aminopeptidase from lactococcus lactis
 
Notes:
Used as a food additive [EAFUS]
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CAS Number: 9031-94-1 
ECHA EC Number: 232-874-6
MDL: MFCD00166325
Formula: unspecified
Category: enzyme preparations and microorganisms
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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FDA Mainterm: AMINOPEPTIDASE FROM LACTOCOCCUS LACTIS
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1985 Aminopeptidase enzyme preparation derived from lactococcus lactis.
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Physical Properties:
Food Chemicals Codex Listed: No
Storage: refrigerate in tightly sealed containers.
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
 None found
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Safety Information:
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: enzyme preparations and microorganisms
Recommendation for aminopeptidase from lactococcus lactis usage levels up to:
 not for fragrance use.
 
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Safety References:
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
Chemidplus: 0009031941
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References:
Pubchem (sid): 135330794
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Other Information:
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): Search
FooDB: FDB008940
VCF-Online: VCF Volatile Compounds in Food
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 cheese cheddar cheese 
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Occurrence (nature, food, other): note
 lactococcus lactis
Search  PMC Picture
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Synonyms:
 aminopeptidase from lactococcus lactis
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Articles:
PubMed: A Novel Glutamyl (Aspartyl)-Specific Aminopeptidase A from Lactobacillus delbrueckii with Promising Properties for Application.
PubMed: Effect of varying the salt and fat content in Cheddar cheese on aspects of the performance of a commercial starter culture preparation during ripening.
PubMed: Statistical optimization of cell disruption techniques for releasing intracellular X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis spp. lactis.
PubMed: Oral administration of Lactococcus lactis-expressed recombinant porcine epidermal growth factor stimulates the development and promotes the health of small intestines in early-weaned piglets.
PubMed: Recombinant porcine epidermal growth factor-secreting Lactococcus lactis promotes the growth performance of early-weaned piglets.
PubMed: Production, active staining and gas chromatography assay analysis of recombinant aminopeptidase P from Lactococcus lactis ssp. lactis DSM 20481.
PubMed: A new binding site involving the C-terminal domain to design specific inhibitors of PepX.
PubMed: Metal preferences of zinc-binding motif on metalloproteases.
PubMed: Characterization of certain bacterial strains for potential use as starter or probiotic cultures in dairy products.
PubMed: Enzymatic activity of lactic acid bacteria (with antimicrobial properties) isolated from a traditional Spanish cheese.
PubMed: To protect peptide pharmaceuticals against peptidases.
PubMed: Regulatory phenotyping reveals important diversity within the species Lactococcus lactis.
PubMed: Genotypic and technological characterization of Lactococcus lactis isolates involved in processing of artisanal Manchego cheese.
PubMed: Rep-PCR characterization and biochemical selection of lactic acid bacteria isolated from the Delta area of Egypt.
PubMed: Use of lantibiotic synthetases for the preparation of bioactive constrained peptides.
PubMed: Diversity analysis of dairy and nondairy Lactococcus lactis isolates, using a novel multilocus sequence analysis scheme and (GTG)5-PCR fingerprinting.
PubMed: Tolerance to high osmolality of the lactic acid bacterium Oenococcus oeni and identification of potential osmoprotectants.
PubMed: Carbohydrate starvation causes a metabolically active but nonculturable state in Lactococcus lactis.
PubMed: Genotypic and phenotypic diversity of Lactococcus lactis isolates from Batzos, a Greek PDO raw goat milk cheese.
PubMed: Effect of high-pressure treatment and a bacteriocin-producing lactic culture on the proteolysis, texture, and taste of Hispánico cheese.
PubMed: Construction and evaluation of food-grade vectors for Lactococcus lactis using aspartate aminotransferase and alpha-galactosidase as selectable markers.
PubMed: Proteolysis of Hispanico cheese manufactured using lacticin 481-producing Lactococcus lactis ssp. lactis INIA 639.
PubMed: The structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity.
PubMed: Characterization and kinetic analysis of enzyme-substrate recognition by three recombinant lactococcal tripeptidases.
PubMed: Phylogenetic analysis of Lactococcus lactis subspecies based on decoding the sequence of the pepT tripeptidase gene, the pepV dipeptidase gene and 16S rRNA.
