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lidocaine hydrochloride
acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1)

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Name:2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride
CAS Number: 73-78-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-803-8
FDA UNII: EC2CNF7XFP
Beilstein Number:3917968
MDL:MFCD00150329
Molecular Weight:270.80251000
Formula:C14 H23 Cl N2 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 350.80 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000043 mmHg @ 25.00 °C. (est)
Flash Point: 331.00 °F. TCC ( 166.00 °C. ) (est)
logP (o/w): 2.359 (est)
Soluble in:
 water, 1473 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American International Chemical, LLC.
Lidocaine Hydrochloride USP
BOC Sciences
For experimental / research use only.
Lidocaine hydrochloride 98%
Odor: characteristic
Use: Lidocaine hydrochloride is the first amino amide type local anesthetic and antiarrhythmic drug, which has anti-inflammatory properties in vitro and in vivo. It was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. Lidocaine hydrochloride is used topically to relieve itching, burning and pain from skin inflammations,
Maypro Industries
Lidocaine HCl
Penta International
LIDOCAINE HYDROCHLORIDE ANHYDROUS USP
Santa Cruz Biotechnology
For experimental / research use only.
Lidocaine Hydrochloride ≥99%
Sigma-Aldrich
For experimental / research use only.
Lidocaine Hydrochloride
European Pharmacopoeia (EP) Reference Standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-child TDLo 60 mg/kg/1H
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Toxicology, Clinical Toxicology. Vol. 24, Pg. 51, 1986.

intravenous-dog LDLo 65700 ug/kg
Journal de Pharmacologie. Vol. 2, Pg. 240, 1971.

parenteral-frog LD50 159 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 289, Pg. 278, 1987.

intravenous-guinea pig LD50 24500 ug/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958.

intravenous-man TDLo 7143 ug/kg
CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP
Chest. Vol. 61, Pg. 682, 1972.

intravenous-man TDLo 9 mg/kg/4H-C
CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION
Drug Intelligence and Clinical Pharmacy. Vol. 19, Pg. 669, 1985.

intramuscular-mouse LD50 177 mg/kg
Drug Development Research. Vol. 21, Pg. 277, 1990.

intraperitoneal-mouse LD50 63 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 274, Pg. 253, 1985.

intravenous-mouse LD50 15 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Pharmacy and Pharmacology. Vol. 14, Pg. 48T, 1962.

oral-mouse LD50 220 mg/kg
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970.

intratracheal-rabbit LD50 28 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 200, Pg. 359, 1972.

intravenous-rabbit LD50 25600 ug/kg
Drugs in Japan Vol. 6, Pg. 879, 1982.

intraperitoneal-rat LD50 122 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 111, Pg. 224, 1954.

intravenous-rat LD50 21 mg/kg
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970.

Dermal Toxicity:
subcutaneous-mouse LD50 163 mg/kg
Proceedings of the Society for Experimental Biology and Medicine. Vol. 103, Pg. 353, 1960.

subcutaneous-rat LD50 570 mg/kg
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 299, 1970.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for lidocaine hydrochloride usage levels up to:
 not for fragrance use.
 
Recommendation for lidocaine hydrochloride flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):73-78-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6314
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride
Chemidplus:0000073789
RTECS:AN7700000 for cas# 73-78-9
 
References:
 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6314
Pubchem (sid):134972951
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D02086
HMDB (The Human Metabolome Database):Search
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, chloride, hydrogen salt (1:1)
 acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, hydrochloride (1:1)
 acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride
2',6'-acetoxylidide, 2-(diethylamino)-, hydrochloride
2',6'-acetoxylidide, 2-(diethylamino)-, monohydrochloride
 anestacon hydrochloride
a-diethylamino-2,6-acetoxylidine hydrochloride
2-diethylamino-2',6'-acetoxylidide hydrochloride
(diethylamino)-2',6'-acetoxylidide monohydrochloride
2-(diethylamino)-n-(2,6-dimethylphenyl)-acetamide hydrochloride
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide monohydrochloride
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide, hydrochloride (1:1)
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide;hydrochloride
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamidhydrochlorid
N-(diethylaminoacetyl)-2,6-dimethylaniline hydrochloride
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide hydrochloride
N-(2,6-dimethylphenyl)-N2,N2-diethylglycinamide hydrochloride
 duncaine hydrochloride
 gravocain hydrochloride
 isicaine hydrochloride
 leostesin hydrochloride
 lidocain hydrochloride
 lidocaine HCl
 lidothesin hydrochloride
 lignocaine hydrochloride
 linocaine hydrochloride
 metaclopramide hydrochloride
 rucaina hydrochloride
 xilina hydrochloride
 xycaine hydrochloride
 xylestesin hydrochloride
 xylocaine hydrochloride
 xylocaine MPF
 xylocitin hydrochloride
 xylotox hydrochloride
 

Articles:

PubMed:Study on patients who underwent suspected diagnosis of allergy to amide-type local anesthetic agents by the leukocyte migration test.
PubMed:Efficacy of articaine formulations: quantitative reviews.
PubMed:Evaluation of middle and distal esophageal diverticuli with transnasal esophagoscopy.
PubMed:Bi-hemispheric contribution to functional motor recovery of the affected forelimb following focal ischemic brain injury in rats.
PubMed:Local and regional anesthesia in ruminants and swine.
PubMed:Factors affecting the voluntary intake of food by sheep. 5. The inhibitory effect of hypertonicity in the rumen.
PubMed:Techniques of local analgesia in ruminants and swine.
PubMed:Stability of sterile aqueous lidocaine hydrochloride and epinephrine injections submitted by U.S. hospitals.
PubMed:Evaluation of preparations of patent blue (Alphazurine 2G) dye for parenteral use.
 
Notes:
a local anesthetic and cardiac depressant used as an antiarrhythmia agent. its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.
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