Name: | 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene |
CAS Number: | 7683-64-9 | 3D/inchi
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Other(deleted CASRN): | 21245-10-3 |
FDA UNII: | Search |
Nikkaji Web: | J8.960E |
XlogP3-AA: | 11.60 (est) |
Molecular Weight: | 410.72850000 |
Formula: | C30 H50 |
NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to pale yellow clear oily liquid (est) |
Assay: | 98.00 to 100.00
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Food Chemicals Codex Listed: | No |
Boiling Point: | 429.00 to 430.00 °C. @ 760.00 mm Hg
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Flash Point: | 309.00 °F. TCC ( 153.89 °C. )
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logP (o/w): | 12.188 (est) |
Soluble in: |
| alcohol | | water, 6.646e-010 mg/L @ 25 °C (est) |
Insoluble in: |
| water |
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | natural substances and extractives |
Recommendation for squalene usage levels up to: | | not for fragrance use.
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Recommendation for squalene flavor usage levels up to: |
| not for flavor use.
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Safety References:
EPI System: View |
Chemical Carcinogenesis Research Information System:Search |
AIDS Citations:Search |
Cancer Citations:Search |
Toxicology Citations:Search |
EPA ACToR:Toxicology Data |
EPA Substance Registry Services (SRS):Registry |
Laboratory Chemical Safety Summary :638072 |
National Institute of Allergy and Infectious Diseases:Data |
2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene |
Chemidplus:0000111024 |
References:
| 2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene |
NIST Chemistry WebBook: | Search Inchi |
Pubchem (cid): | 638072 |
Pubchem (sid): | 134974713 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
2,6,10,15,19,23- | hexamethyl-2,6,10,14,18,22-tetracosahexaene | 2,6,10,15,19,23- | hexamethyltetracosa-2,6,10,14,18,22-hexaene | | skvalen | | spinacene | | supraene |
Articles:
PubMed:Physicochemical properties, antioxidant activities and protective effect against acute ethanol-induced hepatic injury in mice of foxtail millet (Setaria italica) bran oil. |
J-Stage:Thraustochytrid Aurantiochytrium sp. 18W-13a Accummulates High Amounts of Squalene |
PubMed:Cholesterol metabolism and serum non-cholesterol sterols: summary of 13 plant stanol ester interventions. |
PubMed:The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice. |
PubMed:Online LC-GC-based analysis of minor lipids in various tree nuts and peanuts. |
PubMed:Cloning and characterization of squalene synthase gene from Poria cocos and its up-regulation by methyl jasmonate. |
PubMed:A physiologically-based pharmacokinetic (PBPK) model of squalene-containing adjuvant in human vaccines. |
PubMed:Enhancement of skin radical scavenging activity and stratum corneum lipids after the application of a hyperforin-rich cream. |
PubMed:The impact of fruit maturation on bioactive microconstituents, inhibition of serum oxidation and inflammatory markers in stimulated PBMCs and sensory characteristics of Koroneiki virgin olive oils from Messenia, Greece. |
PubMed:Nutritional evaluation and health promoting activities of nuts and seeds cultivated in Greece. |
PubMed:Evaluation of γ-oryzanol content and composition from the grains of pigmented rice-germplasms by LC-DAD-ESI/MS. |
PubMed:Genotoxicity assessment of vaccine adjuvant squalene. |
PubMed:The revival of Amaranth as a third-millennium food. |
PubMed:A novel approach to enhancing ganoderic acid production by Ganoderma lucidum using apoptosis induction. |
PubMed:Formulated squalene for food related applications. |
PubMed:Effect of baking of sardine (Sardina pilchardus) and frying of anchovy (Engraulis encrasicholus) in olive and sunflower oil on their quality. |
PubMed:Discrimination against diacylglycerol ethers in lipase-catalysed ethanolysis of shark liver oil. |
PubMed:Novel bio-active lipid nanocarriers for the stabilization and sustained release of sitosterol. |
PubMed:Lignans and triterpenes from the root of Pseuderanthemum carruthersii var. atropurpureum. |
PubMed:Analytical evaluation of two monovarietal virgin olive oils cultivated in the south of Tunisia: Jemri-Bouchouka and Chemlali-Tataouin cultivars. |
PubMed:Recovery of squalene from wine lees using ultrasound assisted extraction-a feasibility study. |
PubMed:Enhanced production of ganoderic acids and cytotoxicity of Ganoderma lucidum using solid-medium culture. |