PubMed: High-level gene expression in Lactobacillus plantarum using a pheromone-regulated bacteriocin promoter.
PubMed: Catalytic activity of tripeptidase from Lactococcus lactis to which amino acid substitution was introduced according to natural mutation.
PubMed: Use of bacteriocin promoters for gene expression in Lactobacillus plantarum C11.
PubMed: Purification and characterization of the Streptococcus salivarius methionine aminopeptidase (MetAP).
PubMed: Proteolysis, volatile compounds, and sensory evaluation in Hispánico cheese manufactured with the addition of a thermophilic adjunct culture, nisin, and calcium alginate-nisin microparticles.
PubMed: Synthetic peptides as substrate for assaying the proteolytic activity of Lactobacillus helveticus.
PubMed: High pressure effects on proteolytic and glycolytic enzymes involved in cheese manufacturing.
PubMed: Identification and characterization of Lactobacillus helveticus PepO2, an endopeptidase with post-proline specificity.
PubMed: Food-grade host/vector expression system for Lactobacillus casei based on complementation of plasmid-associated phospho-beta-galactosidase gene lacG.
PubMed: Effect of wild strains of Lactococcus lactis on the volatile profile and the sensory characteristics of ewes' raw milk cheese.
PubMed: Overexpression of peptidases in Lactococcus and evaluation of their release from leaky cells.
PubMed: The structural basis for catalysis and specificity of the X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis.
PubMed: Elevated enzyme release from lactococcal starter cultures on exposure to the lantibiotic lacticin 481, produced by Lactococcus lactis DPC5552.
PubMed: A food-grade cloning vector for lactic acid bacteria based on the nisin immunity gene nisI.
PubMed: Proteolysis in Hispánico cheese manufactured using a mesophilic starter, a thermophilic starter, and bacteriocin-producing Lactococcus lactis subsp. lactis INIA 415 adjunct culture.
PubMed: Recombinant Lactococcus starters as a potential source of additional peptidolytic activity in cheese ripening.
PubMed: An X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis: cloning, expression in Escherichia coli, and application for removal of N-terminal Pro-Pro from recombinant proteins.
PubMed: Extracellular arginine aminopeptidase from Streptococcus gordonii FSS2.
PubMed: Influence of adjunct cultures on ripening of reduced fat Edam cheeses.
PubMed: Fluorescent method for monitoring cheese starter permeabilization and lysis.
PubMed: Proteolysis and formation of volatile compounds in cheese manufactured with a bacteriocin-producing adjunct culture.
PubMed: Expression of six peptidases from Lactobacillus helveticus in Lactococcus lactis.
PubMed: Characterization by molecular cloning and sequencing of the gene encoding an aminopeptidase from Listeria monocytogenes.
PubMed: The effects of cultivating lactic starter cultures with bacteriocin-producing lactic acid bacteria.
PubMed: Leaky Lactococcus cultures that externalize enzymes and antigens independently of culture lysis and secretion and export pathways.
PubMed: A food-grade cloning system for industrial strains of Lactococcus lactis.
PubMed: Purification and molecular characterization of a tripeptidase (PepT) from Lactobacillus helveticus.
PubMed: X-prolyl dipeptidyl aminopeptidase gene (pepX) is part of the glnRA operon in Lactobacillus rhamnosus.
PubMed: Introduction of peptidase genes from Lactobacillus delbrueckii subsp. lactis into Lactococcus lactis and controlled expression.
PubMed: PepS from Streptococcus thermophilus. A new member of the aminopeptidase T family of thermophilic bacteria.
PubMed: Purification and characterization of a lysine-p-nitroanilide hydrolase, a broad specificity aminopeptidase, from the cytoplasm of Lactococcus lactis subsp. cremoris AM2.
PubMed: Hydrolysis of alphas1- and beta-casein-derived peptides with a broad specificity aminopeptidase and proline specific aminopeptidases from Lactococcus lactis subsp. cremoris AM2.
PubMed: The expression signals of the Lactobacillus brevis slpA gene direct efficient heterologous protein production in lactic acid bacteria.
PubMed: Cloning, expression, and chromosomal stabilization of the Propionibacterium shermanii proline iminopeptidase gene (pip) for food-grade application in Lactococcus lactis.
