Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | colorless to pale yellow clear liquid (est) |
Assay: | 95.00 to 100.00
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Food Chemicals Codex Listed: | No |
Boiling Point: | 171.60 °C. @ 760.00 mm Hg
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Soluble in: |
| water, 3.12E+04 mg/L @ 26C (exp) |
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | natural substances and extractives |
Recommendation for 2,3,6-trimethyl pyridine usage levels up to: | | not for fragrance use.
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Recommendation for 2,3,6-trimethyl pyridine flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
2,3,6- | collidine | | pyridine, 2,3,6-trimethyl- | 2,3,6- | trimethylpyridine |
Articles:
PubMed:NMR study of CHN hydrogen bond and proton transfer in 1,1-dinitroethane complex with 2,4,6-trimethylpyridine. |
PubMed:Synthesis, antibacterial and antifungal evaluation of novel 1,4-dihydropyridine derivatives. |
PubMed:Grafting of a novel gold(III) complex on nanoporous MCM-41 and evaluation of its toxicity in Saccharomyces cerevisiae. |
PubMed:Intrinsic proton-donating power of zinc-bound water in a carbonic anhydrase active site model estimated by NMR. |
PubMed:[Determination of 2-acetyl-1-pyrroline in aroma rice using gas chromatography-mass spectrometry]. |
PubMed:Structural correlations for (1)H, (13)C and (15)N NMR coordination shifts in Au(III), Pd(II) and Pt(II) chloride complexes with lutidines and collidine. |
PubMed:Syntheses, structures and spectroscopy of uni- and bi-dentate nitrogen base complexes of silver(I) trifluoromethanesulfonate. |
PubMed:Noncovalent synthesis of hierarchical zinc phosphates from a single Zn(4)O(12)P(4) double-four-ring building block: dimensionality control through the choice of auxiliary ligands. |
PubMed:Synthesis and characterization of new Pd(II) complexes of L-ethylphenylalanate. |
PubMed:Shape and electrostatic effects in optical Kerr effect spectroscopy of aromatic liquids. |
PubMed:Heterocyclic compounds: toxic effects using algae, daphnids, and the Salmonella/microsome test taking methodical quantitative aspects into account. |
PubMed:Nuclear magnetic resonance and ab initio studies of small complexes formed between water and pyridine derivatives in solid and liquid phases. |
PubMed:Characterizing hydrogen bonding and proton transfer in 2:1 FH:NH3 and FH:collidine complexes through one- and two-bond spin-spin coupling constants across hydrogen bonds. |
PubMed:pH of solution greatly affects sorption of ionizable compounds into low-density polyethylene film. |
PubMed:Synthesis of 1,3,5-trisubstituted hydantoins by regiospecific domino condensation/aza-Michael/O-->N acyl migration of carbodiimides with activated alpha,beta-unsaturated carboxylic acids. |
PubMed:Adsorption mechanism of substituted pyridines on silica suspensions: an NMR study. |
PubMed:Monomeric, tetrameric, and polymeric copper di-tert-butyl phosphate complexes containing pyridine ancillary ligands. |
PubMed:Low-temperature NMR studies of the structure and dynamics of a novel series of acid-base complexes of HF with collidine exhibiting scalar couplings across hydrogen bonds. |
PubMed:Practical protocols for stepwise solid-phase synthesis of cysteine-containing peptides. |
PubMed:Isolation of regioisomers of N-alkylprotoporphyrin IX from chick embryo liver after treatment with porphyrinogenic xenobiotics. |
PubMed:The 1,2,4-triazolyl cation: thermolytic and photolytic studies. |
PubMed:An improved procedure for N- to C-directed (Inverse) solid-phase peptide synthesis. |
PubMed:The ether lipid ET-18-OCH3 increases cytosolic Ca2+ concentrations in Madin Darby canine kidney cells. |
PubMed:Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal. |
PubMed:Occurrence and Minimization of Cysteine Racemization during Stepwise Solid-Phase Peptide Synthesis(1)(,)(2). |
PubMed:Synthesis of the methyl alpha-glycosides of a di-, tri-, and a tetra-saccharide fragment mimicking the terminus of the O-polysaccharide of Vibrio cholerae O:1, serotype Ogawa. |
PubMed:Evidence for mechanism-based inactivation of rat and chick embryo hepatic cytochrome P4501A and P4503A by dihydropyridines, sydnones, and dihydroquinolines. |
PubMed:Mechanism-based inactivation of hepatic cytochrome P450 2C6 and P450 3A1 following in vivo administration of 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-ethylpyridine to rats: differences from previously observed in vitro results. |
PubMed:Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures. |
PubMed:Inactivation of cytochrome P450 and inhibition of ferrochelatase by analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine with 4-nonyl and 4-dodecyl substituents. |
PubMed:Inhibition of chick embryo hepatic uroporphyrinogen decarboxylase by components of xenobiotic-treated chick embryo hepatocytes in culture. II. |
PubMed:Synthesis and characterization of 6-O-beta-lactosyl-alpha,beta-D-mannopyranoses and 2,6-di-O-beta-lactosyl-alpha,beta-D-mannopyranoses. |
PubMed:Inactivation of rat liver microsomal steroid hydroxylations by 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine: evidence for selectivity among steroid-inducible cytochrome P450IIIA forms. |
