EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

colforsin
7-beta-acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11-one

Supplier Sponsors

Name:[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]acetate
CAS Number: 66575-29-9Picture of molecule3D/inchi
Other(deleted CASRN):64657-11-0
ECHA EINECS - REACH Pre-Reg:266-410-9
FDA UNII: 1F7A44V6OU
Nikkaji Web:J22.273I
Beilstein Number:4300863
MDL:MFCD00082317
XlogP3-AA:1.00 (est)
Molecular Weight:410.50738000
Formula:C22 H34 O7
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 230.00 to 232.00 °C. @ 760.00 mm Hg
Boiling Point: 519.87 °C. @ 760.00 mm Hg (est)
Flash Point: 341.00 °F. TCC ( 171.80 °C. ) (est)
logP (o/w): 2.406 (est)
Soluble in:
 water, 72.38 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Forskolin 98%
BOC Sciences
For experimental / research use only.
Forskolin
ExtraSynthese
For experimental / research use only.
Forskolin
Glentham Life Sciences
Forskolin
Sabinsa Corporation
Forskolin 1% eye drops
Santa Cruz Biotechnology
For experimental / research use only.
Forskolin ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Forskolin from Coleus forskohlii, ≥98% (HPLC), powder
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 68 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Ethnopharmacology. Vol. 3, Pg. 1, 1981.

oral-mouse LD50 3100 mg/kg
Medicinal Research Reviews. Vol. 3, Pg. 201, 1983.

intraperitoneal-rat LD50 92 mg/kg
Journal of Medicinal Chemistry. Vol. 31, Pg. 1872, 1988.

oral-rat LD50 2550 mg/kg
Medicinal Research Reviews. Vol. 3, Pg. 201, 1983.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for colforsin usage levels up to:
 not for fragrance use.
 
Recommendation for colforsin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :47936
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]acetate
Chemidplus:0066428895
RTECS:QL6150000 for cas# 66575-29-9
 
References:
 [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]acetate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):47936
Pubchem (sid):135007682
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C09076
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
7-beta-acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11-one
(3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))-5-(acetyl oxy)-3-ethenyl dodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho(2,1-b)pyran-1-one
 coleonol
 colforsine
 colforsinum
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1H-naphtho(2,1-b)pyran-1-one 5-acetate
[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]acetate
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate
 forskolin
1H-naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate
 

Articles:

