EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

alpha-cyclodextrin
alpha-cycloamylase

Supplier Sponsors

CAS Number: 10016-20-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:233-007-4
FDA UNII:Z1LH97KTRM
Beilstein Number:79627
MDL:MFCD00078207
XlogP3-AA:-12.90 (est)
Molecular Weight:972.85020000
Formula:C36 H60 O30
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:carrier solvents, encapsulating agent for food additives, flavorings, stabilizers and absorbents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 155 alpha-Cyclodextrin View - notice PDF
GRN 678 Alpha-cyclodextrin View - notice PDF
JECFA Food Additive: alpha-Cyclodextrin
GSFA Codex: Cyclodextrin, alpha- (457)
DG SANTE Food Contact Materials:alpha-cyclodextrin
 
Physical Properties:
Appearance:white crystalline solid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 278.00 °C. @ 760.00 mm Hg
logP (o/w): -6.550 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 alcohol, very slightly
 
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Cyclomaltohexaose
Glentham Life Sciences
alpha-Cyclodextrin
Santa Cruz Biotechnology
For experimental / research use only.
alpha-Cyclodextrin ≥98%
Sigma-Aldrich
a-Cyclodextrin FG, produced by Wacker Chemie AG, Burghausen, Germany, Food, =98% (on dry substance)
Certified Food Grade Products
Sigma-Aldrich: Sigma
For experimental / research use only.
alpha-Cyclodextrin ≥98%
TCI AMERICA
For experimental / research use only.
alpha-Cyclodextrin >98.0%(HPLC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-rat LD50 788 mg/kg
American Journal of Pathology. Vol. 83, Pg. 367, 1976.

intraperitoneal-rat LD50 1000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 287, 1983.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
carrier solvents, encapsulating agent for food additives, flavorings, stabilizers and absorbents
Recommendation for alpha-cyclodextrin usage levels up to:
 not for fragrance use.
 
Recommendation for alpha-cyclodextrin flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the substantiation of health claims related to alpha cyclodextrin and reduction of post prandial glycaemic responses (ID 2926, further assessment) pursuant to Article 13(1) of Regulation (EC) No 1924/2006
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):10016-20-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :24796
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
Chemidplus:0010016203
EPA/NOAA CAMEO:hazardous materials
RTECS:GU2292000 for cas# 10016-20-3
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):24796
Pubchem (sid):134990013
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:3505.10.0020
FDA Listing of Food Additive Status:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 alfadex
 alfadexum
alpha-cycloamylase
alpha-cycloamylose
alpha-schardinger dextrin
 

Articles:

