EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

carboxymethyl cellulose cross-linked
cross-linked carboxymethyl cellulose

Supplier Sponsors

CAS Number: 74811-65-7Picture of molecule3D/inchi
FDA UNII: M28OL1HH48
Molecular Weight:263.19888928
Formula:C8 H16 Na O8
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:tabletting agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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JECFA Food Additive: Cross-Linked Sodium Carboxymethyl Cellulose
GSFA Codex: Carboxymethyl cellulose, cross-linked- (cross-linked-Cellulose gum) (468)
 
Physical Properties:
Appearance:white to grayish white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Insoluble in:
 acetone
 alcohol
 toluene
 
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Croscarmellose sodium
Carbosynth
For experimental / research use only.
Crosscarmellose sodium
Universal Preserv-A-Chem Inc.
Croscarmellose Sodium
Odor: characteristic
Use: Croscarmellose sodium is an internally cross-linked sodium carboxymethyl cellulose (NaCMC) that aids in the disintegration and dissolution of pharmaceutical and dietary supplement tablets, capsules, and granules.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
tabletting agents
Recommendation for carboxymethyl cellulose cross-linked usage levels up to:
 not for fragrance use.
 
Recommendation for carboxymethyl cellulose cross-linked flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Re-evaluation of celluloses E 460(i), E 460(ii), E 461, E 462, E 463, E 464, E 465, E 466, E 468 and E 469 as food additives
View page or View pdf

ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):74811-65-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6328154
National Institute of Allergy and Infectious Diseases:Data
acetic acid; 2,3,4,5,6-pentahydroxyhexanal; sodium
Chemidplus:0074811657
 
References:
 acetic acid; 2,3,4,5,6-pentahydroxyhexanal; sodium
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:74811-65-7
Pubchem (cid):6328154
Pubchem (sid):135296413
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 cross-linked carboxymethyl cellulose
 crosscarmellose sodium
cross-linked sodium carboxymethyl cellulose
 

Articles:

