| PubMed:UPLC-MS/MS method for determination of selected pyrrolizidine alkaloids in feed. |
| PubMed:Three new monoterpene glucosides from Senecio solidagineus. |
| PubMed:Correction to Metabolomic and Genomic Evidence for Compromised Bile Acid Homeostasis by Senecionine, a Hepatotoxic Pyrrolizidine Alkaloid. |
| PubMed:Toxicity of pyrrolizidine alkaloids to Spodoptera exigua using insect cell lines and injection bioassays. |
| PubMed:Prenatal exposure to integerrimine N-oxide impaired the maternal care and the physical and behavioral development of offspring rats. |
| PubMed:Mass-spectrometry-directed analysis and purification of pyrrolizidine alkaloid cis/trans isomers in Gynura japonica. |
| PubMed:Metabolomic and genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloid. |
| PubMed:[Determination of five pyrrolizidine alkaloids in honey by liquid chromatography-tandem mass spectrometry]. |
| PubMed:Tusanqi and hepatic sinusoidal obstruction syndrome. |
| PubMed:Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine. |
| PubMed:Development and validation of a rapid multiplex ELISA for pyrrolizidine alkaloids and their N-oxides in honey and feed. |
| PubMed:Assessment of pyrrolizidine alkaloid-induced toxicity in an in vitro screening model. |
| PubMed:Analysis of pyrrolizidine alkaloids and evaluation of some biological activities of Algerian Senecio delphinifolius (Asteraceae). |
| PubMed:The relationship between structurally different pyrrolizidine alkaloids and western flower thrips resistance in F(2) hybrids of Jacobaea vulgaris and Jacobaea aquatica. |
| PubMed:Haematological and immunological effects of repeated dose exposure of rats to integerrimine N-oxide from Senecio brasiliensis. |
| PubMed:[Simultaneous quantitation of adonifoline and senecionine in Senecio herbs by UPLC-MS]. |
| PubMed:Authentication of Senecio scandens and S. vulgaris based on the comprehensive secondary metabolic patterns gained by UPLC-DAD/ESI-MS. |
| PubMed:The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS. |
| PubMed:Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum. |
| PubMed:The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury. |
| PubMed:Chemical composition and antimicrobial activity of the essential oils from Cleome spinosa. |
| PubMed:[Ethyl acetate-soluble chemical constituents from whole plants of Senecio chrysanthemoides]. |
| PubMed:Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arctiids (lepidoptera). |
| PubMed:Glucuronidation, a new metabolic pathway for pyrrolizidine alkaloids. |
| PubMed:Identification of the UDP-glucuronosyltransferase isozyme involved in senecionine glucuronidation in human liver microsomes. |
| PubMed:Pyrrolizidine alkaloids in pollen and pollen products. |
| PubMed:Intracellular glutathione plays important roles in pyrrolizidine alkaloids-induced growth inhibition on hepatocytes. |
| PubMed:Feeding deterrence and detrimental effects of pyrrolizidine alkaloids fed to honey bees (Apis mellifera). |
| PubMed:Simultaneous determination of senecionine, adonifoline and their metabolites in rat serum by UPLC-ESIMS and its application in pharmacokinetic studies. |
| PubMed:Determination of senkirkine and senecionine in Tussilago farfara using microwave-assisted extraction and pressurized hot water extraction with liquid chromatography tandem mass spectrometry. |
| PubMed:Antitrypanosomal and cytotoxic activities of pyrrolizidine alkaloid-producing plants of Ethiopia. |
| PubMed:Simultaneous characterization of pyrrolizidine alkaloids and N-oxides in Gynura segetum by liquid chromatography/ion trap mass spectrometry. |
| PubMed:Safety assessment of food and herbal products containing hepatotoxic pyrrolizidine alkaloids: interlaboratory consistency and the importance of N-oxide determination. |
