EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

2-(4-methoxyphenoxy) propionic acid
2-(4-methoxyphenoxy)propanoic acid

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Name:2-(4-methoxyphenoxy)propanoic acid
CAS Number: 13794-15-5Picture of molecule3D/inchi
Nikkaji Web:J1.119.912G
XlogP3:1.70 (est)
Molecular Weight:196.20244000
Formula:C10 H12 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
Racemate (EFFA, 2010a). CASrn to be introduced in Register 158833-38-6.
Category:flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
DG SANTE Food Flavourings:08.127 2-(4-methoxyphenoxy)propanoic acid
FEMA Number:3773 2-(4-methoxyphenoxy)propanoic acid
FDA:No longer provide for the use of these seven synthetic flavoring substances
Physical Properties:
Appearance:white solid (est)
Assay: 95.00 to 100.00 sum of isomers
Food Chemicals Codex Listed: No
Melting Point: 158.00 °C. @ 760.00 mm Hg
Boiling Point: 377.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.000061 mmHg @ 25.00 °C. (est)
Flash Point: 266.00 °F. TCC ( 130.00 °C. )
logP (o/w): 1.650 (est)
Soluble in:
 water, 3129 mg/L @ 25 °C (est)
Insoluble in:
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
None found
BOC Sciences
For experimental / research use only.
2-(4-methoxyphenoxy)propionic acid
Endeavour Specialty Chemicals
2-(4-Methoxyphenoxy)propanoic acid 99% F&F
Speciality Chemical Product Groups
R C Treatt & Co Ltd
2-(4-Methoxyphenoxy)propionic acid
Halal, Kosher
Robinson Brothers
2-(4-Methoxyphenoxy)propanoic acid F&F
Santa Cruz Biotechnology
For experimental / research use only.
(±)-2-(p-Methoxyphenoxy)propionic acid
Sigma-Aldrich: Sigma
For experimental / research use only.
(±)-2-(p-Methoxyphenoxy)propionic acid ≥98%
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
flavoring agents
Recommendation for 2-(4-methoxyphenoxy) propionic acid usage levels up to:
 not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.011 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3200 (μg/person/day)
Threshold of Concern:90 (μg/person/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 15. Update in publication number(s): 22,23
Click here to view publication 15
 average usual ppmaverage maximum ppm
baked goods: 100.00000150.00000
beverages(nonalcoholic): 80.00000130.00000
beverages(alcoholic): 150.00000250.00000
breakfast cereal: 100.00000150.00000
cheese: 50.0000080.00000
chewing gum: 80.00000130.00000
condiments / relishes: 100.00000150.00000
confectionery froastings: 70.00000100.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 100.00000150.00000
fruit ices: 75.00000125.00000
gelatins / puddings: 85.00000135.00000
granulated sugar: --
gravies: 90.00000140.00000
hard candy: 100.00000150.00000
imitation dairy: 80.00000130.00000
instant coffee / tea: --
jams / jellies: 85.00000135.00000
meat products: 70.00000100.00000
milk products: 5.0000050.00000
nut products: --
other grains: 70.00000100.00000
poultry: --
processed fruits: 50.0000080.00000
processed vegetables: 50.0000080.00000
reconstituted vegetables: --
seasonings / flavors: 100.00000150.00000
snack foods: 100.00000150.00000
soft candy: 100.00000150.00000
soups: --
sugar substitutes: --
sweet sauces: 90.00000140.00000
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 3.0000015.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 2.0000010.00000
Edible ices, including sherbet and sorbet (03.0): 3.0000015.00000
Processed fruit (04.1): 2.0000010.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 10.0000050.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 3.0000015.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 15.0000075.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 23, Revision 1 (FGE.23Rev1): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 26 and 30[1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 23, Revision 2 (FGE.23Rev2): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 23, Revision 3 (FGE.23Rev3): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 23, Revision 4 (FGE.23Rev4): Aliphatic, alicyclic and aromatic ethers including anisole derivatives from chemical groups 15, 16, 22, 26 and 30
View page or View pdf

EPI System: View
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :151199
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(4-methoxyphenoxy)propanoic acid
 2-(4-methoxyphenoxy)propanoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):151199
Pubchem (sid):135107540
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2916.39.9090
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
(±)-2-(4-methoxyphenoxy) propanoic acid
(±)-2-(p-methoxyphenoxy) propanoic acid
(±)-2-(para-methoxyphenoxy) propanoic acid
2-(4-methoxyphenoxy) propanoic acid
2-(p-methoxyphenoxy) propanoic acid
2-(para-methoxyphenoxy) propanoic acid
2-(p-methoxyphenoxy) propionic acid
2-(para-methoxyphenoxy) propionic acid
2-(4-methoxyphenoxy)propanoic acid
(±)-2-(p-methoxyphenoxy)propionic acid
(2-(4-methoxyphenoxy)propionic acid
2-(4-methoxyphenoxy)propionic acid
 propanoic acid, 2-(4-methoxyphenoxy)-
a sweetness inhibitor.
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