EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

iron citrate
citric acid iron salt

Supplier Sponsors

CAS Number: 2338-05-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:219-045-4
FDA UNII: Search
Beilstein Number:4052503
MDL:MFCD00013098
Molecular Weight:247.96916000
Formula:C6 H8 Fe O7
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1307c Ferric citrate View - review
FDA Mainterm (SATF):2338-05-8 ; IRON CITRATE
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1298 Ferric citrate.
 
Physical Properties:
Food Chemicals Codex Listed: No
Boiling Point: 309.60 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000057 mmHg @ 25.00 °C. (est)
Flash Point: 311.00 °F. TCC ( 155.20 °C. ) (est)
logP (o/w): -1.721 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American Elements
Iron(III) Citrate Tribasic Monohydrate 99%
Odor: characteristic
Use: Iron(III) Citrate Tribasic Monohydrate is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
BOC Sciences
For experimental / research use only.
iron citrate 18-20% Fe
Glentham Life Sciences
Iron(III) citrate hydrate
Santa Cruz Biotechnology
For experimental / research use only.
Iron(III) citrate tribasic monohydrate
Sigma-Aldrich
For experimental / research use only.
Iron(III) citrate tribasic monohydrate 18-20% Fe basis (T)
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nutrient supplements
Recommendation for iron citrate usage levels up to:
 not for fragrance use.
 
Recommendation for iron citrate flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):2338-05-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :4989393
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-hydroxypropane-1,2,3-tricarboxylic acid; iron
Chemidplus:0002338058
 
References:
 2-hydroxypropane-1,2,3-tricarboxylic acid; iron
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:2338-05-8
Pubchem (cid):4989393
Pubchem (sid):135017445
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
KEGG (GenomeNet):C06229
HMDB (The Human Metabolome Database):Search
FooDB:FDB009627
FDA Listing of Food Additive Status:View
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 citric acid iron salt
2-hydroxypropane-1,2,3-tricarboxylic acid; iron
 iron 2-hydroxy-1,2,3-propanetricarboxylate
 

Articles:

PubMed:Non-transferrin-bound iron (NTBI) uptake by T lymphocytes: evidence for the selective acquisition of oligomeric ferric citrate species.
PubMed:Mitochondrial DNA instability in cells lacking aconitase correlates with iron citrate toxicity.
PubMed:Structure and magnetic properties of a new iron(II) citrate coordination polymer.
PubMed:Iron and citrate export by a major facilitator superfamily pump regulates metabolism and stress resistance in Salmonella Typhimurium.
PubMed:Effects of short term iron citrate treatments at different pH values on roots of iron-deficient cucumber: a Mössbauer analysis.
PubMed:Characterization of metalloprotease and serine protease activities in batch CHO cell cultures: control of human recombinant IFN-γ proteolysis by addition of iron citrate.
PubMed:Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells.
PubMed:Biogeochemical cycling of ferric oxyhydroxide affecting As partition in groundwater aquitard.
PubMed:Synthesis of carbon-encapsulated iron nanoparticles by pyrolysis of iron citrate and poly(vinyl alcohol): a critical evaluation of yield and selectivity.
PubMed:Evaluation of different column types for the hydrophilic interaction chromatographic separation of iron-citrate and copper-histidine species from plants.
PubMed:A high-performance liquid immunoaffinity chromatography method for determining transferrin-bound iron in serum.
PubMed:Ethanol effect on cell proliferation in the human hepatoma HepaRG cell line: relationship with iron metabolism.
PubMed:R161, K452 and R460 residues are vital for metal-citrate complex transport in Cit(Sc) from Streptomyces coelicolor.
PubMed:Oriented contraction: a facile nonequilibrium heat-treatment approach for fabrication of maghemite fiber-in-tube and tube-in-tube nanostructures.
PubMed:Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone.
PubMed:Modularity of the Mtr respiratory pathway of Shewanella oneidensis strain MR-1.
PubMed:Protein tyrosine phosphatases are regulated by mononuclear iron dicitrate.
PubMed:Transport of iron bound to recombinant human lactoferrin from rice and iron citrate across Caco-2 cell monolayers.
PubMed:Global transcriptional responses of Pseudomonas syringae DC3000 to changes in iron bioavailability in vitro.
PubMed:Synthesis of shape controlled ferrite nanoparticles by sonochemical technique.
PubMed:Microglia and astroglia prevent oxidative stress-induced neuronal cell death: implications for aceruloplasminemia.
PubMed:Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera.
PubMed:Signaling mechanisms for activation of extracytoplasmic function (ECF) sigma factors.
PubMed:Iron-citrate complexes and free radicals generation: is citric acid an innocent additive in foods and drinks?
PubMed:Tannic acid inhibits in vitro iron-dependent free radical formation.
PubMed:Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse.
PubMed:Iron modulates the replication of virulent Mycobacterium bovis in resting and activated bovine and possum macrophages.
PubMed:Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe2+-citrate.
PubMed:Determination of stability constants of U(VI)-Fe(III)-citrate complexes.
PubMed:Mangifera indica L. extract (Vimang) inhibits Fe2+-citrate-induced lipoperoxidation in isolated rat liver mitochondria.
PubMed:A PCR method for detection of bifidobacteria in raw milk and raw milk cheese: comparison with culture-based methods.
PubMed:Estimation of iron absorption in humans using compartmental modelling.
PubMed:Iron accumulation during cellular senescence.
PubMed:Application of a MTT assay for screening nutritional factors in growth media of primary sponge cell culture.
PubMed:Growth of Escherichia coli in iron-enriched medium increases HPI catalase activity.
PubMed:Neuroprotection by tempol in a model of iron-induced oxidative stress in acute ischemic stroke.
PubMed:Quantification of unlabelled non-haem iron absorption in human subjects: a pilot study.
PubMed:Neurotrophic factor effects on oxidative stress-induced neuronal death.
PubMed:Genetic analysis of iron citrate toxicity in yeast: implications for mammalian iron homeostasis.
PubMed:Mechanisms of bFGF and NT-4 potentiation of necrotic neuronal death.
PubMed:Regulation of phagosomal iron release from murine macrophages by nitric oxide.
PubMed:Photodegradation of a ternary iron(III)-uranium(VI)-citric acid complex.
PubMed:Differential effects of iron overload on GST isoform expression in mouse liver and kidney and correlation between GSTA4 induction and overproduction of free radicles.
PubMed:Detection of the isiA gene across cyanobacterial strains: potential for probing iron deficiency.
PubMed:Intravenous infusion of iron and tetrahydrofolate does not influence intrauterine uteroferrin and secreted folate-binding protein content in swine.
PubMed:Iron and citric acid: a fuzzy chemistry of ubiquitous biological relevance.
PubMed:Complexation of iron(III) and iron(II) by citrate. Implications for iron speciation in blood plasma.
PubMed:Identification and characterization of the iron regulatory element in the ferritin gene of a plant (soybean).
PubMed:Use of heme compounds as iron sources by pathogenic neisseriae requires the product of the hemO gene.
PubMed:Cytoprotection and iron mobilization in rat hepatocyte cultures by a new synthetic dihydroxamate chelator.
PubMed:The use of Caco-2 cells as an in vitro method to study bioavailability of iron.
PubMed:Dietary heme iron does not prevent postgastrectomy anemia but fructooligosaccharides improve bioavailability of heme iron in rats.
PubMed:Differential fiu-lacZ fusion regulation linked to Escherichia coli colony development.
PubMed:Characterisation of citrate and iron citrate uptake by cultured rat hepatocytes.
PubMed:Ferric citrate uptake by cultured rat hepatocytes is inhibited in the presence of transferrin.
