sodium carboxymethyl starch
starch, carboxymethyl ether, sodium salt
 
Notes:
None found
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      Product(s):
      19-35950 SODIUM STARCH GLYCOLATE USP/NF
       
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CAS Number: 9063-38-1 
Other: 60351-56-6
FDA UNII: 27NA468985
Category: binding, film forming, viscosity controlling agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: binding agents
emulsion stabilisers
film formers
viscosity controlling agents
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Suppliers:
American International Chemical
Sodium Starch Glycolate
Anhui Haibei
Carboxymethyl starch sodium
Penta International
SODIUM STARCH GLYCOLATE USP/NF
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: binding, film forming, viscosity controlling agents
Recommendation for sodium carboxymethyl starch usage levels up to:
 not for fragrance use.
 
Recommendation for sodium carboxymethyl starch flavor usage levels up to:
 not for flavor use.
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Safety References:
Daily Med: search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 9063-38-1
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
Chemidplus: 0009063381
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References:
Canada Domestic Sub. List: 9063-38-1
Pubchem (sid): 135350084
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Other Information:
HMDB (The Human Metabolome Database): Search
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 carboxymethyl starch sodium
 carboxymethyl starch sodium salt
 explotab
 primojel
 sodium carboxymethoxystarch
 sodium starch glycolate
 sodium starch glycolate NF EP
 sodium starch glycolate USP/NF
 starch, carboxymethyl ether, monosodium salt
 starch, carboxymethyl ether, sodium salt
 starch, carboxymethyl ether, sodium salt
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Articles:
PubMed: Novel sustained release and swellable gastroretentive dosage form for ciprofloxacin hydrochloride.
PubMed: High-amylose sodium carboxymethyl starch matrices: development and characterization of tramadol hydrochloride sustained-release tablets for oral administration.
PubMed: Systematic classification of tablet disintegrants by water uptake and force development kinetics.
PubMed: Functionality of Disintegrants and Their Mixtures in Enabling Fast Disintegration of Tablets by a Quality by Design Approach.
PubMed: Performance of tablet disintegrants: impact of storage conditions and relative tablet density.
PubMed: In vitro determination of aceclofenac Mouth Dissolving Tablets.
PubMed: Comparative binding and disintegrating property of Echinochloa colona starch (difra starch) against maize, sorghum, and cassava starch.
PubMed: Formulation and optimization of orodispersible tablets of flutamide.
PubMed: Phenylalanine-free taste-masked orodispersible tablets of fexofenadine hydrochloride: development, in vitro evaluation and in vivo estimation of the drug pharmacokinetics in healthy human volunteers.
PubMed: Desktop 3D printing of controlled release pharmaceutical bilayer tablets.
PubMed: Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate for respiratory disorders.
PubMed: In vitro and in vivo correlation of disintegration and bitter taste masking using orally disintegrating tablet containing ion exchange resin-drug complex.
PubMed: II. Technological approaches to improve the dissolution behavior of nateglinide, a lipophilic insoluble drug: co-milling.
PubMed: Ultrasonic approach for viscoelastic and microstructure characterization of granular pharmaceutical tablets.
PubMed: Effects of pharmaceutical excipients on membrane permeability in rat small intestine.
PubMed: Stability and repeatability of a continuous twin screw granulation and drying system.
PubMed: An easy-to-use approach for determining the disintegration ability of disintegrants by analysis of available surface area.
PubMed: Compression of coated drug beads for sustained release tablet of glipizide: formulation, and dissolution.
PubMed: Formulation development and in vitro evaluation of solidified self-microemulsion in the form of tablet containing atorvastatin calcium.
PubMed: [Comparative evaluation of the anionic superdisintegrant incorporation mode on the quality of ranitidine tablets].
PubMed: Optimization of fast disintegration tablets using pullulan as diluent by central composite experimental design.
PubMed: Zero-order release profile of metoclopramide hydrochloride sublingual tablet formulation.
PubMed: Development of novel bepotastine salicylate salt bioequivalent to the commercial bepotastine besilate in beagle dogs.
PubMed: Functional assessment of four types of disintegrants and their effect on the spironolactone release properties.
PubMed: Development and optimization of dextromethorphan hydrobromide oral disintegrating tablets: effect of formulation and process variables.
PubMed: Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets.
PubMed: Formulation and evaluation of taste masked mouth dissolving tablets of levocetirizine hydrochloride.
PubMed: Water content determination of superdisintegrants by means of ATR-FTIR spectroscopy.
PubMed: Formulation and evaluation of fast dissolving tablets of cinnarizine using superdisintegrant blends and subliming material.
PubMed: Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules.
PubMed: Preparation of cross-linked carboxymethyl jackfruit starch and evaluation as a tablet disintegrant.
PubMed: Dissolution rate enhancement of gliclazide by ordered mixing.
PubMed: Hordeum vulgare hull in the design of fast disintegrating tablets.
PubMed: Dissofilm: a novel approach for delivery of phenobarbital; design and characterization.
PubMed: Design and evaluation of colon targeted modified pulsincap delivery of 5-fluorouracil according to circadian rhythm.
PubMed: Development and evaluation of fast-dissolving tablets of meloxicam-β-cyclodextrin complex prepared by direct compression.
PubMed: A comparison of chitosan-silica and sodium starch glycolate as disintegrants for spheronized extruded microcrystalline cellulose pellets.
PubMed: Formulation of zolmitriptan sublingual tablets prepared by direct compression with different polymers: in vitro and in vivo evaluation.
PubMed: Microwave assisted synthesis and evaluation of modified pea starch as tablet superdisintegrant.
PubMed: Formulation development and rheological studies of palatable cefetamet pivoxil hydrochloride dry powder suspension.
PubMed: Controlled release of oral tetrahydrocurcumin from a novel self-emulsifying floating drug delivery system (SEFDDS).
PubMed: Formulation, development, and optimization of immediate release nateglinide tablets by factorial design.
PubMed: Formulation and characterization of patient-friendly dosage form of ondansetron hydrochloride.
PubMed: Formulation development, evaluation and comparative study of effects of super disintegrants in cefixime oral disintegrating tablets.
PubMed: Novel mesalamine-loaded beads in tablets for delayed release of drug to the colon.
PubMed: Formulation and In-vitro Evaluation of Orally Disintegrating Tablets of Olanzapine-2-Hydroxypropyl-β-Cyclodextrin Inclusion Complex.
PubMed: Development of taste masked oral formulation of ornidazole.
PubMed: A preformulation study of a new medicine for Chagas disease treatment: physicochemical characterization, thermal stability, and compatibility of benznidazole.
PubMed: Risperidone solid dispersion for orally disintegrating tablet: its formulation design and non-destructive methods of evaluation.
PubMed: Design, development and in vitro-in vivo study of a colon-specific fast disintegrating tablet.
PubMed: Evaluation of the fluid uptake kinetics and drug release from gellan gum tablets containing metronidazole.
PubMed: Solventless visible light-curable coating: II. Drug release, mechanical strength and photostability.
PubMed: Preparation and in vitro evaluation of gliclazide sustained-release matrix pellets: formulation and storage stability.
PubMed: Preparation and evaluation of orodispersible tablets of pheniramine maleate by effervescent method.
PubMed: Fast Dissolving Tablets of Fexofenadine HCl by Effervescent Method.
PubMed: Formulation and optimization of orodispersible tablets of diazepam.
PubMed: Development and characterization of enteric-coated immediate-release pellets of aceclofenac by extrusion/spheronization technique using kappa-carrageenan as a pelletizing agent.
PubMed: Enhanced dissolution and bioavailability of raloxifene hydrochloride by co-grinding with different superdisintegrants.
PubMed: Evaluation of physico-mechanical properties of drug-excipients agglomerates obtained by crystallization.
PubMed: Solventless visible light-curable coating: I. Critical formulation and processing parameters.
PubMed: High-amylose sodium carboxymethyl starch matrices for oral, sustained drug release: development of a spray-drying manufacturing process.
PubMed: Development and optimization of a sublingual tablet formulation for physostigmine salicylate.
PubMed: Preparation and comparative evaluation of sustained release metoclopramide hydrochloride matrix tablets.
PubMed: Design and evaluation of San-huang dispersible tablet--an efficient delivery system for Traditional Chinese Medicine.
PubMed: Compressional behavior of a mixture of granules containing high load of Phyllanthus niruri spray-dried extract and granules of adjuvants: comparison between eccentric and rotary tablet machines.
PubMed: Clinical study shows improved absorption of desmopressin with novel formulation.
PubMed: Formulation and evaluation of swellable and floating gastroretentive ciprofloxacin hydrochloride tablets.
PubMed: Design of floating bilayer tablets of diltiazem hydrochloride and lovastatin.
PubMed: Physicochemical interactions between drugs and superdisintegrants.
PubMed: Design and evaluation of fast dissolving tablets of clonazepam.
PubMed: Effect of starch 1500 as a binder and disintegrant in lamivudine tablets prepared by high shear wet granulation.
PubMed: Design, development and optimization of a novel time and pH-dependent colon targeted drug delivery system.
PubMed: Effect of some commercial grades of microcrystalline cellulose on flowability, compressibility, and dissolution profile of piroxicam liquisolid compacts.
PubMed: Pulsatile drug delivery to ileo-colonic segments by structured incorporation of disintegrants in pH-responsive polymer coatings.
