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glyceryl behenate
docosanoic acid ester with 1,2,3-propanetriol

Supplier Sponsors

CAS Number: 77538-19-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:278-717-5
FDA UNII: Search
Nikkaji Web:J815.979C
XlogP3:9.60 (est)
Molecular Weight:414.67030000
Formula:C25 H50 O4
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:formulation aids
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (SATF):77538-19-3 ; GLYCERYL BEHENATE
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1328 Glyceryl behenate.
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 525.00 to 526.00 °C. @ 760.00 mm Hg (est)
Acid Value: 4.00 max. KOH/g
Saponification Value:145.00 to 165.00
Flash Point: 322.00 °F. TCC ( 161.30 °C. ) (est)
logP (o/w): 9.354 (est)
Soluble in:
 water, 0.0001167 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Glyceryl behenate
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
formulation aids
Recommendation for glyceryl behenate usage levels up to:
 not for fragrance use.
 
Recommendation for glyceryl behenate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5362585
National Institute of Allergy and Infectious Diseases:Data
2,3-dihydroxypropyl docosanoate
Chemidplus:0077538193
 
References:
 2,3-dihydroxypropyl docosanoate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5362585
Pubchem (sid):135252137
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):HMDB32296
FooDB:FDB009509
FDA Listing of Food Additive Status:View
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2,3-dihydroxypropyl docosanoate
 docosanoic acid ester with 1,2,3-propanetriol
1,2,3-propanetriol docosanoate
 

Articles:

