EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

polymixin B sulfate
aerosporin

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CAS Number: 1405-20-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:215-774-7
FDA UNII: 19371312D4
MDL:MFCD00131991
Molecular Weight:1189.36088000
Formula:C48 H84 N16 O17 S
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point:1611.00 °C. @ 760.00 mm Hg (est)
Flash Point:1703.00 °F. TCC ( 928.10 °C. ) (est)
logP (o/w): -6.361 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Polymyxin B sulfate >98%
Odor: characteristic
Use: Polymyxin B sulfate is obtained from Bacillus polymyxa and related species as a mixture of polymyxins B1 and B2. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B (sulfate) is a mixtu Gram-negative bacterial infections.
Glentham Life Sciences
Polymixin B sulfate salt
Penta International
POLYMYXIN-B-SULFATE USP
Santa Cruz Biotechnology
For experimental / research use only.
Polymyxin B Sulfate
Sigma-Aldrich
For experimental / research use only.
Polymyxin B Sulfate
pharmaceutical secondary standard; traceable to USP, PhEur, BP
Sinoway Industrial
For experimental / research use only.
polymyxin B sulphate
TCI AMERICA
For experimental / research use only.
Polymyxin B Sulfate
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LDLo 8 mg/kg
Investigative Urology. Vol. 6, Pg. 505, 1969.

intraperitoneal-mouse LD50 20500 ug(base)
Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960.

intravenous-mouse LD50 5400 ug(base)/
Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960.

oral-mouse LD50 790 mg(base)/k
Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960.

Dermal Toxicity:
subcutaneous-guinea pig LD50 58 mg/kg
Chemotherapy Vol. 16, Pg. 105, 1968.

subcutaneous-mouse LD50 59500 ug(base)
Antibiotics Annual. Vol. 7, Pg. 41, 1959/1960.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for polymixin B sulfate usage levels up to:
 not for fragrance use.
 
Recommendation for polymixin B sulfate flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3083708
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0001405205
RTECS:TR1150000 for cas# 1405-20-5
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):3083708
Pubchem (sid):135231011
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2941.90.5000
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
Wikipedia2:View2
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 aerosporin
 chloromyxin
 neobacimyx
 neosporin plus
 pediotic suspension
neo-polycin
 polymixin-b-sulfate
 polymyxin B sulfate
 polymyxin B sulphate
 polymyxin B, sulfate
 polymyxin B, sulfate (salt)
 polytrim
 

Articles:

PubMed:Identification and characterization of chlorpyrifos-methyl and 3,5,6-trichloro-2-pyridinol degrading Burkholderia sp. strain KR100.
PubMed:Simultaneous identification and quantitative determination of neomycin sulfate, polymixin B sulfate, zinc bacytracin and methyl and propyl hydroxybenzoates in ophthalmic ointment by TLC.
PubMed:Anaphylaxis caused by polymixin B sulfate and zinc bacitracin ointment.
PubMed:Intra-amygdala kinase inhibitors disrupt retention of a learned avoidance response in rats.
PubMed:Effect of antibiotics on motion characteristics of cooled stallion spermatozoa.
PubMed:Bacterial activation of human natural killer cells: role of cell surface lipopolysaccharide.
PubMed:Histamine H2-receptor mediated activation of neonatal rat brain ornithine decarboxylase in vivo.
PubMed:Use of a semen extender containing antibiotic to improve the fertility of a stallion with seminal vesiculitis due to Pseudomonas aeruginosa.
PubMed:Ca2+/diacylglycerol-activated, phospholipid-dependent protein kinase in the Hermissenda CNS.
PubMed:Effects of bacterial lipopolysaccharide on protein synthesis in murine peritoneal macrophages: relationship to activation for macrophage tumoricidal function.
PubMed:Interaction of wheat germ ca-dependent protein kinases with calmodulin antagonists and polyamines.
PubMed:Calcium/phosphatidylserine/diacylglycerol-dependent protein phosphorylation in the Aplysia nervous system.
PubMed:Prophylactic antibiotics in cataract surgery.
PubMed:Increased selectivity of Mitis-Salivarius agar containing polymyxin.
PubMed:Electron microscope observations on the effects of polymixin B sulfate on cell walls of Chlamydia psittaci.
 
Notes:
a mixture of polymyxins b1 and b2, obtained from bacillus polymyxa strains. they are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. polymyxin b is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.
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