PubMed:Uniform cross-linked cellulase aggregates prepared in millifluidic reactors.
PubMed:Carboxymethyl cellulose film as a substrate for microarray fabrication.
PubMed:Sericin-carboxymethyl cellulose porous matrices as cellular wound dressing material.
PubMed:Aluminium and radiation cross-linked carboxymethyl sago pulp beads for colon targeted delivery.
PubMed:Mechanochemical activation of vincamine mediated by linear polymers: assessment of some "critical" steps.
PubMed:The anti-adhesive effect of thermally cross-linked gelatin film and its influence on the intestinal anastomosis in canine models.
PubMed:Al3+ ion cross-linked interpenetrating polymeric network microbeads from tailored natural polysaccharides.
PubMed:Evaluation of submucosally injected polyethylene glycol-based hydrogel and bovine cross-linked collagen in the canine urethra using cystoscopy, magnetic resonance imaging and histopathology.
PubMed:Polyvinyl alcohol hydrogel decreases formation of adhesions in a rat model of peritonitis.
PubMed:Mechanochemically induced disordered structures of vincamine: the different mediation of two cross-linked polymers.
PubMed:Postoperative adhesion prevention with a new barrier: an experimental study.
PubMed:Swelling behaviour and controlled drug release from cross-linked κ-carrageenan/NaCMC hydrogel by diffusion mechanism.
PubMed:Injectable, mixed natural-synthetic polymer hydrogels with modular properties.
PubMed:Postoperative adhesion prevention using a statin-containing cellulose film in an experimental model.
PubMed:Comparison of in vitro methods of measuring mucoadhesion: ellipsometry, tensile strength and rheological measurements.
PubMed:Preparation and In Vitro Evaluation of a Stomach Specific Drug Delivery System based on Superporous Hydrogel Composite.
PubMed:Preparation of cross-linked carboxymethyl jackfruit starch and evaluation as a tablet disintegrant.
PubMed:Use of cross-linked carboxymethyl cellulose for soft-tissue augmentation: preliminary clinical studies.
PubMed:Comparison of the rheological properties of viscosity and elasticity in two categories of soft tissue fillers: calcium hydroxylapatite and hyaluronic acid.
PubMed:Smart swelling biopolymer microparticles by a microfluidic approach: synthesis, in situ encapsulation and controlled release.
PubMed:Evaluation of synthesized cross linked polyvinyl alcohol as potential disintegrant.
PubMed:Wound healing evaluation of sodium fucidate-loaded polyvinylalcohol/sodium carboxymethylcellulose-based wound dressing.
PubMed:Effect of sodium carboxymethylcellulose and fucidic acid on the gel characterization of polyvinylalcohol-based wound dressing.
PubMed:Ionotropically cross-linked pH-sensitive IPN hydrogel matrices as potential carriers for intestine-specific oral delivery of protein drugs.
PubMed:Interpenetrating network hydrogel beads of carboxymethylcellulose and egg albumin for controlled release of lipid lowering drug.
PubMed:Temporary polysaccharide dermal fillers: a model for persistence based on physical properties.
PubMed:Raman spectroscopy and WAXS method as a tool for analysing ion-exchange properties of alginate hydrogels.
PubMed:Carcinogen adsorbent prepared from DNA complex by gamma-ray irradiation.
PubMed:Development of magnetically separable immobilized lipase by using cellulose derivatives and their application in enantioselective esterification of ibuprofen.
PubMed:Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus.
PubMed:Evaluation of in vitro enzymatic degradation of various thiomers and cross-linked thiomers.
PubMed:Development of pulsatile multiparticulate drug delivery system coated with aqueous dispersion Aquacoat ECD.
PubMed:Adhesion formation and reherniation differ between meshes used for abdominal wall reconstruction.
PubMed:Novel carboxymethylcellulose-based microporous hydrogels suitable for drug delivery.
PubMed:Development of biodegradable aluminium carboxymethylcellulose matrices for mosquito larvicides.
PubMed:Floating pellets containing bacterial antagonist for control sheath blight of rice: formulations, viability and bacterial release studies.
PubMed:Formation of defined microporous 3D structures starting from cross-linked hydrogels.
PubMed:Mucoadhesive vaginal tablets as veterinary delivery system for the controlled release of an antimicrobial drug, acriflavine.
PubMed:Evaluation of certain food additives. Fifty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives.
PubMed:Chitosan and sodium alginate-based bioadhesive vaginal tablets.
PubMed:In-vitro evaluation of bioadhesion in particulate systems and possible improvement using interactive mixtures.
PubMed:Isothermal calorimetry study of calcium caseinate and whey protein isolate edible films cross-linked by heating and gamma-irradiation.
PubMed:Fast- and slow-release tablets for oral administration of flavonoids: rutin and quercetin.
PubMed:Interpretation of mucoadhesive properties of polymer gel preparations using a tensile strength method.
PubMed:Efficacy of a hyaluronan derivative gel in postsurgical adhesion prevention in the presence of inadequate hemostasis.
PubMed:Mechanical and barrier properties of cross-linked soy and whey protein based films.
PubMed:Evaluation and preparation of controlled release lipid micropheres of sulphamethizole by a congealable disperse phase encapsulation method.
PubMed:Purification, characterization and amino-acid sequence analysis of a thermostable, low molecular mass endo-beta-1,4-glucanase from blue mussel, Mytilus edulis.
PubMed:Enhancement of ursodeoxycholic acid bioavailability by cross-linked sodium carboxymethyl cellulose.
PubMed:Oil-in water-emulsion gels: determination and mathematical treatment of flow properties.
PubMed:A rheological assessment of the nature of interactions between mucoadhesive polymers and a homogenised mucus gel.
PubMed:A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration.
PubMed:Optimization of sustained-release tablet formulations: a four-component mixture experiment.
PubMed:Buffer uptake and mass loss characteristics of freeze-dried cellulosic and alginate devices.
PubMed:Viscoelasticity of anionic polymers and their mucociliary transport on the frog palate.
PubMed:Compatibility study between acetylcysteine and some commonly used tablet excipients.
PubMed:Black substrate for spectrophotometric determination of cellulase activity in coloured solutions.
PubMed:Mixed-wall microcapsules made of cross-linked proteins and polysaccharides: preparation and properties.
PubMed:Purification and characterization of an outer membrane protein adhesin from Haemophilus parainfluenzae HP-28.
PubMed:A swellable polymer as carbamazepine dissolution rate enhancer.
PubMed:The immunogenicity of soluble haptenated polymers is determined by molecular mass and hapten valence.
PubMed:Cross-linked sodium carboxymethylcellulose as a carrier for dissolution rate improvement of drugs.
PubMed:Cross-linking study on localization of the binding site for elongation factor 1 alpha on rat liver ribosomes.
PubMed:Cross-linking of elongation factor 2 to rat-liver ribosomal proteins by 2-iminothiolane.
PubMed:The subunit structure and active site sequence of porcine spleen deoxyribonuclease.
PubMed:Application of cross-linked carboxymethyl cellulose degradation by beta-glucosidase and vaginal microbes to toxic shock syndrome.
PubMed:Cross-linking study on protein topography of rat liver 60 S ribosomal subunits with 2-iminothiolane.
PubMed:Effect of compressional force on tablets containing cellulosic disintegrators I: Dimensionless disintegration values.
PubMed:Spatial arrangement of proteins within the small subunit of rat liver ribosomes studied by cross-linking.
PubMed:The amino acid sequence of toxin D isolated from the venom of Indian cobra (Naja naja).
PubMed:Effect of disintegrant type upon the relationship between compressional pressure and dissolution efficiency.
PubMed:Isolation and characterization of pepsin-treated type III collagen from calf skin.
PubMed:Collagen molecules: distribution of alpha chains.
 
Notes:
a cellulose derivative which is a beta-(1->4)-d-glucopyranose polymer. it is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.
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