EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

carboxymethyl cellulose cross-linked
cross-linked carboxymethyl cellulose

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CAS Number: 74811-65-7Picture of molecule3D/inchi
Molecular Weight:263.19888928
Formula:C8 H16 Na O8
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:tabletting agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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JECFA Food Additive: Cross-Linked Sodium Carboxymethyl Cellulose
GSFA Codex: Carboxymethyl cellulose, cross-linked- (cross-linked-Cellulose gum) (468)
Physical Properties:
Appearance:white to grayish white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Insoluble in:
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
None found
BOC Sciences
For experimental / research use only.
Croscarmellose sodium
For experimental / research use only.
Crosscarmellose sodium
Universal Preserv-A-Chem Inc.
Croscarmellose Sodium
Odor: characteristic
Use: Croscarmellose sodium is an internally cross-linked sodium carboxymethyl cellulose (NaCMC) that aids in the disintegration and dissolution of pharmaceutical and dietary supplement tablets, capsules, and granules.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
tabletting agents
Recommendation for carboxymethyl cellulose cross-linked usage levels up to:
 not for fragrance use.
Recommendation for carboxymethyl cellulose cross-linked flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Re-evaluation of celluloses E 460(i), E 460(ii), E 461, E 462, E 463, E 464, E 465, E 466, E 468 and E 469 as food additives
View page or View pdf
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):74811-65-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6328154
National Institute of Allergy and Infectious Diseases:Data
acetic acid; 2,3,4,5,6-pentahydroxyhexanal; sodium
 acetic acid; 2,3,4,5,6-pentahydroxyhexanal; sodium
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:74811-65-7
Pubchem (cid):6328154
Pubchem (sid):135296413
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 cross-linked carboxymethyl cellulose
 crosscarmellose sodium
cross-linked sodium carboxymethyl cellulose


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a cellulose derivative which is a beta-(1->4)-d-glucopyranose polymer. it is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.
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