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PubMed:cAMP protects acute promyelocytic leukemia cells from arsenic trioxide-induced caspase-3 activation and apoptosis.
PubMed:Exercise-mimicking treatment fails to increase Fndc5 mRNA & irisin secretion in primary human myotubes.
PubMed:Activation of Bombyx neuropeptide G protein-coupled receptor A4 via a Gαi-dependent signaling pathway by direct interaction with neuropeptide F from silkworm, Bombyx mori.
PubMed:CB2 cannabinoid receptor is a novel target for third-generation selective estrogen receptor modulators bazedoxifene and lasofoxifene.
PubMed:Glucose transport by epithelia prepared from harvested enterocytes.
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PubMed:Rooibos influences glucocorticoid levels and steroid ratios in vivo and in vitro: a natural approach in the management of stress and metabolic disorders?
PubMed:Acute up-regulation of the rat brain somatostatin receptor-effector system by leptin is related to activation of insulin signaling and may counteract central leptin actions.
PubMed:Transepithelial transports of rare sugar D-psicose in human intestine.
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PubMed:E. coli heat labile toxin (LT) inactivation by specific polyphenols is aggregation dependent.
PubMed:Xenin-25 increases cytosolic free calcium levels and acetylcholine release from a subset of myenteric neurons.
PubMed:The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice.
PubMed:Screening for modulatory effects on steroidogenesis using the human H295R adrenocortical cell line: a metabolomics approach.
PubMed:Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy.
PubMed:Dietary Coleus forskohlii extract generates dose-related hepatotoxicity in mice.
PubMed:Inhibitory effect of luteolin on the odorant-induced cAMP level in HEK293 cells expressing the olfactory receptor.
PubMed:Role of the 1,25D3-MARRS receptor in the 1,25(OH)2D3-stimulated uptake of calcium and phosphate in intestinal cells.
PubMed:Quercetin induces rapid eNOS phosphorylation and vasodilation by an Akt-independent and PKA-dependent mechanism.
PubMed:Liver X receptor α is involved in the transcriptional regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.
PubMed:Intestinal cell phosphate uptake and the targeted knockout of the 1,25D3-MARRS receptor/PDIA3/ERp57.
PubMed:Lantana macrophylla Schauer (Verbenaceae) ethanolic extract induces activation of ERK1/2 and p38 MAPKs pathway and Ca2+ imbalance in human trophoblasts derived cell lines.
PubMed:Coleus forskohlii extract induces hepatic cytochrome P450 enzymes in mice.
PubMed:Effects of mixtures of persistent organic pollutants (POPs) derived from cod liver oil on H295R steroidogenesis.
PubMed:Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist.
PubMed:Oral administration of an association of forskolin, rutin and vitamins B1 and B2 potentiates the hypotonising effects of pharmacological treatments in POAG patients.
PubMed:Adaptation of intestinal secretomotor function and nutrient absorption in response to diet-induced obesity.
PubMed:Novel selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models.
PubMed:Sarcopoterium spinosum extract as an antidiabetic agent: in vitro and in vivo study.
PubMed:Modulation of acute steroidogenesis, peroxisome proliferator-activated receptors and CYP3A/PXR in salmon interrenal tissues by tributyltin and the second messenger activator, forskolin.
PubMed:Activation of the cAMP/CREB/inducible cAMP early repressor pathway suppresses andrographolide-induced gene expression of the pi class of glutathione S-transferase in rat primary hepatocytes.
PubMed:A riot of rhythms: neuronal and glial circadian oscillators in the mediobasal hypothalamus.
PubMed:Induction of cells differentiation and ABC transporters expression by a myco-estrogen, zearalenone, in human choriocarcinoma cell line (BeWo).
PubMed:Effects of chromium(III) picolinate on cortisol and DHEAs secretion in H295R human adrenocortical cells.
PubMed:Forskolin decreases phosphorylation of histone H2AX in human cells induced by ionizing radiation.
PubMed:Listeriolysin O affects barrier function and induces chloride secretion in HT-29/B6 colon epithelial cells.
PubMed:Characterization and regulation of basal calcium influx in human peripheral blood lymphocytes.
PubMed:Membrane receptor-initiated signaling in 1,25(OH)2D3-stimulated calcium uptake in intestinal epithelial cells.