| PubMed:Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes. |
| PubMed:The toxicity of Senecio inaequidens DC. |
| PubMed:Identification of five hepatotoxic pyrrolizidine alkaloids in a commonly used traditional Chinese medicinal herb, Herba Senecionis scandentis (Qianliguang). |
| PubMed:Identification and quantification of hepatotoxic pyrrolizidine alkaloids in the Ethiopian medicinal plant Solanecio gigas (Asteraceae). |
| PubMed:Pyrrolizidine alkaloids of the endemic Mexican genus Pittocaulon and assignment of stereoisomeric 1,2-saturated necine bases. |
| PubMed:Determination of pyrrolizidine alkaloids in senecio species by liquid chromatography/thermospray-mass spectrometry and liquid chromatography/nuclear magnetic resonance spectroscopy. |
| PubMed:Pyrrolizidine alkaloid level in Senecio bicolor (Wilid.) Tod, ssp. cineraria (DC.) from middle Europe. |
| PubMed:Dynamic pH junction-sweeping capillary electrophoresis for online preconcentration of toxic pyrrolizidine alkaloids in Chinese herbal medicine. |
| PubMed:Do naïve ruminants degrade alkaloids in the rumen? |
| PubMed:Acquisition, transformation and maintenance of plant pyrrolizidine alkaloids by the polyphagous arctiid Grammia geneura. |
| PubMed:Separation and determination of toxic pyrrolizidine alkaloids in traditional Chinese herbal medicines by micellar electrokinetic chromatography with organic modifier. |
| PubMed:Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. |
| PubMed:Frequent gain and loss of pyrrolizidine alkaloids in the evolution of Senecio section Jacobaea (Asteraceae). |
| PubMed:Specific recognition, detoxification and metabolism of pyrrolizidine alkaloids by the polyphagous arctiid Estigmene acrea. |
| PubMed:Direct evidence for membrane transport of host-plant-derived pyrrolizidine alkaloid N-oxides in two leaf beetle genera. |
| PubMed:Comparison of hepatic in vitro metabolism of the pyrrolizidine alkaloid senecionine in sheep and cattle. |
| PubMed:Preventive activity of pyrrolizidine alkaloids from Seneciobrasiliensis (Asteraceae) on gastric and duodenal induced ulcer on mice and rats. |
| PubMed:Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers. |
| PubMed:Differential metabolism of the pyrrolizidine alkaloid, senecionine, in Fischer 344 and Sprague-Dawley rats. |
| PubMed:Acquired and partially de novo synthesized pyrrolizidine alkaloids in two polyphagous arctiids and the alkaloid profiles of their larval food-plants. |
| PubMed:Variation in pyrrolizidine alkaloid patterns of Senecio jacobaea. |
| PubMed:Evaporative light scattering detection of pyrrolizidine alkaloids. |
| PubMed:Taste receptors for pyrrolizidine alkaloids in a monophagous caterpillar. |
| PubMed:Pyrrolizidine alkaloids as oviposition stimulants for the cinnabar moth, Tyria jacobaeae. |
| PubMed:Uptake and metabolism of pyrrolizidine alkaloids in Longitarsus flea beetles (Coleoptera: Chrysomelidae) adapted and non-adapted to alkaloid-containing host plants. |
| PubMed:Biochemical strategy of sequestration of pyrrolizidine alkaloids by adults and larvae of chrysomelid leaf beetles. |
| PubMed:Toxicity of Senecio vernalis to laying hens and evaluation of residues in eggs. |
| PubMed:Toxic pyrrolyzidine alkaloids from three mongolian plants. a possible risk for cattle poisoning. |
| PubMed:Pyrrolizidine alkaloid profiles of some Senecio species from Egypt. |
| PubMed:Structure-activity relationships of pyrrolizidine alkaloids in insect chemical defense against the orb-weaving spider Nephila clavipes. |
| PubMed:Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase extraction and ion-pair high-performance liquid chromatography. |
| PubMed:Alkaloids from Senecio aquaticus. |