PubMed:Irreversible binding of heme to microsomal protein during inactivation of cytochrome P450 by 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine. |
PubMed:Effects of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on hepatic cytochrome P-450 heme, apoproteins, and catalytic activities following in vivo administration to rats. |
PubMed:Synergistic induction of delta-aminolevulinic acid synthase activity by N-ethylprotoporphyrin IX and 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-isobutylpyridine . |
PubMed:Effects of a series of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on the major inducible cytochrome P-450 isozymes of rat liver. |
PubMed:Systematic chemical synthesis and n.m.r. spectra of methyl alpha-glycosides of isomalto-oligosaccharides and related compounds. |
PubMed:Synthesis of 4-methoxy-2,3,5-trimethylpyridine: a specific building block for compounds with gastric-acid inhibiting activity. |
PubMed:Disruption of hepatic heme biosynthesis after interaction of xenobiotics with cytochrome P-450. |
PubMed:Differential inhibition of hepatic ferrochelatase by regioisomers of N-butyl-, N-pentyl-, N-hexyl-, and N-isobutylprotoporphyrin IX. |
PubMed:Synthesis of methyl 6''-deoxy-6'-fluoro-alpha-isomaltoside and of the corresponding trisaccharide. |
PubMed:Xenobiotic mediated inhibition of hepatic uroporphyrinogen decarboxylase activity in 17-day-old chick embryo liver cells in culture. |
PubMed:Effect of collidine (2,4,6-trimethylpyridine) on rat pineal gland and vas deferens nerves. Further evidence for a monoamine-releasing effect. |
PubMed:Isolation of an N-alkylprotoporphyrin IX from chick embryo livers following the administration of 3,5-diethoxycarbonyl-1,4-dihydro-4-ethyl-2,6-dimethylpyridine. |
PubMed:The 1986 Upjohn award lecture. Interaction of chemicals with hemoproteins: implications for the mechanism of action of porphyrinogenic drugs and nitroglycerin. |
PubMed:Ferrochelatase-inhibitory activity and N-alkylprotoporphyrin formation with analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) containing extended 4-alkyl groups: implications for the active site of ferrochelatase. |
PubMed:Comparison of the effects of 3-ethoxycarbonyl-1,4-dihydro-2,4-dimethylpyridine and 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on ferrochelatase activity and heme biosynthesis in chick embryo liver cells in culture. |
PubMed:Chemical synthesis of the human Pk-antigenic determinant. |
PubMed:Suicidal destruction of cytochrome P-450 and reduction of ferrochelatase activity by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells. |
PubMed:Ferrochelatase and N-alkylated porphyrins. |
PubMed:Synthesis of methyl 3-O- and 2-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-alpha D-galactopyranoside. |
PubMed:Chemical synthesis of the human blood-group P1-antigenic determinant. |
PubMed:Patterns of porphyrin accumulation in response to chemicals in chick embryo liver cells. |
PubMed:Investigation of the membrane-fluidizing properties of porphyrin-inducing drugs. |
PubMed:Inhibition of ferrochelatase by N-methylprotoporphyrin IX is not accompanied by delta-aminolevulinic acid synthetase induction in chick embryo liver cell culture. |
PubMed:Effects of porphyrin-inducing drugs on ferrochelatase activity in isolated mouse hepatocytes. |
PubMed:Ferrochelatase-inhibitory and porphyrin-inducing properties of 3,5-diethoxycarbonyl-1, 4-dihydro-2,4,6-trimethylpyridine and its analogues in chick embryo liver cells. |
PubMed:Comparison of the effects of griseofulvin and 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on ferrochelatase activity in chick embryo liver. |
PubMed:Drug-induced porphyrin biosynthesis--XIX. Potentiation of the porphyrin-inducing effects of SKF 525-A in the chick embryo liver by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine, an antihibitor of ferrochelatase. |
PubMed:Ascorbic acid and cytochrome P-450. |
PubMed:[Free protoporphyrin in murine and rat erythrocytes. Study of experimental porphyrias induced through the administration of griseofulvin to mice and 3,5 diethoxycarbonyl-1,4 dihydro-2,4,6 trimethylpyridine (DDC) to rats]. |
PubMed:Properties of 5-aminolaevulinate synthetase and its relationship to microsomal mixed-function oxidation in the southern armyworm (Spodoptera eridania). |
PubMed:Porphyria-inducing activity of a series of pyridine and dihydropyridine compounds. Investigation in a cell culture system. |
PubMed:[EXPERIMENTAL PROPHYRIA INDUCED IN THE WHITE RAT BY DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE-3,5-DICARBOXYLATE. INHIBITORY ACTION OF INOSINE ON THE EXAGGERATED PORPHYRINOGENESIS]. |
PubMed:Effects of diethyl-1, 4-dihydro-2, 4,6-trimethylpyridine-3,5-dicarboxylate on the metabolism of porphyrins and iron. |
PubMed:Experimental hepatic porphyria caused by feeding 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine. Comparison with sedormid porphyria. |
PubMed:Porphyria induced in the rabbit by diethyl 1,4-dihydro-2,4,6-trimethylpyridine-3,5-dicarboxylate. I. Excretion of 5-aminolaevulic acid, porphobilinogen, coproporphyrin and protoporphyrin. |
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