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gambogic acid
beta-guttilactone

Supplier Sponsors

CAS Number: 2752-65-0Picture of molecule3D/inchi
FDA UNII: 8N585K83U2
MDL:MFCD16878985
XlogP3-AA:7.30 (est)
Molecular Weight:628.76228000
Formula:C38 H44 O8
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 808.95 °C. @ 760.00 mm Hg (est)
Flash Point: 485.00 °F. TCC ( 251.40 °C. ) (est)
logP (o/w): 6.490 (est)
Soluble in:
 water, 2.259e-007 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Gambogic acid 98%
BOC Sciences
For experimental / research use only.
Gambogic acid >95%
Odor: characteristic
Use: Gambogic acid is a natural product inhibitor of Hsp90.
Coompo
For experimental / research use only.
Gambogic Acid from Plants ≥98%
EMD Millipore
For experimental / research use only.
Gambogic Acid, Garcinia hanburyi
Santa Cruz Biotechnology
For experimental / research use only.
Gambogic Acid
Sigma-Aldrich: Sigma
For experimental / research use only.
Gambogic Acid ≥95% (HPLC), powder
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
unreported-mammal (species unspecified) LD50 55 mg/kg
"Zhongliu Yanjiu" Cancer Review, Yu, R., et al., eds., Shanghai Science/Technology Publisher,Peop. Rep. China, 1994Vol. -, Pg. 220, 1994.

intraperitoneal-rat LD50 88 mg/kg
LIVER: OTHER CHANGES
Indian Journal of Experimental Biology. Vol. 5, Pg. 96, 1967.

intravenous-rat LD50 107 mg/kg
LIVER: OTHER CHANGES
Indian Journal of Experimental Biology. Vol. 5, Pg. 96, 1967.

Dermal Toxicity:
subcutaneous-mouse LD50 354 mg/kg
"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 8(1), Pg. 331, 1982.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for gambogic acid usage levels up to:
 not for fragrance use.
 
Recommendation for gambogic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6444190
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
Chemidplus:0002752650
RTECS:PB9268200 for cas# 2752-65-0
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6444190
Pubchem (sid):135174544
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C10062
HMDB (The Human Metabolome Database):HMDB34095
FooDB:FDB012358
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 garcinia hanburryi
Search Trop Picture
 garcinia morella resin
Search Trop Picture
 
Synonyms:
 cambogic acid
 guttatic acid
 guttic acid
beta-guttiferin
beta-guttilactone
(Z)-3a,4,5,7-tetrahydro-8-hydroxy-alpha,3,3,11-tetramethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene
 

Articles:

PubMed:Gambogic Acid and inhibition of tumor growth: a close association.
PubMed:Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid.
PubMed:Gambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways.
PubMed:[Progress in research of the structural optimization of natural product-like Garcinia caged xanthones].
PubMed:Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein of rapamycin pathway in multiple myeloma cells.
PubMed:Gambogic acid induces growth inhibition and differentiation via upregulation of p21waf1/cip1 expression in acute myeloid leukemia cells.
PubMed:ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid.
PubMed:Ultra-high-performance liquid chromatography tandem mass spectrometry method for the determination of gambogenic acid in dog plasma and its application to a pharmacokinetic study.
PubMed:Gambogic acid exhibits anti-psoriatic efficacy through inhibition of angiogenesis and inflammation.
PubMed:Potent anti-inflammatory and antiproliferative effects of gambogic acid in a rat model of antigen-induced arthritis.
PubMed:Toxicity assessment of 7 anticancer compounds in zebrafish.
PubMed:Involvement of RECK in gambogic acid induced anti-invasive effect in A549 human lung carcinoma cells.
PubMed:Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101.
PubMed:Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase.
PubMed:Improving aqueous solubility and antitumor effects by nanosized gambogic acid-mPEG₂₀₀₀ micelles.
PubMed:Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation.
PubMed:In vitro and in vivo antiangiogenic activity of caged polyprenylated xanthones isolated from Garcinia hanburyi Hook. f.
PubMed:Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation.
PubMed:Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling.
PubMed:The combination of proteasome inhibitors bortezomib and gambogic acid triggers synergistic cytotoxicity in vitro but not in vivo.
PubMed:Suppression of NF-κB signaling and P-glycoprotein function by gambogic acid synergistically potentiates adriamycin -induced apoptosis in lung cancer.
PubMed:Gambogic acid suppresses pressure overload cardiac hypertrophy in rats.
PubMed:Synergetic effect of functional cadmium-tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition.
PubMed:Developmental regulated expression of anti- and pro-apoptotic BCL-2 family genes during human early embryonic development.
PubMed:Gambogic acid moderates cardiac responses to chronic hypoxia likely by acting on the proteasome and NF-κB pathway.
PubMed:Viability inhibition effect of gambogic acid combined with cisplatin on osteosarcoma cells via mitochondria-independent apoptotic pathway.
PubMed:N-octyl-N-arginine-chitosan (OACS) micelles for gambogic acid oral delivery: preparation, characterization and its study on in situ intestinal perfusion.
PubMed:Gambogic acid induces EGFR degradation and Akt/mTORC1 inhibition through AMPK dependent-LRIG1 upregulation in cultured U87 glioma cells.
PubMed:An open-labeled, randomized, multicenter phase IIa study of gambogic acid injection for advanced malignant tumors.
PubMed:Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells.
PubMed:A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia xanthones.
PubMed:Α-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach.
PubMed:Gambogic acid inhibits angiogenesis through inhibiting PHD2-VHL-HIF-1α pathway.
PubMed:Studies on lactoferrin nanoparticles of gambogic acid for oral delivery.
PubMed:[Effect of gambogic acid on proliferation of SKM-1 cells and its mechanism].
PubMed:[Silencing pyruvate kinase M2 sensitizes human prostate cancer PC3 cells to gambogic acid-induced apoptosis].
PubMed:Gambogic acid sensitizes ovarian cancer cells to doxorubicin through ROS-mediated apoptosis.
PubMed:Antiproliferative activity of gambogic acid isolated from Garcinia hanburyi in Hep3B and Huh7 cancer cells.
PubMed:Cytotoxic effect of gambogic acid on SH-SY5Y neuroblastoma cells is mediated by intrinsic caspase-dependent signaling pathway.
PubMed:[Content determination of two isomers containd in Garcinia hanburyi by HPLC].
PubMed:Synthesis and evaluation of gambogic acid derivatives as antitumor agents. Part III.
PubMed:New targets for the antitumor activity of gambogic acid in hematologic malignancies.
PubMed:Interaction between Gambogic acid and dihydrofolate reductase and synergistic lethal effects with methotrexate on hepatoma cells.
PubMed:Gambogic acid is a tissue-specific proteasome inhibitor in vitro and in vivo.
PubMed:Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells.
PubMed:Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system.
PubMed:Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1.
PubMed:Garcinia xanthones as orally active antitumor agents.
PubMed:[Study on intestinal absorption kinetics of gambogic acid in rats].
PubMed:Studies on chemical-structure modification and structure-activity relationship of gambogic acid derivatives at carbon(34).