| PubMed:Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae. |
| PubMed:Induction of micronuclei by alkaloids extracted from Senecio brasiliensis and stored for 23 years. |
| PubMed:Interplant alkaloid variation and Senecio vernalis toxicity in cattle. |
| PubMed:Defensive chemistry of Senecio miser. |
| PubMed:Variability in chemical constituents in Petasites hybridus from Austria. |
| PubMed:SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest). |
| PubMed:Hepatotoxicity associated with pyrrolizidine alkaloid (Crotalaria spp) ingestion in a horse on Easter Island. |
| PubMed:Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids. |
| PubMed:[Veno-occlusive disease after prolonged treatment with senecionine (Hemoluol)]. |
| PubMed:The roles of CYP3A and CYP2B isoforms in hepatic bioactivation and detoxification of the pyrrolizidine alkaloid senecionine in sheep and hamsters. |
| PubMed:Generation and characterization of monoclonal antibodies against the pyrrolizidine alkaloid retrorsine. |
| PubMed:Determination of pyrrolizidine alkaloids in honey from selected sites by solid phase extraction and HPLC-MS. |
| PubMed:The two facies of pyrrolizidine alkaloids: the role of the tertiary amine and its N-oxide in chemical defense of insects with acquired plant alkaloids. |
| PubMed:Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster. |
| PubMed:Pyrrolizidine alkaloids from Gynura divaricata. |
| PubMed:A competitive enzyme immunoassay for the pyrrolizidine alkaloids of the senecionine type. |
| PubMed:Preparative separation of pyrrolizidine alkaloids by high-speed counter-current chromatography. |
| PubMed:Enzyme-linked immunosorbent assay detection of pyrrolizidine alkaloids: immunogens based on quaternary pyrrolizidinium salts. |
| PubMed:Pyrrolizidine alkaloids of three species of senecio in British Columbia. |
| PubMed:A cytochrome P4502B form is the major bioactivation enzyme for the pyrrolizidine alkaloid senecionine in guinea pig. |
| PubMed:Analysis of pyrrolizidine alkaloids: a competitive enzyme-linked immunoassay (ELISA) for the quantitative determination of some toxic pyrrolizidine alkaloids. |
| PubMed:The effect of spironolactone treatment on the cytochrome P450-mediated metabolism of the pyrrolizidine alkaloid senecionine by hepatic microsomes from rats and guinea pigs. |
| PubMed:Hepatotoxic pyrrolizidine alkaloids in the Mexican medicinal plant Packera candidissima (Asteraceae: Senecioneae). |
| PubMed:Differing embryotoxic effects of senecionine and senecionine-N-oxide on the chick embryo. |
| PubMed:Structural influences on pyrrolizidine alkaloid-induced cytopathology. |
| PubMed:Pyrrolizidine alkaloids from Senecio leucanthemifolius and Senecio rodriguezii. |
| PubMed:Microsomal formation of a pyrrolic alcohol glutathione conjugate of the pyrrolizidine alkaloid senecionine. |
| PubMed:Hydrolysis of pyrrolizidine alkaloids by guinea pig hepatic carboxylesterases. |
| PubMed:Detection of sulphur-conjugated pyrrolic metabolites in blood and fresh or fixed liver tissue from rats given a variety of toxic pyrrolizidine alkaloids. |
| PubMed:Pyrrolizidine alkaloids from Werneria nubigena. |
| PubMed:Pyrrolizidine alkaloids from Melampyrum pratense. |
| PubMed:Sequestration of ingested [(14)C]senecionineN-oxide in the exocrine defensive secretions of chrysomelid beetles. |
| PubMed:DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: structure-activity relationships. |
| PubMed:Flavin-containing monooxygenase: a major detoxifying enzyme for the pyrrolizidine alkaloid senecionine in guinea pig tissues. |
| PubMed:Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver. |
| PubMed:Mechanisms for pyrrolizidine alkaloid activation and detoxification. |
