EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

gedunin
gedunine

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CAS Number: 2753-30-2Picture of molecule3D/inchi
FDA UNII: Search
XlogP3-AA:4.20 (est)
Molecular Weight:482.57338000
Formula:C28 H34 O7
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 594.29 °C. @ 760.00 mm Hg (est)
Flash Point: 596.00 °F. TCC ( 313.20 °C. ) (est)
logP (o/w): 3.201 (est)
Soluble in:
 water, 0.9604 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Gedunin >98%
Odor: characteristic
Use: Gedunin is a naturally occurring Hsp90 inhibitor.
Santa Cruz Biotechnology
For experimental / research use only.
Gedunin >98%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for gedunin usage levels up to:
 not for fragrance use.
 
Recommendation for gedunin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :114923
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0002753302
RTECS:LK9275200 for cas# 2753-30-2
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):114923
Pubchem (sid):135071968
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 neem
Search Trop Picture
 
Synonyms:
 gedunine
 

Articles:

PubMed:Stimulation of erythrocyte cell membrane scrambling by gedunin.
PubMed:Evaluation of a fluorescence-based method for antibabesial drug screening.
PubMed:Review on pharmacological and toxicologyical effects of oleum azadirachti oil.
PubMed:Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves.
PubMed:The therapeutic properties of Carapa guianensis.
PubMed:Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis.
PubMed:Gedunin, a natural tetranortriterpenoid, modulates T lymphocyte responses and ameliorates allergic inflammation.
PubMed:Antiplasmodial activity of the andiroba (Carapa guianensis Aubl., Meliaceae) oil and its limonoid-rich fraction.
PubMed:Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum.
PubMed:Limonoid Compounds Inhibit Sphingomyelin Biosynthesis by Preventing CERT-dependent Extraction of Ceramides from the Endoplasmic Reticulum.
PubMed:The limonoids and their antitobacco mosaic virus (TMV) activities from Munronia unifoliolata Oliv.
PubMed:Querying genomic databases: refining the connectivity map.
PubMed:The plant limonoid 7-oxo-deacetoxygedunin inhibits RANKL-induced osteoclastogenesis by suppressing activation of the NF-κB and MAPK pathways.
PubMed:Effect of triterpenoids and limonoids isolated from Cabralea canjerana and Carapa guianensis (Meliaceae) against Spodoptera frugiperda (J. E. Smith).
PubMed:Antimalarial activity in Xylocarpus granatum (Koen).
PubMed:Rings D-seco and B,D-seco tetranortriterpenoids from root bark of Entandrophragma angolense.
PubMed:Limonoids from seeds of Thai Xylocarpus moluccensis.
PubMed:Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.
PubMed:Gedunin and photogedunin of Xylocarpus granatum possess antifilarial activity against human lymphatic filarial parasite Brugia malayi in experimental rodent host.
PubMed:Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem).
PubMed:Evaluation of effect of triterpenes and limonoids on cell growth, cell cycle and apoptosis in human tumor cell line.
PubMed:A systematic protocol for the characterization of Hsp90 modulators.
PubMed:Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
PubMed:Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica.
PubMed:Limonoids from the leaves of Cipadessa baccifera.
PubMed:Deoxygedunin, a natural product with potent neurotrophic activity in mice.
PubMed:7-Deacetyl-gedunin.
PubMed:Gedunin and photogedunin of Xylocarpus granatum show significant anti-secretory effects and protect the gastric mucosa of peptic ulcer in rats.
PubMed:Gedunin, a novel natural substance, inhibits ovarian cancer cell proliferation.
PubMed:Granatumins A-G, limonoids from the seeds of a Krishna mangrove, Xylocarpus granatum.
PubMed:Identification of small-molecule HSF1 amplifiers by high content screening in protection of cells from stress induced injury.
PubMed:Effects of limonoids from Cipadessa fruticosa on fall armyworm.
PubMed:Susceptibility of Aedes aegypti and Culex quinquefasciatus Larvae to gedunin-related limonoids.
PubMed:6α-Acetoxy-gedunin.
PubMed:Isolation of limonoids from seeds of Carapa guianensis Aublet (Meliaceae) by high-speed countercurrent chromatography.
PubMed:Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships.
PubMed:Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae).
PubMed:Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro.
PubMed:Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi.
PubMed:Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.
PubMed:The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.
PubMed:Hydroxylated gedunin derivatives from Cedrela sinensis.
PubMed:Inhibition of allergen-induced eosinophil recruitment by natural tetranortriterpenoids is mediated by the suppression of IL-5, CCL11/eotaxin and NFkappaB activation.
PubMed:The toxicity and behavioural effects of neem limonoids on Cnaphalocrocis medinalis (Guenée), the rice leaffolder.
PubMed:Effect of neem limonoids on lactate dehydrogenase (LDH) of the rice leaffolder, Cnaphalocrocis medinalis (Guenée) (Insecta: Lepidoptera: Pyralidae).
PubMed:Insect growth regulatory effects of some extracts and sterols from Myrtillocactus geometrizans (Cactaceae) against Spodoptera frugiperda and Tenebrio molitor.
PubMed:Effects of neem limonoids on the malaria vector Anopheles stephensi Liston (Diptera: Culicidae).
PubMed:Insect growth inhibition by tocotrienols and hydroquinones from Roldana barba-johannis.
PubMed:Antioxidant and insect growth regulatory activities of stilbenes and extracts from Yucca periculosa.
PubMed:6beta-hydroxygedunin from Azadirachta indica. Its potentiation effects with some non-azadirachtin limonoids in neem against lepidopteran larvae.
PubMed:Traditionally-used antimalarials from the Meliaceae.
PubMed:Three new tetranortriterpenoids from neem seed oil.
PubMed:Acetylcholinesterase and insect growth inhibitory activities of Gutierrezia microcephala on fall armyworm Spodoptera frugiperda J.E. Smith.
PubMed:Growth inhibitory effects on fall armyworm Spodoptera frugiperda of some limonoids isolated from Cedrela spp. (Meliaceae).
PubMed:Delevoyin C, a tetranortriterpenoid from Entandrophragma delevoyi.
PubMed:In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae).
PubMed:Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives.
PubMed:Constituents of Azadirachta indica: isolation and structure elucidation of a new antibacterial tetranortriterpenoid, mahmoodin, and a new protolimonoid, naheedin.
PubMed:Isolation and characterization of an antimalarial agent of the neem tree Azadirachta indica.
PubMed:Potential antimalarial candidates from African plants: and in vitro approach using Plasmodium falciparum.
 
Notes:
isolated from neem (azadirachta indica).
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