PubMed: Genetic characterization of pepP, which encodes an aminopeptidase P whose deficiency does not affect Lactococcus lactis growth in milk, unlike deficiency of the X-prolyl dipeptidyl aminopeptidase.
PubMed: Catalytic properties of the cysteine aminopeptidase PepC, a bacterial bleomycin hydrolase.
PubMed: Experimental evidence for the essential role of the C-terminal residue in the strict aminopeptidase activity of the thiol aminopeptidase PepC, a bacterial bleomycin hydrolase.
PubMed: A chloride-inducible gene expression cassette and its use in induced lysis of Lactococcus lactis.
PubMed: Purification and partial characterization of a tripeptidase from Pediococcus pentosaceus K9.2.
PubMed: Food-grade controlled lysis of Lactococcus lactis for accelerated cheese ripening.
PubMed: Proteolytic enzyme activity in lactococci grown in different pretreated milk media.
PubMed: Purification and characterization of aminopeptidase P from Lactococcus lactis subsp. cremoris.
PubMed: Autolysis of Lactococcus lactis caused by induced overproduction of its major autolysin, AcmA.
PubMed: Presence of additional peptidases in Streptococcus thermophilus CNRZ 302 compared to Lactococcus lactis.
PubMed: Structure-function relationships within the peptide deformylase family. Evidence for a conserved architecture of the active site involving three conserved motifs and a metal ion.
PubMed: Characterization of a thiol-dependent endopeptidase from Lactobacillus helveticus CNRZ32.
PubMed: A survey of polypeptide deformylase function throughout the eubacterial lineage.
PubMed: The possible role of aminopeptidases from starter culture Lactococcus lactis subspecies cremoris AM2 in cheese making.
PubMed: Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin.
PubMed: The proteolytic system of Lactobacillus sanfrancisco CB1: purification and characterization of a proteinase, a dipeptidase, and an aminopeptidase.
PubMed: Fate of peptides in peptidase mutants of Lactococcus lactis.
PubMed: Detection and localization of peptidases in Lactococcus lactis with monoclonal antibodies.
PubMed: A new, broad-substrate-specificity aminopeptidase from the dairy organism Lactobacillus helveticus SBT 2171.
PubMed: Peptides inhibitory to endopeptidase and aminopeptidase from Lactococcus lactis ssp. lactis MG1363, released from bovine beta-casein by chymosin, trypsin or chymotrypsin.
PubMed: Food-grade cloning and expression system for Lactococcus lactis.
PubMed: DNA sequence analysis, expression, distribution, and physiological role of the Xaa-prolyldipeptidyl aminopeptidase gene from Lactobacillus helveticus CNRZ32.
PubMed: Regulation of Proteolytic Enzyme Activity in Lactococcus lactis.
PubMed: A study of the substrate specificity of aminopeptidase N from Lactococcus lactis subsp. cremoris Wg2.
PubMed: An X-prolyl dipeptidyl aminopeptidase (pepX) gene from Lactobacillus helveticus.
PubMed: Immunological and electrophoretic study of the proteolytic enzymes from various Lactococcus and Lactobacillus strains.
PubMed: Comparison of proteolytic activities in various lactobacilli.
PubMed: A non-essential glutamyl aminopeptidase is required for optimal growth of Lactococcus lactis MG1363 in milk.
PubMed: Sequence analysis, distribution and expression of an aminopeptidase N-encoding gene from Lactobacillus helveticus CNRZ32 [gene 155 (1995) 89-93].
PubMed: Purification, crystallization, and preliminary X-ray analysis of PepX, an X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis.
PubMed: Nucleotide sequence of the lantibiotic Pep5 biosynthetic gene cluster and functional analysis of PepP and PepC. Evidence for a role of PepC in thioether formation.
PubMed: Sequence analysis, distribution and expression of an aminopeptidase N-encoding gene from Lactobacillus helveticus CNRZ32.
PubMed: Isolation of Lactococcus lactis nonsense suppressors and construction of a food-grade cloning vector.
PubMed: An aminopeptidase P from Lactococcus lactis with original specificity.
