| PubMed:Evaluation of single and joint effect of metabolites isolated from marine sponges, Fasciospongia cavernosa and Axinella donnani on antimicrobial properties. |
| PubMed:A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. |
| PubMed:Inhibition of hepatitis C virus NS3 helicase by manoalide. |
| PubMed:Therapeutic application of natural inhibitors against snake venom phospholipase A(2). |
| PubMed:Influence of experimental subarachnoid hemorrhage on nicotine-induced contraction of the rat basilar artery in relation to arachidonic acid metabolites signaling pathway. |
| PubMed:Anti-biofilm compounds derived from marine sponges. |
| PubMed:Hippolides A-H, acyclic manoalide derivatives from the marine sponge Hippospongia lachne. |
| PubMed:A ClpP protein model as tuberculosis target for screening marine compounds. |
| PubMed:Marine natural products targeting phospholipases A2. |
| PubMed:Bioactive sesterterpenes and triterpenes from marine sponges: occurrence and pharmacological significance. |
| PubMed:Retinoids as a perspective in treatment of Alzheimer's disease. |
| PubMed:ESI FTICR-MS analysis of larvae from the marine sponge Luffariella variabilis. |
| PubMed:Deoxymanoalides from the nudibranch Chromodoris willani. |
| PubMed:Aromatic cyclic peroxides and related keto-compounds from the Plakortis sp. component of a sponge consortium. |
| PubMed:Coordinate regulation of TLR-mediated arachidonic acid mobilization in macrophages by group IVA and group V phospholipase A2s. |
| PubMed:24-O-ethylmanoalide, a manoalide-related sesterterpene from the marine sponge Luffariella cf. variabilis. |
| PubMed:Clinical status of anti-cancer agents derived from marine sources. |
| PubMed:Nox1 downstream of 12-lipoxygenase controls cell proliferation but not cell spreading of colon cancer cells. |
| PubMed:Phospholipase A2-like activity of human bocavirus VP1 unique region. |
| PubMed:Quorum sensing antagonism from marine organisms. |
| PubMed:Production of manoalide and its analogues by the sponge Luffariella variabilis Is hardwired. |
| PubMed:Scalaradial, a dialdehyde-containing marine metabolite that causes an unexpected noncovalent PLA2 Inactivation. |
| PubMed:Activation and inactivation of the volume-sensitive taurine leak pathway in NIH3T3 fibroblasts and Ehrlich Lettre ascites cells. |
| PubMed:Effect of serum from cardiovascular patients on catalytic activity of secretory phospholipase A2 (IIA). |
| PubMed:Acetylated sesterterpenes from the Great Barrier Reef sponge Luffariella variabilis. |
| PubMed:Roles of phospholipase A2 isoforms in swelling- and melittin-induced arachidonic acid release and taurine efflux in NIH3T3 fibroblasts. |
| PubMed:Manoalide derivatives from a sponge, Luffariella sp. |
| PubMed:PLA2 inhibitory activity of marine sesterterpenoids cladocorans, their diastereomers and analogues. |
| PubMed:Phospholipase A2 is involved in muscarinic receptor-mediated sAPPalpha release independently of cyclooxygenase or lypoxygenase activity in SH-SY5Y cells. |
| PubMed:L-selectin expression on neutrophils from allergic patients. |
| PubMed:Late-gestation rat myometrial cells express multiple isoforms of phospholipase A2 that mediate PCB 50-induced release of arachidonic acid with coincident prostaglandin production. |
| PubMed:The catalytically active secretory phospholipase A2 type IIA is involved in restenosis development after PTCA in human coronary arteries and generation of atherogenic LDL. |
| PubMed:A phospholipase C-dependent intracellular Ca2+ release pathway mediates the capsaicin-induced apoptosis in HepG2 human hepatoma cells. |
| PubMed:Role of intracellular Ca2+ signal in the ascorbate-induced apoptosis in a human hepatoma cell line. |
| PubMed:Antitubercular sesterterpenes from the Thai sponge Brachiaster sp. |
| PubMed:Lipoxygenase-dependent superoxide release in skeletal muscle. |
| PubMed:Characterisation of some pharmacological effects of the venom from Vipera lebetina. |
| PubMed:Advanced glycation end products stimulate an enhanced neutrophil respiratory burst mediated through the activation of cytosolic phospholipase A2 and generation of arachidonic Acid. |
