PubMed:Gambogic Acid and inhibition of tumor growth: a close association. |
PubMed:Nanoparticle delivery and combination therapy of gambogic acid and all-trans retinoic acid. |
PubMed:Gambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways. |
PubMed:[Progress in research of the structural optimization of natural product-like Garcinia caged xanthones]. |
PubMed:Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein of rapamycin pathway in multiple myeloma cells. |
PubMed:Gambogic acid induces growth inhibition and differentiation via upregulation of p21waf1/cip1 expression in acute myeloid leukemia cells. |
PubMed:ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid. |
PubMed:Ultra-high-performance liquid chromatography tandem mass spectrometry method for the determination of gambogenic acid in dog plasma and its application to a pharmacokinetic study. |
PubMed:Gambogic acid exhibits anti-psoriatic efficacy through inhibition of angiogenesis and inflammation. |
PubMed:Potent anti-inflammatory and antiproliferative effects of gambogic acid in a rat model of antigen-induced arthritis. |
PubMed:Toxicity assessment of 7 anticancer compounds in zebrafish. |
PubMed:Involvement of RECK in gambogic acid induced anti-invasive effect in A549 human lung carcinoma cells. |
PubMed:Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101. |
PubMed:Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase. |
PubMed:Improving aqueous solubility and antitumor effects by nanosized gambogic acid-mPEG₂₀₀₀ micelles. |
PubMed:Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation. |
PubMed:In vitro and in vivo antiangiogenic activity of caged polyprenylated xanthones isolated from Garcinia hanburyi Hook. f. |
PubMed:Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation. |
PubMed:Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling. |
PubMed:The combination of proteasome inhibitors bortezomib and gambogic acid triggers synergistic cytotoxicity in vitro but not in vivo. |
PubMed:Suppression of NF-κB signaling and P-glycoprotein function by gambogic acid synergistically potentiates adriamycin -induced apoptosis in lung cancer. |
PubMed:Gambogic acid suppresses pressure overload cardiac hypertrophy in rats. |
PubMed:Synergetic effect of functional cadmium-tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition. |
PubMed:Developmental regulated expression of anti- and pro-apoptotic BCL-2 family genes during human early embryonic development. |
PubMed:Gambogic acid moderates cardiac responses to chronic hypoxia likely by acting on the proteasome and NF-κB pathway. |
PubMed:Viability inhibition effect of gambogic acid combined with cisplatin on osteosarcoma cells via mitochondria-independent apoptotic pathway. |
PubMed:N-octyl-N-arginine-chitosan (OACS) micelles for gambogic acid oral delivery: preparation, characterization and its study on in situ intestinal perfusion. |
PubMed:Gambogic acid induces EGFR degradation and Akt/mTORC1 inhibition through AMPK dependent-LRIG1 upregulation in cultured U87 glioma cells. |
PubMed:An open-labeled, randomized, multicenter phase IIa study of gambogic acid injection for advanced malignant tumors. |
PubMed:Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells. |
PubMed:A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia xanthones. |
PubMed:Α-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach. |
PubMed:Gambogic acid inhibits angiogenesis through inhibiting PHD2-VHL-HIF-1α pathway. |
PubMed:Studies on lactoferrin nanoparticles of gambogic acid for oral delivery. |
PubMed:[Effect of gambogic acid on proliferation of SKM-1 cells and its mechanism]. |
PubMed:[Silencing pyruvate kinase M2 sensitizes human prostate cancer PC3 cells to gambogic acid-induced apoptosis]. |
PubMed:Gambogic acid sensitizes ovarian cancer cells to doxorubicin through ROS-mediated apoptosis. |
PubMed:Antiproliferative activity of gambogic acid isolated from Garcinia hanburyi in Hep3B and Huh7 cancer cells. |
PubMed:Cytotoxic effect of gambogic acid on SH-SY5Y neuroblastoma cells is mediated by intrinsic caspase-dependent signaling pathway. |
PubMed:[Content determination of two isomers containd in Garcinia hanburyi by HPLC]. |
PubMed:Synthesis and evaluation of gambogic acid derivatives as antitumor agents. Part III. |
PubMed:New targets for the antitumor activity of gambogic acid in hematologic malignancies. |
PubMed:Interaction between Gambogic acid and dihydrofolate reductase and synergistic lethal effects with methotrexate on hepatoma cells. |
PubMed:Gambogic acid is a tissue-specific proteasome inhibitor in vitro and in vivo. |
PubMed:Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells. |
PubMed:Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system. |
PubMed:Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1. |
PubMed:Garcinia xanthones as orally active antitumor agents. |
PubMed:[Study on intestinal absorption kinetics of gambogic acid in rats]. |
PubMed:Studies on chemical-structure modification and structure-activity relationship of gambogic acid derivatives at carbon(34). |