PubMed: Preparation of bacterial X-prolyl dipeptidyl aminopeptidase and its stabilization by organic cosolvents.
PubMed: Cloning and nucleotide sequence analysis of the Lactobacillus delbrueckii ssp. lactis DSM7290 cysteine aminopeptidase gene pepC.
PubMed: Effect of genetically modifying the lactococcal proteolytic system on ripening and flavor development in cheddar cheese.
PubMed: Purification and characterization of a general aminopeptidase (St-PepN) from Streptococcus salivarius ssp. thermophilus CNRZ 302.
PubMed: Characterization and expression of the Lactobacillus helveticus pepC gene encoding a general aminopeptidase.
PubMed: Aminopeptidase N from Streptococcus salivarius subsp. thermophilus NCDO 573: purification and properties.
PubMed: Gene cloning and characterization of PepC, a cysteine aminopeptidase from Streptococcus thermophilus, with sequence similarity to the eucaryotic bleomycin hydrolase.
PubMed: Xaa-Pro-dipeptidyl-aminopeptidase from Lactococcus lactis catalyses kinetically controlled synthesis of peptide bonds involving proline.
PubMed: Tripeptidase gene (pepT) of Lactococcus lactis: molecular cloning and nucleotide sequencing of pepT and construction of a chromosomal deletion mutant.
PubMed: Crystallization and preliminary X-ray analysis of PepC, a thiol aminopeptidase from Lactoccocus lactis homologous to bleomycin hydrolase.
PubMed: Cloning, sequencing and characterization of the pepIP gene encoding a proline iminopeptidase from Lactobacillus delbrueckii subsp. bulgaricus CNRZ 397.
PubMed: Characterization of the Lactobacillus helveticus CNRZ32 pepC gene.
PubMed: Effect of X-Prolyl Dipeptidyl Aminopeptidase Deficiency on Lactococcus lactis.
PubMed: Degradation and debittering of a tryptic digest from beta-casein by aminopeptidase N from Lactococcus lactis subsp. cremoris Wg2.
PubMed: Monitoring tripeptidase activity using capillary electrophoresis. Comparison with the ninhydrin assay.
PubMed: Cloning and sequencing of pepC, a cysteine aminopeptidase gene from Lactococcus lactis subsp. cremoris AM2.
PubMed: Identification of the active site serine of the X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis.
PubMed: Characterization of the Lactococcus lactis pepN gene encoding an aminopeptidase homologous to mammalian aminopeptidase N.
PubMed: Catalytic properties of X-prolyl dipeptidyl aminopeptidase from Lactococcus lactis subsp. cremoris nTR.
PubMed: Sequence of a gene (lap) encoding a 95.3-kDa aminopeptidase from Lactococcus lactis ssp. cremoris Wg2.
PubMed: Localization of peptidases in lactococci.
PubMed: Purification and characterization of an endopeptidase from Lactococcus lactis subsp. cremoris Wg2.
PubMed: Characterization and overexpression of the Lactococcus lactis pepN gene and localization of its product, aminopeptidase N.
PubMed: Ultrasound treatment for harvesting an aminopeptidase from lactic Acid bacteria and quantitation of the enzyme by enzyme-linked immunosorbent assays.
PubMed: Replacement recombination in Lactococcus lactis.
PubMed: Aminopeptidase A from Lactococcus lactis.
PubMed: Aminotripeptidase activity in Lactococcus lactis subsp cremoris AM2.
PubMed: Cloning and DNA sequence analysis of an X-prolyl dipeptidyl aminopeptidase gene from Lactococcus lactis subsp. lactis NCDO 763.
PubMed: Molecular cloning and sequence analysis of the X-prolyl dipeptidyl aminopeptidase gene from Lactococcus lactis subsp. cremoris.
PubMed: Purification and Characterization of an Aminopeptidase from Lactococcus lactis subsp. cremoris Wg2.
PubMed: Enzyme activities of cell-free extracts from mutant strains of lactic streptococci subjected to sublethal heating or freeze-thawing.
PubMed: Purification and Characterization of an Aminopeptidase from Lactococcus lactis subsp. cremoris AM2.
PubMed: Comparative peptide specificity of cell wall, membrane and intracellular peptidases of group N streptococci.
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