PubMed:Gambogic acid protects from endotoxin shock by suppressing pro-inflammatory factors in vivo and in vitro.
PubMed:Vascular endothelial growth factor signals through platelet-derived growth factor receptor β in meningiomas in vitro.
PubMed:Computational Study on the Conformations of Gambogic Acid.
PubMed:Involvement of p53 and nuclear factor-kappaB signaling pathway for the induction of G1-phase cell cycle arrest of cholangiocarcinoma cell lines by isomorellin.
PubMed:Studies on chemical structure modification and structure-activity relationship of derivatives of gambogic acid at C(39).
PubMed:Synergistic effect of a combination of nanoparticulate Fe3O4 and gambogic acid on phosphatidylinositol 3-kinase/Akt/Bad pathway of LOVO cells.
PubMed:Induction of programmed erythrocyte death by gambogic acid.
PubMed:Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS.
PubMed:Gambogic acid as a non-competitive inhibitor of ATP-binding cassette transporter B1 reverses the multidrug resistance of human epithelial cancers by promoting ATP-binding cassette transporter B1 protein degradation.
PubMed:[Gambogic acid induces apoptosis of Jurkat cell through the MAPK signal pathway].
PubMed:Gambogic acid activates AMP-activated protein kinase in mammalian cells.
PubMed:Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain.
PubMed:Synthesis and antiangiogenic activity of novel gambogic acid derivatives.
PubMed:Apoptosis induced by 1,3,6,7-tetrahydroxyxanthone in Hepatocellular carcinoma and proteomic analysis.
PubMed:Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents.
PubMed:Synergistic anti-proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines.
PubMed:[Reversal effect of gambogic acid on multidrug resistance of K562/A02 cell line].
PubMed:Subcellular localization and activity of gambogic acid.
PubMed:Studies on gambogic acid (IV): Exploring structure-activity relationship with IκB kinase-beta (IKKβ).
PubMed:Enhancement of anticancer efficacy of chemotherapeutics by gambogic acid against gastric cancer cells.
PubMed:Gambogic acid inhibits TNF-α-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-κB signaling pathways.
PubMed:Gambogic acid-loaded magnetic Fe(3)O(4) nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1.
PubMed:Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer.
PubMed:Gambogic acid is a novel anti-cancer agent that inhibits cell proliferation, angiogenesis and metastasis.
PubMed:Fighting fire with fire: poisonous Chinese herbal medicine for cancer therapy.
PubMed:Targeting renal cell carcinoma with gambogic acid in combination with sunitinib in vitro and in vivo.
PubMed:Autophagy inhibition promotes gambogic acid-induced suppression of growth and apoptosis in glioblastoma cells.
PubMed:Prenylated caged xanthones: chemistry and biology.
PubMed:Synthesis and biological evaluation of novel derivatives of gambogic acid as anti-hepatocellular carcinoma agents.
PubMed:Cancer cell signaling pathways targeted by spice-derived nutraceuticals.
PubMed:Gambogic acid inhibits tumor cell adhesion by suppressing integrin β1 and membrane lipid rafts-associated integrin signaling pathway.
PubMed:Study of the enhanced anticancer efficacy of gambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe3O4 nanoparticles.
PubMed:Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance?
PubMed:[Role of chloride channels in gambogic acid-induced apoptosis of poorly differentiated nasopharyngeal carcinoma cells].
PubMed:Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival.
PubMed:Anti-cancer natural products isolated from chinese medicinal herbs.
PubMed:Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication.
PubMed:Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis.
PubMed:Gambogic acid, a natural product inhibitor of Hsp90.
PubMed:Studies on chemical modification and biology of a natural product, gambogic acid (III): determination of the essential pharmacophore for biological activity.
PubMed:Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest.
PubMed:Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP.
PubMed:Gambogic acid enhances proteasome inhibitor-induced anticancer activity.
PubMed:Metabolism of gambogic acid in rats: a rare intestinal metabolic pathway responsible for its final disposition.
PubMed:Gambogic acid inhibits Hsp90 and deregulates TNF-α/NF-κB in HeLa cells.
PubMed:Absolute configuration of (-)-gambogic acid, an antitumor agent.
PubMed:Comparison of electron capture-atmospheric pressure chemical ionization and electrospray ionization for the analysis of gambogic acid and its main circulating metabolite in dog plasma.
PubMed:Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.
PubMed:In vitro screening for angiostatic potential of herbal chemicals.
PubMed:Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect schistosoma viability.
