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calcium cyclamate dihydrate
cyclohexyl sulfamic acid calcium salt (2:1) dihydrate

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Name:	calcium N-cyclohexylsulfamate dihydrate
CAS Number:	5897-16-5	3D/inchi
FDA UNII:	OK71859Z12
Molecular Weight:	432.57076000
Formula:	C12 H28 Ca N2 O8 S2
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:information only not used for fragrances or flavors

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search
JECFA Food Additive:	Calcium Cyclamate
GSFA Codex:	Calcium cyclamate (952(ii))
FDA Mainterm (SATF):	5897-16-5 ; CALCIUM CYCLAMATE--PROHIBITED
FDA Regulation:
FDA PART 189 -- SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD Subpart C--Substances Generally Prohibited From Direct Addition or Use as Human Food Sec. 189.135 Cyclamate and its derivatives.

Physical Properties:

Appearance:	white crystals (est)
Assay:	98.00 to 100.00
Food Chemicals Codex Listed:	No
Flash Point:	32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w):	0.979 (est)
Soluble in:
	water, 1e+006 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

None found

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-rabbit LD50 125 mg/kg FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 82, 1967. oral-mouse LD50 7200 mg/kg FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 82, 1967. intravenous-mouse LD50 570 mg/kg FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 82, 1967.
Dermal Toxicity:
subcutaneous-rat LD50 100 mg/kg FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 82, 1967.
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
information only not used for fragrances or flavors
Recommendation for calcium cyclamate dihydrate usage levels up to:
	not for fragrance use.

Recommendation for calcium cyclamate dihydrate flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :22186

National Institute of Allergy and Infectious Diseases:Data

calcium N-cyclohexylsulfamate dihydrate

Chemidplus:0005897165

References:

	calcium N-cyclohexylsulfamate dihydrate
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	22186
Pubchem (sid):	134987157

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
HMDB (The Human Metabolome Database):	Search
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

not found in nature

Synonyms:

	calcium cyclohexane sulfamate dihydrate (1:2)
	calcium cyclohexyl sulfamate dihydrate (1:2)
	calcium N-cyclohexylsulfamate dihydrate
	cyclamate calcium dihydrate
	cyclohexane sulfamic acid calcium salt (2:1) dihydrate
	cyclohexyl sulfamic acid calcium salt (2:1) dihydrate

Articles:

PubMed:The metabolism of cyclamate to cyclohexylamine in humans during long-term administration.

PubMed:Effects of a saccharin and cyclamate mixture on rat embryos.

PubMed:Taste qualities of solutions preferred by hamsters.

PubMed:Gustatory neural coding in the monkey cortex: the quality of sweetness.

PubMed:The metabolism of cyclamate to cyclohexylamine and its cardiovascular consequences in human volunteers.

PubMed:Assessment of the genotoxicity of calcium cyclamate and cyclohexylamine.

PubMed:Myocardial effects of calcium cyclamate in the BIO F1D Alexander Syrian golden hamster.

PubMed:No evidence found for induction of dominant lethal mutations and heritable translocations in male mice by calcium cyclamate.

PubMed:Caffeine intensifies taste of certain sweeteners: role of adenosine receptor.

PubMed:Sensory evaluation of soft drinks with various sweeteners.

PubMed:Cytogenetic effects of cyclamates.

PubMed:The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays.

PubMed:Effects of cyclamate calcium on the immune response in rabbits.

PubMed:Chemical induction of sperm abnormalities in mice.

PubMed:A toxicity method with calcium cyclamate for chronic carcinogenesis experiments.

PubMed:Cytogenetic studies on calcium cyclamate in Meriones unguiculatus (gerbil) in vivo.

PubMed:In vitro cytogenetic investigation of calcium cyclamate, cyclohexylamine and triflupromazine.

PubMed:Aspartylphenylalanine methyl ester: a low-calorie sweetener.

PubMed:Effect of maternal calcium cyclamate intake on cellular development in the young rat.

PubMed:Calcium cyclamate and renal tubular acidosis.

PubMed:Photosensitive dermatitis and renal tubular acidosis after ingestion of calcium cyclamate.

PubMed:Sugar substitute, sodium and calcium cyclamate.

PubMed:Myocardial lesions: a reassessment of the toxicology of calcium cyclamate.

PubMed:Cytogenetic effects of cyclamates on human cells in vitro.

PubMed:[Effects on rat's intestinal mucosa of prolonged calcium cyclamate administration].

PubMed:Feeding and reproduction of rats fed calcium cyclamate.

PubMed:NEW and nonofficial remedies: cyclamate calcium.

Notes:

None found

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