| PubMed:Synthesis of (+)-manoalide via a copper(I)-mediated 1,2-metalate rearrangement. |
| PubMed:Modulatory effect of bolinaquinone, a marine sesquiterpenoid, on acute and chronic inflammatory processes. |
| PubMed:Role of intracellular Ca2+ in endothelium-dependent contraction and relaxation of rabbit intrapulmonary arteries. |
| PubMed:Molecular basis of phospholipase A2 inhibition by petrosaspongiolide M. |
| PubMed:Inhibition of crotoxin phospholipase A(2) activity by manoalide associated with inactivation of crotoxin toxicity and dissociation of the heterodimeric neurotoxic complex. |
| PubMed:4-Bromophenacyl bromide induces Ca2+ influx in human gingival fibroblasts. |
| PubMed:The VP1 unique region of parvovirus B19 and its constituent phospholipase A2-like activity. |
| PubMed:ATP-induced histamine release is in part related to phospholipase A2-mediated arachidonic acid metabolism in rat peritoneal mast cells. |
| PubMed:Protamine augments stretch induced calcium increase in vascular endothelium. |
| PubMed:New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte functions. |
| PubMed:Dysidotronic acid, a new sesquiterpenoid, inhibits cytokine production and the expression of nitric oxide synthase. |
| PubMed:Effects of mercuric chloride exposure on the glutamate uptake by cultured retinal pigment epithelial cells. |
| PubMed:The involvement of phospholipase A(2) in ethanol-induced gastric muscle contraction. |
| PubMed:Role of pertussis toxin-sensitive G-proteins in intracellular Ca2+ release and apoptosis induced by inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels in HepG2 human hepatoblastoma cells. |
| PubMed:Activation of human neutrophils by the plant lectin Viscum album agglutinin-I: modulation of de novo protein synthesis and evidence that caspases are involved in induction of apoptosis. |
| PubMed:Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils. |
| PubMed:PLA(2) dependence of diaphragm mitochondrial formation of reactive oxygen species. |
| PubMed:Light activation of phospholipase A2 in the photoreceptor of the crayfish (Procambarus clarkii). |
| PubMed:Tumor necrosis factor-alpha augments contraction and cytosolic Ca(2+) sensitivity through phospholipase A(2) in bovine tracheal smooth muscle. |
| PubMed:New pyridinium alkaloids from a marine sponge of the genus Spongia with a human phospholipase A(2) inhibitor profile. |
| PubMed:Simultaneous inhibition of renal phospholipase A(2) and glutathione synthesis by manoalide and DL-buthionine sulfoximine induces acute tubular dysfunction in rats. |
| PubMed:Phospholipase A2 is involved in chemotaxis of human leukocytes. |
| PubMed:Activation of cPLA2 in vascular smooth muscle. |
| PubMed:An 18.5 kDa protein from the amebocyte of Limulus polyphemus, homologous to the previously described amebocyte aggregation factor, expresses alternative phospholipase A2 activity. |
| PubMed:Formation of reactive oxygen species by the contracting diaphragm is PLA(2) dependent. |
| PubMed:Effect of manoalide on apoptosis induced by deprivation of growth factors in vascular endothelial cells. |
| PubMed:Effect of protein kinase C and phospholipase A2 inhibitors on the impaired ability of human diabetic platelets to cause vasodilation. |
| PubMed:Role of prostaglandin H synthase isoforms in murine ear edema induced by phorbol ester application on skin. |
| PubMed:Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. |
| PubMed:Involvement of phospholipase A2 activation in anthrax lethal toxin-induced cytotoxicity. |
| PubMed:Manoalide. |
| PubMed:Cyclosporin A, but not FK506, increases arachidonic acid release and inhibits proliferation of pituitary corticotrope tumor cells. |
| PubMed:Effects of petrosaspongiolide M, a novel phospholipase A2 inhibitor, on acute and chronic inflammation. |
| PubMed:Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A2. |
| PubMed:Phospholipase A2 is not responsible for lysophosphatidylcholine-induced damage in cardiomyocytes. |
| PubMed:Manoalide, a phospholipase A2 inhibitor, inhibits arachidonate incorporation and turnover in brain phospholipids of the awake rat. |