PubMed:Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development. |
PubMed:Flavonoids with potent antioxidant activity found in young green barley leaves. |
PubMed:Squalene ameliorates atherosclerotic lesions through the reduction of CD36 scavenger receptor expression in macrophages. |
PubMed:Bioactive compounds and nutritional significance of virgin argan oil--an edible oil with potential as a functional food. |
PubMed:Valuable Nutrients and Functional Bioactives in Different Parts of Olive (Olea europaea L.)-A Review. |
PubMed:Investigation of unsaponifiable matter of plant oils and isolation of eight phytosterols by means of high-speed counter-current chromatography. |
PubMed:Lipid composition of wine strains of Saccharomyces kudriavzevii and Saccharomyces cerevisiae grown at low temperature. |
PubMed:Biological importance and applications of squalene and squalane. |
PubMed:Anti-inflammatory effects of polyphenolic-enriched red raspberry extract in an antigen-induced arthritis rat model. |
PubMed:The influence of bearing cycles on olive oil quality response to irrigation. |
PubMed:Ethnobotanical survey, chemical composition, and antioxidant capacity of methanolic extract of the root bark of Annona cuneata Oliv. |
PubMed:Enhanced squalene production by wild-type Saccharomyces cerevisiae strains using safe chemical means. |
PubMed:Modulation of doxorubicin-induced genotoxicity by squalene in Balb/c mice. |
PubMed:MF59 adjuvant enhances diversity and affinity of antibody-mediated immune response to pandemic influenza vaccines. |
PubMed:The effect of consecutive steps of refining on squalene content of vegetable oils. |
PubMed:Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. |
PubMed:An unusual plant triterpene synthase with predominant α-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica. |
PubMed:New hydrothermal treatment of alperujo enhances the content of bioactive minor components in crude pomace olive oil. |
PubMed:Influence of harvest method and period on olive oil composition: an NMR and statistical study. |
PubMed:Squalene as novel food factor. |
PubMed:On the effects of a plant extract of Orthosiphon stamineus on sebum-related skin imperfections. |
PubMed:gamma-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes. |
PubMed:Characterization of a potential nutraceutical ingredient: pomegranate (Punica granatum L.) seed oil unsaponifiable fraction. |
PubMed:Enhanced production of squalene in the thraustochytrid Aurantiochytrium mangrovei by medium optimization and treatment with terbinafine. |
PubMed:Cytoprotective effects of DL-alpha-lipoic acid or squalene on cyclophosphamide-induced oxidative injury: an experimental study on rat myocardium, testicles and urinary bladder. |
PubMed:High throughput screening of mutants of oat that are defective in triterpene synthesis. |
PubMed:Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6. |
PubMed:Optimization of nitrogen source for enhanced production of squalene from thraustochytrid Aurantiochytrium sp. |
PubMed:Vaccines with MF59 adjuvant expand the antibody repertoire to target protective sites of pandemic avian H5N1 influenza virus. |
PubMed:Cloning and characterization of the lanosterol 14alpha-demethylase gene from Antrodia cinnamomea. |
PubMed:Analysis of sterol and other components present in unsaponifiable matters of mahua, sal and mango kernel oil. |
PubMed:13C nuclear magnetic resonance spectroscopic detection of the adulteration of extra virgin olive oils extracted from different cultivars with cold-pressed hazelnut oil. |
PubMed:Squalene protects against oxidative DNA damage in MCF10A human mammary epithelial cells but not in MCF7 and MDA-MB-231 human breast cancer cells. |
PubMed:Novel fractionation method for squalene and phytosterols contained in the deodorization distillate of rice bran oil. |
PubMed:[Culture of transgenic Glycyrrhiza uralensis hairy root with licorice squalene synthase (SQS) gene]. |
PubMed:Terpene-mediated parasitoid host location behavior on transgenic and classically bred apple genotypes. |
PubMed:Synthesis and characterization of a structured lipid from amaranth oil as a partial fat substitute in milk-based infant formula. |
PubMed:Gingival vascular damage in atherosclerotic rabbits: hydroxytyrosol and squalene benefits. |
PubMed:Squalene versus ergosterol formation using Saccharomyces cerevisiae: combined effect of oxygen supply, inoculum size, and fermentation time on yield and selectivity of the bioprocess. |