PubMed: Mechanoradical-induced degradation in a pharmaceutical blend during high-shear processing.
PubMed: Design, development, and optimization of orally disintegrating tablets of etoricoxib using vacuum-drying approach.
PubMed: Rapid development and optimization of tablet manufacturing using statistical tools.
PubMed: Development of fast dispersible aceclofenac tablets: effect of functionality of superdisintegrants.
PubMed: High-amylose sodium carboxymethyl starch matrices for oral, sustained drug-release: formulation aspects and in vitro drug-release evaluation.
PubMed: Development of a rapidly dispersing tablet of a poorly wettable compound: formulation DOE and mechanistic study of effect of formulation excipients on wetting of celecoxib.
PubMed: Changes in the mucoadhesion of powder formulations after drug application investigated with a simplified method.
PubMed: Fast dispersible/slow releasing ibuprofen tablets.
PubMed: Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride.
PubMed: Thermal behavior of water in the selected starch- and cellulose-based polymeric hydrogels.
PubMed: Formulation and evaluation of rapidly disintegrating fenoverine tablets: effect of superdisintegrants.
PubMed: Modulation of a pulsatile release drug delivery system using different swellable/rupturable materials.
PubMed: Solventless photocurable film coating: evaluation of drug release, mechanical strength, and photostability.
PubMed: Effect of hydrophilic swellable polymers on dissolution enhancement of carbamazepine solid dispersions studied using response surface methodology.
PubMed: Effect of moisture on the compressibility and compactibility of sodium starch glycolate.
PubMed: Interaction of moisture with sodium starch glycolate.
PubMed: Development and characterisation of interactive mixtures with a fine-particulate mucoadhesive carrier for nasal drug delivery.
PubMed: Preparation and assessment of novel coprocessed superdisintegrant consisting of crospovidone and sodium starch glycolate: a technical note.
PubMed: High-amylose carboxymethyl starch matrices for oral sustained drug-release: in vitro and in vivo evaluation.
PubMed: Effect of fiber length of carbon nanotubes on the absorption of erythropoietin from rat small intestine.
PubMed: pH-independent pulsatile drug delivery system based on hard gelatin capsules and coated with aqueous dispersion Aquacoat ECD.
PubMed: Development of pulsatile multiparticulate drug delivery system coated with aqueous dispersion Aquacoat ECD.
PubMed: [Optimization of formulation of Fufang Danshen immediate release tablet by colligation score].
PubMed: Compression behavior of formulations from Phyllanthus niruri spray dried extract.
PubMed: Differential scanning calorimetry as a screening technique in compatibility studies of DHEA extended release formulations.
PubMed: The influence of granulation on super disintegrant performance.
PubMed: Spray dried excipient base: a novel technique for the formulation of orally disintegrating tablets.
PubMed: Drug-excipient compatibility testing using a high-throughput approach and statistical design.
PubMed: Licorice: a possible anti-inflammatory and anti-ulcer drug.
PubMed: The influence of swelling capacity of superdisintegrants in different pH media on the dissolution of hydrochlorothiazide from directly compressed tablets.
PubMed: Development and mathematical simulation of theophylline pulsatile release tablets.
PubMed: Effect of gamma radiation on amlodis and its potential for radiosterilization.
PubMed: A comparative study of the utility of two superdisintegrants in microcrystalline cellulose pellets prepared by extrusion-spheronization.
PubMed: Dynamic vapor sorption properties of sodium starch glycolate disintegrants.
PubMed: Molecular interaction in alginate beads reinforced with sodium starch glycolate or magnesium aluminum silicate, and their physical characteristics.
PubMed: Development of an enteric-coated pellet formulation of F4 fimbriae for oral vaccination of suckling piglets against enterotoxigenic Escherichia coli infections.
PubMed: Dissolution behaviour of nalidixic acid solid dispersions using water soluble dispersion carriers.
PubMed: Novel chewable sustained-release tablet containing verapamil hydrochloride.
PubMed: Thermal porosity analysis of croscarmellose sodium and sodium starch glycolate by differential scanning calorimetry.
PubMed: Evaluation of the swelling, hydration and rupturing properties of the swelling layer of a rupturable pulsatile drug delivery system.
PubMed: Exploration of melt granulation technique for the development of coprocessed directly compressible adjuvant containing lactose and microcrystalline cellulose.
PubMed: Pharmaceutical formulation of a fixed-dose anti-tuberculosis combination.
PubMed: Differential scanning calorimetry to investigate the compatibility of ciprofloxacin hydrochloride with excipients.
PubMed: Development and in vitro evaluation of an enteric-coated multiparticulate drug delivery system for the administration of piroxicam to dogs.
PubMed: Powder compaction properties of sodium starch glycolate disintegrants.
