EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

L-ascorbyl stearate
6-(stearoyloxy)-L-ascorbic acid

Supplier Sponsors

Name:[(2S)-2-[(2R)-3,4-dihydroxy-5-oxo-2H-furan-2-yl]-2-hydroxyethyl] octadecanoate
CAS Number: 10605-09-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:234-231-5
FDA UNII: 7Z1QT341US
Nikkaji Web:J227.029C
XlogP3-AA:7.30 (est)
Molecular Weight:442.59314000
Formula:C24 H42 O7
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:indirect food additives: adhesives and components of coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Google Patents:Search
US Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
DG SANTE Food Contact Materials:L-ascorbyl stearate
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.005839 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
6-o-stearylascorbic acid 95%
Santa Cruz Biotechnology
For experimental / research use only.
6-O-Stearoyl-L-ascorbic Acid
Sigma-Aldrich
For experimental / research use only.
L-Ascorbic acid 6-stearate analytical reference material
TCI AMERICA
For experimental / research use only.
6-O-Stearoyl-L-ascorbic Acid >95.0%(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 25070 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 10, Pg. 1, 1963.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
indirect food additives: adhesives and components of coatings
Recommendation for L-ascorbyl stearate usage levels up to:
 not for fragrance use.
 
Recommendation for L-ascorbyl stearate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :54725318
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
[(2S)-2-[(2R)-3,4-dihydroxy-5-oxo-2H-furan-2-yl]-2-hydroxyethyl] octadecanoate
Chemidplus:0010605091
 
References:
 [(2S)-2-[(2R)-3,4-dihydroxy-5-oxo-2H-furan-2-yl]-2-hydroxyethyl] octadecanoate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):54725318
Pubchem (sid):134991129
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEMBL:View
KEGG (GenomeNet):C20340
HMDB (The Human Metabolome Database):HMDB38242
FooDB:FDB017534
ChemSpider:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
L-ascorbic acid, 6-stearate
L-ascorbol stearate
[(2S)-2-[(2R)-3,4-dihydroxy-5-oxo-2H-furan-2-yl]-2-hydroxyethyl] octadecanoate
6-(stearoyloxy)-L-ascorbic acid
6-O-stearylascorbic acid
 vitamin C monostearate
 

Articles:

PubMed:Ascorbyl Stearate Promotes Apoptosis Through Intrinsic Mitochondrial Pathway in HeLa Cancer Cells.
PubMed:Spray Drying of Rhodomyrtus tomentosa (Ait.) Hassk. Flavonoids Extract: Optimization and Physicochemical, Morphological, and Antioxidant Properties.
PubMed:Metabolism in orange fruits is driven by photooxidative stress in the leaves.
PubMed:Targeted antitumoral dehydrocrotonin nanoparticles with L-ascorbic acid 6-stearate.
PubMed:P53 enhances ascorbyl stearate-induced G2/M arrest of human ovarian cancer cells.
PubMed:Production of ascorbyl palmitate by surfactant-coated lipase in organic media.
PubMed:Ascorbyl stearate inhibits cell proliferation and tumor growth in human ovarian carcinoma cells by targeting the PI3K/AKT pathway.
PubMed:Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics.
PubMed:L-ascorbic acid microencapsulated with polyacylglycerol monostearate for milk fortification.
PubMed:The microencapsulated ascorbic acid release in vitro and its effect on iron bioavailability.
PubMed:Vitamin C in human health and disease is still a mystery? An overview.
PubMed:Antiproliferative and proapoptotic effect of ascorbyl stearate in human pancreatic cancer cells: association with decreased expression of insulin-like growth factor 1 receptor.
PubMed:Antiproliferative and apoptotic effect of ascorbyl stearate in human glioblastoma multiforme cells: modulation of insulin-like growth factor-I receptor (IGF-IR) expression.
PubMed:A kinetic study of the synthesis of ascorbate fatty acid esters catalysed by immobilized lipase in organic media.
PubMed:Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands.
PubMed:Mixtures of Ascorbyl-stearate and Vitamin D3: A Monolayer Study at the Gas/Water Interface
PubMed:Inhibition of human glioma cell proliferation and glutathione S-transferase by ascorbyl esters and interferon.
PubMed:Inhibition of cell proliferation and glutathione S-transferase by ascorbyl esters and interferon in mouse glioma.
PubMed:Carbon tetrachloride-induced alterations in hepatic glutathione and ascorbic acid contents in mice fed a diet containing ascorbate esters.
PubMed:Inhibition of human term placental and fetal liver glutathione-S-transferases by fatty acids and fatty acid esters.
PubMed:Effect of ascorbic acid esters on hepatic glutathione levels in mice treated with a hepatotoxic dose of acetaminophen.
PubMed:Influence of ascorbic acid esters on acetaminophen-induced hepatotoxicity in mice.
PubMed:Absence of promotion potential for calcium L-ascorbate, L-ascorbic dipalmitate, L-ascorbic stearate and erythorbic acid on rat urinary bladder carcinogenesis.
PubMed:Mechanical properties, dissolution behavior and stability to oxidation of L-ascorbylmonostearate microcapsules prepared by a spray-drying polycondensation technique.
 
Notes:
Preservative for margarine Ascorbyl stearate (C24H42O7) is an ester formed from ascorbic acid and stearic acid. In addition to its use as a source of vitamin C, it is used as an antioxidant food additive in margarine (E number E305). The USDA limits its use to 0.02% individually or in conjunction with other antioxidants.
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