PubMed:Improved separation and quantification of neutral and polar lipid classes by HPLC-ELSD using a monolithic silica phase: application to exceptional marine lipids. |
PubMed:Characterization and quantification of the aliphatic hydrocarbon fraction during linseed development ( Linum usitatissimum L.). |
PubMed:[The oil, fatty acid and squalene content of varieties of raw and processed amaranth grain]. |
PubMed:Screening and characterization of squalene-producing thraustochytrids from Hong Kong mangroves. |
PubMed:Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety. |
PubMed:Processing stability of squalene in amaranth and antioxidant potential of amaranth extract. |
PubMed:Chemical characterization and DNA tracking of Sardinian botargo by Mugil cephalus from different geographical origins. |
PubMed:Lipase catalyzed synthesis of neutral glycerides rich in micronutrients from rice bran oil fatty acid distillate. |
PubMed:Chemical composition of Greek avgotaracho prepared from mullet (Mugil cephalus): nutritional and health benefits. |
PubMed:Comparison of the skin sensitizing potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT). |
PubMed:Isolation and structural determination of squalene synthase inhibitor from Prunus mume fruit. |
PubMed:Supercritical carbon dioxide fractionation of nonesterified alkoxyglycerols obtained from shark liver oil. |
PubMed:[Changes in lipid metabolism in patients in the active phase of Crohn's disease]. |
PubMed:How heating affects extra virgin olive oil quality indexes and chemical composition. |
PubMed:Synthesis and antifungal activity of a series of N-substituted [2-(2,4-dichlorophenyl)-3-(1,2,4-triazol-1-yl)]propylamines. |
PubMed:Molecular mechanisms of the effects of olive oil and other dietary lipids on cancer. |
PubMed:Ion-trap tandem mass spectrometric analysis of squalene monohydroperoxide isomers in sunlight-exposed human skin. |
PubMed:Exudation of allelopathic substances in buckwheat (Fagopyrum esculentum Moench). |
PubMed:Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes. |
PubMed:Cholesterol synthesis prevails over absorption in metabolic syndrome. |
PubMed:[Virgin olive oil. From legend to scientific knowledge of the nutraceutical aspects]. |
PubMed:Importance of functional foods in the Mediterranean diet. |
PubMed:Antioxidant activities and volatile constituents of various essential oils. |
PubMed:Moderate increase in dietary sucrose does not influence fasting or postprandial serum lipids regardless of the presence of apolipoprotein E2 allele in healthy subjects. |
PubMed:Cardioprotective effect of squalene on lipid profile in isoprenaline-induced myocardial infarction in rats. |
PubMed:Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts. |
PubMed:Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. |
PubMed:Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase. |
PubMed:Analysis of unsaponifiable compounds of edible oils by automated on-line coupling reversed-phase liquid chromatography-gas chromatography using the through oven transfer adsorption desorption interface. |
PubMed:Distribution of Vitamin E, squalene, epicatechin, and rutin in common buckwheat plants (Fagopyrum esculentum Moench). |
PubMed:[Functional components in fish and algae oils]. |
PubMed:Polyunsaturated fatty acids, phytosterols and cholesterol metabolism in the Mediterranean diet. |
PubMed:Components of olive oil and chemoprevention of colorectal cancer. |
PubMed:Effect of the difference in vehicles on gene expression in the rat liver--analysis of the control data in the Toxicogenomics Project Database. |
PubMed:Laser desorption/ionization time-of-flight mass spectrometry of squalene in oil samples. |
PubMed:Race is on for flu vaccine. |
PubMed:New phenylenediamine antiozonants for commodities based on natural and synthetic rubber. |
PubMed:Variation of chemical composition of the lipophilic extracts from yellow birch (Betula alleghaniensis) foliage. |
PubMed:Relation between the endogenous antioxidant system and the quality of extra virgin olive oil under accelerated storage conditions. |
PubMed:Comparison of the chemical composition and nutritional value of Amaranthus cruentus flour and its protein concentrate. |
PubMed:Analysis of minor components in olive oil. |
PubMed:A real-time polymerase chain reaction-based method for rapid and specific detection of spoilage Alicyclobacillus spp. in apple juice. |
PubMed:Countercurrent supercritical fluid extraction and fractionation of high-added-value compounds from a hexane extract of olive leaves. |