PubMed: Multiple sources of sodium starch glycolate, NF: evaluation of functional equivalence and development of standard performance tests.
PubMed: Action of carriers on Carbamazepine dissolution.
PubMed: Influence of excipients, drugs, and osmotic agent in the inner core on the time-controlled disintegration of compression-coated ethylcellulose tablets.
PubMed: Chemical characterisation of sodium starch glycolate particles.
PubMed: Fast- and slow-release tablets for oral administration of flavonoids: rutin and quercetin.
PubMed: Influence of adjuvants on the dissolution profile of tablets containing high doses of spray-dried extract of Maytenus ilicifolia.
PubMed: Effect of pharmacotechnical design on the in vitro interaction of ketoconazole tablets with non-systemic antacids.
PubMed: Evaluation of the functional equivalence of crospovidone NF from different sources. I. Physical characterization.
PubMed: Bioadhesive properties of hydroxypropylcellulose topical films produced by hot-melt extrusion.
PubMed: Physical-mechanical, moisture absorption and bioadhesive properties of hydroxypropylcellulose hot-melt extruded films.
PubMed: Influence of pharmacotechnical design on the interaction and availability of norfloxacin in directly compressed tablets with certain antacids.
PubMed: The antimicrobial activity of vancomycin in the presence and absence of sodium carboxymethyl starch.
PubMed: Polymers for sustained release formulations of dipyridamole-alginate microspheres and tabletted microspheres.
PubMed: Formulation factors affecting drug release from poly(lactic acid) (PLA) microcapsule tablets.
PubMed: Evaluation of fast disintegrants in terfenadine tablets containing a gas-evolving disintegrant.
PubMed: Development of diclofenac sodium controlled release solid dispersion powders and capsules by freeze drying technique using ethylcellulose and chitosan as carriers.
PubMed: Effect of Explotab on the tabletability of a poorly soluble drug.
PubMed: Identification of formulation and manufacturing variables that influence in vitro dissolution and in vivo bioavailability of propranolol hydrochloride tablets.
PubMed: Automated system for the on-line monitoring of powder blending processes using near-infrared spectroscopy. Part II. Qualitative approaches to blend evaluation.
PubMed: Dissolution difference between acidic and neutral media of acetaminophen tablets containing a super disintegrant and a soluble excipient. II.
PubMed: [Pharmaceutical technology of Tensiomin].
PubMed: Evaluation of in vitro release rate and in vivo absorption characteristics of four metoprolol tartrate immediate-release tablet formulations.
PubMed: The role of intra- and extragranular microcrystalline cellulose in tablet dissolution.
PubMed: A practical procedure for the cryopreservation of marrow cells intended for autotransplantation.
PubMed: The combined use of DSC and TGA for the thermal analysis of atenolol tablets.
PubMed: Effect of mode of incorporation of disintegrants on the characteristics of fluid-bed wet-granulated tablets.
PubMed: Effect of the mode of super disintegrant incorporation on dissolution in wet granulated tablets.
PubMed: Methods for the assessment of the stability of tablet disintegrants.
PubMed: Influence of the physicochemical properties and concentration of native and modified potato starch on the release of a hydrophobic drug from hard gelatin capsules.
PubMed: Effect of formulation solubility and hygroscopicity on disintegrant efficiency in tablets prepared by wet granulation, in terms of dissolution.
PubMed: [Tablet residues in gastrointestinal contents? A polarization microscopy screening method for rapid evaluation at the autopsy table].
PubMed: Effect of sodium bicarbonate and sodium starch glycolate on the in vivo disintegration of hard gelatin capsules--a radiological study in the dog.
PubMed: An evaluation of As-Di-Sol primojel and polyplasdone XL as adjuvants in antacid tablets.
PubMed: Effect of tablet solubility and hygroscopicity on disintegrant efficiency in direct compression tablets in terms of dissolution.
PubMed: Optimization of a formulation for direct compression using a simplex lattice design.
PubMed: The comparative investigation of the effect of Esma spreng fine Primojel and Polyplasdone XL on the disintegration time of direct compressed tablets.
PubMed: Drug-excipient interactions resulting from powder mixing. III: Solid state properties and their effect on drug dissolution.
PubMed: The investigation of the influence of Explotab on the disintegrations of tablets.
PubMed: Effect of molecular structure variation on the disintegrant action of sodium starch glycolate.
PubMed: Improvement by super disintegrants of the properties of tablets containing lactose, prepared by wet granulation.
PubMed: Interaction of tablet disintegrants and magnesium stearate during mixing I: Effect on tablet disintegration.
PubMed: Effect of storage at specified temperature and humidity on properties of three directly compressible tablet formulations.
PubMed: Effect of disintegrant type upon the relationship between compressional pressure and dissolution efficiency.
PubMed: Water-sorption properties of tablet disintegrants.
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