EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

nicotine

Supplier Sponsors

Name:2-(1-methylpyrrolidin-2-yl)pyridine
CAS Number: 23950-04-1Picture of molecule3D/inchi
FDA UNII: Search
Nikkaji Web:J38.662F
XlogP3:1.20 (est)
Molecular Weight:162.23558000
Formula:C10 H14 N2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
o-Nicotine 96%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
unreported-frog LDLo 600 mg/kg
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 584, 1948.

Dermal Toxicity:
subcutaneous-rat LDLo 320 mg/kg
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 584, 1948.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for nicotine usage levels up to:
 not for fragrance use.
 
Recommendation for nicotine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :212128
National Institute of Allergy and Infectious Diseases:Data
2-(1-methylpyrrolidin-2-yl)pyridine
Chemidplus:0023950041
 
References:
 2-(1-methylpyrrolidin-2-yl)pyridine
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):212128
Pubchem (cas):23950-04-1
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Metabolomics Database:Search
KEGG (GenomeNet):C00745
HMDB (The Human Metabolome Database):HMDB01934
FooDB:FDB003968
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 celery plant
Search Trop Picture
 nicotiana attenuata
Search Trop Picture
 nicotiana suaveolens
Search Trop Picture
 papaya leaf
Search Trop Picture
 papaya plant
Search Trop Picture
 potato tuber
Search Trop Picture
 tobacco aztec tobacco
Search Trop Picture
 walnut english walnut leaf
Search Trop Picture
 
Synonyms:
2-(1-methyl pyrrolidin-2-yl)-pyridine
2-(1-methylpyrrolidin-2-yl)-pyridine
2-(1-methylpyrrolidin-2-yl)pyridine
alpha-nicotine
 pyridine, 2-(1-methyl-2-pyrrolidinyl)-
alpha-pyridyl-alpha-methylpyrrolidine
 

Articles:

Info:Nicotine
PubMed:Phagocytosis and Inflammation: Exploring the effects of the components of E-cigarette vapor on macrophages.
PubMed:Social learning promotes nicotine self-administration by facilitating the extinction of conditioned aversion in isogenic strains of rats.
PubMed:Use of higher-nicotine/tar-yield (regular full-flavor) cigarettes is associated with nicotine dependence and smoking during pregnancy among U.S. women.
PubMed:Impact of e-liquid flavors on nicotine intake and pharmacology of e-cigarettes.
PubMed:Mining online e-liquid reviews for opinion polarities about e-liquid features.
PubMed:Electronic Cigarettes in Germany: Patterns of Use and Perceived Health Improvement.
PubMed:Consumers' Preferences for Electronic Nicotine Delivery System Product Features: A Structured Content Analysis.
PubMed:Evidentiary Support in Public Comments to the FDA's Center for Tobacco Products.
PubMed:A comparative study of electronic cigarette vapor extracts on airway-related cell lines in vitro.
PubMed:Nicotine, aerosol particles, carbonyls and volatile organic compounds in tobacco- and menthol-flavored e-cigarettes.
PubMed:Availability, price, and packaging of electronic cigarettes and e-liquids in Guatemala City retailers.
PubMed:Sales of Nicotine-Containing Electronic Cigarette Products: United States, 2015.
PubMed:Benzene formation in electronic cigarettes.
PubMed:Electronic cigarettes and mental illness: Reviewing the evidence for help and harm among those with psychiatric and substance use disorders.
PubMed:Identifying Topics for E-Cigarette User-Generated Contents: A Case Study From Multiple Social Media Platforms.
PubMed:A Device-Independent Evaluation of Carbonyl Emissions from Heated Electronic Cigarette Solvents.
PubMed:A method for classifying user-reported electronic cigarette liquid flavors.
PubMed:Cytotoxic and Genotoxic Effects of Electronic Cigarette Liquids on Human Mucosal Tissue Cultures of the Oropharynx.
PubMed:Quit Intentions Moderate Subjective and Physiological Responses to Acute Nicotine Replacement Therapy Administration in Dependent Smokers.
PubMed:Determination of volatile organic compounds including alcohols in refill fluids and cartridges of electronic cigarettes by headspace solid-phase micro extraction and gas chromatography-mass spectrometry.
PubMed:Effects of sweet flavorings and nicotine on the appeal and sensory properties of e-cigarettes among young adult vapers: Application of a novel methodology.
PubMed:Current and Former Smokers' Use of Electronic Cigarettes for Quitting Smoking: An Exploratory Study of Adolescents and Young Adults.
PubMed:Caffeine Concentrations in Coffee, Tea, Chocolate, and Energy Drink Flavored E-liquids.
PubMed:"They're Pretty Much Made for Blunts": Product Features That Facilitate Marijuana Use Among Young Adult Cigarillo Users in the United States.
PubMed:Socioeconomic Disadvantage and Other Risk Factors for Using Higher-Nicotine/Tar-Yield (Regular Full-Flavor) Cigarettes.
PubMed:Analysis of symptoms and their potential associations with e-liquids' components: a social media study.
PubMed:[Testing of the composition of e-cigarette liquids - Manufacturer-declared vs. true contents in a selected series of products].
PubMed:Concentration of Nicotine and Glycols in 27 Electronic Cigarette Formulations.
PubMed:E-cigarettes, Hookah Pens and Vapes: Adolescent and Young Adult Perceptions of Electronic Nicotine Delivery Systems.
PubMed:Socially acquired nicotine self-administration with an aversive flavor cue in adolescent female rats.
PubMed:Inactivation of CYP2A6 by the Dietary Phenylpropanoid trans-Cinnamic Aldehyde (Cinnamaldehyde) and Estimation of Interactions with Nicotine and Letrozole.
PubMed:Toxicological assessment of a prototype e-cigaret device and three flavor formulations: a 90-day inhalation study in rats.
PubMed:Sensory Effects of Menthol and Nicotine in an E-Cigarette.
PubMed:The effects of alcohol-containing e-cigarettes on young adult smokers.
PubMed:Real-Time Chemical Analysis of E-Cigarette Aerosols By Means Of Secondary Electrospray Ionization Mass Spectrometry.
PubMed:Update on flavoring-induced lung disease.
PubMed:Electronic Cigarette and Electronic Hookah: A Pilot Study Comparing Two Vaping Products.
PubMed:The effect of potential electronic nicotine delivery system regulations on nicotine product selection.
PubMed:Use of High-Nicotine/Tar-Yield (Full-Flavor) Cigarettes and Risk for Nicotine Dependence in Nationally Representative Samples of US Smokers.
