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alpha-acetolactate decarboxylase

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FDA internal no.: 977164-02-5
FDA UNII: Search
MDL:MFCD00211578
Category:brewing of beer and fermentation step of alcohol production
 
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JECFA Food Additive: alpha-Acetolactate Decarboxylase from Bacillus brevis expressed in Bacillus subtilis
FDA Mainterm (SATF):977164-02-5 ; ALPHA-ACETOLACTATE DECARBOXYLASE ENZYME PREPARATION FROM BACILLUS SUBTILIS RECOMBINANT
FDA Regulation:
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart B--Enzyme Preparations and Microorganisms
Sec. 173.115 Alpha-acetolactate decarboxylase ([alpha]-ALDC) enzyme preparation derived from a recombinant Bacillus subtilis.
 
Physical Properties:
Appearance:brown liquid (est)
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Sigma-Aldrich: Sigma
For experimental / research use only.
a-Acetolactate Decarboxylase from Bacillus subtilis lyophilized powder, ∼60 units/mg solid
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
brewing of beer and fermentation step of alcohol production
Recommendation for alpha-acetolactate decarboxylase usage levels up to:
 not for fragrance use.
 
Recommendation for alpha-acetolactate decarboxylase flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
Chemidplus:0977164025
 
References:
Pubchem (cas):977164-02-5
 
Other Information:
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):HMDB32156
FooDB:FDB008885
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
FAO:ACETOLACTATE DECARBOXYLASE FROM BACILLUS BREVIS EXPRESSED IN BACILLUS SUBTILIS
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 bacillus brevis
Search PMC Picture
 bacillus subtilis
Search PMC Picture
 
Synonyms:
alpha-acetolactate decarboxylase (a-ALDC) enzyme preparation derived from a recombinant Bacillus subtilis
alpha-acetolactate decarboxylase enzyme preparation from bacillus subtilis recombinant
alpha-acetolactate decarboxylase from bacillus brevis expressed in bacillus subtilis
(S)-2-hydroxy-2-methyl-oxobutanoate carboxylase
 

Articles:

PubMed:Structural and enzymatic characterization of acetolactate decarboxylase from Bacillus subtilis
PubMed:Improving the acidic stability of Staphylococcus aureus ą-acetolactate decarboxylase in Bacillus subtilis by changing basic residues to acidic residues
PubMed:Safety evaluation of the food enzyme acetolactate decarboxylase from a genetically modified Bacillus’licheniformis (strain NZYM-JB)
PubMed:Structural characterization of an acetolactate decarboxylase from Klebsiella pneumoniae
PubMed:Cloning of aldB, which encodes alpha-acetolactate decarboxylase, an exoenzyme from Bacillus brevis
PubMed:Structure and catalytic mechanistic insight into Enterobacter aerogenes acetolactate decarboxylase
PubMed:Synthetic operon for (R,R)-2,3-butanediol production in Bacillus subtilis and Escherichia coli
PubMed:Production of 2,3-dihydroxyisovalerate by Enterobacter cloacae
PubMed:Effect of alpha-acetolactate decarboxylase inactivation on alpha-acetolactate and diacetyl production by Lactococcus lactis subsp. lactis biovar diacetylactis
PubMed:Acetoin production via unbalanced fermentation in Shewanella oneidensis
PubMed:Dual role of alpha-acetolactate decarboxylase in Lactococcus lactis subsp. lactis
PubMed:Efficient biochemical production of acetoin from carbon dioxide using Cupriavidus necator H16
PubMed:Establishment and application of multiplexed CRISPR interference system in Bacillus licheniformis
PubMed:A simple biosynthetic pathway for 2,3-butanediol production in Thermococcus onnurineus NA1
PubMed:Surface-engineered Saccharomyces cerevisiae displaying ą-acetolactate decarboxylase from Acetobacter aceti ssp xylinum
PubMed:Enhanced Production of Tetramethylpyrazine in Bacillus licheniformis BL1 through aldC Over-expression and acetaldehyde Supplementation
PubMed:Metabolic engineering of Saccharomyces cerevisiae for 2,3-butanediol production
PubMed:Acetoin metabolism in bacteria
PubMed:Comparative Assessment of Factors Involved in Acetoin Synthesis by Bacillus subtilis 168
PubMed:Regulation of branched-chain amino acid biosynthesis by alpha-acetolactate decarboxylase in Streptococcus thermophilus
PubMed:[Alpha-acetolactate decarboxylase from B. licheniformis AS10106: cloning and expression gene in E. coli and S. cerevisiae]
PubMed:Metabolic engineering of Parageobacillus thermoglucosidasius for the efficient production of (2R, 3R)-butanediol
PubMed:Isobutanol and 2-ketoisovalerate production by Klebsiella pneumoniae via a native pathway
PubMed:Structure and mechanism of acetolactate decarboxylase
PubMed:N-Acyl-Homoserine Lactone Quorum Sensing Switch from Acidogenesis to Solventogenesis during the Fermentation Process in Serratia marcescens MG1
PubMed:Production of diacetyl by metabolically engineered Enterobacter cloacae
PubMed:The transcription factor AlsR binds and regulates the promoter of the alsSD operon responsible for acetoin formation in Bacillus subtilis
PubMed:Nucleotide sequence and expression of the Enterobacter aerogenes alpha-acetolactate decarboxylase gene in brewer's yeast
PubMed:Engineering Corynebacterium glutamicum for the production of 2,3-butanediol
PubMed:Purification and properties of the alpha-acetolactate decarboxylase from Lactococcus lactis subsp. lactis NCDO 2118
PubMed:Selection and properties of alpha-acetolactate decarboxylase-deficient spontaneous mutants of Streptococcus thermophilus
PubMed:Toxicological Evaluation of Acetolactate Decarboxylase
PubMed:Enhanced production of butanol and acetoin by heterologous expression of an acetolactate decarboxylase in Clostridium acetobutylicum
PubMed:[Expression of alpha-acetolactate decarboxylase gene from Bacillus subtilis in Brewer's yeast]
PubMed:Electrode-assisted acetoin production in a metabolically engineered Escherichia coli strain
PubMed:Purification and characterization of ą-acetolactate decarboxylase (ALDC) from newly isolated Lactococcus lactis DX
PubMed:Chromosomal Integration and Expression of Two Bacterial alpha-Acetolactate Decarboxylase Genes in Brewer's Yeast
PubMed:Bacillus subtilis ccpA gene mutants specifically defective in activation of acetoin biosynthesis
PubMed:Construction of a brewer's yeast having alpha-acetolactate decarboxylase gene from Acetobacter aceti ssp. xylinum integrated in the genome
PubMed:Cloning and expression of an alpha-acetolactate decarboxylase gene from Streptococcus lactis subsp. diacetylactis in Escherichia coli
PubMed:Glucose/citrate cometabolism in Lactococcus lactis subsp. lactis biovar diacetylactis with impaired alpha-acetolactate decarboxylase
PubMed:Application of a ribosomal DNA integration vector in the construction of a brewer's yeast having alpha-acetolactate decarboxylase activity
PubMed:A thermophilic cell-free cascade enzymatic reaction for acetoin synthesis from pyruvate
PubMed:Effect of Respiratory Growth on the Metabolite Production and Stress Robustness of Lactobacillus casei N87 Cultivated in Cheese Whey Permeate Medium
PubMed:Industrial Production of 2,3-Butanediol from the Engineered Corynebacterium glutamicum
PubMed:Moderate expression of the transcriptional regulator ALsR enhances acetoin production by Bacillus subtilis
