice.

PubMed:Taste preference and nerve response to 5'-inosine monophosphate are enhanced by glutathione in mice.

PubMed:Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes.

PubMed:Response properties of the pharyngeal branch of the glossopharyngeal nerve for umami taste in mice and rats.

PubMed:Umami taste responses are mediated by alpha-transducin and alpha-gustducin.

PubMed:Taste of glutamate salts in young and elderly subjects: role of inosine 5'-monophosphate and ions.

PubMed:Taste effectiveness of glutamate compounds with different cations in rat.

PubMed:Glutamate neurotoxicity in culture depends on the presence of glutamine: implications for the role of glial cells in normal and pathological brain development.

PubMed:High-performance liquid chromatographic assay for pteroylpolyglutamate hydrolase.

Notes:

salts and esters of glutamic acid. Flavour enhancer; salt substitute Monopotassium glutamate is a compound with formula KC5H8NO4. It is a potassium acid salt of glutamic acid.; See glutamic acid for more information. This compound is a non-sodium MSG alternative.

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monopotassium glutamate L-glutamic acid potassium salt (1:1)

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Articles:

monopotassium glutamate
L-glutamic acid potassium salt (1:1)