PubMed:Effect of desferrioxamine and deferiprone (L1) on the proliferation of MG-63 bone cells and on phosphatase alkaline activity.
PubMed:Intranigral iron infusion in the rat. Acute elevations in nigral lipid peroxidation and striatal dopaminergic markers with ensuing nigral degeneration.
PubMed:Inhibition of uptake of transferrin-bound iron by human hepatoma cells by nontransferrin-bound iron.
PubMed:Inhibition of iron toxicity in human hepatocyte cultures by pyoverdins Pa A and Pf, the peptidic siderophores of Pseudomonas aeruginosa and fluorescens.
PubMed:Iron may induce both DNA synthesis and repair in rat hepatocytes stimulated by EGF/pyruvate.
PubMed:Non-promoting effects of iron from beef in the rat colon carcinogenesis model.
PubMed:[Effects of iron deficiency on expression of transferrin receptor in human lymphocytes].
PubMed:Mobilferrin is an intermediate in iron transport between transferrin and hemoglobin in K562 cells.
PubMed:Iron coordination by catechol derivative antioxidants.
PubMed:Iron transport across Caco-2 cell monolayers. Effect of transferrin, lactoferrin and nitric oxide.
PubMed:Oxidative damage of bovine serum albumin and other enzyme proteins by iron-chelate complexes.
PubMed:Inhibition of iron toxicity in rat and human hepatocyte cultures by the hydroxypyridin-4-ones CP20 and CP94.
PubMed:Uptake of iron by symbiosomes and bacteroids from soybean nodules.
PubMed:The H(+)-ATPase from reticulocyte endosomes reconstituted into liposomes acts as an iron transporter.
PubMed:Iron absorption by CaCo 2 cells cultivated in serum-free medium as in vitro model of the human intestinal epithelial barrier.
PubMed:[Effects of pretreating target cells with iron citrate on cytolysis, mediated by tumor necrosis factor and lymphokine-activated killer cells].
PubMed:Iron polymers impair the function and maturation of macrophages.
PubMed:Uptake of iron from ferric-citrate in the cyanobacteria Synechocystis PCC6803.
PubMed:Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies.
PubMed:Apotransferrin can elevate intracellular free calcium ion and stimulate mitogenesis in human leukemic HL60 cells.
PubMed:Influence of complex structure on the biodegradation of iron-citrate complexes.
PubMed:Growth of cells in a new defined protein-free medium.
PubMed:8-Azido-ATP labelling of the FecE protein of the Escherichia coli iron citrate transport system.
PubMed:Iron transport systems of Serratia marcescens.
PubMed:Interaction of iron polymers with blood mononuclear cells and its detection with the Prussian Blue reaction.
PubMed:Experimental skin calciphylaxis induced by iron citrate sorbitol in young dogs.
PubMed:[GELUM oral-rd: blood pH regulator and oxygen activator. Documentation No.27].
PubMed:Calciphylaxis induced by iron-citrate sorbitol.
PubMed:Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis. Characterization by high performance liquid chromatography and nuclear magnetic resonance spectroscopy.
PubMed:Early changes in the ground substance of articular cartilage in experimental hemarthrosis in dogs, measured by the fixed-charge density method.
PubMed:Physiological and non-physiological forms of iron affect differently proliferation and ferritin synthesis in human mononuclear cells in vitro.
PubMed:Effect of extracellular hemin on hemoglobin and ferritin content of erythroleukemia cells.
PubMed:Oxygen radical-induced erythrocyte hemolysis by neutrophils. Critical role of iron and lactoferrin.
PubMed:The role of iron chelates in hydroxyl radical production by rat liver microsomes, NADPH-cytochrome P-450 reductase and xanthine oxidase.
PubMed:Non-enzymatic heme formation in the presence of fatty acids and thiol reductants.
PubMed:The role of ferritin in the intracellular distribution of gallium 67.
PubMed:Iron uptake from ferrichrome A and iron citrate in Ustilago sphaerogena.
PubMed:Studies of the antimicrobial activity of ovotransferrin.
PubMed:Action of iron and iron-complexes on Klebsiella pneumoniae (Klebsiella aerogenes).
PubMed:Iron incorporation into ferritin and hemoglobin during differentiation of murine erythroleukemia cells.
PubMed:Energy-independent uptake of iron from citrate by isolated outer membranes of Neisseria meningitidis.
PubMed:Comparative study of different iron compounds in inhibition of sphaerotilus growth.
PubMed:In vitro binding of various biological substances by two hypocholesterolaemic resins. Cholestyramine and colestipol.
PubMed:[Investigations of the bioavailability of iron from bi- and trivalent iron salts (author's transl)].
PubMed:On the effect of iron-citrate on the growth of the Flordia red-tide organism, Gymnodinium breve.
PubMed:[Intestinal absorption of labelled lipids, vitamin B 12 and iron citrate after gamma irradiation].
PubMed:[Preparation of xylitol-iron-citrate complexes of various molecular weight, and effect of molecular weight on blood level and urinary excretion of iron after intramuscular injection of their complexes].
PubMed:[On the simultaneous use of the Jirgl test and the iron citrate reaction in the differential diagnosis of jaundices].
PubMed:Translocation of iron citrate and phosphorus in xylem exudate of soybean.
PubMed:[Evaluation of the practical usefulness of the contemporary utilization of several reactions (Jirgl test, iron citrate test, quinine-oxydase test) in the diagnosis of icterus].
PubMed:Growth of Scenedesmus obliquus in relation to the supply of iron.
PubMed:Iron Translocation II. Citrate/Iron Ratios in Plant Stem Exudates.
PubMed:Iron translocation I. Plant culture, exudate sampling, iron-citrate analysis.
PubMed:[A SIMPLE TEST IN THE STUDY OF MYCOBACTERIA: THE TRANSFORMATION OF AMMONIACAL IRON-CITRATE].
PubMed:IRON CITRATE REACTIONS.
 
Notes:
Used as a food additive [EAFUS]
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