PubMed:Regulation of the Bacillus subtilis alsS, alsD, and alsR genes involved in post-exponential-phase production of acetoin
PubMed:2-Ketogluconic acid production by Klebsiella pneumoniae CGMCC 1.6366
PubMed:Acetolactate decarboxylase from Aerobacter aerogenes. Purification and properties
PubMed:Complete amino acid sequence of alpha-acetolactate decarboxylase from Bacillus brevis
PubMed:Anaerobic gene expression in Staphylococcus aureus
PubMed:Production of 2,3-butanediol by engineered Saccharomyces cerevisiae
PubMed:Effect of ILV6 Deletion and Expression of aldB from Lactobacillus plantarum in Saccharomyces uvarum on Diacetyl Production and Wine Flavor
PubMed:Cyanobacterial conversion of carbon dioxide to 2,3-butanediol
PubMed:Purification, crystallization and preliminary X-ray crystallographic studies on acetolactate decarboxylase
PubMed:Fermentative metabolism of Bacillus subtilis: physiology and regulation of gene expression
PubMed:Efficient production of acetoin in Saccharomyces cerevisiae by disruption of 2,3-butanediol dehydrogenase and expression of NADH oxidase
PubMed:Purification and characterisation of acetolactate decarboxylase from Leuconostoc lactis NCW1
PubMed:Production of 2-butanol from crude glycerol by a genetically-engineered Klebsiella pneumoniae strain
PubMed:The current strategies and parameters for the enhanced microbial production of 2,3-butanediol
PubMed:[Isolation and purification of acetolactate synthase and acetolactate decarboxylase from a Lactococcus lactis culture]
PubMed:Efficient production of 2,3-butanediol in Saccharomyces cerevisiae by eliminating ethanol and glycerol production and redox rebalancing
PubMed:[Gene regulation to lactic acid bacteria for increasing production of flavor metabolite]
PubMed:Characterization and regulation of the 2,3-butanediol pathway in Serratia marcescens
PubMed:Ca2+-citrate uptake and metabolism in Lactobacillus casei ATCC 334
PubMed:Cloning and expression of the gene encoding alpha-acetolactate decarboxylase from Acetobacter aceti ssp. xylinum in brewer's yeast
PubMed:Mechanism of 2,3-butanediol stereoisomer formation in Klebsiella pneumoniae
PubMed:Reconstruction of an acetogenic 2,3-butanediol pathway involving a novel NADPH-dependent primary-secondary alcohol dehydrogenase
PubMed:Characterization of acetoin production in a budC gene disrupted mutant of Serratia marcescens G12
PubMed:Identification of acetoin reductases involved in 2,3-butanediol pathway in Klebsiella oxytoca
PubMed:Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp. T241
PubMed:Transcriptional and translational regulation of alpha-acetolactate decarboxylase of Lactococcus lactis subsp. lactis
PubMed:Selection of an endogenous 2,3-butanediol pathway in Escherichia coli by fermentative redox balance
PubMed:Metabolic engineering of Zymomonas mobilis for 2,3-butanediol production from lignocellulosic biomass sugars
PubMed:Hydroxy-pentanones production by Bacillus sp. H15-1 and its complete genome sequence
PubMed:Enhanced production of 2,3-butanediol by overexpressing acetolactate synthase and acetoin reductase in Klebsiella pneumoniae
PubMed:Diacetyl and alpha-acetolactate overproduction by Lactococcus lactis subsp. lactis biovar diacetylactis mutants that are deficient in alpha-acetolactate decarboxylase and have a low lactate dehydro
PubMed:Efficient production of 2,3-butanediol by recombinant Saccharomyces cerevisiae through modulation of gene expression by cocktail ė-integration
PubMed:Enhanced 2,3-butanediol production in recombinant Klebsiella pneumoniae via overexpression of synthesis-related genes
PubMed:Metabolic engineering of acetoin and meso-2, 3-butanediol biosynthesis in E. coli
PubMed:Enhancement of acetoin production in Candida glabrata by in silico-aided metabolic engineering
PubMed:The LysR-type transcriptional regulator (LTTR) AlsR indirectly regulates expression of the Bacillus subtilis bdhA gene encoding 2,3-butanediol dehydrogenase
PubMed:A central role for carbon-overflow pathways in the modulation of bacterial cell death
PubMed:Disruption of the alsSD operon of Enterococcus faecalis impairs growth on pyruvate at low pH
PubMed:Genetic manipulation of the pathway for diacetyl metabolism in Lactococcus lactis
PubMed:Metabolic engineering of a Saccharomyces cerevisiae strain capable of simultaneously utilizing glucose and galactose to produce enantiopure (2R,3R)-butanediol
PubMed:Improved performances and control of beer fermentation using encapsulated alpha-acetolactate decarboxylase and modeling
PubMed:Thermophilic fermentation of acetoin and 2,3-butanediol by a novel Geobacillus strain
PubMed:The influence of budA deletion on glucose metabolism related in 2,3-butanediol production by Klebsiella pneumoniae
PubMed:Characterization of CidR-mediated regulation in Bacillus anthracis reveals a previously undetected role of S-layer proteins as murein hydrolases
PubMed:Volatile organic compounds profile during milk fermentation by Lactobacillus pentosus and correlations between volatiles flavor and carbohydrate metabolism
