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lysozyme hydrochloride
muramidase hydrochloride

Supplier Sponsors

CAS Number: 9066-59-5
ECHA EC Number:232-954-0
FDA UNII: 4YRW73H69V
MDL:MFCD00131557
Category:preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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JECFA Food Additive: Lysozyme Hydrochloride
GSFA Codex: Lysozyme (1105)
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Sigma-Aldrich: Sigma
For experimental / research use only.
Lysozyme chloride form from chicken egg white Grade VI, ≥45,000 units/mg protein (E1%/282)
TCI AMERICA
For experimental / research use only.
Lysozyme Chloride from Egg white
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-rat LD50 3800 mg/kg
Drugs in Japan Vol. -, Pg. 1429, 1995.

oral-rabbit LD50 > 12000 mg/kg
Drugs in Japan Vol. -, Pg. 1429, 1995.

oral-mouse LD50 > 5000 mg/kg
Drugs in Japan Vol. -, Pg. 1429, 1995.

intravenous-mouse LD50 3350 mg/kg
Drugs in Japan Vol. -, Pg. 1429, 1995.

intraperitoneal-mouse LD50 5800 mg/kg
Drugs in Japan Vol. -, Pg. 1429, 1995.

intraperitoneal-mouse LD50 5800 mg/kg
Drugs in Japan Vol. 6, Pg. 141, 1982.

intravenous-mouse LD50 3350 mg/kg
Drugs in Japan Vol. -, Pg. 1242, 1990.

intravenous-rat LD50 3800 mg/kg
Drugs in Japan Vol. -, Pg. 1242, 1990.

Dermal Toxicity:
subcutaneous-mouse LD50 > 3000 mg/kg
Drugs in Japan Vol. -, Pg. 1429, 1995.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
preservatives
Recommendation for lysozyme hydrochloride usage levels up to:
 not for fragrance use.
 
Recommendation for lysozyme hydrochloride flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
Chemidplus:0009066595
 
References:
Pubchem (sid):135355724
 
Other Information:
HMDB (The Human Metabolome Database):Search
Export Tariff Code:3507.90.9000
FDA Listing of Food Additive Status:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 lysozyme chloride
 muramidase hydrochloride
 neuzym
 

Articles:

PubMed:Protective effect of lysozyme chloride on gastric oxidative stress and hemorrhagic ulcers in severe atherosclerotic rats.
PubMed:The effect of salt on protein chemical potential determined by ternary diffusion in aqueous solutions.
PubMed:Effect of lysozyme chloride on betel quid chewing aggravated gastric oxidative stress and hemorrhagic ulcer in diabetic rats.
PubMed:Modulation of gastric hemorrhage and ulceration by oxidative stress and histamine release in Salmonella typhimurium-infected rats.
PubMed:The effect of the presence of foreign salts on the formation of gaseous ions for electrospray and laser spray.
PubMed:Protective effects of lysozyme chloride and reduced glutathione on betel quid chewing-produced gastric oxidative stress and haemorrhagic ulcer in rats.
PubMed:Gastric oxidative stress and hemorrhagic ulcer in Salmonella typhimurium-infected rats.
PubMed:Mathematical model for diffusion of a protein and a precipitant about a growing protein crystal in microgravity.
PubMed:Strong and specific effects of cations on lysozyme chloride solubility.
PubMed:Role of acid back-diffusion, glutathione, oxyradical, and histamine in antral hemorrhagic ulcer in rats: the protective effect of lysozyme chloride and antioxidants.
PubMed:A case of toxic epidermal necrolysis-type drug eruption induced by oral lysozyme chloride.
PubMed:Fixed drug eruption due to amlexanox.
PubMed:No salting-in of lysozyme chloride observed at low ionic strength over a large range of pH.
PubMed:New occupational allergen in a pharmaceutical industry: serratial peptidase and lysozyme chloride.
PubMed:Effect of topical application of a stable prostacyclin analogue, SM-10902 on wound healing in diabetic mice.
PubMed:A histological study of cutaneous thermal wounds using a Clostridium perfringens-derived wound healing substance with wound healing stimulation activity.
PubMed:Observations on the antimetastatic action of lysozyme in mice bearing Lewis lung carcinoma.
PubMed:Evaluation of the effects of antigen specific immunotherapy on chronic sinusitis in children with allergy.
PubMed:[Clinical evaluation of ACDEMIN in the field of dentistry].
PubMed:[The effects of lysozyme chloride on the immune response of patients with head and neck cancer].
PubMed:[Clinical effect of a toothpaste containing lysozyme chloride on chronic marginal periodontitis].
PubMed:[Effect of a dentifrice containing lysozyme chloride on periodontal disease].
PubMed:Determination of lysozyme chloride in antiphlogistics by reversed-phase high-performance liquid chromatography.
PubMed:[Effects of lysozyme chloride on immune responses of patients with uterine cervical cancer].
PubMed:[Clinical effects of the dentifrice, "Dentake toothpaste", containing lysozyme chloride, on periodontal disease].
PubMed:[Evaluation on the clinical effect of lysozyme chloride in radiotherapy].
PubMed:Diffusion of lysozyme chloride in water and aqueous potassium chloride solutions.
PubMed:[Anti-inflammatory, analgesic effect of lysozyme chloride following direct pulpectomy and root canal filling].
PubMed:A random controlled study of the prophylactic effect of lysozyme chloride on post-transfusion hepatitis.
PubMed:[Effect of lysozyme chloride on calcification of dentin of the rabbit].
PubMed:[Transfer of lysozyme chloride into nasal, paranasal mucosa and surrounding tissues].
PubMed:[E.P.R. spectra of a gamma-irradiated monocrystal of lysozyme chloride].
PubMed:[Clinical experience with an ophthalmic solution "My Tear" (0.1 percent lysozyme chloride)].
PubMed:Crystallization of human lysozyme.
PubMed:[Action of lysozyme chloride on leukocyte reservoirs in the rat].
PubMed:[Changes in the bone marrow of rats caused by intensive treatment with lysozyme chloride].
PubMed:Optical and crystallographic properties of lysozyme chloride.
 
Notes:
None found
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