| PubMed:Excretion and blood radioactivity levels following [14C]senecionine administration in the rat. |
| PubMed:N-acetylcysteine-conjugated pyrrole identified in rat urine following administration of two pyrrolizidine alkaloids, monocrotaline and senecionine. |
| PubMed:The effect of the pyrrolizidine alkaloid integerrimine on the chromosomes of mouse bone marrow cells. |
| PubMed:Honeydew analysis for detecting phloem transport of plant natural products : Implications for host-plant resistance to sap-sucking insects. |
| PubMed:[Studies on the alkaloids of Gynura segetum (Lour.) Merr]. |
| PubMed:Pyrrolizidine alkaloids in Senecio vulgaris L. growing in Iceland. |
| PubMed:Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver. |
| PubMed:The role of flavin-containing monooxygenase in the N-oxidation of the pyrrolizidine alkaloid senecionine. |
| PubMed:Human embryotoxicity of pyrrolizidine-containing drugs. |
| PubMed:Effects of the pyrrolizidine alkaloid senecionine and the alkenals trans-4-OH-hexenal and trans-2-hexenal on intracellular calcium compartmentation in isolated hepatocytes. |
| PubMed:Sites of synthesis, translocation and accumulation of pyrrolizidine alkaloid N-oxides in Senecio vulgaris L. |
| PubMed:Alkaloid N-oxides as transport and vacuolar storage compounds of pyrrolizidine alkaloids in Senecio vulgaris L. |
| PubMed:Metabolic links between the biosynthesis of pyrrolizidine alkaloids and polyamines in root cultures of Senecio vulgaris. |
| PubMed:Macrocyclic pyrrolizidine alkaloids from Senecio anonymus. Separation of a complex alkaloid extract using droplet counter-current chromatography. |
| PubMed:Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris. |
| PubMed:Determination of pyrrolizidine alkaloid metabolites from mouse liver microsomes using tandem mass spectrometry and gas chromatography/mass spectrometry. |
| PubMed:Hepatic veno-occlusive disease in newborn infant of a woman drinking herbal tea. |
| PubMed:Livestock poisoning in South America by species of the Senecio plant. |
| PubMed:Species differences in the hepatic microsomal metabolism of the pyrrolizidine alkaloid senecionine. |
| PubMed:Alkaloid patterns and biosynthetic capacity of root cultures from some pyrrolizidine alkaloid producing Senecio species. |
| PubMed:Lipid peroxidation and cellular damage caused by the pyrrolizidine alkaloid senecionine, the alkenal trans-4-hydroxy-2-hexenal, and related alkenals. |
| PubMed:Toxic actions of senaetnine, a new pyrrolizidine-type alkaloid, in rats. |
| PubMed:Microsomal metabolism of pyrrolizidine alkaloids: N-oxidation of seneciphylline and senecionine. |
| PubMed:[Solvent extraction and isolation of alkaloids A and B from Senecio fuberi]. |
| PubMed:Metabolism and toxicity of anacrotine, a pyrrolizidine alkaloid, in rats. |
| PubMed:Role of cellular calcium homeostasis in toxic liver injury induced by the pyrrolizidine alkaloid senecionine and the alkenal trans-4-OH-2-hexenal. |
| PubMed:Microsomal metabolism of pyrrolizidine alkaloids from Senecio jacobaea. Isolation and quantification of 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine and N-oxides by high performance liquid chromatography. |
| PubMed:Genotoxicity and cytotoxicity of selected pyrrolizidine alkaloids, a possible alkenal metabolite of the alkaloids, and related alkenals. |
| PubMed:Formation of cyclic adducts of deoxyguanosine with the aldehydes trans-4-hydroxy-2-hexenal and trans-4-hydroxy-2-nonenal in vitro. |
| PubMed:Selective uptake of pyrrolizidine N-oxides by cell suspension cultures from pyrrolizidine alkaloid producing plants. |
| PubMed:The formation of 6,7-dihydro-7-hydroxy-1-hydroxy-methyl-5H-pyrrolizine, a metabolite of pyrrolizidine alkaloids. |
