EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

4'-hydroxychalcone
2-propen-1-one, 1-(4-hydroxyphenyl)-3-phenyl- (9CI)

Supplier Sponsors

Name:1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one
CAS Number: 2657-25-2Picture of molecule3D/inchi
FDA UNII: Search
MDL:MFCD00016484
XlogP3:2.70 (est)
Molecular Weight:224.25904000
Formula:C15 H12 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 419.60 °C. @ 760.00 mm Hg (est)
Flash Point: 354.00 °F. TCC ( 179.10 °C. ) (est)
logP (o/w): 3.650 (est)
Soluble in:
 water, 240.3 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
4'-Hydroxychalcone 97%
BOC Sciences
For experimental / research use only.
4'-Hydroxychalcone >95.0%(GC)
ExtraSynthese
For experimental / research use only.
4'-Hydroxychalcone (HPLC) ≥95%
Matrix Scientific
For experimental / research use only.
4'-Hydroxychalcone, 97%
sds
TCI AMERICA
For experimental / research use only.
4'-Hydroxychalcone >95.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for 4'-hydroxychalcone usage levels up to:
 not for fragrance use.
 
Recommendation for 4'-hydroxychalcone flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :94240
National Institute of Allergy and Infectious Diseases:Data
1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one
Chemidplus:0002657252
 
References:
 1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):94240
Pubchem (sid):135049878
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2914.50.3000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 chalcone, 4'-hydroxy- (8CI)
1-(4-hydroxyphenyl)-3-phenyl-2-propen-1-one
1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one
2-propen-1-one, 1-(4-hydroxyphenyl)-3-phenyl- (9CI)
 

Articles:

PubMed:Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation.
PubMed:The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition.
PubMed:Cytotoxic activity of 4'-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I.
PubMed:Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites.
PubMed:Chalcones as potent tyrosinase inhibitors: the importance of a 2,4-substituted resorcinol moiety.
PubMed:Chalcones: structural requirements for antioxidant, estrogenic and antiproliferative activities.
PubMed:Inhibition of glutathione reductase by plant polyphenols.
PubMed:The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction.
 
Notes:
inhibits tnfalpha-induced nf-?b activation.
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