PubMed:Gambogic acid protects from endotoxin shock by suppressing pro-inflammatory factors in vivo and in vitro. |
PubMed:Vascular endothelial growth factor signals through platelet-derived growth factor receptor β in meningiomas in vitro. |
PubMed:Computational Study on the Conformations of Gambogic Acid. |
PubMed:Involvement of p53 and nuclear factor-kappaB signaling pathway for the induction of G1-phase cell cycle arrest of cholangiocarcinoma cell lines by isomorellin. |
PubMed:Studies on chemical structure modification and structure-activity relationship of derivatives of gambogic acid at C(39). |
PubMed:Synergistic effect of a combination of nanoparticulate Fe3O4 and gambogic acid on phosphatidylinositol 3-kinase/Akt/Bad pathway of LOVO cells. |
PubMed:Induction of programmed erythrocyte death by gambogic acid. |
PubMed:Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS. |
PubMed:Gambogic acid as a non-competitive inhibitor of ATP-binding cassette transporter B1 reverses the multidrug resistance of human epithelial cancers by promoting ATP-binding cassette transporter B1 protein degradation. |
PubMed:[Gambogic acid induces apoptosis of Jurkat cell through the MAPK signal pathway]. |
PubMed:Gambogic acid activates AMP-activated protein kinase in mammalian cells. |
PubMed:Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain. |
PubMed:Synthesis and antiangiogenic activity of novel gambogic acid derivatives. |
PubMed:Apoptosis induced by 1,3,6,7-tetrahydroxyxanthone in Hepatocellular carcinoma and proteomic analysis. |
PubMed:Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents. |
PubMed:Synergistic anti-proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines. |
PubMed:[Reversal effect of gambogic acid on multidrug resistance of K562/A02 cell line]. |
PubMed:Subcellular localization and activity of gambogic acid. |
PubMed:Studies on gambogic acid (IV): Exploring structure-activity relationship with IκB kinase-beta (IKKβ). |
PubMed:Enhancement of anticancer efficacy of chemotherapeutics by gambogic acid against gastric cancer cells. |
PubMed:Gambogic acid inhibits TNF-α-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-κB signaling pathways. |
PubMed:Gambogic acid-loaded magnetic Fe(3)O(4) nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1. |
PubMed:Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer. |
PubMed:Gambogic acid is a novel anti-cancer agent that inhibits cell proliferation, angiogenesis and metastasis. |
PubMed:Fighting fire with fire: poisonous Chinese herbal medicine for cancer therapy. |
PubMed:Targeting renal cell carcinoma with gambogic acid in combination with sunitinib in vitro and in vivo. |
PubMed:Autophagy inhibition promotes gambogic acid-induced suppression of growth and apoptosis in glioblastoma cells. |
PubMed:Prenylated caged xanthones: chemistry and biology. |
PubMed:Synthesis and biological evaluation of novel derivatives of gambogic acid as anti-hepatocellular carcinoma agents. |
PubMed:Cancer cell signaling pathways targeted by spice-derived nutraceuticals. |
PubMed:Gambogic acid inhibits tumor cell adhesion by suppressing integrin β1 and membrane lipid rafts-associated integrin signaling pathway. |
PubMed:Study of the enhanced anticancer efficacy of gambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe3O4 nanoparticles. |
PubMed:Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance? |
PubMed:[Role of chloride channels in gambogic acid-induced apoptosis of poorly differentiated nasopharyngeal carcinoma cells]. |
PubMed:Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival. |
PubMed:Anti-cancer natural products isolated from chinese medicinal herbs. |
PubMed:Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication. |
PubMed:Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis. |
PubMed:Gambogic acid, a natural product inhibitor of Hsp90. |
PubMed:Studies on chemical modification and biology of a natural product, gambogic acid (III): determination of the essential pharmacophore for biological activity. |
PubMed:Gambogic acid inhibits the growth of osteosarcoma cells in vitro by inducing apoptosis and cell cycle arrest. |
PubMed:Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP. |
PubMed:Gambogic acid enhances proteasome inhibitor-induced anticancer activity. |
PubMed:Metabolism of gambogic acid in rats: a rare intestinal metabolic pathway responsible for its final disposition. |
PubMed:Gambogic acid inhibits Hsp90 and deregulates TNF-α/NF-κB in HeLa cells. |
PubMed:Absolute configuration of (-)-gambogic acid, an antitumor agent. |
PubMed:Comparison of electron capture-atmospheric pressure chemical ionization and electrospray ionization for the analysis of gambogic acid and its main circulating metabolite in dog plasma. |
PubMed:Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. |
PubMed:In vitro screening for angiostatic potential of herbal chemicals. |
PubMed:Development and validation of a quantitative, high-throughput, fluorescent-based bioassay to detect schistosoma viability. |