PubMed:Compritol 888 ATO: a multifunctional lipid excipient in drug delivery systems and nanopharmaceuticals.
PubMed:In vivo pharmacokinetics and biodistribution of resveratrol-loaded solid lipid nanoparticles for brain delivery.
PubMed:Polymorphism of glyceryl behenates: From the individual compounds to the pharmaceutical excipient.
PubMed:Compression parameters of hexagonal boron nitride on direct compression mixture of microcrystalline cellulose and modified starch.
PubMed:Simvastatin Solid Lipid Nanoparticles for Oral Delivery: Formulation Development and In vivo Evaluation.
PubMed:Lipid nanoparticles for oral delivery of raloxifene: optimization, stability, in vivo evaluation and uptake mechanism.
PubMed:Evaluation of Shirasu Porous Glass (SPG) membrane emulsification for the preparation of colloidal lipid drug carrier dispersions.
PubMed:Preparation and evaluation of once-daily sustained-release coated tablets of tolterodine-L-tartrate.
PubMed:Formulation and evaluation of metoclopramide solid lipid nanoparticles for rectal suppository.
PubMed:Effect of freeze-drying, cryoprotectants and storage conditions on the stability of secondary structure of insulin-loaded solid lipid nanoparticles.
PubMed:Evaluation of the cytotoxic effect of camptothecin solid lipid nanoparticles on MCF7 cells.
PubMed:Risk based approach for design and optimization of stomach specific delivery of rifampicin.
PubMed:Design, characterization, and in vitro cellular inhibition and uptake of optimized genistein-loaded NLC for the prevention of posterior capsular opacification using response surface methodology.
PubMed:Diclofenac sodium sustained release hot melt extruded lipid matrices.
PubMed:Sustained release solid lipid matrices processed by hot-melt extrusion (HME).
PubMed:Preparation, in vitro evaluation and statistical optimization of carvedilol-loaded solid lipid nanoparticles for lymphatic absorption via oral administration.
PubMed:Development and evaluation of glyceryl behenate based solid lipid nanoparticles (SLNs) using hot self-nanoemulsification (SNE) technique.
PubMed:Formulation and characterization of nanostructured lipid carrier of ubiquinone (Coenzyme Q10).
PubMed:Compritol®888 ATO a lipid excipient for sustained release of highly water soluble active: formulation, scale-up and IVIVC study.
PubMed:Novel pH-sensitive lipid-polymer composite microspheres of 10-hydroxycamptothecin exhibiting colon-specific biodistribution and reduced systemic absorption.
PubMed:Effects of some lubricants and evaluation of compression parameters on directly compressible powders.
PubMed:Development of solid lipid nanoparticles based controlled release system for topical delivery of terbinafine hydrochloride.
PubMed:Experimental design towards an optimal lipid nanosystem: a new opportunity for paclitaxel-based therapeutics.
PubMed:Formulation optimization and topical delivery of quercetin from solid lipid based nanosystems.
PubMed:Technology of stable, prolonged-release eye-drops containing Cyclosporine A, distributed between lipid matrix and surface of the solid lipid microspheres (SLM).
PubMed:Comparison of spray congealing and melt emulsification methods for the incorporation of the water-soluble salbutamol sulphate in lipid microparticles.
PubMed:Nanostructured lipid carriers (NLC) based topical gel of flurbiprofen: design, characterization and in vivo evaluation.
PubMed:Development of terbinafine solid lipid nanoparticles as a topical delivery system.
PubMed:[Taste-masking possibilities in solid dosage forms].
PubMed:Preparation, in vitro release, and pharmacokinetics in rabbits of lyophilized injection of sorafenib solid lipid nanoparticles.
PubMed:Assessment of granulation technologies for an API with poor physical properties.
PubMed:Complete inhibition of extranodal dissemination of lymphoma by edelfosine-loaded lipid nanoparticles.
PubMed:Development of cationic solid lipid nanoparticles with factorial design-based studies for topical administration of doxorubicin.
PubMed:Effect of pharmaceutical excipients on the stability of angiotensin-converting enzyme inhibitors in their solid dosage formulations.
PubMed:Solid lipid nanoparticles with and without hydroxypropyl-β-cyclodextrin: a comparative study of nanoparticles designed for colonic drug delivery.
PubMed:Preparation and in vitro evaluation of salbutamol-loaded lipid microparticles for sustained release pulmonary therapy.
PubMed:Development and evaluation of sustained-release Compritol® 888 ATO matrix mini-tablets.
PubMed:Controlled release of a highly hydrophilic API from lipid microspheres obtained by prilling: analysis of drug and water diffusion processes with X-ray-based methods.
PubMed:Selection and characterization of suitable lipid excipients for use in the manufacture of didanosine-loaded solid lipid nanoparticles and nanostructured lipid carriers.
PubMed:Development of a new delivery system consisting in "drug--in cyclodextrin--in nanostructured lipid carriers" for ketoprofen topical delivery.