| PubMed:Calcium influx inhibition by steroids and analogs in C2C12 skeletal muscle cells. |
| PubMed:Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues. |
| PubMed:A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides. |
| PubMed:Effects of local anesthetics on acetylcholine-induced desensitization of guinea pig ileal longitudinal muscle. |
| PubMed:Role of protein kinase C alpha in endothelin-1 stimulation of cytosolic phospholipase A2 and arachidonic acid release in cultured cat iris sphincter smooth muscle cells. |
| PubMed:Paraquat-induced phosphatidylserine oxidation and apoptosis are independent of activation of PLA2. |
| PubMed:Petrosaspongiolides M-R: new potent and selective phospholipase A2 inhibitors from the New Caledonian marine sponge Petrosaspongia nigra. |
| PubMed:Norepinephrine stimulates arachidonic acid release from vascular smooth muscle via activation of cPLA2. |
| PubMed:Investigation on the effect of experimental phospholipase A2 inhibitors on the formyl-methionyl-leucyl-phenylalanine-stimulated chemotaxis of human leukocytes in vitro. |
| PubMed:Novel aspect on metal fume fever: zinc stimulates oxygen radical formation in human neutrophils. |
| PubMed:Intracellular Ca2+ homeostasis in trypomastigotes of Trypanosoma cruzi. |
| PubMed:A phospholipase A2-related snake venom (from Crotalus durissus terrificus) stimulates neuroendocrine and immune functions: determination of different sites of action. |
| PubMed:Purification and characterization of a catalytic domain of rat intestinal phospholipase B/lipase associated with brush border membranes. |
| PubMed:Endotoxin-induced macrophage gene expression depends on platelet-activating factor. |
| PubMed:Endothelin-1 stimulates the release of arachidonic acid and prostaglandins in cultured human ciliary muscle cells: activation of phospholipase A2. |
| PubMed:The mechanisms of compound 48/80-induced superoxide generation mediated by A-kinase in rat peritoneal mast cells. |
| PubMed:Protection against methoxyacetic-acid-induced spermatocyte apoptosis with calcium channel blockers in cultured rat seminiferous tubules: possible mechanisms. |
| PubMed:Inhibitors of phospholipase promote apoptosis of human endothelial cells. |
| PubMed:Upregulation of Na(+)-K(+)-2Cl- cotransporter activity in rat parotid acinar cells by muscarinic stimulation. |
| PubMed:Luffasterols A-C, 9,11-secosterols from the Palauan sponge Luffariella sp. |
| PubMed:Pharmacological targeting of signaling pathways in protein kinase C-stimulated superoxide generation in neutrophil-like HL-60 cells: effect of phorbol ester, arachidonic acid and inhibitors of kinase(s), phosphatase(s) and phospholipase A2. |
| PubMed:Regulation of intracellular pH by phospholipase A2 and protein kinase C upon neutrophil adhesion to solid substrata. |
| PubMed:Endothelin-1-evoked arachidonic acid release: a Ca(2+)-dependent pathway. |
| PubMed:The effects of the phospholipase A2 inhibitor, manoalide, on cartilage degradation, stromelysin expression, and synovial fluid cell count induced by intraarticular injection of human recombinant interleukin-1 alpha in the rabbit. |
| PubMed:Effect of manoalide on human 5-lipoxygenase activity. |
| PubMed:Involvement of secretory phospholipase A2 activity in the zymosan rat air pouch model of inflammation. |
| PubMed:Prostaglandin E2 production by endotoxin-stimulated alveolar macrophages is regulated by phospholipase C pathways. |
| PubMed:Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls. |
| PubMed:Possible involvement of endothelial leukotrienes in acetylcholine-induced contraction in rabbit coronary artery. |
| PubMed:The effects of two phospholipase A2 inhibitors on the neuromuscular blocking activities of homologous phospholipases A2 from the venom of Pseudechis australis, the Australian king brown snake. |
| PubMed:Regulation of prostaglandin H synthase 2 expression in human monocytes by the marine natural products manoalide and scalaradial. Novel effects independent of inhibition of lipid mediator production. |
