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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 724.29 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 468.00 °F. TCC ( 242.20 °C. ) (est)
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| logP (o/w): | 0.393 (est) |
| Soluble in: |
| | water, 108 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for brusatol usage levels up to: | | | not for fragrance use.
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| Recommendation for brusatol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (11b,12a,15b)-13,20- | epoxy-3,11,12-trihydroxy-15-((3-methyl-1-oxo-2-butenyl)oxy)-2,16-dioxopicras-3-en-21-oic acid, methyl ester | | | picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-((3-methyl-1-oxo-2-butenyl)oxy)-2,16-dioxo-, methyl ester, (11b,12a,15b)- | | | picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-, methyl ester, (11b,12a,15b)- | | | picras-3-en-21-oicacid,13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-,methyl ester, (11b,12a,15b)- | | | yatansin |
Articles:
| PubMed:Effect of Tacrine-3-caffeic Acid, A Novel Multifunctional Anti-Alzheimer's Dimer, Against Oxidative-Stress-Induced Cell Death in HT22 Hippocampal Neurons: Involvement of Nrf2/HO-1 Pathway. |
| PubMed:Hydrogen gas protects against serum and glucose deprivation‑induced myocardial injury in H9c2 cells through activation of the NF‑E2‑related factor 2/heme oxygenase 1 signaling pathway. |
| PubMed:Brusatol. |
| PubMed:[Quantitative determination of contents of three components in Brucea javanica by HPLC]. |
| PubMed:One new pregnane glycoside from the seeds of cultivated Brucea javanica. |
| PubMed:Seven quassinoids from Fructus Bruceae with cytotoxic effects on pancreatic adenocarcinoma cell lines. |
| PubMed:Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. |
| PubMed:Anti-tobacco mosaic virus (TMV) Quassinoids from Brucea javanica (L.) Merr. |
| PubMed:In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica. |
| PubMed:New quassinoids, javanicolides C and D and javanicosides B--F, from seeds of Brucea javanica. |
| PubMed:Brusatol-induced HL-60 cell differentiation involves NF-kappaB activation. |
| PubMed:[Studies on the chemical components of Brucea javanica]. |
| PubMed:Brusatol-mediated induction of leukemic cell differentiation and G(1) arrest is associated with down-regulation of c-myc. |
| PubMed:Discovery of cancer preventive agents from natural products: from plants to prevention. |
| PubMed:Novel esters of glaucarubolone as inducers of terminal differentiation of promyelocytic HL-60 cells and inhibitors of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesion formation in mouse mammary organ culture. |
| PubMed:Conversion of quassinoids for enhancement of inhibitory effect against Epstein-Barr virus early antigen activation. Introduction of lipophilic side chain and esterification of diosphenol. |
| PubMed:Synthesis of cytotoxic fluorinated quassinoids. |
| PubMed:A lignan and four terpenoids from Brucea javanica that induce differentiation with cultured HL-60 promyelocytic leukemia cells. |
| PubMed:Quassinoids exhibit greater selectivity against Plasmodium falciparum than against Entamoeba histolytica, Giardia intestinalis or Toxoplasma gondii in vitro. |
| PubMed:Antimalarial agents, 4. Synthesis of a brusatol analog and biological activity of brusatol-related compounds. |
| PubMed:Antitumor agents, 65. Brusatol and cleomiscosin-A, antileukemic principles from Brucea javanica. |
| PubMed:Reversibility of protein synthesis inhibition by quassinoid antineoplastic agents in a rabbit reticulocyte system. |
| PubMed:Anti-inflammatory agents III: Structure-activity relationships of brusatol and related quassinoids. |
| PubMed:Antitumor agents LIX: effects of quassinoids on protein synthesis of a number of murine tumors and normal cells. |
| PubMed:Antitumor agents XLVIII: Structure-activity relationships of quassinoids as in vitro protein synthesis inhibitors of P-388 lymphocytic leukemia tumor cell metabolism. |
| PubMed:Antitumor agents XLVI: In vitro effects of esters of brusatol, bisbrusatol, and related compounds on nucleic acid and protein synthesis of P-388 lymphocytic leukemia cells. |
| PubMed:Antitumor agents XLV: Bisbrusatolyl and brusatolyl esters and related compounds as novel potent antileukemic agents. |
| PubMed:Antitumor agents XLII: Comparison of antileukemic activity of helenalin, brusatol, and bruceantin and their esters on different strains of P-388 lymphocytic leukemic cells. |
| PubMed:Mechanism of eukaryotic protein synthesis inhibition by brusatol. |
| PubMed:Antitumor agents. XXXIV: Mechanism of action of bruceoside A and brusatol on nucleic acid metabolism of P-388 lymphocytic leukemia cells. |
| PubMed:Antitumor agents. XXXV: Effects of brusatol, bruceoside A, and bruceantin on P-388 lymphocytic leukemia cell respiration. |
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3D/inchi