EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

chocolate brown HT
brown HT

Supplier Sponsors

Name:disodium;4-[(2E)-2-[(5E)-3-(hydroxymethyl)-4,6-dioxo-5-[(4-sulfonatonaphthalen-1-yl)hydrazinylidene]cyclohex-2-en-1-ylidene]hydrazinyl]naphthalene-1-sulfonate
CAS Number: 4553-89-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:224-924-0
FDA UNII:067L3J47ID
Molecular Weight:652.57079856
Formula:C27 H18 N4 Na2 O9 S2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:coloring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
EU SANCO Brown HT View - review
JECFA Food Additive: Brown HT
GSFA Codex: Brown HT (155)
DG SANTE Food Additives:brown HT
 
Physical Properties:
Appearance:brown powder (est)
Assay: 70.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): 3.383 (est)
Soluble in:
 water, 0.002612 mg/L @ 25 °C (est)
Insoluble in:
 alcohol
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Chocolate Brown HT
Glentham Life Sciences
Chocolate Brown HT (C.I. 20285)
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 2000 mg/kg
Food and Cosmetics Toxicology. Vol. 4, Pg. 143, 1966.

intraperitoneal-rat LD50 375 mg/kg
Food and Cosmetics Toxicology. Vol. 4, Pg. 143, 1966.

oral-mouse LD50 > 2000 mg/kg
Food and Cosmetics Toxicology. Vol. 4, Pg. 143, 1966.

intraperitoneal-mouse LD50 220 mg/kg
Food and Cosmetics Toxicology. Vol. 4, Pg. 143, 1966.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: coloring agents
Recommendation for chocolate brown HT usage levels up to:
 not for fragrance use.
 
Recommendation for chocolate brown HT flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of Brown HT (E 155) as a food additive
View page or View pdf

Refined exposure assessment of Brown HT (E 155)
View page or View pdf

EPI System: View
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):4553-89-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :9570176
National Institute of Allergy and Infectious Diseases:Data
disodium;4-[(2E)-2-[(5E)-3-(hydroxymethyl)-4,6-dioxo-5-[(4-sulfonatonaphthalen-1-yl)hydrazinylidene]cyclohex-2-en-1-ylidene]hydrazinyl]naphthalene-1-sulfonate
Chemidplus:0004553893
 
References:
 disodium;4-[(2E)-2-[(5E)-3-(hydroxymethyl)-4,6-dioxo-5-[(4-sulfonatonaphthalen-1-yl)hydrazinylidene]cyclohex-2-en-1-ylidene]hydrazinyl]naphthalene-1-sulfonate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:4553-89-3
Pubchem (cid):9570176
Pubchem (sid):134985404
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB37512
FooDB:FDB016590
FDA Listing of Food Additive Status:View
FDA Color Additive Status ListView
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 1538 brown
 brown HT
 c.i. 20285
 C.I. food brown 3, disodium salt
 certicol brown N extra
 certicol brown RS
 ci 20285
 CI food brown 3
2,4-dihydroxy-3,5-di(4-sulpho-1-naphthylazo)benzyl alcohol, disodium salt
 disodium 4,4'- (2,4-dihydroxy-5-hydroxymethyl-1,3-phenylene-bisazo) di-1-naphthalene-sulfonate
 disodium 4,4'-((2,4-dihydroxy-5-(hydroxymethyl)-1,3-phenylene)bis(azo))bisnaphthalene-1-sulphonate
 disodium 4,4'-[[2,4-dihydroxy-5-(hydroxymethyl)-1,3-phenylene]didiazene-2,1-diyl]dinaphthalene-1-sulfonate
 disodium 4,4'-{[2,4-dihydroxy-5-(hydroxymethyl)benzene-1,3-diyl]di(E)diazene-2,1-diyl}dinaphthalene-1-sulfonate
 hexacol chocolate brown HT
 hned potravinarska 3
1-naphthalenesulfonic acid, 4,4'-((2,4-dihydroxy-5-(hydroxymethyl)- m-phenylene)bis(azo))di-, disodium salt
1-naphthalenesulfonic acid, 4,4'-((2,4-dihydroxy-5-(hydroxymethyl)-1,3-phenylene)bis(azo))bis-, disodium salt
 

Articles:

PubMed:Health safety issues of synthetic food colorants.
PubMed:Methods for the analysis of azo dyes employed in food industry--A review.
PubMed:Physiological effects of some synthetic food colouring additives on rats.
PubMed:A program for computer-assisted scoring of Southern blots.
PubMed:Three-generation toxicity study of rats ingesting Brown HT in the diet.
PubMed:Metabolic disposition of 14C-labelled Brown HT in the rat, mouse and guinea-pig.
PubMed:Teratogenicity and embryotoxicity study of Brown HT in the rat.
PubMed:The use of continuous flow systems for studying the metabolic activity of the hindgut microflora in vitro.
PubMed:Direct differential-pulse polarographic determinaion of mixtures of food coloring matters, Chocolate Brown HT, tartrazine and Green S.
PubMed:Long-term toxicity studies on Chocolate Brown HT in rats.
PubMed:Short-term toxicity study of Chocolate Brown HT in pigs.
PubMed:Long-term toxicity studies of chocolate brown HT in mice.
PubMed:Short-term study of chocolate brown HT in rats.
PubMed:Acute (mouse and rat) and short-term (rat) toxicity studies on chocolate brown HT.
PubMed:United States Dispensatory, 25th edition, 1955.
 
Notes:
Food colourant. Prohibited in USA, France, Norway and Sweden
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