PubMed:Chemistry and biology of the caged Garcinia xanthones.
PubMed:Studies on chemical modification and biology of a natural product, gambogic acid (II): Synthesis and bioevaluation of gambogellic acid and its derivatives from gambogic acid as antitumor agents.
PubMed:Gambogic acid induces G0/G1 cell cycle arrest and cell migration inhibition via suppressing PDGF receptor β tyrosine phosphorylation and Rac1 activity in rat aortic smooth muscle cells.
PubMed:Apoptotic activity of caged xanthones from Garcinia hanburyi in cholangiocarcinoma cell lines.
PubMed:Gambogic acid triggers DNA damage signaling that induces p53/p21(Waf1/CIP1) activation through the ATR-Chk1 pathway.
PubMed:Inhibition of NF-kappaB and Akt pathways by an antibody-avidin fusion protein sensitizes malignant B-cells to cisplatin-induced apoptosis.
PubMed:Spectacular modification of Gambogic acid on microwave irradiation in methanol: isolation and structure identification of two products with potent anti-tumor activity.
PubMed:Gambogenic acid inhibits proliferation of A549 cells through apoptosis-inducing and cell cycle arresting.
PubMed:Identification and quantitative determination of a major circulating metabolite of gambogic acid in human.
PubMed:[Effects of gambogic acid on the regulation of steroid receptor coactivator-3 in A549 cells].
PubMed:[Research advance on transferrin receptor in hematological malignant tumor treatment].
PubMed:Effects of magnetic nanoparticle of Fe3O4 on apoptosis induced by Gambogic acid in U937 leukemia cells.
PubMed:Mechanisms of gambogic acid-induced apoptosis in non-small cell lung cancer cells in relation to transferrin receptors.
PubMed:[Apoptosis-inducing effect of gambogic acid on K562 cells and its mechanism].
PubMed:Synergistic effect of magnetic nanoparticles of Fe(3)O(4) with gambogic acid on apoptosis of K562 leukemia cells.
PubMed:General pharmacological properties, developmental toxicity, and analgesic activity of gambogic acid, a novel natural anticancer agent.
PubMed:An oxidative analogue of gambogic acid-induced apoptosis of human hepatocellular carcinoma cell line HepG2 is involved in its anticancer activity in vitro.
PubMed:Effect of Gambogic acid on the regulation of hERG channel in K562 cells in vitro.
PubMed:The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma.
PubMed:Caged Garcinia xanthones: development since 1937.
PubMed:Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells.
PubMed:Modified chitosan derivative micelle system for natural anti-tumor product gambogic acid delivery.
PubMed:Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells.
PubMed:Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells.
PubMed:Gambogic acid down-regulates MDM2 oncogene and induces p21(Waf1/CIP1) expression independent of p53.
PubMed:[Inhibition effect of gambogic acid on MUTZ-1 cell line and its possible mechanism].
PubMed:Specific and slow inhibition of the kir2.1 K+ channel by gambogic acid.
PubMed:GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms.
PubMed:[Mechanism of gambogic acid-induced apoptosis in Raji cells].
PubMed:Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl-2 and enhancing caspase-3 activity in human malignant melanoma A375 cells.
PubMed:Fused xanthone derivatives as antiproliferative agents.
PubMed:Gambogic acid covalently modifies IkappaB kinase-beta subunit to mediate suppression of lipopolysaccharide-induced activation of NF-kappaB in macrophages.
PubMed:Bioassay guided discovery of apoptosis inducers from gamboge by high-speed counter-current chromatography and high-pressure liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry.
PubMed:Proteomic identification of molecular targets of gambogic acid: role of stathmin in hepatocellular carcinoma.
PubMed:Synergistic effect of 5-fluorouracil with gambogic acid on BGC-823 human gastric carcinoma.
PubMed:Involvement of regulations of nucleophosmin and nucleoporins in gambogic acid-induced apoptosis in Jurkat cells.
PubMed:[Effects of gambogic acid on the regulation of nucleoporin Nup88 in HL-60 cells].
PubMed:Studies on chemical structure modification and biology of a natural product, gambogic acid (I): Synthesis and biological evaluation of oxidized analogues of gambogic acid.
PubMed:Water-soluble gambogic acid PEGylated prodrugs: synthesis, characterization, physicochemical properties and in vitro hydrolysis.
PubMed:[Analysis of xanthones in gamboge by HPLC-PDA-ESI/MS].
PubMed:Enhanced cytotoxicity of an anti-transferrin receptor IgG3-avidin fusion protein in combination with gambogic acid against human malignant hematopoietic cells: functional relevance of iron, the receptor, and reactive oxygen species.
PubMed:Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells.
PubMed:Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells.
PubMed:Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis.
PubMed:Potential of spice-derived phytochemicals for cancer prevention.