PubMed:Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist.
PubMed:Changed sensitivity of adenylate cyclase signaling system to biogenic amines and peptide hormones in tissues of starving rats.
PubMed:Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents.
PubMed:pH stat studies on bicarbonate secretion in the isolated mouse ileum.
PubMed:The antilipolytic action of bis(alpha-furancarboxylato)oxovanadium(IV) in adipocytes.
PubMed:A neutral CB1 receptor antagonist reduces weight gain in rat.
PubMed:Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6.
PubMed:Effects of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) hull extracts on the secretion of progesterone and estradiol in vivo and in vitro.
PubMed:Cloning and activation of the bullfrog apelin receptor: Gi/o coupling and high affinity for [Pro1]apelin-13.
PubMed:Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons.
PubMed:Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents.
PubMed:Effects of adenosine monophosphate-activated kinase activators on bovine oocyte nuclear maturation in vitro.
PubMed:Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".
PubMed:In vivo and in vitro effects of tea extracts on enterotoxigenic Escherichia coli-induced intestinal fluid loss in animal models.
PubMed:Effects of crude adlay hull acetone extract on corticosterone release from rat zona fasciculata-reticularis cells.
PubMed:Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production.
PubMed:The H295R system for evaluation of endocrine-disrupting effects.
PubMed:Molecules involved in the modulation of rapid cell death in Xanthomonas.
PubMed:A vitamin A-free diet results in impairment of the rat hippocampal somatostatinergic system.
PubMed:Benzo[a]pyrene impairs beta-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice. A novel molecular mechanism of toxicity for a common food pollutant.
PubMed:Suppression of food intake and food-reinforced behavior produced by the novel CB1 receptor antagonist/inverse agonist AM 1387.
PubMed:The regulatory mechanism of Tremella mesenterica on steroidogenesis in MA-10 mouse Leydig tumor cells.
PubMed:Development and optimization of a Q-RT PCR method to quantify CYP19 mRNA expression in testis of male adult Xenopus laevis: comparisons with aromatase enzyme activity.
PubMed:Effects of culture media and energy sources on the inhibition of nuclear maturation in bovine oocytes.
PubMed:Downregulation of progesterone biosynthesis in rat granulosa cells by adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) bran extracts.
PubMed:Body fat-lowering effect of conjugated linoleic acid is not due to increased lipolysis.
PubMed:Aryl hydrocarbon receptor activation by cAMP vs. dioxin: divergent signaling pathways.
PubMed:Cloning, characterization and expression of the D2 dopamine receptor from the tilapia pituitary.
PubMed:Effects of Coleus forskohlii on fat storage in ovariectomized rats.
PubMed:PGE/cAMP and GM-CSF synergise to induce a pro-tolerance cytokine profile in monocytic cell lines.
PubMed:Cobalt complex with GnRH stimulates the LH release and PKA signaling pathway in pig anterior pituitary cells in vitro.
PubMed:Similarities and differences in the transcriptional regulation of the leptin gene promoter in gastric and adipose cells.
PubMed:Synthesis of new benzoxazinone derivatives as neuropeptide Y5 antagonists for the treatment of obesity.
PubMed:Regulatory mechanism of Toona sinensis on mouse leydig cell steroidogenesis.
PubMed:Short-term fasting and lipolytic activity in rat adipocytes.
PubMed:Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants.
PubMed:SR147778 [5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a new potent and selective antagonist of the CB1 cannabinoid receptor: biochemical and pharmacological characterization.
PubMed:Effects of the mycotoxins alpha- and beta-zearalenol on regulation of progesterone synthesis in cultured granulosa cells from porcine ovaries.
PubMed:Role of p38 MAPK in lupeol-induced B16 2F2 mouse melanoma cell differentiation.
PubMed:Direct, rapid effects of 25-hydroxyvitamin D3 on isolated intestinal cells.
PubMed:Cyclic AMP response element-binding (CREB)-like proteins in a molluscan brain: cellular localization and learning-induced phosphorylation.
PubMed:Evidence of increased dopamine receptor signaling in food-restricted rats.
PubMed:Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization.