| PubMed:Method for determination of pyrrolizidine alkaloids and their metabolites by high-performance liquid chromatography. |
| PubMed:Determination of pyrrolizidine alkaloids in Senecio inaequidens D.C. by capillary gas chromatography. |
| PubMed:In vivo covalent binding of trans-4-hydroxy-2-hexenal to rat liver macromolecules. |
| PubMed:Comparative cytopathology of primary rat hepatocyte cultures exposed to aflatoxin B1, acetaminophen, and other hepatotoxins. |
| PubMed:trans-4-Hydroxy-2-hexenal: a reactive metabolite from the macrocyclic pyrrolizidine alkaloid senecionine. |
| PubMed:Initiation and selection of resistant hepatocyte nodules in rats given the pyrrolizidine alkaloids lasiocarpine and senecionine. |
| PubMed:Genotoxicity of a variety of pyrrolizidine alkaloids in the hepatocyte primary culture-DNA repair test using rat, mouse, and hamster hepatocytes. |
| PubMed:In vivo covalent binding of retronecine-labelled [3H]seneciphylline and [3H]senecionine to DNA of rat liver, lung and kidney. |
| PubMed:Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. |
| PubMed:Senecionine from Gynura segetum. |
| PubMed:New guaianolides from Centaurea kandavanensis. |
| PubMed:Influences of various xenobiotic inducers on cytocidal toxicity of lasiocarpine and senecionine in primary cultures of rat hepatocytes. |
| PubMed:Two dihydropyrrolizine alkaloid metabolites isolated from mouse hepatic microsomes in vitro. |
| PubMed:Transfer of [3H]pyrrolizidine alkaloids from Senecio vulgaris L. and metabolites into rat milk and tissues. |
| PubMed:Comparison of the toxicities of Senecio jacobaea, Senecio vulgaris and Senecio glabellus in rats. |
| PubMed:A new pyrrolizidine alkaloid metabolite, 19-hydroxysenecionine isolated from mouse hepatic microsomes in vitro. |
| PubMed:Covalent binding of two pyrrolizidine alkaloids, senecionine and seneciphylline, to hepatic macromolecules and their distribution, excretion, and transfer into milk of lactating mice. |
| PubMed:Carcinogenic and mutagenic activity of an alkaloidal extract of Senecio nemorensis ssp. fuchsii. |
| PubMed:Alkaloids from Senecio aegyptius and S. desfontainei. |
| PubMed:Metabolism, cytotoxicity, and genotoxicity of the pyrrolizidine alkaloid senecionine in primary cultures of rat hepatocytes. |
| PubMed:Effects of the pyrrolizidine alkaloids senecionine, retrorsine and seneciphylline on aminopyrine N-demethylase activity on the rat liver S-10 fraction. |
| PubMed:[On the gas-chromatographical determination of the pyrrolizidine alkaloids of some Senecio-species]. |
| PubMed:[Spasmolytic properties of pyrrolizidine alkaloids]. |
| PubMed:Pyrrolizidine alkaloids: their occurrence in honey from tansy ragwort (Senecio jacobaea L.) |
| PubMed:Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure. |
| PubMed:Senecionine, Seneciphylline, Jacobine and Otosenine from Senecio cineraria. |
| PubMed:Pyrrolizidine alkaloid biosynthesis. Relative rates of incorporation of the isomers of isoleucine into the necic acid component of senecionine. |
| PubMed:[Various biochemical changes in the rat liver following acute senecionine poisoning. I. Changes in content of reduced glutathione, plasma proteins and bilirubin]. |
| PubMed:Pyrrolizidine alkaloids: actions on muscarinic receptors in the guinea-pig ileum. |
| PubMed:Pharmacological properties of integerrimine, an alkaloid isolated from Crotalaria brevifolia. |
| PubMed:Tumor inhibitors. XXII. Senecionine and senecionine N-oxide, the active principles of Senecio triangularis. |
| PubMed:The action of alloxan, senecionine, sulfadiazine, and thiouracil in the hamster. |
| PubMed:The effects of senecionine on the monkey. |
| PubMed:Effects of senecionine on the hamster and monkey. |
3D/inchi