PubMed:Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells.
PubMed:Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H22 transplanted mice.
PubMed:Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.
PubMed:Inhibition of alpha(4) integrin mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated with gambogic acid.
PubMed:Studies on the toxicity of gambogic acid in rats.
PubMed:Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling.
PubMed:Synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones: Evaluating the minimum structure for apoptosis induction by gambogic acid.
PubMed:Gambogic acid induces death inducer-obliterator 1-mediated apoptosis in Jurkat T cells.
PubMed:Improved high-performance liquid chromatographic method for simultaneous determination of 12 cytotoxic caged xanthones in gamboges, a potential anticancer resin from Garcinia hanburyi.
PubMed:Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells.
PubMed:Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells.
PubMed:Preparation, physical properties, and stability of gambogic acid-loaded micelles based on chitosan derivatives.
PubMed:Inhibition of glioblastoma growth and angiogenesis by gambogic acid: an in vitro and in vivo study.
PubMed:Structure elucidation of metabolites of gambogic acid in vivo in rat bile by high-performance liquid chromatography-mass spectrometry and high-performance liquid chromatography-nuclear magnetic resonance.
PubMed:Five novel prenylated xanthones from Resina Garciniae.
PubMed:Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1.
PubMed:Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death.
PubMed:Gambogic acid inhibits the catalytic activity of human topoisomerase IIalpha by binding to its ATPase domain.
PubMed:Effects of gambogic acid on the regulation of nucleoporin Nup88 in U937 cells.
PubMed:Pharmacokinetics, tissue distribution and excretion of gambogic acid in rats.
PubMed:Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes.
PubMed:Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway.
PubMed:Caspase-8 preferentially senses the apoptosis-inducing action of NG-18, a Gambogic acid derivative, in human leukemia HL-60 cells.
PubMed:Rapid determination of polyprenylated xanthones in gamboge resin of Garcinia hanburyi by HPLC.
PubMed:Simultaneous identification of natural dyes in the collection of drawings and maps from The Royal Chancellery Archives in Granada (Spain) by CE.
PubMed:Synthesis and evaluation of caged Garcinia xanthones.
PubMed:Determination of gambogic acid in dog plasma by high-performance liquid chromatography for a pharmacokinetic study.
PubMed:Cytotoxic and anti-HIV-1 caged xanthones from the resin and fruits of Garcinia hanburyi.
PubMed:A chemical genetics approach for the discovery of apoptosis inducers: from phenotypic cell based HTS assay and structure-activity relationship studies, to identification of potential anticancer agents and molecular targets.
PubMed:Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells.
PubMed:Determination of gambogic acid in human plasma by liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.
PubMed:Metabolism and metabolic inhibition of gambogic acid in rat liver microsomes.
PubMed:Toxicological studies of gambogic acid and its potential targets in experimental animals.
PubMed:Preparative separation of gambogic acid and its C-2 epimer using recycling high-speed counter-current chromatography.
PubMed:Sampling and identification of natural dyes in historical maps and drawings by liquid chromatography with diode-array detection.
PubMed:Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi.
PubMed:Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells.
PubMed:Stability and cytotoxicity of gambogic acid and its derivative, gambogoic acid.
PubMed:Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells.
PubMed:A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid.
PubMed:Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823.
PubMed:Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation.
PubMed:Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells.
PubMed:Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells.
PubMed:Unified synthesis of caged Garcinia natural products based on a site-selective Claisen/Diels-Alder/Claisen rearrangement.
PubMed:General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice.
PubMed:Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay.
PubMed:Cytotoxic xanthones from Garcinia hanburyi.
PubMed:[Effect of gamboge acid on the cell cycle of HeLa cells with flow cytometry].
PubMed:[Isolation and structure of neo-gambogic acid from Gamboge (Garcinia hanburryi)].
PubMed:[The constitution of gambogic acid and its isomerization. 4. Chemistry of gum-resin].
 
Notes:
Isol. from Gamboge resin (exudate of Garcinia morella)
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