PubMed:Lipid nanoparticles for brain targeting I. Formulation optimization.
PubMed:Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique.
PubMed:Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain delivery.
PubMed:Diclofenac salts, part 6: release from lipid microspheres.
PubMed:Encapsulation of the UV filters ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane in lipid microparticles: effect on in vivo human skin permeation.
PubMed:Enhanced delivery of lopinavir to the CNS using Compritol-based solid lipid nanoparticles.
PubMed:Controlled release of oral tetrahydrocurcumin from a novel self-emulsifying floating drug delivery system (SEFDDS).
PubMed:Oral solid compritol 888 ATO nanosuspension of simvastatin: optimization and biodistribution studies.
PubMed:Encapsulation of ethylhexyl methoxycinnamate, a light-sensitive UV filter, in lipid nanoparticles.
PubMed:Correlation between in vitro and in vivo erosion behaviour of erodible tablets using gamma scintigraphy.
PubMed:Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting.
PubMed:Preparation and characterization of solid lipid nanoparticles containing cyclosporine by the emulsification-diffusion method.
PubMed:Theophylline-loaded compritol microspheres prepared by ultrasound-assisted atomization.
PubMed:Effect of lipid matrix on repaglinide-loaded solid lipid nanoparticles for oral delivery.
PubMed:The influence of lipid characteristics on the formation, in vitro release, and in vivo absorption of protein-loaded SLN prepared by the double emulsion process.
PubMed:Potential use of nanostructured lipid carriers for topical delivery of flurbiprofen.
PubMed:Non-destructive methods of characterization of risperidone solid lipid nanoparticles.
PubMed:Effects of lubricants on binary direct compression mixtures.
PubMed:Box-Behnken experimental design in the development of pectin-compritol ATO 888 compression coated colon targeted drug delivery of mesalamine.
PubMed:Influence of humidity and hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate or magnesium stearate on the degradation kinetics of quinapril hydrochloride in solid phase.
PubMed:Simple preparation of coated resin complexes and their incorporation into fast-disintegrating tablets.
PubMed:The effect of geometric shape on the release properties of metronidazole from lipid matrix tablets.
PubMed:Fabrication and evaluation of captopril modified-release oral formulation.
PubMed:Innovation of novel sustained release compression-coated tablets for lornoxicam: formulation and in vitro investigations.
PubMed:An oral controlled release system for ambroxol hydrochloride containing a wax and a water insoluble polymer.
PubMed:In vitro controlled release of colon targeted mesalamine from compritol ATO 888 based matrix tablets using factorial design.
PubMed:Controlled-release carbamazepine matrix granules and tablets comprising lipophilic and hydrophilic components.
PubMed:Incorporation in lipid microparticles of the UVA filter, butyl methoxydibenzoylmethane combined with the UVB filter, octocrylene: effect on photostability.
PubMed:Mechanistic evaluation of the effect of sintering on Compritol 888 ATO matrices.
PubMed:Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery.
PubMed:Diazepam-loaded solid lipid nanoparticles: design and characterization.
PubMed:Entrapment and release of saquinavir using novel cationic solid lipid nanoparticles.
PubMed:Co-loading of a photostabilizer with the sunscreen agent, butyl methoxydibenzoylmethane in solid lipid microparticles.
PubMed:Microsphere-based once-daily modified release matrix tablets for oral administration in angina pectoris.
PubMed:[Preliminary study on brain-targeted drug delivery via inner ear].
PubMed:Solid lipid microparticles for the stability enhancement of the polar drug N6-cyclopentyladenosine.
PubMed:In vitro release--in vivo microbiological and toxicological studies on ketoconazole lipid granules.
PubMed:Hexagonal boron nitride as a tablet lubricant and a comparison with conventional lubricants.
PubMed:Enhanced retention of celecoxib-loaded solid lipid nanoparticles after intra-articular administration.
PubMed:Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells.
PubMed:[Microstructure of novel solid lipid nanoparticle loaded triptolide].
PubMed:Development of a new solid lipid nanoparticle formulation containing retinoic acid for topical treatment of acne.
PubMed:In-vitro/in-vivo correlation of pulsatile drug release from press-coated tablet formulations: a pharmacoscintigraphic study in the beagle dog.
PubMed:Solid lipid microparticles containing the sunscreen agent, octyl-dimethylaminobenzoate: effect of the vehicle.
PubMed:Lymphatic uptake of lipid nanoparticles following endotracheal administration.
PubMed:Employment of cationic solid-lipid nanoparticles as RNA carriers.
PubMed:Structural and thermal characterization of glyceryl behenate by X-ray diffraction coupled to differential calorimetry and infrared spectroscopy.