PubMed:How Menthol Alters Tobacco-Smoking Behavior: A Biological Perspective.
PubMed:Flavored Tobacco Products in the United States: A Systematic Review Assessing Use and Attitudes.
PubMed:Effect of full flavor and denicotinized cigarettes exposure on the brain microvascular endothelium: a microarray-based gene expression study using a human immortalized BBB endothelial cell line.
PubMed:Comprehensive chemical characterization of Rapé tobacco products: Nicotine, un-ionized nicotine, tobacco-specific N'-nitrosamines, polycyclic aromatic hydrocarbons, and flavor constituents.
PubMed:Corrective Taxes and Cigarette Characteristics.
PubMed:Flavour chemicals in electronic cigarette fluids.
PubMed:Nicotine concentrations with electronic cigarette use: effects of sex and flavor.
PubMed:Factors Associated With Electronic Cigarette Users' Device Preferences and Transition From First Generation to Advanced Generation Devices.
PubMed:Multicomponent analysis of replacement liquids of electronic cigarettes using chromatographic techniques.
PubMed:Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung.
PubMed:Chemical Composition and Evaluation of Nicotine, Tobacco Alkaloids, pH, and Selected Flavors in E-Cigarette Cartridges and Refill Solutions.
PubMed:Custom Mentholation of Commercial Cigarettes for Research Purposes.
PubMed:The Impact of Flavor Descriptors on Nonsmoking Teens' and Adult Smokers' Interest in Electronic Cigarettes.
PubMed:E-Cigarette Market Trends in Traditional U.S. Retail Channels, 2012-2013.
PubMed:Patterns of Longitudinal Transitions in Menthol Use Among US Young Adult Smokers.
PubMed:Aerosol deposition doses in the human respiratory tree of electronic cigarette smokers.
PubMed:Toxicological assessment of kretek cigarettes. Part 7: the impact of ingredients added to kretek cigarettes on inhalation toxicity.
PubMed:Comparison of select analytes in aerosol from e-cigarettes with smoke from conventional cigarettes and with ambient air.
PubMed:Identification and Quantification of Several Contaminated Compounds in Replacement Liquids of Electronic Cigarettes by Gas Chromatography-Mass Spectrometry.
PubMed:Comparative in vitro toxicity profile of electronic and tobacco cigarettes, smokeless tobacco and nicotine replacement therapy products: e-liquids, extracts and collected aerosols.
PubMed:Comparison of puff topography, toxicant exposure, and subjective effects in low- and high-frequency waterpipe users: a double-blind, placebo-control study.
PubMed:The association between smokers' perceived importance of the appearance of cigarettes/cigarette packs and smoking sensory experience: a structural equation model.
PubMed:Evaluation of electronic cigarette liquids and aerosol for the presence of selected inhalation toxins.
PubMed:Prenatal alcohol exposure increases postnatal acceptability of nicotine odor and taste in adolescent rats.
PubMed:Investigation of the chemical compositions in tobacco of different origins and maturities at harvest by GC-MS and HPLC-PDA-QTOF-MS.
PubMed:Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells.
PubMed:Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?
PubMed:The role of cocoa as a cigarette additive: opportunities for product regulation.
PubMed:Direct action and modulating effect of (+)- and (-)-nicotine on ion channels expressed in trigeminal sensory neurons.
PubMed:Comparison of tobacco-containing and tobacco-free waterpipe products: effects on human alveolar cells.
PubMed:Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models.
PubMed:Flavored and nonflavored smokeless tobacco products: rate, pattern of use, and effects.
PubMed:Youth access, creation, and content of smokeless tobacco ("dip") videos in social media.
PubMed:Does switching to a tobacco-free waterpipe product reduce toxicant intake? A crossover study comparing CO, NO, PAH, volatile aldehydes, "tar" and nicotine yields.
PubMed:Electronic cigarettes: effective nicotine delivery after acute administration.
PubMed:Scientific assessment of the use of sugars as cigarette tobacco ingredients: a review of published and other publicly available studies.
PubMed:Use of the target group index survey to evaluate the cigarette smoking profile in Saudi Arabia.
PubMed:Effect of ammonia in cigarette tobacco on nicotine absorption in human smokers.
PubMed:The health effects of menthol cigarettes as compared to non-menthol cigarettes.
PubMed:Acute effects of waterpipe tobacco smoking: a double-blind, placebo-control study.
