EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

halazuchrome B
valtrate

Supplier Sponsors

Name:[(1S,6S,7R,7aS)-4-(acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate
CAS Number: 18296-44-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:242-174-2
FDA UNII: L3JQ035X9B
Nikkaji Web:J14.326J
XlogP3-AA:1.80 (est)
Molecular Weight:422.47470000
Formula:C22 H30 O8
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 8.463 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Valtrate 98%
BOC Sciences
For experimental / research use only.
Valtrate >98%
Odor: characteristic
Use: Valtrate is a natural iridoid compound isolated from the roots of Valeriana officinalis L. Valtrate is a new class of cytotoxic and antitumor agent. Valtrate may also have a potential anxiolytic effect on the psychic symptoms of anxiety. antitumor
Santa Cruz Biotechnology
For experimental / research use only.
Valtrate
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for halazuchrome B usage levels up to:
 not for fragrance use.
 
Recommendation for halazuchrome B flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :442436
National Institute of Allergy and Infectious Diseases:Data
[(1S,6S,7R,7aS)-4-(acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate
Chemidplus:0018296441
 
References:
 [(1S,6S,7R,7aS)-4-(acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):442436
Pubchem (cas):18296-44-1
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C09801
HMDB (The Human Metabolome Database):HMDB34493
FooDB:FDB012986
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 radix valerianae mexicanae
Search Trop Picture
 
Synonyms:
4-acetoxymethyl-1,6,7,7a-tetrahydro-1,6-bis(isovaleryloxy)cyclopenta(c)pyran-7-spiro-2'-oxiran
[(1S,6S,7R,7aS)-4-(acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate
 baldrisedon
1,7a-dihydro-1,6-dihydroxyspiro(cyclopenta(c)pyran-7-(6H),2'-oxirane)-4-methanol 4-acetate 1,6-diisovalerate
 valepotriate
 valtrate
 valtratum
 

Articles:

PubMed:Flexible and powerful strategy for qualitative and quantitative analysis of valepotriates in Valeriana jatamansi Jones using high-performance liquid chromatography with linear ion trap Orbitrap mass spectrometry.
PubMed:Three minor valepotriate isomers from Valeriana jatamansi and their cytotoxicity.
PubMed:Mass spectrometric profiling of valepotriates possessing various acyloxy groups from Valeriana jatamansi.
PubMed:Development of a LC-MS-MS Method for Quantification of Valtrate and Its Application to Pharmacokinetic Study.
PubMed:Nucleo-cytoplasmic transport as a therapeutic target of cancer.
PubMed:The anxiolytic effects of valtrate in rats involves changes of corticosterone levels.
PubMed:[Mass spectrum characterization of five valepotriates by electrospray ionization tandem mass spectrometry].
PubMed:Valeriana jatamansi constituent IVHD-valtrate as a novel therapeutic agent to human ovarian cancer: in vitro and in vivo activities and mechanisms.
PubMed:Nuclear export of proteins and drug resistance in cancer.
PubMed:Effect of storage time and conditions on the diene valepotriates content of the extract of Valeriana glechomifolia obtained by supercritical carbon dioxide.
PubMed:In vitro effect of valepotriates isolated from Valeriana glechomifolia on rat P-type ATPases.
PubMed:Controlling protein transport by small molecules.
PubMed:Anti-influenza viral effects of novel nuclear export inhibitors from Valerianae Radix and Alpinia galanga.
PubMed:Concise synthesis of 5,6-dihydrovaltrate leading to enhanced Rev-export inhibitory congener.
PubMed:Bioisostere of valtrate, anti-HIV principle by inhibition for nuclear export of Rev.
PubMed:[Study on quality specification of Rhizoma et Radix Valeriana Jatamansi].
PubMed:Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia(1).
PubMed:A new iridoid tetraester from Valeriana jatamansi.
PubMed:Preserved pharmacological activity of hepatocytes-treated extracts of valerian and St. John's wort.
PubMed:Control of development and valepotriate production by auxins in micropropagated Valeriana glechomifolia.
PubMed:New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix.
PubMed:Effect of valerian, Valeriana edulis, on sleep difficulties in children with intellectual deficits: randomised trial.
PubMed:Quantitative determination of valepotriates from Valeriana native to South Brazil.
PubMed:Comparative study of differentiation levels and valepotriate content of in vitro cultures and regenerated and wild plants of Valeriana edulis ssp.procera.
PubMed:Cytotoxic potential of valerian constituents and valerian tinctures.
PubMed:Production of valepotriates by hairy root cultures of Centranthus ruber DC.
PubMed:Effect of valepotriates on the behavior of rats in the elevated plus-maze during diazepam withdrawal.
PubMed:Effects of a prolonged administration of valepotriates in rats on the mothers and their offspring.
PubMed:High-yield production of valepotriates by hairy root cultures of Valeriana officnalis L. var. sambucifolia Mikan.
PubMed:Valerian-derived sedative agents. I. On the structure and spectral assignment of the constituents of valmane using the selective INEPT nuclear magnetic resonance technique.
PubMed:Effects of thiol compounds versus the cytotoxicity of valepotriates on cultured hepatoma cells.
PubMed:Bacterial mutagenicity of the tranquilizing constituents of Valerianaceae roots.
PubMed:In vitro mutagenicity of valepotriates.
PubMed:The Structure of New Valepotriates from Tissue Cultures of Valeriana wallichii.
PubMed:Influence of valtrate/isovaltrate on the hematopoiesis and metabolic liver activity in mice in vivo.
PubMed:[In vivo effect of valtrate/isovaltrate on bone marrow cells and the metabolic activity of the liver in mice].
PubMed:[The effects of valtrate on the EEG of the isolated, perfused rat brain].
PubMed:[Effect of valeprotriate on spontaneous motor activity in mice].
PubMed:Valepotriate content in different in vitro cultures of Valerianaceae and characterization of Valeriana officinalis L. callus during a growth period.
PubMed:Antispasmodic effects of valeriana compounds: an in-vivo and in-vitro study on the guinea-pig ileum.
PubMed:Separation of valtrate and isovaltrate by means of preparative liquid chromatography.
PubMed:HPCL Separation and quantitative determination of valepotriates from Valeriana kilimandascharica.
PubMed:[Autonomic disorders in general practice. Possibilities of drug therapy with Baldrisedon].
PubMed:[Pharmacological studies of Centranthus ruber].
PubMed:[Determination of valtrate in drugs].
 
Notes:
Constit. of Valeriana spp.
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