PubMed:Polymorphic behaviour of Compritol888 ATO as bulk lipid and as SLN and NLC.
PubMed:In vitro controlled release of sodium ferulate from Compritol 888 ATO-based matrix tablets.
PubMed:Development and in vitro evaluation of a novel floating multiple unit dosage form obtained by melt pelletization.
PubMed:In vitro and in vivo evaluation of floating riboflavin pellets developed using the melt pelletization process.
PubMed:[Effect of particle size on oral absorption of silymarin-loaded solid lipid nanoparticles].
PubMed:Solid lipid microparticles (SLM) containing juniper oil as anti-acne topical carriers: preliminary studies.
PubMed:SLN and NLC for topical delivery of ketoconazole.
PubMed:Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy.
PubMed:Solid lipid nanoparticles can effectively bind DNA, streptavidin and biotinylated ligands.
PubMed:Evaluation of hexagonal boron nitride as a new tablet lubricant.
PubMed:Study of formulation variables influencing the drug release rate from matrix tablets by experimental design.
PubMed:Solid lipid nanoparticles (SLN) and oil-loaded SLN studied by spectrofluorometry and Raman spectroscopy.
PubMed:Adaptation and optimization of the emulsification-diffusion technique to prepare lipidic nanospheres.
PubMed:[Preparation of solid lipid nanoparticles loaded with all-trans retinoic acid and their evaluation in vitro and in vivo].
PubMed:The effect of wax on compaction of microcrystalline cellulose beads made by extrusion and spheronization.
PubMed:Evaluation and comparison of five matrix excipients for the controlled release of acrivastine and pseudoephedrine.
PubMed:Final report of the amended safety assessment of Glyceryl Laurate, Glyceryl Laurate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Glyceryl Cocoate, Glyceryl Collagenate, Glyceryl Erucate, Glyceryl Hydrogenated Rosinate, Glyceryl Hydrogenated Soyate, Glyceryl Hydroxystearate, Glyceryl Isopalmitate, Glyceryl Isostearate, Glyceryl Isostearate/Myristate, Glyceryl Isostearates, Glyceryl Lanolate, Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Montanate, Glyceryl Myristate, Glyceryl Isotridecanoate/Stearate/Adipate, Glyceryl Oleate SE, Glyceryl Oleate/Elaidate, Glyceryl Palmitate, Glyceryl Palmitate/Stearate, Glyceryl Palmitoleate, Glyceryl Pentadecanoate, Glyceryl Polyacrylate, Glyceryl Rosinate, Glyceryl Sesquioleate, Glyceryl/Sorbitol Oleate/Hydroxystearate, Glyceryl Stearate/Acetate, Glyceryl Stearate/Maleate, Glyceryl Tallowate, Glyceryl Thiopropionate, and Glyceryl Undecylenate.
PubMed:Effect of formulation composition on the properties of controlled release tablets prepared by roller compaction.
PubMed:Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy.
PubMed:Comparative study of the lubricant performance of Compritol 888 ATO either used by blending or by hot melt coating.
PubMed:Physical and thermal characterisation of Precirol and Compritol as lipophilic glycerides used for the preparation of controlled-release matrix pellets.
PubMed:Melt granulation and heat treatment for wax matrix-controlled drug release.
PubMed:Comparative study of the lubricant performance of Compritol HD5 ATO and Compritol 888 ATO: effect of polyethylene glycol behenate on lubricant capacity.
PubMed:Development and evaluation of prolonged release pellets obtained by the melt pelletization process.
PubMed:Controlled release of tramadol hydrochloride from matrices prepared using glyceryl behenate.
PubMed:Hot-melt coating: water sorption behavior of excipient films.
PubMed:Thermodynamic analysis of water interaction with excipient films.
PubMed:Encapsulation of retinoids in solid lipid nanoparticles (SLN).
PubMed:Solid lipid nanoparticles (SLN) based on binary mixtures of liquid and solid lipids: a (1)H-NMR study.
PubMed:Hot melt coating technology: influence of Compritol 888 Ato and granule size on chloroquine release.
PubMed:Formulation and release behavior of diclofenac sodium in Compritol 888 matrix beads encapsulated in alginate.
PubMed:Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin.
PubMed:Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties.
PubMed:Preserved solid lipid nanoparticles (SLN) at low concentrations do cause neither direct nor indirect cytotoxic effects in peritoneal macrophages.
PubMed:Comparison of wax and glyceride solid lipid nanoparticles (SLN).
PubMed:Hot-melt coating technology. I. Influence of Compritol 888 Ato and granule size on theophylline release.
PubMed:Compritol 888 ATO: an innovative hot-melt coating agent for prolonged-release drug formulations.
PubMed:Stability determination of solid lipid nanoparticles (SLN) in aqueous dispersion after addition of electrolyte.
PubMed:Atomic force microscopy studies of solid lipid nanoparticles.
PubMed:Sustained release phenylpropanolamine hydrochloride from ATO 888 matrix.
PubMed:Glyceroglucolipids of the human saliva.
 
Notes:
Used as a food additive [EAFUS]
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