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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 305.00 to 307.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.001000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 279.00 °F. TCC ( 137.22 °C. )
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| logP (o/w): | 5.369 (est) |
| Soluble in: |
| | water, 0.1005 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for furanodiene usage levels up to: | | | not for fragrance use.
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| Recommendation for furanodiene flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (5Z,9Z)-3,6,10-trimethyl-4,7,8,11-tetrahydrocyclodeca[b]furan |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5317424 |
| Pubchem (sid): | 135154531 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (Z,E)-8,12- | epoxygermacra-1(10),4,7,11-tetraene | | (5E,9Z)-4,7,8,11- | tetrahydro-3,6,10-trimethyl cyclodeca(b)furan | | (5Z,9Z)-3,6,10- | trimethyl-4,7,8,11-tetrahydrocyclodeca[b]furan |
Articles:
| PubMed:Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria. |
| PubMed:Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro. |
| PubMed:[Transport of PLGA nanoparticles across caco-2/HT29-MTX co-cultured cells]. |
| PubMed:Effects of furanodiene on 95-D lung cancer cells: apoptosis, autophagy and G1 phase cell cycle arrest. |
| PubMed:Characterization of in vivo and in vitro metabolites of furanodiene in rats by high performance liquid chromatography-electrospray ionization mass spectrometry and nuclear magnetic resonance spectra. |
| PubMed:Impact of fixed-dose combination of germacrone, curdione, and furanodiene on breast cancer cell proliferation. |
| PubMed:Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. |
| PubMed:GC/MS analysis of high-performance liquid chromatography fractions from Sophora flavescens and Torilis japonica extracts and their in vitro anti-neosporal effects on Neospora caninum. |
| PubMed:2-Bromo-1,6,6-trimethyl-6,7,8,9-tetra-hydro-phenanthro[1,2-b]furan-10,11-dione. |
| PubMed:Pharmacokinetics and tissue distribution of furanodiene W/O/W multiple emulsions in rats by a fast and sensitive HPLC-APCI-MS/MS method. |
| PubMed:Furanodiene presents synergistic anti-proliferative activity with paclitaxel via altering cell cycle and integrin signaling in 95-D lung cancer cells. |
| PubMed:In vitro biological activity of essential oils and isolated furanosesquiterpenes from the neglected vegetable Smyrnium olusatrum L. (Apiaceae). |
| PubMed:Simultaneous determination of multiple sesquiterpenes in Curcuma wenyujin herbal medicines and related products with one single reference standard. |
| PubMed:Furanodien-6-one from Commiphora erythraea inhibits the NF-κB signalling and attenuates LPS-induced neuroinflammation. |
| PubMed:Furanodiene induces endoplasmic reticulum stress and presents antiproliferative activities in lung cancer cells. |
| PubMed:Furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo. |
| PubMed:Analysis of volatile components in Curcuma rhizome by microemulsion electrokinetic chromatography. |
| PubMed:Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae--a review. |
| PubMed:Furanodiene enhances tamoxifen-induced growth inhibitory activity of ERa-positive breast cancer cells in a PPARγ independent manner. |
| PubMed:A sensitive method for determination of furanodiene in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. |
| PubMed:Anti-angiogenic effect of furanodiene on HUVECs in vitro and on zebrafish in vivo. |
| PubMed:Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells. |
| PubMed:Free radical scavenging activity and characterization of sesquiterpenoids in four species of Curcuma using a TLC bioautography assay and GC-MS analysis. |
| PubMed:[HPLC determination of six components in zedoary turmeric oil and its related injections]. |
| PubMed:Potential anti-cancer activities of Furanodiene, a Sesquiterpene from Curcuma wenyujin. |
| PubMed:Induction of apoptosis by furanodiene in HL60 leukemia cells through activation of TNFR1 signaling pathway. |
| PubMed:Sesquiterpenes from Curcuma comosa. |
| PubMed:Furanodiene induces G2/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells. |
| PubMed:Simultaneous determination of 11 characteristic components in three species of Curcuma rhizomes using pressurized liquid extraction and high-performance liquid chromatography. |
| PubMed:Anti-inflammatory sesquiterpenes from Curcuma zedoaria. |
| PubMed:Optimization of GC-MS conditions based on resolution and stability of analytes for simultaneous determination of nine sesquiterpenoids in three species of Curcuma rhizomes. |
| PubMed:Identification and quantitation of eleven sesquiterpenes in three species of Curcuma rhizomes by pressurized liquid extraction and gas chromatography-mass spectrometry. |
| PubMed:Irritant potential of some constituents from oleo-gum-resin of Commiphora myrrha. |
| PubMed:Medicinal foodstuffs. XXIX. Potent protective effects of sesquiterpenes and curcumin from Zedoariae Rhizoma on liver injury induced by D-galactosamine/lipopolysaccharide or tumor necrosis factor-alpha. |
| PubMed:Essential oil composition of smyrnium olusatrum. |
| PubMed:Identification and quantitative determination of furanodiene, a heat-sensitive compound, in essential oil by 13C-NMR. |
| PubMed:Chemical variability of the volatile metabolites from the Caribbean corals of the genus Gorgonia. |
| PubMed:Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh. |
| PubMed:Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae Rhizoma on D-galactosamine/lipopolysaccharide-induced liver injury. |
| PubMed:A pyrazoline derivative of eunicin acetate. |
| PubMed:Constituents of essential oil of Commiphora guidotti. |
| PubMed:[Constituents of the essential oil of myrrh]. |
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3D/inchi