PubMed:Chemistry and biology of the caged Garcinia xanthones. |
PubMed:Studies on chemical modification and biology of a natural product, gambogic acid (II): Synthesis and bioevaluation of gambogellic acid and its derivatives from gambogic acid as antitumor agents. |
PubMed:Gambogic acid induces G0/G1 cell cycle arrest and cell migration inhibition via suppressing PDGF receptor β tyrosine phosphorylation and Rac1 activity in rat aortic smooth muscle cells. |
PubMed:Apoptotic activity of caged xanthones from Garcinia hanburyi in cholangiocarcinoma cell lines. |
PubMed:Gambogic acid triggers DNA damage signaling that induces p53/p21(Waf1/CIP1) activation through the ATR-Chk1 pathway. |
PubMed:Inhibition of NF-kappaB and Akt pathways by an antibody-avidin fusion protein sensitizes malignant B-cells to cisplatin-induced apoptosis. |
PubMed:Spectacular modification of Gambogic acid on microwave irradiation in methanol: isolation and structure identification of two products with potent anti-tumor activity. |
PubMed:Gambogenic acid inhibits proliferation of A549 cells through apoptosis-inducing and cell cycle arresting. |
PubMed:Identification and quantitative determination of a major circulating metabolite of gambogic acid in human. |
PubMed:[Effects of gambogic acid on the regulation of steroid receptor coactivator-3 in A549 cells]. |
PubMed:[Research advance on transferrin receptor in hematological malignant tumor treatment]. |
PubMed:Effects of magnetic nanoparticle of Fe3O4 on apoptosis induced by Gambogic acid in U937 leukemia cells. |
PubMed:Mechanisms of gambogic acid-induced apoptosis in non-small cell lung cancer cells in relation to transferrin receptors. |
PubMed:[Apoptosis-inducing effect of gambogic acid on K562 cells and its mechanism]. |
PubMed:Synergistic effect of magnetic nanoparticles of Fe(3)O(4) with gambogic acid on apoptosis of K562 leukemia cells. |
PubMed:General pharmacological properties, developmental toxicity, and analgesic activity of gambogic acid, a novel natural anticancer agent. |
PubMed:An oxidative analogue of gambogic acid-induced apoptosis of human hepatocellular carcinoma cell line HepG2 is involved in its anticancer activity in vitro. |
PubMed:Effect of Gambogic acid on the regulation of hERG channel in K562 cells in vitro. |
PubMed:The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma. |
PubMed:Caged Garcinia xanthones: development since 1937. |
PubMed:Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells. |
PubMed:Modified chitosan derivative micelle system for natural anti-tumor product gambogic acid delivery. |
PubMed:Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells. |
PubMed:Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells. |
PubMed:Gambogic acid down-regulates MDM2 oncogene and induces p21(Waf1/CIP1) expression independent of p53. |
PubMed:[Inhibition effect of gambogic acid on MUTZ-1 cell line and its possible mechanism]. |
PubMed:Specific and slow inhibition of the kir2.1 K+ channel by gambogic acid. |
PubMed:GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms. |
PubMed:[Mechanism of gambogic acid-induced apoptosis in Raji cells]. |
PubMed:Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl-2 and enhancing caspase-3 activity in human malignant melanoma A375 cells. |
PubMed:Fused xanthone derivatives as antiproliferative agents. |
PubMed:Gambogic acid covalently modifies IkappaB kinase-beta subunit to mediate suppression of lipopolysaccharide-induced activation of NF-kappaB in macrophages. |
PubMed:Bioassay guided discovery of apoptosis inducers from gamboge by high-speed counter-current chromatography and high-pressure liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry. |
PubMed:Proteomic identification of molecular targets of gambogic acid: role of stathmin in hepatocellular carcinoma. |
PubMed:Synergistic effect of 5-fluorouracil with gambogic acid on BGC-823 human gastric carcinoma. |
PubMed:Involvement of regulations of nucleophosmin and nucleoporins in gambogic acid-induced apoptosis in Jurkat cells. |
PubMed:[Effects of gambogic acid on the regulation of nucleoporin Nup88 in HL-60 cells]. |
PubMed:Studies on chemical structure modification and biology of a natural product, gambogic acid (I): Synthesis and biological evaluation of oxidized analogues of gambogic acid. |
PubMed:Water-soluble gambogic acid PEGylated prodrugs: synthesis, characterization, physicochemical properties and in vitro hydrolysis. |
PubMed:[Analysis of xanthones in gamboge by HPLC-PDA-ESI/MS]. |
PubMed:Enhanced cytotoxicity of an anti-transferrin receptor IgG3-avidin fusion protein in combination with gambogic acid against human malignant hematopoietic cells: functional relevance of iron, the receptor, and reactive oxygen species. |
PubMed:Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells. |
PubMed:Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells. |
PubMed:Involvement of matrix metalloproteinase 2 and 9 in gambogic acid induced suppression of MDA-MB-435 human breast carcinoma cell lung metastasis. |