| PubMed:Identification of two specific lysines responsible for the inhibition of phospholipase A2 by manoalide. |
| PubMed:Modulation of superoxide generation in in vivo lipopolysaccharide-primed rat alveolar macrophages by arachidonic acid and inhibitors of protein kinase C, phospholipase A2, protein serine-threonine phosphatase(s), protein tyrosine kinase(s) and phosphatase(s). |
| PubMed:Retinoic acid induced death of ovarian carcinoma cells correlates with c-myc stimulation. |
| PubMed:Chemical modification and inactivation of phospholipases A2 by a manoalide analogue. |
| PubMed:Endothelium-dependent contraction induced by acetylcholine in isolated rat renal arteries. |
| PubMed:Sodium orthovanadate increases phospholipase A2 activity in isolated rat fat pads: a role of phospholipase A2 in the vanadate-stimulated release of lipoprotein lipase activity. |
| PubMed:Cellular and topical in vivo inflammatory murine models in the evaluation of inhibitors of phospholipase A2. |
| PubMed:The endoperoxides/TxA2 analogue, U46619, inhibits human polymorphonuclear leukocyte function. |
| PubMed:Specificity of phospholipase D activation by cholecystokinin and phorbol myristate acetate but not by carbamylcholine and A23187 in rat pancreatic acini. |
| PubMed:Regulation of phospholipase A2 enzymes: selective inhibitors and their pharmacological potential. |
| PubMed:Mechanically induced calcium mobilization in cultured endothelial cells is dependent on actin and phospholipase. |
| PubMed:Biochemical and pharmacological comparison of a cytosolic, high molecular weight phospholipase A2, human synovial fluid phospholipase A2 and CoA-independent transacylase. |
| PubMed:Phospholipase A2 activation in cultured mouse hepatocytes exposed to tumor necrosis factor-alpha. |
| PubMed:Alpha 1-adrenoceptors in rat dorsal raphe neurons: regulation of two potassium conductances. |
| PubMed:Inactivation of bee venom phospholipase A2 by a sesquiterpene furanoic acid marine natural product. |
| PubMed:Rapid protein synthesis and turnover is involved in interleukin-1-induced relaxation of the rabbit isolated mesenteric artery. Analysis of the arachidonate cascade. |
| PubMed:Rapid induction of arachidonic acid release by monocyte chemotactic protein-1 and related chemokines. Role of Ca2+ influx, synergism with platelet-activating factor and significance for chemotaxis. |
| PubMed:Marine natural products. XXXII. Absolute configurations of C-4 of the manoalide family, biologically active sesterterpenes from the marine sponge Hyrtios erecta. |
| PubMed:An endothelium-dependent contraction in canine mesenteric artery caused by caffeine. |
| PubMed:Acyl transfer reactions associated with cis Golgi apparatus of rat liver. |
| PubMed:Modulation of superoxide generation in in vivo lipopolysaccharide-primed Kupffer cells by staurosporine, okadaic acid, manoalide, arachidonic acid, genistein and sodium orthovanadate. |
| PubMed:Initiation of RVD response in human platelets: mechanical-biochemical transduction involves pertussis-toxin-sensitive G protein and phospholipase A2. |
| PubMed:Phospholipase A2 activation influences the processing and secretion of the amyloid precursor protein. |
| PubMed:Regulation of CD11b/CD18 expression in human neutrophils by phospholipase A2. |
| PubMed:Involvement of phospholipase D in caerulein-induced phosphatidylcholine hydrolysis in rat pancreatic acini. |
| PubMed:Modulation of superoxide anion generation by manoalide, arachidonic acid and staurosporine in liver infiltrated neutrophils in a rat model of endotoxemia. |
| PubMed:Arachidonic acid, a growth signal in murine P815 mastocytoma cells. |
| PubMed:Molecular model of the interaction of bee venom phospholipase A2 with manoalide. |
| PubMed:Botulinum toxin inhibits arachidonic acid release associated with acetylcholine release from PC12 cells. |
| PubMed:A requirement for membrane-associated phospholipase A2 in platelet cytotoxicity activated by receptors for immunoglobulin G and complement. |
| PubMed:Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion. |