PubMed:Determination of hazardous VOCs and nicotine released from mainstream smoke by the combination of the SPME and GC-MS methods.
PubMed:The effect of chewing gum flavor on the negative affect associated with tobacco abstinence among dependent cigarette smokers.
PubMed:Cellular basis for the olfactory response to nicotine.
PubMed:The effect of chewing gum on self-reported nicotine withdrawal: is it the flavor, the act of chewing, or both?
PubMed:Comparison of methods for measurement of smoking behavior: mouthpiece-based computerized devices versus direct observation.
PubMed:Surveillance of moist snuff: total nicotine, moisture, pH, un-ionized nicotine, and tobacco-specific nitrosamines.
PubMed:A randomized, controlled exposure study in adult smokers of full flavor Marlboro cigarettes switching to Marlboro Lights or Marlboro Ultra Lights cigarettes.
PubMed:The menthol smoker: tobacco industry research on consumer sensory perception of menthol cigarettes and its role in smoking behavior.
PubMed:Genotoxicity of 10 cigarette smoke condensates in four test systems: comparisons between assays and condensates.
PubMed:Internal tobacco industry research on olfactory and trigeminal nerve response to nicotine and other smoke components.
PubMed:Toxicological evaluation of potassium sorbate added to cigarette tobacco.
PubMed:Do increases in cigarette prices lead to increases in sales of cigarettes with high tar and nicotine yields?
PubMed:Determination of 10 carcinogenic polycyclic aromatic hydrocarbons in mainstream cigarette smoke.
PubMed:Cytotoxicity and gene expression profiles in cell cultures exposed to whole smoke from three types of cigarettes.
PubMed:Cadmium, lead, and thallium in mainstream tobacco smoke particulate.
PubMed:Characterization of measured menthol in 48 U.S. cigarette sub-brands.
PubMed:Toxicological evaluation of glycerin as a cigarette ingredient.
PubMed:Scope for regulation of cigarette smoke toxicity according to brand differences in published toxicant emissions.
PubMed:Smoking topography predicts abstinence following treatment with nicotine replacement therapy.
PubMed:Adolescent and adult rats' aversion to flavors previously paired with nicotine.
PubMed:Extinguishing the rewarding value of smoke cues: pharmacological and behavioral treatments.
PubMed:Application, function, and effects of menthol in cigarettes: a survey of tobacco industry documents.
PubMed:Efficacy of oral transmucosal nicotine lozenge for suppression of withdrawal symptoms in smoking abstinence.
PubMed:Relationship between FTC 'tar' and urine mutagenicity in smokers of tobacco-burning or Eclipse cigarettes.
PubMed:Flavor improvement does not increase abuse liability of nicotine chewing gum.
PubMed:Subjective and discriminative stimulus effects of two de-nicotinized cigarettes with different tar yields.
PubMed:Acute effects of smoking of cigarettes with different tar content on plasma oxidant/antioxidant status.
PubMed:Toxicologic evaluation of flavor ingredients added to cigarette tobacco: skin painting bioassay of cigarette smoke condensate in SENCAR mice.
PubMed:Indian cigarettes gain popularity, but don't let the flavor fool you.
PubMed:Glass fiber contamination of cigarette filters: an additional health risk to the smoker?
PubMed:Preferences for tastes paired with a nicotine antagonist in rats chronically treated with nicotine.
PubMed:Genetic differences in nicotine-induced conditioned taste aversion.
PubMed:Comparison of measured and FTC-predicted nicotine uptake in smokers.
PubMed:Nicotine and addiction. The Brown and Williamson documents.
PubMed:Rewarding drugs produce taste avoidance, but not taste aversion.
PubMed:Nicotine polacrilex dose effects: serum nicotine levels and sensory characteristics.
PubMed:Clinical evaluation of a citric acid inhaler for smoking cessation.
PubMed:The use of flavor in cigarette substitutes.
PubMed:Withdrawal from chronic nicotine fails to produce a conditioned taste aversion to saccharin in rats.
PubMed:Development of a citric acid aerosol as a smoking cessation aid.
PubMed:Neuromuscular disorder associated with a defect in mitochondrial energy supply.
 
Notes:
Alkaloid from Nicotiana tabacum and other Nicotiana spp., Asclepias syriaca, Lycopodium spp., and other spp. (Solanaceae, Asclepiadaceae, Crassulaceae). Rare spread of occurrence between angiosperms and cryptogametes (CCD) Nicotine is an alkaloid found in the nightshade family of plants (Solanaceae). (Wikipedia)
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