PubMed:Analysis of gene expression in the bovine corpus luteum through generation and characterisation of 960 ESTs. |
PubMed:Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut. |
PubMed:Influence of agronomic variables on the composition of mate tea leaves (Ilex paraguariensis) extracts obtained from CO2 extraction at 30 degrees C and 175 bar. |
PubMed:Extraction and characterization of volatile compounds in Maytenus ilicifolia, using high-pressure CO2. |
PubMed:Fatty acid composition and squalene content of the marine microalga Schizochytrium mangrovei. |
PubMed:Squalene in oils and fats from domestic and commercial fryings of potatoes. |
PubMed:Supercritical carbon dioxide extraction of oil and squalene from amaranthus grain. |
PubMed:Oil and squalene in amaranthus grain and leaf. |
PubMed:Antioxidant effect of phenolic compounds, alpha-tocopherol, and other minor components in virgin olive oil. |
PubMed:Phytonutrient deficiency: the place of palm fruit. |
PubMed:Triacylglycerol and fatty acid compositions of French virgin olive oils. Characterization by chemometrics. |
PubMed:Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effects. |
PubMed:Effect of squalene and shark liver oil on serum cholesterol level in hamsters. |
PubMed:3,4-Dihydroxymandelic acid, a noradrenalin metabolite with powerful antioxidative potential. |
PubMed:Rate of degradation of alpha-tocopherol, squalene, phenolics, and polyunsaturated fatty acids in olive oil during different storage conditions. |
PubMed:Squalene content and antioxidant activity of Terminalia catappa leaves and seeds. |
PubMed:Determination of esters of fatty acids with low molecular weight alcohols in olive oils. |
PubMed:Olive oil as a functional food: epidemiology and nutritional approaches. |
PubMed:Biological properties of olive oil phytochemicals. |
PubMed:Phytosterol content in American ginseng seed oil. |
PubMed:Stability of virgin olive oil. 2. Photo-oxidation studies. |
PubMed:Stability of virgin olive oil. 1. Autoxidation studies. |
PubMed:Extraction and purification of squalene from amaranthus grain. |
PubMed:Interpretation of Fourier transform Raman spectra of the unsaponifiable matter in a selection of edible oils. |
PubMed:Changes in lipids and sterols during composting. |
PubMed:Comparing palmolein with different predominantly monounsaturated oils: effect on plasma lipids. |
PubMed:An olive oil-rich diet results in higher concentrations of LDL cholesterol and a higher number of LDL subfraction particles than rapeseed oil and sunflower oil diets. |
PubMed:Phenolic compounds and squalene in olive oils: the concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignansand squalene. |
PubMed:First report of the characterization of the threatened plant species Amaranthus pumilus (Seabeach amaranth). |
PubMed:Unsaponifiable lipid constituents of some underutilized tropical seed oils. |
PubMed:On the role of squalene in olive oil stability. |
PubMed:Increased carotenoid production by the food yeast Candida utilis through metabolic engineering of the isoprenoid pathway. |
PubMed:Inhibition of ergosterol biosynthesis is not accompanied by a change in fatty acid composition in Saccharomyces cerevisiae treated with the antifungal agent 6-amino-2-n-pentylthiobenzothiazole. |
PubMed:Amaranth and its oil inhibit cholesterol biosynthesis in 6-week-old female chickens. |
PubMed:Inhibition of sterol 4-demethylation in Candida albicans by 6-amino-2-n-pentylthiobenzothiazole, a novel mechanism of action for an antifungal agent. |
PubMed:Simultaneous liquid chromatographic determination of cholesterol, phytosterols and tocopherols in foods. |
PubMed:Regulation of squalene synthetase activity in rat liver: elevation by cholestyramine, but no diurnal variation. |
PubMed:[Studies on therapeutic effect of 13-cis retinoic acid and squalene on symptoms of PCDFs poisoning in monkeys]. |
PubMed:Biochemical controls of liver cholesterol biosynthesis. |
PubMed:The composition of a simulated American diet. Comparison of chemical analyses and estimates from food composition tables. |
PubMed:Measurement of squalene in human tissues and plasma: validation and application. |
PubMed:Quantitative changes in some unsaponifiable components of soya bean oil due to refining. |
PubMed:Model studies in terpene biosynthesis. |
PubMed:Hydrocarbons in digestive tract and liver of a basking shark. |
PubMed:VITAMIN A AND ISOPRENOID SYNTHESIS IN THE RAT. |
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