EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

salvianolic acid B
(2R-(2alpha,3beta(R*),4(E(R*))))-3-(1-carboxy-2-(3,4-dihydroxyphenyl)ethyl) 4-(3-(1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy)-3-oxo-1-propenyl)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofura

Supplier Sponsors

CAS Number: 115939-25-8Picture of molecule3D/inchi
Other(deleted CASRN):115939-25-8
FDA UNII: C1GQ844199
XlogP3-AA:4.00 (est)
Molecular Weight:718.62230000
Formula:C36 H30 O16
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:yellow-brown powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point:1020.27 °C. @ 760.00 mm Hg (est)
Flash Point: 612.00 °F. TCC ( 322.10 °C. ) (est)
logP (o/w): 2.140 (est)
Soluble in:
 water, 1.04 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Salvianolicacid B >98%
Odor: characteristic
Use: Salvianolic acid A is extracted from the root of Salvia miltiorrhiza Bge.
Coompo
For experimental / research use only.
Salvianolic Acid B from Plants ≥96%
Odor: characteristic
Use: Salvianolic acid B showed a protective action against the ischemia-reperfusion induced injury in rat brain by reducing lipid peroxides, scavenging free radicals and improving the energy metabolism. In cerebral ischemia rats, Sal B reduced learning and memory dysfunctions induced by ischemia. Moreover, salvianolic acids, including Sal B, were shown to improve regional cerebral blood flow in the ischemic hemisphere and inhibit platelet aggregation in rats. More recently, Sal B was reported to be capable of improving the recovery of motor function after cerebral ischemia in rats. However, the mechanism responsible for such protective effects remains largely unknown. It has been considered that cerebral endothelium apoptosis caused by reactive oxygen species including hydrogen peroxide (H2O2) is implicated in the pathogenesis of cerebrovascular disorders. It was shown to inhibit apoptosis in many cell types, also inhibits apoptosis that is induced by the death receptor in the HL-7702 hepatocyte cell line. Sal B can effectively inhibit hepatocyte apoptosis as well as the underlying mechanisms related to regulating mediators in death receptor and mitochondrial pathways.
ExtraSynthese
For experimental / research use only.
Salvianolic Acid B (HPLC) ≥95%
Qingdao Dacon Trading
Salvianolic acid B+Tanshinone IIA
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for salvianolic acid B usage levels up to:
 not for fragrance use.
 
Recommendation for salvianolic acid B flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :13991587
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0115939258
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):13991587
Pubchem (sid):135120056
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 sage red sage
Search Trop Picture
 
Synonyms:
(2R-(2alpha,3beta(R*),4(E(R*))))-3-(1-carboxy-2-(3,4-dihydroxyphenyl)ethyl) 4-(3-(1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy)-3-oxo-1-propenyl)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofura
 salvianolicacid B
 

Articles:

PubMed:Transformation of salvianolic acid B to salvianolic acid a in aqueous solution and the in vitro liver protective effect of the main products.
PubMed:Effects of Danshensu and Salvianolic Acid B from Salvia miltiorrhiza Bunge (Lamiaceae) on cell proliferation and collagen and melanin production.
PubMed:Comparison of the inhibitory effect against copper ion-induced oxidation in rat plasma after oral administration of salvianolic acid B and its decocted solutions.
PubMed:[Study on chemical changes of salvianolic acid B and lithospermic acid aqueous under conditions of high temperature and high pressure].
PubMed:Chemical conversions of salvianolic acid B by decoction in aqueous solution.
PubMed:Salvianolic acid B inhibits low-density lipoprotein oxidation and neointimal hyperplasia in endothelium-denuded hypercholesterolaemic rabbits.
PubMed:Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B.
PubMed:Dan-Qi prescription ameliorate insulin resistance through overall corrective regulation of glucose and fat metabolism.
PubMed:Comparative pharmacokinetic and tissue distribution profiles of four major bioactive components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe.
PubMed:The profiling of bioactive ingredients of differently aged Salvia miltiorrhiza roots.
PubMed:Antioxidant activities of leaf extract of Salvia miltiorrhiza Bunge and related phenolic constituents.
PubMed:A pair of new antioxidant phenolic acid stereoisomers isolated from danshen injection (lyophilized powder).
PubMed:Nematicidal activity of mint aqueous extracts against the root-knot nematode Meloidogyne incognita.
PubMed:The stability investigation of compound Danshen injection (a traditional medicine) with a new high-performance liquid chromatography method.
PubMed:Characterisation of phenolic antioxidants in aqueous extract of Orthosiphon grandiflorus tea by LC-ESI-MS/MS coupled to DPPH assay.
PubMed:The Arabidopsis PAP1 transcription factor plays an important role in the enrichment of phenolic acids in Salvia miltiorrhiza.
PubMed:Genetic stability, active constituent, and pharmacoactivity of Salvia miltiorrhiza hairy roots and wild plant.
PubMed:Chemical characteristics of Salvia miltiorrhiza (Danshen) collected from different locations in China.
PubMed:[Absorption and isolation of macroporous resin for five salvianolic acids from Salviae mitiorrhizae].
PubMed:Separation and identification of water-soluble salvianolic acids from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography and ESI-MS analysis.
PubMed:Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress.
 
Notes:
isolated from salvia miltiorrhiza.
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy