EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

calcium laevo-5-methyl tetrahydrofolate
calcium L-5-methyltetrahydrofolate

Supplier Sponsors

Name:calcium (2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
CAS Number: 151533-22-1Picture of molecule3D/inchi
FDA UNII: A9R10K3F2F
MDL:MFCD15146358
Molecular Weight:497.52551000
Formula:C20 H23 Ca N7 O6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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JECFA Food Additive: Calcium L-5-Methyltetrahydrofolate
 
Physical Properties:
Appearance:whit to pale yellow crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 alkaline solutions
 water, very slightly
 
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American International Chemical, LLC.
Calcium L-5-Methyltetradydrofolate USP (5-MTHF)
BOC Sciences
For experimental / research use only.
Calcium levomefolate >98%
Carbosynth
For experimental / research use only.
L-5-Methyltetrahydrofolate calcium
Indis NV
For experimental / research use only.
L-Methylfolate Calcium
Santa Cruz Biotechnology
For experimental / research use only.
L-5-Methyletrahydrofolate calcium
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nutrient supplements
Recommendation for calcium laevo-5-methyl tetrahydrofolate usage levels up to:
 not for fragrance use.
 
Recommendation for calcium laevo-5-methyl tetrahydrofolate flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Calcium L-Methylfolate.
View page or View pdf

ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :15341110
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
calcium (2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
Chemidplus:0151533221
 
References:
 calcium (2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):15341110
Pubchem (sid):135253403
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D09354
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
N-{4-[[((6S)-2-amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl}-L-glutamic acid calcium salt
N-{4-[[((6S)-2-amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl}-laevo-glutamic acid calcium salt
 calcium (2S)-2-[[4-[[(6S)-2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
 calcium L-5-methyl tetrahydrofolate
 calcium L-5-methyltetrahydrofolate
 calcium laevo-5-methyltetrahydrofolate
 calcium N-(4-((((6S)-2-amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamate
 metafolin
laevo-methylfolate, calcium
laevo-5-methyltetrahydrofolic acid calcium salt
 nutrifolin
 

Articles:

PubMed:[Metafolin--alternative for folate deficiency supplementation in pregnant women].
PubMed:Folate status and homocysteine levels during a 24-week oral administration of a folate-containing oral contraceptive: a randomized, double-blind, active-controlled, parallel-group, US-based multicenter study.
PubMed:Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone.
PubMed:Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics.
PubMed:Bioequivalence of two leucovorin calcium tablet formulations.
 
Notes:
an ingredient in contraceptives, oral, combined
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