PubMed:Simultaneous production of butanol and acetoin by metabolically engineered Clostridium acetobutylicum
PubMed:Promoters inducible by aromatic amino acids and ?-aminobutyrate (GABA) for metabolic engineering applications in Saccharomyces cerevisiae
PubMed:The regulation of 2,3-butanediol synthesis in Klebsiella pneumoniae as revealed by gene over-expressions and metabolic flux analysis
PubMed:Cloning and sequencing of the gene encoding alpha-acetolactate decarboxylase from Leuconostoc oenos
PubMed:Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: transcription regulation is important but not sufficient to account for metabolic adaptation
PubMed:Stereospecificity of Corynebacterium glutamicum 2,3-butanediol dehydrogenase and implications for the stereochemical purity of bioproduced 2,3-butanediol
PubMed:Bio-molecular characterisation of indigenous Oenococcus oeni strains from Negroamaro wine
PubMed:Synthesis of 2,3-butanediol by Synechocystis sp. PCC6803 via heterologous expression of a catabolic pathway from lactic acid- and enterobacteria
PubMed:Synthetic 2,3-butanediol pathway integrated using Tn7-tool and powered via elimination of sporulation and acetate production in acetogen biocatalyst
PubMed:Influence of blocking of 2,3-butanediol pathway on glycerol metabolism for 1,3-propanediol production by Klebsiella oxytoca
PubMed:An efficient method using Gluconacetobacter europaeus to reduce an unfavorable flavor compound, acetoin, in rice vinegar production
PubMed:The production of D-acetoin by a transgenic Escherichia coli
PubMed:Synthesis of pure meso-2,3-butanediol from crude glycerol using an engineered metabolic pathway in Escherichia coli
PubMed:Expression of Recombinant alpha-Acetolactate Decarboxylase and Its Characterization
PubMed:A general method for selection of alpha-acetolactate decarboxylase-deficient Lactococcus lactis mutants to improve diacetyl formation
PubMed:Identification of up-regulated genes of Bacillus amyloliquefaciens B55 during the early stage of direct surface contact with rice R109 root
PubMed:Increased 2,3-butanediol production by changing codon usages in Escherichia coli
PubMed:High-yield production of (R)-acetoin in Saccharomyces cerevisiae by deleting genes for NAD(P)H-dependent ketone reductases producing meso-2,3-butanediol and 2,3-dimethylglycerate
PubMed:Use of a modified alcohol dehydrogenase, ADH1, promoter in construction of diacetyl non-producing brewer's yeast
PubMed:Lactococcus lactis as a cell factory for high-level diacetyl production
PubMed:Recombinant brewer's yeast strains suitable for accelerated brewing
PubMed:A simple method to generate chromosomal mutations in Lactobacillus plantarum strain TF103 to eliminate undesired fermentation products
PubMed:Complete sequences of four plasmids of Lactococcus lactis subsp. cremoris SK11 reveal extensive adaptation to the dairy environment
PubMed:Monitoring the acetohydroxy acid synthase reaction and related carboligations by circular dichroism spectroscopy
PubMed:Metabolic operons in Lactococci
PubMed:Evaluation of certain food additives. Fifty-first report of the Joint FAO/WHO Expert Committee on Food Additives
PubMed:Identification of the transcriptional activator controlling the butanediol fermentation pathway in Klebsiella terrigena
PubMed:Cloning, sequence and expression of a linear plasmid-based and a chromosomal homolog of chloroacetaldehyde dehydrogenase-encoding genes in Xanthobacter autotrophicus GJ10
PubMed:Identification of genes negatively regulated by Fis: Fis and RpoS comodulate growth-phase-dependent gene expression in Escherichia coli
PubMed:Development of industrial-medium-required elimination of the 2,3-butanediol fermentation pathway to maintain ethanol yield in an ethanologenic strain of Klebsiella oxytoca
PubMed:Imbalance of leucine flux in Lactococcus lactis and its use for the isolation of diacetyl-overproducing strains
PubMed:Characterization of the genes of the 2,3-butanediol operons from Klebsiella terrigena and Enterobacter aerogenes
PubMed:[Construction of a set of secreting expression vectors for Saccharomyces cerevisiea]
PubMed:Identification of conserved promoter elements for aldB and isozyme specific residues in aldolase B
PubMed:[Effects of knockout of 2,3-butanediol synthesis key enzyme genes on 1,3-propandediol production in Klebsiella pneumoniae]
PubMed:Evaluation of certain food additives and contaminants. Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives
PubMed:A simple method to generate chromosomal mutations in Lactobacillus plantarum strain TF103 to eliminate undesired fermentation products
PubMed:Diacetyl production mechanism by a strain of Lactococcus lactis spp. lactis bv. diacetylactis. Study of alpha-acetolactic acid extracellular accumulation under anaerobiosis
PubMed:Development and Use of a Screening Procedure for Production of (alpha)-Acetolactate by Lactococcus lactis subsp. lactis biovar diacetylactis Strains
PubMed:[Integration and expression of beta-endoglucanase I from Trichoderma reesei in brewing yeast]
 
Notes:
Used as a food additive [EAFUS]
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