EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

dextromethorphan hydrobromide monohydrate
morphinan, 3-methoxy-17-methyl-, (9a,13a,14a)-, hydrobromide, hydrate (1:1:2)

Supplier Sponsors

CAS Number: 6700-34-1Picture of molecule3D/inchi
FDA UNII: 9D2RTI9KYH
Beilstein Number:6453793
MDL:MFCD02173901
Molecular Weight:388.34570000
Formula:C18 H30 Br N O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 543.80 °C. @ 760.00 mm Hg (est)
Flash Point: 541.00 °F. TCC ( 282.70 °C. ) (est)
logP (o/w): 1.351 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American International Chemical, LLC.
Dextromethorphan HBr
BOC Sciences
For experimental / research use only.
Dextromethorphan hydrobromide hydrate ≥98%
Odor: characteristic
Use: Dextromethorphan, a dextratrorotatory morphinan, is a non-competitive, low affinity NMDA receptor antagonist. Antitussive, anticonvulsive and neuroprotective agent.
Glentham Life Sciences
Dextromethorphan hydrobromide monohydrate
Maypro Industries
Dextromethorphan HBr
Penta International
DEXTROMETHORPHAN HYDROBROMIDE MONOHYDRATE
Sigma-Aldrich
For experimental / research use only.
Dextromethorphan Hydrobromide meets USP testing specifications
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for dextromethorphan hydrobromide monohydrate usage levels up to:
 not for fragrance use.
 
Recommendation for dextromethorphan hydrobromide monohydrate flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5462351
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
Chemidplus:0006700341
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5462351
Pubchem (sid):135022500
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D00848
HMDB (The Human Metabolome Database):HMDB01920
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 dextromethorphan hydrobromide
 drixoral cough
 endotussin-NN pediatric
(9a,13a,14a)-3-methoxy-17-methylmorphinan hydrobromide dihydrate
 morphinan, 3-methoxy-17-methyl-, (9a,13a,14a)-, hydrobromide, hydrate (1:1:2)
 pediacare 1
 robitussin cough calmers
 robitussin maximum strength cough
 robitussin pediatric cough
 SAM001247062
 st. joseph cough syrup
 tylenol cough liquid
 

Articles:

PubMed:Dextromethorphan/quinidine for the treatment of pseudobulbar affect.
PubMed:Pseudobulbar affect: prevalence and management.
PubMed:Selective inhibition of the cytochrome P450 isoform by hyperoside and its potent inhibition of CYP2D6.
PubMed:Effects of Ougan juice on P450 activities using a cocktail method.
PubMed:Randomized open-label drug-drug interaction trial of dextromethorphan/quinidine and paroxetine in healthy volunteers.
PubMed:Therapeutic options for acute cough due to upper respiratory infections in children.
PubMed:Suppressive effect of the ethanolic extract of adlay bran on cytochrome P-450 enzymes in rat liver and lungs.
PubMed:Advisers vote against declaring dextromethorphan a controlled substance.
PubMed:Ion mobility spectrometry for the rapid analysis of over-the-counter drugs and beverages.
PubMed:Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations.
PubMed:Postherpetic neuralgia.
PubMed:(13)C breath tests in personalized medicine: fiction or reality?
PubMed:Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: multidisciplinary care, symptom management, and cognitive/behavioral impairment (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.
PubMed:Involuntary emotional expression disorder in Alzheimer's disease - psychopharmacotherapy aspects.
PubMed:Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles.
PubMed:Overdose in infant caused by over-the-counter cough medicine.
PubMed:Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design.
PubMed:Dextromethorphan/quinidine sulfate for pseudobulbar affect.
PubMed:Central mechanisms IV: conscious control of cough and the placebo effect.
PubMed:Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants.
PubMed:Complementary DNA cloning, functional expression and characterization of a novel cytochrome P450, CYP2D50, from equine liver.
PubMed:Cough and cold medication use by US children, 1999-2006: results from the slone survey.
PubMed:Unexpected infant deaths associated with use of cough and cold medications.
PubMed:The causes and treatment of pseudobulbar affect in ischemic stroke.
PubMed:The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes.
PubMed:The effect of dextromethorphan in preventing cholecalciferol-induced poison shyness and sickness-induced anorexia in the laboratory Norway rat.
PubMed:FDA halts sales of some anti-vomiting suppositories...and are cough medications effective in children?
PubMed:Involuntary emotional expression disorder: treating the untreated.
PubMed:Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers.
PubMed:A real reason for patients with pseudobulbar affect to smile.
PubMed:Postherpetic neuralgia.
PubMed:Effects of dextromethorphan on rats' acquisition of responding with delayed reinforcement.
PubMed:Review of pseudobulbar affect including a novel and potential therapy.
PubMed:Bitterness suppression with zinc sulfate and na-cyclamate: a model of combined peripheral and central neural approaches to flavor modification.
PubMed:Dextromethorphan-induced delirium and possible methadone interaction.
PubMed:Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats.
PubMed:Fast screening method for the analysis of total flavonoid content in plants and foodstuffs by high-performance liquid chromatography/electrospray ionization time-of-flight mass spectrometry with polarity switching.
PubMed:Down-regulation of hepatic CYP3A in chronic renal insufficiency.
PubMed:Clinical pharmacokinetics of linezolid, a novel oxazolidinone antibacterial.
PubMed:Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers.
PubMed:Dietary levels of quinine in tonic water do not inhibit CYP2D6 in vivo.
PubMed:Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions.
PubMed:Clinical pharmacokinetics of tegaserod, a serotonin 5-HT(4) receptor partial agonist with promotile activity.
PubMed:The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein.
PubMed:Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine.
PubMed:Cardiovascular sympathomimetic amine interactions in rats treated with monoamine oxidase inhibitors and the novel oxazolidinone antibiotic linezolid.
PubMed:Cytochrome P450 expression and related metabolism in human buccal mucosa.
PubMed:Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression.
PubMed:Phencyclidine-induced discriminative stimulus is mediated via phencyclidine binding sites on the N-methyl-D-aspartate receptor-ion channel complex, not via sigma(1) receptors.
PubMed:Dextromethorphan alters methamphetamine self-administration in the rat.
PubMed:Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
PubMed:MorphiDex pharmacokinetic studies and single-dose analgesic efficacy studies in patients with postoperative pain.
PubMed:Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase.
PubMed:Evaluation of the reinforcing properties and phencyclidine-like discriminative stimulus effects of dextromethorphan and dextrorphan in rats and rhesus monkeys.
PubMed:[Non-ketotic hyperglycinemia: clinical and therapeutic course in three patients].
PubMed:The stimulus properties of two common over-the-counter drug mixtures: dextromethorphan + ephedrine and dextromethorphan + diphenhydramine.
PubMed:A massive outbreak of food poisoning--a reminder of the importance of proper toxic waste control.
PubMed:Discriminative stimulus properties of dextromethorphan in rats.
PubMed:Hazards of nonprescription medications.
PubMed:Pharmacological specificity of the discriminative stimulus properties of 2-amino-4,5-(1,2-cyclohexyl)-7-phosphono-heptanoic acid (NPC 12626), a competitive N-methyl-D-aspartate receptor antagonist.
PubMed:Polymorphisms in oxidative drug metabolism: relationship to food preference.
PubMed:Subsensitivity to the cough-depressant effects of opioid and nonopioid antitussives in morphine-dependent rats: relationship to central serotonin function.
PubMed:Discriminative stimulus effects of dextrorphan in pigeons.
PubMed:Discriminative stimulus effects of pentobarbital in rhesus monkeys: tests of stimulus generalization and duration of action.
 
Notes:
None found
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