PubMed:In vitro potassium transport in the mouse small intestine.
PubMed:Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway.
PubMed:1,25(OH)2D3-mediated phosphate uptake in isolated chick intestinal cells: effect of 24,25(OH)2D3, signal transduction activators, and age.
PubMed:Effects of fasting on corticosterone production by zona fasciculata-reticularis cells in ovariectomized rats.
PubMed:T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist.
PubMed:Seasonal differences in progesterone production by luteinized bovine thecal and granulosa cells.
PubMed:Dihydropyridine neuropeptide Y Y(1) receptor antagonists.
PubMed:The effect of cAMP on electrogenic Na(+) absorption in the rat distal colon.
PubMed:Sex, sensitivity, and second messengers: differential effect of cyclic nucleotide mediated inhibition in the chemosensory system of fiddler crabs.
PubMed:Identification of potent and selective neuropeptide Y Y(1) receptor agonists with orexigenic activity in vivo.
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PubMed:Cloning, pharmacological characterization and brain distribution of the rat apelin receptor.
PubMed:Effects of fasting on aldosterone secretion in ovariectomized rats.
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PubMed:Molecular identification of adenylyl cyclase 3 in bovine corpus luteum and its regulation by prostaglandin F2alpha-induced signaling pathways.
PubMed:Reversal of propranolol blockade of adrenergic receptors and related toxicity with drugs that increase cyclic AMP.
PubMed:Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.
PubMed:Characterization and regulation of type A endothelin receptor gene expression in bovine luteal cell types.
PubMed:Leptin modulates the glucocorticoid-induced ovarian steroidogenesis.
PubMed:Hormonal regulation of messenger ribonucleic acid expression for steroidogenic factor-1, steroidogenic acute regulatory protein, and cytochrome P450 side-chain cleavage in bovine luteal cells.
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PubMed:Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice.
PubMed:Molecular cloning and characterization of an invertebrate homologue of a neuropeptide Y receptor.
PubMed:Augmentation of leptin synthesis and secretion through activation of protein kinases A and C in cultured human trophoblastic cells.
PubMed:Effects of LH, prostaglandin E2, 8-bromo-cyclic AMP and forskolin on progesterone secretion by pig luteal cells.
PubMed:The second messenger cAMP elicits eating by an anatomically specific action in the perifornical hypothalamus.
PubMed:LH receptor mRNA and cytochrome P450 side-chain cleavage expression in bovine theca and granulosa cells luteinized by LH or forskolin.
PubMed:Characterization of messenger ribonucleic acid expression for prostaglandin F2 alpha and luteinizing hormone receptors in various bovine luteal cell types.
PubMed:Long-term potentiation of synaptic transmission in the avian hippocampus.
PubMed:Lithium increases melanin-concentrating hormone mRNA stability and inhibits tyrosine hydroxylase gene expression in PC12 cells.
PubMed:Intracavernosal forskolin: role in management of vasculogenic impotence resistant to standard 3-agent pharmacotherapy.
PubMed:Stimulation of eating by the second messenger cAMP in the perifornical and lateral hypothalamus.
PubMed:Cytochrome P450 1A-like proteins expressed in the islets of Langerhans and altered pancreatic beta-cell secretory responsiveness.
PubMed:Mechanisms of CCK regulation of monitor peptide mRNA expression in pancreatic acinar AR42J cells.
PubMed:Effects of beta-adrenoceptor subtype stimulation on obese gene messenger ribonucleic acid and on leptin secretion in mouse brown adipocytes differentiated in culture.
PubMed:Regulation of Na+/glucose cotransporters.
PubMed:Regulation of lipolysis in fat cells of obese women during long-term hypocaloric diet.
PubMed:Irreversible inhibition of forskolin interactions with type I adenylyl cyclase by a 6-isothiocyanate derivative of forskolin.
PubMed:Forskolin carbamates: binding and activation studies with type I adenylyl cyclase.
PubMed:Carbachol, but not forskolin, increases mucosal-to-serosal transport of intact protein in rat ileum in vitro.
PubMed:Purification of bovine brain adenylyl cyclase with a novel derivative of forskolin: evidence for a high specific activity form of the enzyme.
PubMed:Changes in IP3 and cytosolic Ca2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat.
