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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 394.00 to 395.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 336.00 °F. TCC ( 168.60 °C. ) (est)
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| logP (o/w): | 2.911 (est) |
| Soluble in: |
| | water, 240.3 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for 4-hydroxychalcone usage levels up to: | | | not for fragrance use.
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| Recommendation for 4-hydroxychalcone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4- | hydroxy chalcone | | 4- | hydroxybenzylidene acetophenone | | 3-(4- | hydroxyphenyl)-1-phenyl-2-propen-1-one | | 3-(4- | hydroxyphenyl)-1-phenylprop-2-en-1-one | | 3.2- | propen-1-one, 3-(4-hydroxyphenyl)-1-phenyl- |
Articles:
| PubMed:4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. |
| PubMed:Effect of TSHAC on human cytochrome P450 activity, and transport mediated by P-glycoprotein. |
| PubMed:Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics. |
| PubMed:Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. |
| PubMed:Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation. |
| PubMed:The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. |
| PubMed:Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1). |
| PubMed:Differential inhibition of transmembrane 4 L six family member 5 (TM4SF5)-mediated tumorigenesis by TSAHC and sorafenib. |
| PubMed:4'-Acetoamido-4-hydroxychalcone, a chalcone derivative, inhibits glioma growth and invasion through regulation of the tropomyosin 1 gene. |
| PubMed:PPARα activation by culinary herbs and spices. |
| PubMed:Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone. |
| PubMed:Blockade of four-transmembrane L6 family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative. |
| PubMed:Cytotoxic activity of 4'-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I. |
| PubMed:New prenylchalcones from the hops of Humulus lupulus. |
| PubMed:Sulfonate chalcone as new class voltage-dependent K+ channel blocker. |
| PubMed:Comparison of the effects of selected chalcones, dihydrochalcones and some cyclic flavonoids on mitochondrial outer membrane determined by fluorescence spectroscopy. |
| PubMed:A LC-MS/MS method to quantify the novel cholesterol lowering drug ezetimibe in human serum, urine and feces in healthy subjects genotyped for SLCO1B1. |
| PubMed:Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites. |
| PubMed:The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase. |
| PubMed:Chalcones as potent tyrosinase inhibitors: the importance of a 2,4-substituted resorcinol moiety. |
| PubMed:Hydroxychalcones exhibit differential effects on XRE transactivation. |
| PubMed:Chalcones as potent tyrosinase inhibitors: the effect of hydroxyl positions and numbers. |
| PubMed:Chalcones: structural requirements for antioxidant, estrogenic and antiproliferative activities. |
| PubMed:Electron ionization induced fragmentation of 4-hydroxychalcone derivatives. |
| PubMed:Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities. |
| PubMed:Inhibition of glutathione reductase by plant polyphenols. |
| PubMed:The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction. |
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3D/inchi