PubMed:Potential of spice-derived phytochemicals for cancer prevention. |
PubMed:Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells. |
PubMed:Gambogic acid induced tumor cell apoptosis by T lymphocyte activation in H22 transplanted mice. |
PubMed:Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins. |
PubMed:Inhibition of alpha(4) integrin mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated with gambogic acid. |
PubMed:Studies on the toxicity of gambogic acid in rats. |
PubMed:Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling. |
PubMed:Synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones: Evaluating the minimum structure for apoptosis induction by gambogic acid. |
PubMed:Gambogic acid induces death inducer-obliterator 1-mediated apoptosis in Jurkat T cells. |
PubMed:Improved high-performance liquid chromatographic method for simultaneous determination of 12 cytotoxic caged xanthones in gamboges, a potential anticancer resin from Garcinia hanburyi. |
PubMed:Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells. |
PubMed:Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells. |
PubMed:Preparation, physical properties, and stability of gambogic acid-loaded micelles based on chitosan derivatives. |
PubMed:Inhibition of glioblastoma growth and angiogenesis by gambogic acid: an in vitro and in vivo study. |
PubMed:Structure elucidation of metabolites of gambogic acid in vivo in rat bile by high-performance liquid chromatography-mass spectrometry and high-performance liquid chromatography-nuclear magnetic resonance. |
PubMed:Five novel prenylated xanthones from Resina Garciniae. |
PubMed:Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1. |
PubMed:Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death. |
PubMed:Gambogic acid inhibits the catalytic activity of human topoisomerase IIalpha by binding to its ATPase domain. |
PubMed:Effects of gambogic acid on the regulation of nucleoporin Nup88 in U937 cells. |
PubMed:Pharmacokinetics, tissue distribution and excretion of gambogic acid in rats. |
PubMed:Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes. |
PubMed:Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway. |
PubMed:Caspase-8 preferentially senses the apoptosis-inducing action of NG-18, a Gambogic acid derivative, in human leukemia HL-60 cells. |
PubMed:Rapid determination of polyprenylated xanthones in gamboge resin of Garcinia hanburyi by HPLC. |
PubMed:Simultaneous identification of natural dyes in the collection of drawings and maps from The Royal Chancellery Archives in Granada (Spain) by CE. |
PubMed:Synthesis and evaluation of caged Garcinia xanthones. |
PubMed:Determination of gambogic acid in dog plasma by high-performance liquid chromatography for a pharmacokinetic study. |
PubMed:Cytotoxic and anti-HIV-1 caged xanthones from the resin and fruits of Garcinia hanburyi. |
PubMed:A chemical genetics approach for the discovery of apoptosis inducers: from phenotypic cell based HTS assay and structure-activity relationship studies, to identification of potential anticancer agents and molecular targets. |
PubMed:Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells. |
PubMed:Determination of gambogic acid in human plasma by liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. |
PubMed:Metabolism and metabolic inhibition of gambogic acid in rat liver microsomes. |
PubMed:Toxicological studies of gambogic acid and its potential targets in experimental animals. |
PubMed:Preparative separation of gambogic acid and its C-2 epimer using recycling high-speed counter-current chromatography. |
PubMed:Sampling and identification of natural dyes in historical maps and drawings by liquid chromatography with diode-array detection. |
PubMed:Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi. |
PubMed:Repression of telomerase reverse transcriptase mRNA and hTERT promoter by gambogic acid in human gastric carcinoma cells. |
PubMed:Stability and cytotoxicity of gambogic acid and its derivative, gambogoic acid. |
PubMed:Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cells. |
PubMed:A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. |
PubMed:Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823. |
PubMed:Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation. |
PubMed:Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells. |
PubMed:Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells. |
PubMed:Unified synthesis of caged Garcinia natural products based on a site-selective Claisen/Diels-Alder/Claisen rearrangement. |
PubMed:General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice. |
PubMed:Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay. |
PubMed:Cytotoxic xanthones from Garcinia hanburyi. |
PubMed:[Effect of gamboge acid on the cell cycle of HeLa cells with flow cytometry]. |
PubMed:[Isolation and structure of neo-gambogic acid from Gamboge (Garcinia hanburryi)]. |
PubMed:[The constitution of gambogic acid and its isomerization. 4. Chemistry of gum-resin]. |