PubMed:Effects of sodium saccharin diet on fat-cell lipolysis: evidence for increased function of the adenylyl cyclase catalyst.
PubMed:Parathyroid hormone (PTH)/PTH-related protein receptor messenger ribonucleic acid expression and PTH response in a rat model of secondary hyperparathyroidism associated with vitamin D deficiency.
PubMed:Sulfation and uptake of the maturation-inducing steroid, 17α,20β-dihydroxy-4-pregnen-3-one by rainbow trout ovarian follicles.
PubMed:Regulation of forskolin interactions with type I, II, V, and VI adenylyl cyclases by Gs alpha.
PubMed:Tumour necrosis factor-alpha differentially alters progesterone and prostaglandin F2 alpha production by porcine luteal cells.
PubMed:Localization of the forskolin labeling sites to both halves of P-glycoprotein: similarity of the sites labeled by forskolin and prazosin.
PubMed:Interaction of 7-bromoacetyl-7-desacetylforskolin, and alkylating derivative of forskolin, with bovine brain adenylyl cyclase and human erythrocyte glucose transporter.
PubMed:[125I]-labeled forskolin analogs which discriminate adenylyl cyclase and a glucose transporter: pharmacological characterization and localization of binding sites in rat brain by in vitro receptor autoradiography.
PubMed:Differential identification and localization of adenylyl cyclase and glucose transporter in brain using iodinated derivatives of forskolin.
PubMed:Increased intracellular cyclic AMP inhibits inositol phospholipid hydrolysis induced by perturbation of the T cell receptor/CD3 complex but not by G-protein stimulation. Association with protein kinase A-mediated phosphorylation of phospholipase C-gamma 1.
PubMed:Interaction of aminoalkylcarbamates of forskolin with adenylyl cyclase: synthesis of an iodinated derivative of forskolin with high affinity for adenylyl cyclase.
PubMed:Inhibition of release of arachidonic acid, superoxide, and IL-1 from human monocytes by monoclonal anti-HLA class II antibodies: effects at proximal and distal points of inositol phospholipid hydrolysis pathway.
PubMed:Noradrenergic receptor mechanisms in neophobia.
PubMed:Inhibition of alpha 1-adrenoceptor-mediated inositol phosphate accumulation in cultured cardiac myocytes by cyclic AMP-generating compounds.
PubMed:(Aminoalkyl)carbamates of forskolin: intermediates for the synthesis of functionalized derivatives of forskolin with different specificities for adenylyl cyclase and the glucose transporter.
PubMed:Interaction of forskolin with the P-glycoprotein multidrug transporter.
PubMed:Forskolin photoaffinity labels with specificity for adenylyl cyclase and the glucose transporter.
PubMed:Fura-2 imaging of thyrotropin-releasing hormone and dopamine effects on calcium homeostasis of bovine lactotrophs.
PubMed:cAMP and human neutrophil chemotaxis. Elevation of cAMP differentially affects chemotactic responsiveness.
PubMed:In vitro effect of high doses of morphine on Con A induced lymphokine production.
PubMed:Immunoprecipitation of adenylate cyclase with an antibody to a carboxyl-terminal peptide from Gs alpha.
PubMed:3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.
PubMed:Alterations in adipocyte adenylate cyclase activity in morbidly obese and formerly morbidly obese humans.
PubMed:Single and combined effects of desimipramine and lithium on serotonergic receptor number and second messenger function in rat brain.
PubMed:Irreversible loss of [3H]forskolin binding sites in human platelets by alpha-haloacetyl analogs of forskolin.
PubMed:Modulation of cyclic AMP and autoregulation of renal blood flow, analysed by the use of forskolin and 1-methyl-3-isobutylxanthine.
PubMed:Binding of [3H]forskolin to solubilized preparations of adenylate cyclase.
PubMed:Food restriction modulates beta-adrenergic-sensitive adenylate cyclase in rat liver during aging.
PubMed:Modulation of receptors and adenylate cyclase activity during sucrose feeding, food deprivation, and cold exposure.
PubMed:Diet restriction retards the age-related loss of beta-adrenergic receptors and adenylate cyclase activity in rat lung.
PubMed:H2-receptor antagonist and gastric acid antisecretory properties of Wy-45,662.
PubMed:Interstrain correlation between behavioural effects of lithium and effects on cortical cyclic AMP.
 
Notes:
acts as direct activator of adenyl cyclase; improves drug-induced cardiac failure
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