PubMed:Effects of addition of alpha-cyclodextrin on the sensory quality, volatile compounds, and color parameters of fresh pear juice.
PubMed:The effect of solvent interactions on alpha-, beta-, and gamma-cyclodextrin/flavor molecular inclusion complexes.
PubMed:Encapsulation of shiitake (Lenthinus edodes) flavors by spray drying.
PubMed:Cyclodextrin encapsulation to prevent the loss of l-menthol and its retention during drying.
PubMed:Mutations enhance β-cyclodextrin specificity of cyclodextrin glycosyltransferase from Bacillus circulans.
PubMed:An experimental design based strategy to optimize a capillary electrophoresis method for the separation of 19 polycyclic aromatic hydrocarbons.
PubMed:Transglycosylation of engineered cyclodextrin glucanotransferases as O-glycoligases.
PubMed:Engineering a hollow nanocontainer platform with multifunctional molecular machines for tumor-targeted therapy in vitro and in vivo.
PubMed:Calcium ion contribution to thermostability of cyclodextrin glycosyltransferase is closely related to calcium-binding site CaIII.
PubMed:Molecular cloning and enzymatic characterization of cyclomaltodextrinase from hyperthermophilic archaeon Thermococcus sp. CL1.
PubMed:Intravenous topiramate: comparison of pharmacokinetics and safety with the oral formulation in healthy volunteers.
PubMed:Structure selective complexation of cyclodextrins with five polyphenols investigated by capillary electrokinetic chromatography.
PubMed:Empirical, thermodynamic and quantum-chemical investigations of inclusion complexation between flavanones and (2-hydroxypropyl)-cyclodextrins.
PubMed:An investigation into the supramolecular structure, solubility, stability and antioxidant activity of rutin/cyclodextrin inclusion complex.
PubMed:Production of α-cyclodextrin glycosyltransferase in Bacillus megaterium MS941 by systematic codon usage optimization.
PubMed:Enhanced mineralization of diuron using a cyclodextrin-based bioremediation technology.
PubMed:Sorption of ochratoxin A from aqueous solutions using β-cyclodextrin-polyurethane polymer.
PubMed:In vitro and in vivo characterization of amorphous, nanocrystalline, and crystalline ziprasidone formulations.
PubMed:Encapsulation of ethylene gas into α-cyclodextrin and characterisation of the inclusion complexes.
PubMed:[Enhanced storage stability of recombinant enzyme preparation of alpha-CGTase from Paenibacillus macerans by chemical additives].
PubMed:High-level extracellular production of α-cyclodextrin glycosyltransferase with recombinant Escherichia coli BL21 (DE3).
PubMed:Extracellular expression and biochemical characterization of alpha-cyclodextrin glycosyltransferase from Paenibacillus macerans.
PubMed:Effect of alpha-cyclodextrin-cinnamic acid inclusion complexes on populations of Escherichia coli O157:H7 and Salmonella enterica in fruit juices.
PubMed:Effects of addition of alpha-cyclodextrin on the sensory quality, volatile compounds, and color parameters of fresh pear juice.
PubMed:Mutations of Lysine 47 in cyclodextrin glycosyltransferase from Paenibacillus macerans enhance beta-cyclodextrin specificity.
PubMed:Delayed supplementation of glycine enhances extracellular secretion of the recombinant alpha-cyclodextrin glycosyltransferase in Escherichia coli.
PubMed:Calcium leads to further increase in glycine-enhanced extracellular secretion of recombinant alpha-cyclodextrin glycosyltransferase in Escherichia coli.
PubMed:Mutations at subsite -3 in cyclodextrin glycosyltransferase from Paenibacillus macerans enhancing alpha-cyclodextrin specificity.
PubMed:Kinetics of molecular encapsulation of 1-methylcyclopropene into alpha-cyclodextrin.
PubMed:Release of 1-methylcyclopropene from heat-pressed polymer films.
PubMed:Changes in the catalytic properties of Pyrococcus furiosus thermostable amylase by mutagenesis of the substrate binding sites.
PubMed:Effects of estradiol on cocaine self-administration and cocaine discrimination by female rhesus monkeys.
PubMed:Biochemical and structural features of a novel cyclodextrinase from cow rumen metagenome.
PubMed:Stereoisomeric distribution of 3-mercaptohexan-1-ol and 3-mercaptohexyl acetate in dry and sweet white wines made from Vitis vinifera (Var. Sauvignon Blanc and Semillon).
PubMed:Retention of a European pear aroma model mixture using different types of saccharides.
PubMed:Cyclodextrin (CD) complexes of cholesterol--their potential use in reducing dietary cholesterol intake.
PubMed:The effects of a new soluble dietary fiber on weight gain and selected blood parameters in rats.
PubMed:Evaluation of certain food additives.
PubMed:The effect of solvent interactions on alpha-, beta-, and gamma-cyclodextrin/flavor molecular inclusion complexes.
PubMed:Enzymatic analysis of an amylolytic enzyme from the hyperthermophilic archaeon Pyrococcus furiosus reveals its novel catalytic properties as both an alpha-amylase and a cyclodextrin-hydrolyzing enzyme.
PubMed:Disposition of 14C-alpha-cyclodextrin in germ-free and conventional rats.
PubMed:Safety evaluation of an alpha-cyclodextrin glycosyltranferase preparation.
PubMed:Embryotoxicity and teratogenicity study with alpha-cyclodextrin in rabbits.
PubMed:Embryotoxicity and teratogenicity study with alpha-cyclodextrin in rats.
PubMed:Subchronic (13-week) oral toxicity study of alpha-cyclodextrin in dogs.
PubMed:Encapsulation of shiitake (Lenthinus edodes) flavors by spray drying.
PubMed:Paenibacillus stellifer sp. nov., a cyclodextrin-producing species isolated from paperboard.
PubMed:Evaluation of certain food additives and contaminants.
PubMed:Green-leaf-derived C6-aroma compounds with potent antibacterial action that act on both Gram-negative and Gram-positive bacteria.
PubMed:Inclusion complex of conjugated linoleic acid (CLA) with cyclodextrins.
PubMed:Enantioseparation of chiral thiobarbiturates using cyclodextrin-modified capillary electrophoresis.
PubMed:Hydrolytic action of alpha-amylase on high-amylose starch of low molecular mass.
PubMed:Enantiomeric purity and odor characteristics of 2- and 3-acetoxy-1, 8-cineoles in the rhizomes of Alpinia galanga willd.
PubMed:Cloning and sequencing of a cyclodextrin glycosyltransferase gene from Brevibacillus brevis CD162 and its expression in Escherichia coli.
PubMed:Crystal structure of recombinant soybean beta-amylase complexed with beta-cyclodextrin.
PubMed:Comparison of the binding of beta-cyclodextrin and alpha- and gamma-cyclodextrins with pullulanase from Klebsiella pneumoniae as studied by equilibrium and kinetic fluorometry.
PubMed:Two sulfhydryl groups near the active site of soybean beta-amylase.
PubMed:Affinity purification of beta-amylases originating from plant using cyclomaltohexaose-immobilized Sepharose 6B in the presence of ammonium sulfate.
PubMed:Evidence for beta-galactosidase catalyzed hydrolysis of paranitrophenyl-beta-D-galactopyranoside anchored in cyclodextrins.
PubMed:Expression and mutation of soybean beta-amylase in Escherichia coli.
PubMed:Interaction between pullulanase from Klebsiella pneumoniae and cyclodextrins.
PubMed:Effect of some constituents of chicken egg yolk lipoprotein on the growth and IgM production of human-human hybridoma cells and other human-derived cells.
PubMed:Three-dimensional structure of soybean beta-amylase determined at 3.0 A resolution: preliminary chain tracing of the complex with alpha-cyclodextrin.
PubMed:Affinity labeling of a subsite of Taka-amylase A by the fluorescent reagent o-phthalaldehyde.
PubMed:Repeating use of Chalara paradoxa amylase by alpha-cyclodextrin affinity column.
 
Notes:
None found
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