| PubMed:Luffariolides F and G, new manoalide derivatives from the Okinawan marine sponge Luffariella sp. |
| PubMed:Inhibition of phospholipase A2 purified from human herniated disc. |
| PubMed:The novel natural product YM-26567-1 [(+)-trans-4-(3-dodecanoyl-2,4,6- trihydroxyphenyl)-7-hydroxy-2-(4-hydroxyphenyl)chroman]: a competitive inhibitor of group II phospholipase A2. |
| PubMed:Phospholipase A2 inhibitors from marine organisms. |
| PubMed:Phospholipase activation during monocyte adherence and spreading. |
| PubMed:Phospholipase A2 inhibition by alkylbenzoylacrylic acids. |
| PubMed:Natural products. Sponges to wipe away pain. |
| PubMed:Four new antibacterial sesterterpenes from a marine sponge of the genus Luffariella. |
| PubMed:Agonist-sensitive and -insensitive intracellular Ca2+ pools. Separate Ca(2+)-releasing mechanisms revealed by manoalide and benzohydroquinone. |
| PubMed:Kinetic characterization of phospholipase A2 modified by manoalogue. |
| PubMed:Inhibition of venom phospholipases A2 by manoalide and manoalogue. Stoichiometry of incorporation. |
| PubMed:[Inhibitors for enzymes involving arachidonate cascade]. |
| PubMed:Antiflammin-2 (HDMNKVLDL) does not inhibit phospholipase A2 activities. |
| PubMed:AGN 190383, a novel phospholipase inhibitor with topical anti-inflammatory activity. |
| PubMed:Arachidonic acid is essential for IgG Fc receptor-mediated phagocytosis by human monocytes. |
| PubMed:Purification and characterization of a soluble phospholipase A2 from guinea pig lung. |
| PubMed:Inhibition by manoalide of fMLP-stimulated elastase release from human neutrophils. |
| PubMed:Inactivation of human synovial fluid phospholipase A2 by the marine natural product, manoalide. |
| PubMed:Macrophage phospholipase A2 activity and eicosanoid production: studies with phospholipase A2 inhibitors in P388D1 cells. |
| PubMed:Manoalide: structure-activity studies and definition of the pharmacophore for phospholipase A2 inactivation. |
| PubMed:Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. |
| PubMed:Luffolide, a novel anti-inflammatory terpene from the sponge Luffariella sp.. |
| PubMed:Platelet-activating factor-induced phosphoinositide metabolism in differentiated U-937 cells in culture. |
| PubMed:[Manoalide: a new phospholipase A2 inhibitor of marine origin with potential immunoregulatory effect]. |
| PubMed:Inactivation of phospholipase A2 by manoalide. Localization of the manoalide binding site on bee venom phospholipase A2. |
| PubMed:Preferential inhibition of 5-lipoxygenase activity by manoalide. |
| PubMed:Purification and characterization of a lysophospholipase from a macrophage-like cell line P388D1. |
| PubMed:Solubilization, purification, and characterization of a membrane-bound phospholipase A2 from the P388D1 macrophage-like cell line. |
| PubMed:Regulation of eicosanoid biosynthesis in vitro and in vivo by the marine natural product manoalide: a potent inactivator of venom phospholipases. |
| PubMed:Inhibition of platelet aggregation by manoalide: preliminary results. |
| PubMed:The inhibition of release of endothelium-derived relaxant factor by manoalide, a potent inhibitor of phospholipase A2. |
| PubMed:Inhibition of phosphoinositide-specific phospholipase C by manoalide. |
| PubMed:Inactivation of bee venom phospholipase A2 by manoalide. A model based on the reactivity of manoalide with amino acids and peptide sequences. |
| PubMed:Manoalide, a natural sesterterpenoid that inhibits calcium channels. |
| PubMed:Differential effects of manoalide on secreted and intracellular phospholipases. |
| PubMed:The inhibition of phospholipase A2 by manoalide and manoalide analogues. |
| PubMed:The role of polyphosphoinositides and their breakdown products in A23187-induced release of arachidonic acid from rabbit polymorphonuclear leucocytes. |
| PubMed:Molecular pharmacology of manoalide. Inactivation of bee venom phospholipase A2. |
| PubMed:Cobra venom phospholipase A2 inhibition by manoalide. A novel type of phospholipase inhibitor. |
| PubMed:In vitro inactivation of the neurotoxic action of beta-bungarotoxin by the marine natural product, manoalide. |
3D/inchi